Reza A. Badian

Oslo University Hospital

The study investigated the seasonal variations of presenting symptoms and signs of dry eye disease (DED) in Norway. 652 consecutive DED patients examined between August 2012 and May 2015 in Oslo, Norway, were included. Presenting symptoms and signs were related to the season according to when each patient was examined. Weather report data from the...

In the present study, the relationship between dry eyes and dry mouth was explored in 150 65-year-old subjects randomly selected from the general population in Oslo, Norway. The number of drugs, including xerogenic drugs, and current and previous systemic diseases were recorded. Ocular parameters recorded were the McMonnies Dry Eye Questionnaire, t...

Analyses of meibography may help in the diagnosis, prevention, and management of meibomian gland dysfunction (MGD). However, there is currently a paucity of data regarding meibography analyses in the young elderly populations in the Nordic countries. In the current study, meibography of the upper and lower eyelids of 117 65-year-old residents in Os...

To investigate the prevalence of meibomian gland dysfunction (MGD) in patients presenting with subjective dry eye-related symptoms at their first-time consultation in a Norwegian specialized ocular surface clinic. Additionally, to explore the accuracy of the ocular surface disease index score (OSDI) as an extensively applied tool to assess the seve...

In vivo confocal microscopy (IVCM) is a non-invasive imaging technique facilitating real-time acquisition of images from the live cornea and its layers with high resolution (1-2 µm) and high magnification (600 to 800-fold). IVCM is extensively used to examine the cornea at a cellular level, including the subbasal nerve plexus (SBNP). IVCM of the co...

Patients undergoing intensity-modulated radiotherapy (IMRT) for head and neck cancer may have increased incidence of dry eye disease and the exact mechanism is unclear. The present study aims to assess tear film and meibomian gland (MG) features in patients who received IMRT for head and neck cancer not involving the orbital area. Twenty-seven pati...

Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease (DED). In this study, we aimed to compare the effects of eyelid warming treatment using either TheraPearl Eye Mask (Bausch & Lomb Inc., New York, USA) or Blephasteam (Spectrum Thea Pharmaceuticals LTD, Macclesfield, UK) in a Norwegian population with mild to moderate MGD-...

Purpose To describe the pattern of the nerves in the inferocentral whorl region of the human corneal subbasal nerve plexus (SBNP) in health and diseases known to affect the subbasal nerves. Methods Laser-scanning in vivo confocal microscopy (IVCM) was used to image the SBNP bilaterally in 91 healthy subjects, 39 subjects with type 2 diabetes melli...

Small fiber neuropathy (SFN) has been suggested as a trigger of restless legs syndrome (RLS). An increased prevalence of peripheral neuropathy has been demonstrated in Parkinson’s disease (PD). We aimed to investigate, in a cross-sectional manner, whether SFN is overrepresented in PD patients with concurrent RLS relative to PD patients without RLS,...

Purpose To investigate sex and age differences in symptoms and signs in a Norwegian clinic-based cohort of patients with dry eye disease (DED). Methods Visitors at the Norwegian Dry Eye Clinic were examined using Ocular Surface Disease Index (OSDI) questionnaire score, tear osmolarity, tear break-up time (TFBUT), ocular surface staining, corneal s...

In vivo confocal microscopy (IVCM) imaging of the corneal subbasal nerve plexus (SBNP) is a clinical imaging modality gaining popularity for the diagnosis and follow-up of corneal neuropathy in various conditions such as diabetes mellitus. There remain, however, major limitations to the method, hindering its widespread clinical use. Finding the sam...

Purpose: To investigate corneal sublayer alterations during the postoperative period after small-incision lenticule extraction (SMILE). Setting: Synslaser clinic, Oslo, Norway. Study design: Retrospective. Methods: The right eyes of 51 patients who underwent SMILE for treating myopia were included. The thicknesses of the corneal epithelium,...

Type 2 diabetes mellitus is characterized by a low-grade inflammation; however, mechanisms leading to this inflammation in specific tissues are not well understood. The eye can be affected by diabetes; thus, we hypothesized that inflammatory changes in the eye may parallel the inflammation that develops with diabetes. Here, we developed a non-invas...

Type 2 diabetes mellitus is characterized by a low-grade inflammation; however, mechanisms leading to this inflammation in specific tissues are not well understood. The eye can be affected by diabetes; thus, we hypothesized that inflammatory changes in the eye may parallel the inflammation that develops with diabetes. Here, we developed a non-invas...

Introduction: Integrating person-centered values with randomized controlled trials methodology is a novel idea. Person-centeredness is gaining steadily more prominence and attention in healthcare and health-related policy and research. Randomized controlled trials are considered as the gold standard in evidence-based medicine for evaluating the eff...

A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnos...

Purpose: To determine if corneal subbasal nerve plexus (SBP) parameters derived from wide-area depth-corrected mosaic images are associated with type 2 diabetes. Methods: One hundred sixty-three mosaics were produced from eyes of 82 subjects by laser-scanning in vivo confocal microscopy (IVCM). Subjects were of the same age, without (43 subjects...

Purpose: To quantify and compare mature dendritic cells (mDCs), immature dendritic cells (imDCs) and globular cells (GCs) in the sub-basal layer of the central cornea in healthy and Type 2 diabetes mellitus (T2DM) patients, using IVCM obtained large-area mosaic images. Methods: 82 subjects, including healthy and T2DM patients were included in the...

Transplantation of cultured oral mucosal epithelial cells (OMECs) is a promising treatment strategy for limbal stem cell deficiency. In order to improve the culture method, we investigated the effects of four culture media and tissue harvesting sites on explant attachment, growth, and phenotype of OMECs cultured from Sprague-Dawley rats. Neither ch...

Purpose To investigate whether pollen counts are associated with severity of symptoms and signs of dry eye disease (DED) in Oslo, Norway. Methods The mean daily number of birch or grass pollen grains per cubic meter of air (pollen count) in Oslo from 2012 to 2015 between March and September were provided by The Norwegian University of Science and...

Purpose: Very little is known about the subbasal nerve plexus architecture and density over a wide field of view in type 2 diabetes. We therefore performed a cross-sectional observational study to examine qualitative plexus changes and subbasal nerve density in type 2 diabetes relative to an age- and sex-matched healthy control group. Methods: Las...

Purpose: To quantify and examine the distribution of inflammatory dendritic cells (DCs) in large-area mosaic images of the cornea obtained by In Vivo Confocal Microscopy (IVCM). Methods: 82 subjects were included in the study. Using laser-scanning in vivo confocal microscopy (Hidelberg HRT 3 with Rostck corneal module), the central cornea in both...

Purpose: To assess the effect of dry eye disease (DED) treatment according to the guidelines reported by the International Dry Eye WorkShop (DEWS) in 2007. Methods: Dry eye disease patients with or without meibomian gland dysfunction (MGD), treated at the Norwegian Dry Eye Clinic, with at least 6 months follow-up time were consecutively included in...

To evaluate the relationship between age and signs and symptoms of dry eye disease (DED) in a Norwegian cohort of patients with DED

To investigate the parameters that characterize the patients that responds or do not respond to dry eye disease (DED) therapy as recommended by the International Dry Eye WorkShop 2007.

To evaluate the relationship between osmolarity and signs and symptoms of dry eye disease (DED) in a Norwegian cohort of patients with DED.

To investigate the seasonal variations of presenting symptoms and signs of dry eye disease (DED) in Norway

Purpose: To quantify corneal sub-basal nerve and inflammatory cell density from large-area corneal mosaics in order to evaluate the possible differences between right and left eye and to compare the results of manual versus automated analysis. Methods: Using laser-scanning in vivo confocal microscopy, the central cornea of 83 subjects (166 eyes) w...

Purpose: To evaluate the preliminary effects of treatment of dry eye disease at one year follow-up according to the guidelines given by the Tear Film and Ocular Surface Society (The International Dry Eye Workshop (2007). Methods: All patients received an extensive ophthalmological work-up including screening for subjective symptoms, conjunctival...

Purpose To assess if the ocular surface disease index (OSDI) and McMonnie’s self-report questionnaires can be used as predictive tests for obtaining pathological Schirmer I, tear film break-up time (TFBUT) and ocular protection index (OPI) scores in a Norwegian cohort of dry eye disease (DED) patients.Methods Two hundred and fifty-two patients with...

Purpose To assess symptoms and signs in a Norwegian cohort of dry eye disease (DED) patients by investigating the relationship between Ocular Protection Index (OPI) and Ocular Surface Index (OSDI).Methods DED patients of mixed etiologies were consecutively included in the study and defined as OPIhigh (OPI ≥ 1) or OPIlow (OPI < 1). All patients rece...