Reza Shahhosseini

Metastatic disease and cancer recurrence are the primary causes of cancer-related deaths. Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are the driving forces behind the spread of cancer cells. The emergence and development of liquid biopsy using rare CTCs as a minimally invasive strategy for early-stage tumor detection and imp...

The heterogeneity of the solid tumor microenvironment (TME) impairs the therapeutic efficacy of standard therapies and also reduces the infiltration of antitumor immune cells, all of which lead to tumor progression and invasion. In addition, self‐renewing cancer stem cells (CSCs) support tumor dormancy, drug resistance, and recurrence, all of which...

Plant-derived immunomodulators and antitumor factors have appealed lots of attention from natural product scientists for their efficiency and safety and their important contribution to well-designed targeted drug action and delivery mechanisms. Zerumbone (ZER), the chief component of Zingiber zerumbet rhizomes, has been examined for its wide-spectr...

Introduction: Primary Central Nervous System Lymphoma (PCNSL) is a rare malignancy primarily located in the brain, spinal cord, leptomeninges, and eyes. The origin of PCNSL is uncertain, but it is thought to arise from lymphocytes within the central nervous system. Diagnosis and treatment can be complex, especially in immunocompetent patients. Case...

Immunotherapies using immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T-cell therapy have achieved successful results against several types of human tumors, particularly hematological malignancies. However, their clinical results for the treatment of solid tumors remain poor and unsatisfactory. The immunosuppressive tumor mi...