Renjith Nair

Renjith Nair
Louisiana State University Health Sciences Center, Shreveport,United States. · Biochemistry and Molecular Biology

PhD

About

30
Publications
2,867
Reads
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164
Citations
Citations since 2017
16 Research Items
143 Citations
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2017201820192020202120222023010203040
2017201820192020202120222023010203040
Additional affiliations
January 2014 - April 2015
Sree Chitra Tirunal Institute for Medical Sciences and Technology
Position
  • PROJECT SCIENTIST
June 2008 - May 2014
Sree Chitra Tirunal Institute for Medical Sciences and Technology
Position
  • PhD Student

Publications

Publications (30)
Article
Three dimensional (3D) bioprinting technology has been making a progressive advancement in the field of tissue engineering to produce tissue constructs that mimic the shape, framework, and microenvironment of an organ. The technology has not only paved the way to organ development but has been widely studied for its application in drug and cosmetic...
Chapter
Blood compatibility is defined as the ability of a material to stay in contact with blood for a clinically relevant amount of time without altering the blood or blood components. This definition implies that all materials comes into contact with blood directly or indirectly. Here, we elaborate on the various factors that affect blood-material inter...
Chapter
Blood, a life-saving liquid organ, is a colloidal mixture of red blood cells, white blood cells, platelets, and plasma, which itself consists of several growth factors, proteins, immunoglobulins, clotting factors, minerals, and water. As a clinically relevant product, blood is widely used to treat several disease conditions. Currently, unlike earli...
Chapter
Blood components are a therapeutic choice for wound healing since 1980s and their applications are increasing day by day. The presence of growth factors, proteins, cytokines in blood plasma and in the granules of the blood cells makes blood-derived products a regenerative tool for various wound healing applications. However, short life span, stabil...
Article
Introduction: Biofabrication of skin tissue equivalents using 3D bioprinting technology has gained much attention in recent times due to the simplicity, the versatility of the technology and its ability in bioengineering biomimetic tissue histology. The key component being the bioink, several groups are actively working on the development of vario...
Article
Full-text available
Immunochromatographic assay kits are used in primary diagnostics which is based on the principle of antigen and antibody interaction. These kits play pivotal role in rapid surveillance of infectious diseases at early stages as well as for the surveillance of the contagious diseases. The immunochromatographic test kits lacks sensitivity and specific...
Article
Conjugation of quantum dots (Q-dots) into tissue engineering scaffolds is extremely beneficial for designing composite scaffolds imparting multifunctional properties. In the present work, we report the efficacy of incorporating the PEGylated CdSe-ZnS (Q-dots) into electrospun poly(caprolactone)(PCL) scaffolds whose properties were evaluated for sma...
Article
Full-text available
Human amniotic membrane (AM) is reported to possess remarkable therapeutic potential for wound healing due to its inherent bioactive and biocompatible properties. However, poor handling characteristics have limited its clinical use on wounds to a great extent. Reinforcement of AM with a biodegradable polymer is therefore expected to provide adequat...
Article
Full-text available
Oral radiotoxicity is often a limiting factor in cancer treatment. Previously, we demonstrated that transfer of cell-permeable, TAT-fusion Tousled-like kinase 1B (TLK1B) protein in salivary glands effectively mitigates radiation-induced salivary dysfunction. However, similar to most radioprotectors, TLK1B can carry the risk of limiting cancer treat...
Article
Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put...
Article
Full-text available
Bone is a unique tissue that has the ability to repair itself and return to full function. Bone regeneration is a well synchronized biological process that recapitulates embryonic bone development. The establishment of a functional vascular supply has been shown to be essential for proper ossification of newly deposited bone, and impaired angiogene...
Article
Monomer 2-hydroxy ethyl methacrylate containing small amounts of poly(caprolactone) and poly(ethylene glycol) incorporated with an antibiotic ofloxacin was polymerized by photopolymerization technique using 2,4,6 trimethyl benzoyl diphenyl phosphine oxide (TPO) as photoinitiator. Encapsulation efficiency and in vitro drug release was studied using...
Article
Monomer 2-hydroxy ethyl methacrylate containing small amounts of poly(caprolactone) and poly(ethylene glycol) incorporated with an antibiotic ofloxacin was polymerized by photopolymerization technique using 2,4,6 trimethyl benzoyl diphenyl phosphine oxide (TPO) as photoinitiator. Encapsulation efficiency and in vitro drug release was studied using...
Article
Full-text available
More than 0.5 million new cases of head and neck cancer are diagnosed worldwide each year, and approximately 75% of them are treated with radiation alone or in combination with other cancer treatments. A majority of patients treated with radiotherapy develop significant oral off-target effects because of the unavoidable irradiation of normal tissue...
Article
Normal tissues that lie within the portals of radiation are inadvertently damaged. Salivary glands are often injured during head and neck radiotherapy. Irreparable cell damage results in a chronic loss of salivary function that impairs basic oral activities, and increases the risk of oral infections and dental caries. Salivary hypofunction and its...
Article
Full-text available
Human Tousled kinase 1 (TLK1) plays an important role in chromatin remodeling, replication, and DNA damage response and repair. TLK1 activity is immediately, but transiently, downregulated after genotoxic insult, and its recovery is important for exit from checkpoint arrest and cell survival after radiation. The data in this article compliments res...
Article
Full-text available
Accidental or medical radiation exposure of the salivary glands can gravely impact oral health. Previous studies have shown the importance of Tousled-like kinase 1 (TLK1) and its alternate start variant TLK1B in cell survival against genotoxic stresses. Through a high-throughput library screening of natural compounds, the phenolic phytochemical, ga...
Article
Full-text available
Tissue-engineered skin with mechanical and biological properties that match the native tissue could be a valuable graft to treat non-healing chronic wounds. Fibroblasts grown on a suitable biodegradable scaffold are a feasible strategy for the development of a dermal substitute above which epithelialization may occur naturally. Cell growth and phen...
Article
Non-healing wounds can be a major problem in diabetic and burn victims. Identified causes of chronic wound formation include angiopathy, neuropathy, infection and loss of extra cellular matrix (ECM) due to increased protease action. Currently available conventional therapy is not efficient enough to promote wound healing. Tissue-engineered skin sub...
Article
Full-text available
Introduction In the event of chronic diabetes or burn wounds, accomplishing skin regeneration is a major concern. Autologous skin grafting is the most effective remedy, but the tissue harvest may create more nonhealing wounds. Currently available skin substitutes have a limited clinical outcome because of immune reactions arising from the xenobioti...

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