Rex Jeya Rajkumar .S

Walter Reed Army Institute of Research | WRAIR

Although there is growing evidence that cellular senescence influences wound healing, a clear understanding of how senescence can be beneficial and/or detrimental to wound healing is unknown. Wound healing may also be influenced by the baseline tissue senescence, which is elevated in aging and chronic wounds, both of which have significant healing...

Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease. How a cell transitions to a senescent state is multifactorial and often requires transcriptional regulation of multiple genes. Epigenetic alterations to DNA a...

Society and our healthcare system are facing unprecedented challenges due to the expansion of the older population. As plastic surgeons, we can improve care of our older patients through understanding the mechanisms of aging that inevitably impact their outcomes and well-being. One of the major hallmarks of aging, cellular senescence, has recently...

Two new self-adjustable acyclic diiminodipyrromethane Schiff‘s bases of composition [(Ph)(CH3)C(2,6-ⁱPr2C6H3-N = CH-C4H2NH)2] (L1) and [(Ph)(CH3)C(Ph3C-N = CH-C4H2NH)2] (L2) their zinc complexes of chemical composition [Zn{(Ph)(CH3)C(2,6-ⁱPr2C6H3-N = CH-C4H2N)(2,6-ⁱPr2C6H3-N = CH-C4H2NH)}2] (1) and [ZnCl2{(Ph)(CH3)C(Ph3C-NH = CH-C4H2N)2}] (2) are s...

Cellular senescence has been found to have beneficial roles in development, tissue regeneration, and wound healing. However, in aging senescence increases, and the ability to properly repair and heal wounds significantly declines across multiple tissues. This age-related accumulation of senescent cells may cause loss of tissue homeostasis leading t...

Four Ru(II) carbonyl complexes of 4-oxo-4H-chromene-3-carbaldehyde thiosemicarbazones (C1-C4) were synthesized and characterized through spectroscopic techniques. The coordination behaviour of the ligands to the metal ion was confirmed by solving the single crystal X-ray structure of a representative complex C4, in which the ligand showed coordinat...

Palmyra Palm (Borassus flabellifer Linn) is a native tree with various ecological, medicinal, economic, and sociological benefits from Asian countries. Palmyra Palm tree-based self-reliant lifestyle and Eco-friendly community living which leads to sustainable development can be called as palmyraculture. For each component, it is the most beneficial...

The present work deals with the synthesis and characterization of four Co(III) complexes derived from 7-hydroxy-4-oxo-4H-chromene-3-carbaldehyde-4(N)-substituted thiosemicarbazones. Structural confirmation of the complexes 2 and 3 were aided by X-ray crystallographic analysis, which revealed the coordination of azomethine nitrogen, ring carbonyl ox...

In this article, we report Mn(II), Fe(II) and Cu(I) complexes (BIP-Mn, BIP-Fe and BIP-Cu) bearing a non-innocent, NNN pincer ligand, 4-aminoantipyrine tethered 2,6-bis(iminoantipyrine)pyridine (BIP) and structural diversity. The complexes were characterized by different spectroscopic and single-crystal X-ray analysis. Superoxide dismutase (SOD) act...

This is the first study to evaluate the topical application of Lobelia alsinoides Lam (LT) ethanolic extract on burns in rats. A deep third‐degree burn wound was inflicted in adult male Wistar rats and the burns were dressed daily with a topical ointment formulation (Patent filed) comprising of Lobelia alsinoides Lam (5% and 10% w/w). The wound had...

This is the first study to report the green synthesis of Lobelia trigona Roxb-mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet-visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X-ray....

Four binuclear Ni(II) complexes [[Ni2(H-DEAsal-tsc)2(μ-dppm)]·2Cl (1), [Ni2(DEAsal-mtsc)2(μ-dppm)] (2), [Ni2(DEAsal-etsc)2(μ-dppm)] (3) and [Ni2(DEAsal-ptsc)2(μ-dppm)] (4)] were synthesized from the ligands namely 4(N,N)-diethylaminosalicylaldehyde-4(N)-thiosemicarbazone [H2-DEAsal-tsc] H2L¹/4(N,N)-diethylaminosalicylaldehyde-4(N)-methyl thiosemica...

In this work, a series of 2-(1H-benzo[d]thiazole-2-yl)-N-arylbenzamides is synthesized by using diethyl phthalate, anilines and 2-amino-benzenethiol by one-pot three component synthesis in glycerol medium. Phosphoric acid is used as an effective reagent for this one-pot three component reaction. This reaction got completed in a short time, easy wor...

Titanium(IV)-complex of chemical composition [{(NNO)2Ti}3O3] (2) bearing bidentate heteroditopic Schiff base [(C5H4OH)-N=CH-C4H3-NH] (L1) ligand in titanium coordination sphere was reported and its biological significance was evaluated. The in vitro cytotoxicity of L1 and 2 were evaluated by using MTT assay on cancer cell lines (MCF-7 & A549) and o...

This paper fortifies the idea of smart drug vehicles, by exploring nickel ferrite nanoparticles. The material is made smart by covering with a novel biocompatible dextran fastened with a hydrophobic cavity containing molecule, β-cyclodextrin (β-CD). The approximately 6 nm MNPs, embodied with the β-CD-dextran conjugate, permit a sustained in vitro r...

7-Hydroxy-4-oxo-4H-chromene Schiff bases and their corresponding water soluble copper(II) complexes were synthesized and characterized by various spectral techniques. The structural confirmation of the complexes 2 and 3 has been provided by X-ray crystallographic analysis. The binding affinities of the ligands and complexes with Calf Thymus DNA (CT...

This study investigated the wound healing properties of the aqueous extract of Morinda tinctoria Roxb leaves in rats. The study also provides information on the purification, qualitative, and quantitative analysis of phytochemical components present in M. tinctoria Roxb. Wound contraction and period of epithelialization was determined and topical a...

Four different mononuclear palladium(II) complexes of 3‐acetyl‐8‐methoxycoumarin Schiff bases were synthesized and characterized by spectrochemical techniques. Further analysis through X‐ray crystallography confirmed the structures of the complexes. Their interactive ability with Calf Thymus DNA and protein (Bovine Serum Albumin and Human Serum Alb...

Magnetic ferrite nanoparticles (MNPs) coated with biocompatible polymers capable of drug loading and release are fascinating nanostructures for delivering anti-cancer drugs. Herein, we report the synthesis and characterization of a novel β-cyclodextrin-folate-tethered dextran polymer. Nickel–zinc ferrite nanoparticles are prepared and coated with t...

A pyrene scaffold bearing a phenol molecule has been designed and synthesized as a chemosensor L1 by an aldol type of condensation reaction. The sensor showed high sensitivity and selectivity for Al³⁺ ions by the enhancement of fluorescene intensity and distinguishes from the other potentially competing metal ions. The effect of pH, time and the re...

A series of 3-acetyl-8-methoxycoumarin appended thiosemicarbazones (1-4) was prepared from the reaction of 3-acetyl-8-methoxycoumarin with 4(N)-substituted thiosemicarbazides in a view of ascertaining their biological properties with the change of N-terminal substitution in the thiosemicarbazide moiety. Comprehensive characterization was brought ab...

A series of four new, cyclometallated ruthenium (II) complexes was synthesized from 3-acetyl-8-methoxy-2H-chromen-2-one functionalized 4(N)- substituted thiosemicarbazones and characterized through various spectral and analytical methods. The molecular structures of the complexes 1, 2 and 4 were determined by single-crystal X-ray diffraction analys...

New Schiff base ligands are prepared by the condensation of 7-hydroxy-3-formylchromone with semicarbazone and phenyl semicarbazone. The complexation of these ligands with Cu(II) ion is proposed in the light of spectral studies (IR, UV-Vis, 1H NMR, 13C NMR, Mass and ESR). In the complexes 1 and 2, the ligands coordinate to the Cu(II) ion in a neutra...

Wounds are the result of damages or injuries that disturb the normal structure of the skin tissue. Wound healing is a natural but a protracted and complex process of tissue repairing, regenerating, and remodelling in response to wounding injury. Various plant products have been used in the treatment of wounds over the years. Compounds that are deri...

New cyclometallated ruthenium(II) complexes of 3-acetyl-7-methoxycoumarin-4N-substituted thiosemicarbazones were synthesized and characterized by analytical and spectral techniques. The crystal structures of the ligands H2L1–3 and complexes (1, 2 and 4) were confirmed by X-ray crystallography. The analysis showed that the ligands have undergone C–H...

The presented work focuses on the synthesis and biological evaluation of 3-acetylcoumarin Schiff bases and their cyclometallated ruthenium( ii ) metallates.

Four new water soluble chromone appended copper(II) complexes of the type [Cu(L)Cl] were synthesized from CuCl2·2H2O and 3-formylchromone-4N-substituted thiosemicarbazones (HL1–HL4). Characterization of the compounds was done by using analytical and spectral techniques such as elemental analyses, IR, UV–Visible, EPR and Mass spectrometry, which con...

Nanosized manganese ferrite (MnFe2O4) particles were prepared by sol–gel method using natural polymers like wheat flour (WF) and potato flour (PF) as surfactants and its structural, morphological, optical and magnetic characteristics were studied by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), scanning electron microsco...

Nickel ferrite NiFe2O4 nanoparticles (NPs) were successfully synthesized by using nickel nitrate, ferric nitrate, citric acid, and ethyl cellulose as a surfactant by a simple sol–gel-assisted combustion method (SACM) and microwave-assisted combustion method (MACM). Structural, morphological, optical, and magnetic properties of the obtained powder w...

A wound is a type of injury which happens normally due to the torn, cut, or punctured and it can be easily cured manually. In case of diabetic foot ulcers they are slow, non-healing wounds that can persist for weeks. It can be treated with synthetic drugs which are available in the market. The herbal treatments can be used for treating the diabetic...

This is the first study to investigate the phytochemical constituents present in Lobelia trigona Roxb. The whole plant (Lobelia trigona Roxb) was used to extract phytochemicals using various solvents (ethanol, methanol, chloroform, petroleum ether, acetone and water) and the total yield of extracts were calculated and expressed as percentage dry we...