Reury F P Bacurau

• PhD
• Professor at University of São Paulo

Background: COVID-19 is a new disease that causes severe health problems and is responsible for significant complications even after recovery, including disabilities that lead to motor impairment. In this sense, there is currently no protocol for physical exercises for people with physical disabilities caused by the disease. Therefore, it is necess...

Background: Type 2 diabetes Mellitus (T2DM) is a chronic disease whose prevalence is increasing worldwide. It is characterized by insulin resistance in insulin-dependent tissues (e.g. skeletal muscle, adipose tissue). Despite new evidence that stretching may aid in glycemic control, this form of physical exercise remains underutilized in the therap...

O objetivo do presente trabalho foi avaliar a alteração nos hábitos alimentares de atletas brasileiros durante a pandemia do Coronavírus. Por meio de questionário online estruturado, 249 atletas com pelo menos 10 anos de prática e/ou pelo menos uma convocação pela seleção brasileira de sua respectiva modalidade, tiveram suas respostas analisadas. H...

This study aimed to describe and compare the pacing strategy and performance of world level under 19 (U19), under 23(U23) and senior single scullers during world championship races. Data are from 8 years of Rowing World Championships A and B finals of single scull races for U19, U23 and senior age scullers. Pacing was determined for velocity, strok...

Background: COPD, called Chronic Obstructive Non-transmitted Pulmonary Disease, is a disease that causes severe sequelae in the respiratory system, which in combination with other types of viruses such as covid-19 aggravates the disease, with major effects on the locomotor system due to saturation instabilities. The main victims of the disease are...

Purpose The present study included two related investigations that explored the acute and chronic effects of high-speed resistance training (HSRT) on blood pressure (BP) in older adults. Methods The first study involved a randomized crossover study that compared the acute effects of traditional resistance exercise (TRT) and high-speed resistance t...

The aim of the present study was to assess the effects of beta-alanine supplementation on muscle strength and thickness. Nineteen resistance-trained men (age: 27.3 ±5.5 years; height: 178 ±10 cm; body mass: 83.4 ±9.7 kg; training experience: 5.9 ±3.9 years) were allocated to one of the following groups: Beta-alanine (BA) (6.4 g/day of beta-alanine)...

Background: Patients with chronic kidney disease (CKD) often present with comorbidities like hypertension and diabetes. These conditions are often associated with loss of strength, which is a strong predictor of mortality. In this sense, it is reasonable to investigate genetic and physiological markers that could be related to strength and identify...

The aim of the present study was to evaluate the effects of 2 different intensities of resistance training (RT) bouts, performed with the equated total load lifted (TLL), on the acute responses of neurotrophic factors (NFs) (brain-derived neurotrophic factor [BDNF]; and nerve growth factor [NGF]), as well as on metabolic (lactate concentration) and...

O objetivo do presente estudo foi avaliar os efeitos da suplementação com o aminoácido arginina (ARG) sobre marcadores indiretos do dano muscular induzido pelo exercício (DMIE). Participaram do estudo 24 jovens universitários do sexo masculino com experiência mínima de 1 ano em treinamento de força. Os indivíduos foram randomizados em 2 grupos, em...

The understanding of fatigue development during Archery competition would guide sports scientists, coaches and athletes on how to optimize the training routines of athletes from different competitive levels. This study investigated the effect of expertise level on physiological responses, during simulated archery competition (double-round 70m, 12 s...

This study investigated whether naproxen has an ergogenic effect on neuromuscular performance. A randomized, double-blind, placebo-controlled, crossover trial was conducted on 11 resistance-trained men who performed one strength-training session after taking 500 mg of naproxen and another session after taking a placebo. Participants performed three...

Resistance training (RT) is performed at distinct levels of intensity from the beginning to the end of exercise sets, increasing the sensation of effort as the exercise progress to more vigorous levels, commonly leading to changes on the facial expression of RT practitioners. The objective of this study is to evaluate changes in facial expressions...

The present study aimed at investigating the effects of a daily undulating periodization (DUP) and non-periodized (NP) resistance training programs on hemodynamic parameters of older women. Forty-two older women were randomized into one of the three experimental groups: NP, DUP, and control group (CG). Evaluations of the hemodynamic parameters occu...

Introduction: Chronic kidney disease (CKD) is considered a significant world health problem with elevated mortality rates. Patients with CKD are restricted to mild physical activity, present chronic inflammatory state and loss of muscle strength. Currently, the influence of resistance exercise (RE) on the progression of renal disease has not being...

(1) Background: The present work aims to conduct a systematic review and meta-analysis of observational studies, in order to investigate the association of relative protein intake and physical function in older adults; (2) Methods: Observational studies, that investigated the association between protein intake and physical function in older adults,...

Patients with chronic kidney disease (CKD) have progressive renal fibrosis, inflammation, and reduced muscle mass and strength. Resistance training (RT) has been suggested to mitigate the loss of muscle mass, of strength and the inflammation in CKD, but the mechanisms are unknown. The aim of this study was to evaluate the influence of RT on renal f...

Background: Resistance training (RT) has been recommended as a non-pharmacological treatment for moderate hypertension. In spite of the important role of exercise intensity on training prescription, there is still no data regarding the effects of RT intensity on severe hypertension (SH). Objective: This study examined the effects of two RT proto...

Background: Physical exercise induces positive alterations in gene expression involved in the metabolism of obesity. Maternal exercise provokes adaptations soon after birth in the offspring. Here, we investigated whether adult mouse offspring of swim-trained mothers is protected against the development of the deleterious effects of high fat diet (...

Metabolic syndrome is a cluster of metabolic risk factors such as obesity, diabetes and car-diovascular diseases. Mitochondria is the main site of ATP production and its dysfunction leads to decreased oxidative phosphorylation, resulting in lipid accumulation and insulin resistance. Our group has demonstrated that kinins can modulate glucose and li...

AIM: To investigate a potential protective role of the kinin B2 receptor in a glycerol-induced rhabdomyolysis mouse model. METHODS: We separated 28 C57Bl/6 male mice into 4 groups: untreated WT animals, untreated B2 knockout mice, glycerol-treated WT and glycerol-treated B2 knockout mice. Glycerol-treated animals received one intramuscular injectio...

INTRODUÇÃO: A prática de exercícios de alongamento é muito comum como parte do aquecimento em diversas modalidades esportivas, porém, esta prática pode ser negativa para aqueles que desejam o aprimoramento da força e potência muscular, consequentemente, o rendimento dos saltos pode ficar reduzido após exercícios de alongamento, que depende do tempo...

Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1β and TNF-α). The kinin B2 receptor has been associated with t...

Glucose and glutamine are important energetic and biosynthetic nutrients for T and B lymphocytes. These cells consume both nutrients at high rates in a function-dependent manner. In other words, the pathways that control lymphocyte function and survival directly control the glucose and glutamine metabolic pathways. Therefore, lymphocytes in differe...

The purpose of this study was to compare the influence of measuring the overall session rating of perceived exertion (session-RPE) at 10 vs. 30 minutes following exercise. Eight boxers completed three different standardized training sessions of different intensities (easy, moderate and hard) in a matchedpairs, randomized research design. Exercise i...

Athletes engaged in strenuous training might experience transient immune suppression that could lead to greater incidence of upper respiratory tract infections (URTI). Since interleukin 21 (IL-21) stimulates immunoglobulin A (IgA) secreting cells and a low level of this immunoglobulin is associated with increased incidence of URTI, the aim of the p...

Although aging compromises the functionality of macrophages (MÈ) and lymphocytes (LY), and dietary restriction (DR) and exercise partially counterbalance immunosenes-cence, it is unknown what effects of both strategies have on the functionality of these immune cells. Rats were randomly distributed into adult control (AD), older group (OLD), older s...

Although aging compromises the functionality of macrophages (MΦ) and lymphocytes (LY), and dietary restriction (DR) and exercise partially counterbalance immunosenescence, it is unknown what effects of both strategies have on the functionality of these immune cells. Rats were randomly distributed into adult control (AD), older group (OLD), older su...

Arterial hypertension is a serious health problem affecting mainly the elderly population. Recent studies have considered both aerobic and resistance exercises as a non-pharmacological aid for arterial hypertension treatment. However, the cardiovascular responses of the elderly to isometric resistance exercise (eg, isometric handgrip [IHG]) have no...

In aged rats, insulin signaling pathway (ISP) is impaired in tissues that play a pivotal role in glucose homeostasis, such as liver, skeletal muscle, and adipose tissue. Moreover, the aging process is also associated with obesity and reduction in melatonin synthesis from the pineal gland and other organs. The aim of the present work was to evaluate...

Abstract There is a consensus in the scientific literature that supports the importance of the kallikrein kinin and renin angiotensin systems in renal physiology, but notably few studies have investigated their importance after renal transplantation. The aim of this study was to investigate the clinical effects of the insertion/deletion polymorphis...

There is a consensus in the scientific literature that supports the importance of the kallikrein kinin and renin angiotensin systems in renal physiology, but few studies have investigated their importance after renal transplantation. The aim of this study was to investi-gate the clinical effects of the insertion/deletion poly-morphism in the angiot...

As the size of adipocytes increases during obesity, the establishment of resident immune cells in adipose tissue becomes an important source of proinflammatory mediators. Exercise and caloric restriction are two important, nonpharmacological tools against body mass increase. To date, their effects on the immune cells of adipose tissue in obese orga...

Exercise modulates both glucose and glutamine metabolism which influences lymphocyte function. We investigated the influence of chronic moderate exercise on glucose and glutamine metabolism in lymphocytes, the associated influence on proliferation, and cytokine and immunoglobulin production. Male Wistar rats (8 weeks old) were placed in an exercise...

Objetivo: Analisar os efeitos da alteração na ordem habitual de execução de exercícios do treinamento de força sobre o dano muscular, número de repetições e dor muscular de início tardio (DMIT) em jovens adultos treinados. Métodos: Dez jovens adultos saudáveis com experiência mínima de 6 meses em treinamento de força para hipertrofia muscula...

The kallikrein–kinin system (KKS) has been previously linked to glucose homeostasis. In isolated muscle or fat cells, acute bradykinin (BK) stimulation was shown to improve insulin action and increase glucose uptake by promoting glucose transporter 4 translocation to plasma membrane. However, the role for BK in the pathophysiology of obesity and ty...

The kallikrein-kinin system (KKS) has been previously linked to glucose homeostasis. In isolated muscle or fat cells, acute bradykinin (BK) stimulation was shown to improve insulin action and increase glucose uptake by promoting glucose transporter 4 translocation to plasma membrane. However, the role for BK in the pathophysiology of obesity and ty...

The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins and des-Arg-kinins are the major effectors of this system and promote their effects by binding to two different receptors, the kinin B2 and B1 receptors, respectively. To understand the influe...

Mass of organs and tissues. (DOCX)

Primers sequences for qPCR. (DOCX)

We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is...

Resistive exercise (RE) may induce muscle damage and acute inflammatory response. A single bout of intense resistive exercise may induce transient immunosuppressive effect. However, the manner that the immune system will be challenged depends in great part of the characteristic of the training session. The aim of this investigation was to determine...

To investigate the antihypertensive effects of conventional resistance exercise (RE) on the blood pressure (BP) of hypertensive subjects, 15 middle-aged (46 ± 3 years) hypertensive volunteers, deprived of antihypertensive medication (reaching 153 ± 6/93 ± 2 mm Hg systolic/diastolic BP after a 6-week medication washout period) were submitted to a 12...

Post-exercise hypotension (PEH), the reduction of blood pressure (BP) after a single bout of exercise, is of great clinical relevance. As the magnitude of this phenomenon seems to be dependent on pre-exercise BP values and chronic exercise training in hypertensive individuals leads to BP reduction; PEH could be attenuated in this context. Therefore...

The present study compared the changes in markers of muscle damage after bouts of resistance exercise employing the Multiple-sets (MS) and Half-pyramid (HP) training systems. Ten healthy men (26.1±6.3 years), who had been involved in regular resistance training, performed MS and HP bouts, 14 days apart, in a randomised, counter-balanced manner. For...

The aim of the present study was to inves-tigate the immediate effects of static and proprioceptive neuromuscular facilitation (PNF) stretching on the flexibility of hip adductors in female ballet dancers. Forty-five subjects (age: 28.5 ± 8.0 years; minimum two years of ballet training) were randomly assigned to three groups: PNF (contract-release...

Intense physical training and dietary energy restriction have been associated with consequences such as nutritional amenorrhea. We investigated the effects of intense physical training, food restriction or the combination of both strategies on estrous cyclicity in female rats, and the relationship between leptin ad these effects. Twenty-seven femal...

The purpose of the present study was to compare the effect of different resistance training systems (Multiple-set [MS] and Pyramid [P]) on hormonal, metabolic and perceptual markers of internal load. Ten healthy men performed two resistance training sessions (MS and P) which consisted of three exercises (bench press, peck deck and decline bench pre...

This study aimed to investigate the effects of physical training, and different levels of protein intake in the diet, on the growth and nutritional status of growing rats. Newly-weaned Wistar rats (n=48) were distributed into six experimental groups; three of them were subjected to physical swim training (1 h per day, 5 d per week, for 4 wk, after...

Active lymphocytes (LY) and macrophages (MΦ) are involved in the pathophysiology of rheumatoid arthritis (RA). Due to its anti-inflammatory effect, physical exercise may be beneficial in RA by acting on the immune system (IS). Thus, female Wistar rats with type II collagen-induced arthritis (CIA) were submitted to swimming training (6 weeks, 5 days...

Angiotensin I-converting enzyme (ACE) is recognized as one of the main effector molecules involved in blood pressure regulation. In the last few years some polymorphisms of ACE such as the insertion/deletion (I/D) polymorphism have been described, but their physiologic relevance is poorly understood. In addition, few studies investigated if the spe...

In lymphocytes (LY), the well-documented antiproliferative effects of IFN-α are associated with inhibition of protein synthesis, decreased amino acid incorporation, and cell cycle arrest. However, the effects of this cytokine on the metabolism of glucose and glutamine in these cells have not been well investigated. Thus, mesenteric and spleen LY of...

This study assessed the effect of different resistance exercise scheme (RES) designs of similar total of load lifted on the responses of testosterone, cortisol, and creatine kinase (CK). Twenty-seven healthy males performed 1 of 4 bench press workouts described by the 1 repetition maximum (1RM) load: 4 sets of maximum repetitions at 50%-1RM (50%-1R...

The aims of the present study were to compare the effects of two periodization models on metabolic syndrome risk factors in obese adolescents and verify whether the angiotensin-converting enzyme (ACE) genotype is important in establishing these effects. A total of 32 postpuberty obese adolescents were submitted to aerobic training (AT) and resistan...

Leptin-deficient mice (Lep(ob)/Lep(ob), also known as ob/ob) are of great importance for studies of obesity, diabetes and other correlated pathologies. Thus, generation of animals carrying the Lep(ob) gene mutation as well as additional genomic modifications has been used to associate genes with metabolic diseases. However, the infertility of Lep(o...

Resistive exercise (RE) may induce muscle damage and acute inflammatory response. A single bout of intense resistive exercise may induce transient immunosuppressive effect. However, the manner that the immune system will be challenged depends in great part of the characteristic of the training session. The aim of this investigation was to determine...

Suplementos nutricionais, supostamente, capazes de potencializar a produção endógena de óxido nítrico (NO) têm experimentado crescente popularidade entre os indivíduos fisicamente ativos. Diante da carência de informações sobre o assunto, o objetivo do presente estudo foi avaliar o efeito de um suplemento comercial à base de proteínas e aminoácidos...

Suplementos nutricionais, supostamente, capazes de potencializar a produção endógena de óxido nítrico (NO) têm experimentado crescente popularidade entre os indivíduos fisicamente ativos. Diante da carência de informações sobre o assunto, o objetivo do presente estudo foi avaliar o efeito de um suplemento comercial à base de proteínas e aminoácidos...

Different stretching techni- ques have been used during warm-up routines. However, these routines may decrease force production. The purpose of this study was to compare the acute effect of a ballistic and a static stretching protocol on lower-limb maximal strength. Fourteen physically active women (169.3 6 8.2 cm; 64.9 6 5.9 kg; 23.1 6 3.6 years)...

OBJETIVO: O presente estudo avaliou o efeito do exercício de endurance (corrida) sobre o subseqüente desempenho de força de músculos dos membros superiores e do tronco. METODOLOGIA: A amostra foi composta por 13 universitárias, saudáveis e fisicamente ativas. A primeira fase do experimento consistiu na realização de um teste de corrida, simulando u...

AIM: the present study evaluated the effect of endurance exercise (running) on the subsequent strength performance of muscles of upper limbs and trunk. METHODOLOGY: Thirteen healthy female, university students, physically active were selected to compose the sample. The first phase of the experiment the subjects were submitted to an endurance exerci...

Kallikrein-kinin system exerts cardioprotective effects against pathological hypertrophy. These effects are modulated mainly via B2 receptor activation. Chronic physical exercise can induce physiological cardiac hypertrophy characterized by normal organization of cardiac structure. Therefore, the aim of this work was to verify the influence of kini...

Branched-chain amino acids (BCAA) supplementation is one of the most popular dietary manipulations used by endurance athletes. However, the ergogenic role of these amino acids in endurance exercise is not well established yet. Therefore, the aim of this study was to evaluate the effect of BCAA supplementation upon endurance exercise performed until...

Previous studies demonstrated a reduction in blood pressure level immediately after different types of exercises, like running, cycling and resistance training, a phenomenon called post-exercise hypotension (PEH). Since PEH can persist for hours it could be suggested as a non-pharmacological therapy for hypertensive individuals. Unfortunately, usua...

The aim of the present study was to evaluate the post-exercise blood pressure (BP) responses to two different methods of resistance exercise (RE, traditional multiple set and tri-set). Young adult men (n = 30, 19.6  0.7 years old; 76.0 ± 2.7 kg; 178.2 ± 6.7 cm; 90.5 ± 5.8 MBP) with six months of previous experience in RE were selected. The volunte...

Epidemiologic studies suggest that moderately intense training promotes augmented immune function, whereas strenuous exercise can cause immunosupression. Because the combat of cancer requires high immune function, high-intensity exercise could negatively affect the host organism; however, despite the epidemiologic data, there is a lack of experimen...

Post-exercise hypotension is an important event for blood pressure regulation, especially in hypertensive individuals. Although post-exercise hypotension is a well-known phenomenon, the mechanism responsible is still unclear. The kallikrein-kinin system is involved in blood pressure control, but its role in post-exercise hypotension has not yet bee...