Reza Zandi Shafagh

Reza Zandi Shafagh
Karolinska Institutet | KI · Department of Physiology and Pharmacology

PhD in Micro and Nanosystems

About

24
Publications
4,507
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
321
Citations
Introduction
Reza Zandi Shafagh currently works at the Department of Physiology and Pharmacology, Karolinska Institutet.

Publications

Publications (24)
Article
Full-text available
The number of successful drug development projects has been stagnant for decades despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target identification and poor translatability of preclinical models have been identified as major causes of failure. To improve predictions of clinical efficacy and safety, interest...
Article
Full-text available
Obesity and type 2 diabetes are strongly associated with adipose tissue dysfunction and impaired adipogenesis. Understanding the molecular underpinnings that control adipogenesis is thus of fundamental importance for the development of novel therapeutics against metabolic disorders. However, translational approaches are hampered as current models d...
Article
Full-text available
The liver plays a central role in glucose homeostasis and hepatic insulin resistance constitutes a key feature of type 2 diabetes. However, platforms that accurately mimic human hepatic glucose disposition and allow for rapid and scalable quantification of glucose consumption dynamics are lacking. Here, we developed and optimized a colorimetric glu...
Article
Full-text available
High-aspect-ratio and hierarchically nanostructured surfaces are common in nature. Synthetic variants are of interest for their specific chemical, mechanic, electric, photonic, or biologic properties but are cumbersome in fabrication or suffer from structural collapse. Here, we replicated and directly biofunctionalized robust, large-area, and high-...
Article
Despite extensive breakthroughs in chemistry, molecular biology and genetics in the last decades the success rates of drug development projects remain low. To improve predictions of clinical efficacy and safety of new compounds a plethora of 3D culture methods of human cells have been developed in which the cultured cells retain physiologically and...
Article
Full-text available
Simultaneous microstructuring and surface modification of microfluidic bioreactors Researchers from Sweden and Belgium have developed a simplified technique to create microfluidic devices with patterns of modified surface properties. Microfluidic devices, such as the one demonstrated here by a team led by Wouter van der Wijngaart, from KTH Royal In...
Article
Full-text available
Recent research has shown that the maintenance of relevant liver functions ex vivo requires models in which the cells exhibit an in vivo‐like phenotype, often achieved by reconstitution of appropriate cellular interactions. Multiple different models have been presented that differ in the cells utilized, media and culture conditions. Furthermore, se...
Article
Electron beam lithography (EBL) is of major importance for ultraminiaturized bio- hybrid system fabrication, as it allows combining biomolecular patterning and mechan- ical structure denition on the nanoscale. Existing methods are limited by multi-step biomolecule immobilization procedures, harsh processing conditions that are harmful to sensitive...
Article
Full-text available
Quartz crystal microbalance (QCM) sensing is an established technique commonly used in laboratory based life-science applications. However, the relatively complex, multi-part design and multi-step fabrication and assembly of state-of-the-art QCM cartridges make them unsuited for disposable applications such as point-of-care (PoC) diagnostics. In th...
Article
This Letter reports the electro-optical (EO) effect of Poly(3-hexylthiophene-2,5-diyl) (P3HT) nanofibers colloid in a polymer micro-fluidic EO cell. P3HT nanofibers are high aspect ratio semiconducting nanostructures, and can be collectively aligned by an external alternating electric field. Optical transmission modulated by the electric field is a...
Article
Bead-based microwell array technology is growing as an ultrasensitive target detection tool. However, dissemination of the technology and its commercial use are hampered by current fabrication methods for hydrophilic-in-hydrophobic microwell arrays, which are either expensive or labour-intensive to manufacture, or which results in low bead seeding...
Article
Full-text available
This paper demonstrates flexible and stretchable microneedle patches that combine soft and flexible base substrates with hard and sharp stainless steel microneedles. An elastomeric polymer base enables conformal contact between the microneedle patch and the complex topography and texture of the underlying skin, while robust and sharp stainless stee...
Data
Details of the mold insert for the base substrate of microneedle patch type B. (DOCX)
Data
Details of setup for measuring needle detachment force. (DOCX)
Data
Illustrations of the mold insert. (TIF)
Data
Illustration of the bond test equipment (Dage PC2400, Nordson DAGE, UK) and the setup for measuring the detachment force between the base substrate and the microneedles. To fasten the microneedle patch, a holder with 500 μm diameter holes and a pitch of 2 mm (identical to the pitch of the microneedle array) was fabricated. A stripe with one row of...
Article
Full-text available
In this article, we present OSTE+RIM, a novel reaction injection molding (RIM) process that combines the merits of off-stoichiometric thiol–ene epoxy (OSTE+) thermosetting polymers with the fabrication of high quality microstructured parts. The process relies on the dual polymerization reactions of OSTE+ polymers, where the first curing step is use...
Article
Full-text available
We present a novel integration method for packaging silicon photonic sensors with polymer microfluidics, designed to be suitable for wafer-level production methods. The method addresses the previously unmet manufacturing challenges of matching the microfluidic footprint area to that of the photonics, and of robust bonding of microfluidic layers to...
Conference Paper
Full-text available
We demonstrate a method for the fast and simple packaging of silicon sensors into a microfluidic package consisting of the recently introduced OSTE polymer. The microfluidic layer is first microstructured and thereafter dry-bonded to a silicon photonic sensor, in a process compatible with wafer-level production, and with the entire packaging proces...
Conference Paper
Full-text available
We propose and demonstrate a novel one step method to integrate gold coated sensors with cartridges by dry covalent bonding. The cartridges are replica molded in an UV-curable off-stoichiometry thiol-ene (OSTE) polymer, featuring an excess of thiol functional groups that covalently bond to the surface of gold coated sensors upon contact. The method...

Network

Cited By

Projects

Projects (5)
Project
Here is our oste and oste+ work collected. The focus is on materials characterization, surface modification, micromachining and microfluidic devices.
Project
A porous silicon-based lab-on-a-chip for diagnosis of food allergies