Rene Ecochard

Rene Ecochard
Hospices Civils de Lyon (Centre Hospitalier Universitaire de Lyon) | CHU Lyon · Service Biostatistique

Professor

About

394
Publications
38,389
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8,177
Citations
Citations since 2017
75 Research Items
3219 Citations
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20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500

Publications

Publications (394)
Article
Objectives During normal menstrual cycles, serum levels of progesterone vary widely between cycles of same woman and between women. This study investigated the profiles of pregnanediol during the luteal phase. Methods Data stemmed from a previous multicenter prospective observational study and concerned 107 women (who contributed 326 menstrual cyc...
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INTRODUCTION Determination of steroid levels in the amniotic fluid gives some insight on foetal adrenal and gonadal functions. Our objectives were to establish reference ranges of 12 steroid levels throughout pregnancy and to compare them with steroid levels from pregnancies with foetuses presenting 21-hydroxylase deficiency (21OHD). MATERIALS AND...
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To assess quality of care, groups of care units that cared for the same patients at various stages of end-stage renal disease, might be more appropriate than the centre level. These groups constitute “communities” that need to be delineated to evaluate their practices and outcomes. In this article, we describe the use of an agglomerative (Fast Gree...
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Introduction Les patients atteints du syndrome de Klinefelter (SK) homogène ont longtemps été considérés infertiles. L’extraction testiculaire de spermatozoïdes (TESE) leur permet maintenant d’accéder à la paternité. L’âge a été évoqué comme facteur influençant le résultat de la TESE. Faut-il proposer une préservation de la fertilité aux adolescent...
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Study question: Should testicular sperm extraction (TESE) in non-mosaic 47,XXY Klinefelter syndrome (KS) patients be performed soon after puberty or could it be delayed until adulthood? Summary answer: The difference in sperm retrieval rate (SRR) in TESE was not significant between the 'Young' (15-22 years old) cohort and the 'Adult' (23-43 year...
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Contexte Il n'existe que très peu de données à long terme sur la cinétique des anticorps chez les survivants de la maladie à virus Ebola (MVE). L'objectif de cette étude était de modéliser la réponse humorale en anticorps chez les survivants de la MVE en Guinée. Méthodes A travers une étude de cohorte prospective, nous avons collecté des échantill...
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Poor vitamin D status and high parathyroid hormone (PTH) level are associated with impaired bone microarchitecture, but these data are mainly cross‐sectional. We studied the association of the baseline PTH and 25‐hydroxycholecalciferol (25OHD) levels with the prospectively assessed deterioration of bone microarchitecture and in estimated bone stren...
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BACKGROUND AND AIMS Although associated with better quality of life and potential economic advantages, home dialysis use varies greatly internationally and appears to be underused in many countries. This study aimed to estimate the dialysis-network variability in home dialysis use and identify factors associated with (i) the uptake in home dialysis...
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Introduction L'hétérogénéité des réponses du système immunitaire au sein d'une population après une infection a été observée dans plusieurs études. Cela suggère que la description d'une population à l'aide d'une seule trajectoire omet la variabilité intra- et interindividuelle complexe du contexte clinique de la vie réelle. L'objectif de cette étud...
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Patients with a Klinefelter syndrome (KS), defined by a 47 XXY karyotype, were long considered infertile. Testicular sperm extraction (TESE) now allows them to access fatherhood We will present the data of studies since first experiment of TESE. Several factor influencing TESE outcome were proposed in these different studies. Among them, clinical a...
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Background Although associated with better quality of life and potential economic advantages, home dialysis use varies greatly internationally and appears to be underused in many countries. This study aimed to estimate the dialysis-network variability in home dialysis use and identify factors associated with 1) the uptake in home dialysis, 2) the p...
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Objective Describe the relationship between basal body temperature (BBT) and pregnanediol-3 alpha-glucuronide (PDG, the urine metabolite of progesterone) across the menstrual cycle. Design: Observational study. Setting: Study carried out from 1996 to 1997 in eight European family planning clinics. Participant(s): One hundred and seven normally fert...
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Background Worldwide, COVID-19 outbreaks in nursing homes have often been sudden and massive. The study investigated the role SARS-CoV-2 virus spread in nearby population plays in introducing the disease in nursing homes. Material and methods This was carried out through modelling the occurrences of first cases in each of 943 nursing homes of Auve...
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Background Quality care during childbirth requires that health care providers have not only excellent skills but also appropriate and considerate attitudes and behavior. Few studies have examined the proportion of women in Western countries expressing dissatisfaction with such inappropriate or inconsiderate behavior. This study evaluated this propo...
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Background Insufficient long-term data are available on antibody kinetics in survivors of Ebola virus disease (EVD). Likewise, few studies, with very small sample sizes, have investigated cross-reactions between Ebolavirus spp. In this study, we aimed to assess the humoral antibody response and its determinants in survivors of EVD and assess cross-...
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Introduction La dialyse à domicile reste peu développée en France. Description L’objectif de ce travail est d’analyser les sources de variations et les facteurs associés à l’accès et au temps passé en dialyse à domicile. Méthodes Les patients adultes traités par dialyse en France métropolitaine sur la période 2017-2019 ont été inclus. Leur temps...
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Le but de cette étude était d’étudier le vécu des mères insatisfaites de la prise en charge en salle de naissance en le comparant avec celui de mères satisfaites, à partir des données recueillies par évocations hiérarchisées dans l’Étude du Vécu de l’Accouchement (EVA). Il s’agissait d’une étude qualitative, contrôlée par témoins, en population, ré...
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Introduction Des analyses longitudinales sont nécessaires pour mieux comprendre l’apparition des symptômes à long terme de la maladie à virus Ebola (MVE) chez les survivants. Les études précédentes ont rapporté des analyses transversales ponctuelles à chaque visite d’étude, ignorant l’évolution temporelle des symptômes et leur caractère intermitten...
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Despite national guidelines, medical practices and kidney transplant waiting list registration policies may differ from one dialysis/transplant unit to another. Benefit risk assessment variations, especially for elderly patients, have also been described. The aim of this study was to identify sources of variation in early kidney transplant waiting...
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Trajectory classification has become frequent in clinical research to understand the heterogeneity of individual trajectories. The standard classification model for trajectories assumes no between‐individual variance within groups. However, this assumption is often not appropriate, which may overestimate the error variance of the model, leading to...
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Objectives: The aim of the study was to assess the efficacy and safety of an enhanced recovery program (ERP) after robot-assisted partial nephrectomy (RAPN) for cancer. Methods: It was a monocentric, retrospective, comparative study. An ERP after RAPN was introduced at our institution in 2015 and proposed to all consecutive patients admitted for...
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Objective The outbreak of COVID-19 in South Kivu (DRC) raised the fear of added morbidity and mortality. Updating these indicators before a second wave seems essential to prepare for additional help. Methods From mid-May to mid-December 2020, weekly surveys in sampled streets from ten Health Areas quantified the application of barrier measures and...
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Background: Longitudinal analyses are needed to better understand long-term Ebola virus disease (EVD) sequelae. We aimed to estimate the prevalence, incidence and duration of sequelae and identify risk factors associated with symptom occurrence among EVD survivors in Guinea. Methods: We followed 802 EVD survivors over 48 months and recorded clin...
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Background: In most health areas, an information system is necessary for an effective fight against COVID-19. Current methods for surveillance of diseases with epidemic potential do not include monitoring the adherence to preventive measures. Furthermore, modern data collection methods depend often on technologies (e.g., cameras or drones) that ar...
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Background: No prospective study has evaluated the long-term effect on mortality of the new acid concentrates added to bicarbonate dialysate. The aim of this pharmacoepidemiological study was to evaluate the association between hydrochloric or citric acid-based dialysate and mortality on haemodialysis (HD). Methods: This study included 117 796 p...
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Background and objectives Identifying virilisation of the genitalia in female newborns early during the neonatal period is important to diagnose pathologies. However, there is no clear threshold for clitoromegaly or for the anogenital ratio. The objective of this study was to define reference values for the external genitalia of full-term and pre-t...
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Motivated by the potential devastating effect of a COVID-19 outbreak in retirement homes and long-term facilities for dependent elderly, we present the impact of worst-case scenarios in French institutions using a specific age structure and case–age fatality ratios. The death toll could equal the yearly death toll caused by seasonal influenza in th...
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Treatment selection markers are generally sought for when the benefit of an innovative treatment in comparison with a reference treatment is considered, and this benefit is suspected to vary according to the characteristics of the patients. Classically, such quantitative markers are detected through testing a marker‐by‐treatment interaction in a pa...
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Objective and Background: Men’s experiences of first-fatherhood discovery differ widely with various circumstances; they were examined according to the intended/unintended occurrence of partner’s pregnancy. Methods: An Associative Network study targeted 44 first-time fathers and analysed their reactions to a stimulus-sentence ‘In the first days aft...
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Introduction: Preoperative information is a key to adherence to treatment for the patients, but may be misunderstood because of its density and complexity. The aim of this study was to assess comprehension and satisfaction of patients about preoperative information of benign prostatic hyperplasia (BPH) surgery. Factors influencing patient understa...
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Background: Care goals are often implicit, although their identification is a key element of any prescription process. This study aimed to describe the clinical goals of drug prescriptions in general practice, their determinants and the agreement between physicians and patients. Methods: This was a cross-sectional study conducted by 11 resident...
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Objectifs La réhabilitation améliorée après chirurgie (RAAC) a montré de nombreux avantages notamment en chirurgie digestive et actuellement pour la cystectomie en urologie. L’objectif de notre étude était d’évaluer l’intérêt et la sécurité d’un programme de RAAC pour la néphrectomie partielle robot-assistée (NPRA) pour cancer. Méthodes Il s’agiss...
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Background The prevalence of Ebola virus infection among people who have been in contact with patients with Ebola virus disease remains unclear, but is essential to understand the dynamics of transmission. This study aimed to identify risk factors for seropositivity and to estimate the prevalence of Ebola virus infection in unvaccinated contact per...
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Introduction L’épidémiologie des uvéites varie selon de nombreux facteurs : géographiques, ethniques, génétiques, environnementaux, ainsi que le mode de recrutement des patients dans les cohortes. En France, peu d’études épidémiologiques ont été conduites, avec essentiellement une série de 927 patients atteints d’uvéite chronique dans un centre d’o...
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Rationale Ovulation confirmation is a fundamental component of the evaluation of infertility. Purpose To inform the design of a larger clinical trial to determine the effectiveness of a new home-based pregnanediol glucuronide (PDG) urine test to confirm ovulation when compared with the standard of serum progesterone. Methods In this observational...
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Background: The prevalence of Ebola virus infection among people who have been in contact with patients with Ebola virus disease remains unclear, but is essential to understand the dynamics of transmission. This study aimed to identify risk factors for seropositivity and to estimate the prevalence of Ebola virus infection in unvaccinated contact p...
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The use of a quantitative treatment selection marker to choose between two treatment options requires the estimate of an optimal threshold above which one of these two treatments is preferred. Herein, the optimal threshold expression is based on the definition of a utility function which aims to quantify the expected utility of the population (e.g....
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Objectives Preterm premature rupture of fetal membranes (PPROM) exposes the fetus to preterm birth, and optimal timing for delivery is controversial. The aim of this study was to compare intentional early delivery (“active management”) with expectant management in very preterm birth (28–32 weeks). Study design We conducted a prospective randomized...
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Background: With the increase of life expectancy, *On behalf of the REIN registry. end-stage renal disease (ESRD) is affecting a growing number of people. Simultaneously, renal replacement therapies (RRTs) have considerably improved patient survival. We investigated the way current RRT practices would affect patients' survival. Methods: We used...
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Background: There is evidence that adipokines have roles in brain functioning and cognitive decline. Objective: Assess the role of leptin and adiponectin levels in predicting changes in neuro-cognitive disorders (NCD). Methods: The study included 205 patients over 65 years of age presenting for a one-day hospitalization for current assessment...
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Objectifs L’objectif de notre étude est d’évaluer l’intérêt et la sécurité de l’absence de sondage urinaire pour les chirurgies de tumorectomie rénale par voie robot-assistée (rapn) dans le cadre d’un protocole réhabilitation améliorée après chirurgie (raac). Méthodes Il s’agit d’une étude monocentrique et comparative non randomisée. Tous les pati...
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Objective To assess the benefits and safety of noncatheterization during robot-assisted partial nephrectomy within an enhanced recovery protocol. Materials and Methods A single-center retrospective comparative study was carried out of consecutive patients who underwent a robot-assisted partial nephrectomy between February 2015 and December 2017 wi...
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Background: The prognostic impact of nutrition and chronic kidney disease (CKD) complications has already been described in elderly haemodialysis patients but their relative weights on risk of death remain uncertain. Using structural equation models (SEMs), we aimed to model a single variable for nutrition, each CKD complication and cardiovascular...
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Classifying patients into groups according to longitudinal series of measurements (ie, trajectory classification) has become frequent in clinical research. Most classification models suppose an equal intra-group variance across groups. This assumption is sometimes inappropriate because measurements in diseased subjects are often more heterogeneous...
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Introduction/Background For hospitalizations in Rehabilitation Centers (RCs), the quantification of the health care givers’ activity is based on the variable dependency of the patients. The tools currently used to quantify it are not sufficiently precise. The stages of the construction of a new tool, the SAS scoring (SOFMER Activity Score), which a...
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Objectives: Micronutrient supplementation in critically ill adults remains controversial. In the pediatric setting, the impact of oxidative stress on the overall micronutrient status has been poorly explored, due to the limited number of studies and to confounding factors (i.e., malnutrition or extra losses). In order to better understand this phe...
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Low muscle mass and strength are associated with poor bone microarchitecture. We studied the association of muscle mass and strength with changes in bone microarchitecture of distal radius in 821 older men during an 8‐year prospective follow‐up. Bone microarchitecture was assessed by high resolution peripheral quantitative computed tomography (Xtre...
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Background: Even in normally cycling women, hormone level shapes may widely vary between cycles and between women. Over decades, finding ways to characterize and compare cycle hormone waves was difficult and most solutions, in particular polynomials or splines, do not correspond to physiologically meaningful parameters. Objective: We present an ori...
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Introduction L’analyse de mesures longitudinales – appelées trajectoires – est de plus en plus utilisée en recherche médicale. L’un des intérêts de cette analyse est d’identifier des groupes d’individus ayant des trajectoires similaires. La classification obtenue peut être utilisée pour mieux comprendre l’hétérogénéité des évolutions entre individu...
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Objectives: For hospitalizations in rehabilitation centers (RCs) in France, the quantification of healthcare givers' activity is based on the dependency of the patients, defined as a total or partial inability to perform activities required for daily living without help. The tools currently used to quantify dependency are not sufficiently precise....
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Objectives: All patients with lower extremity peripheral arterial disease (LE-PAD) should benefit from recommended pharmacologic therapies including antiplatelet agents, angiotensin converting enzyme inhibitors (ACE) or Angiotensin receptor blockers (ARB), and HMG-CoA-reductase inhibitors (statins). In the present study, this triple therapy was de...
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Objective: Explore potential relationships between preovulatory, periovulatory, and luteal-phase characteristics in normally cycling women. Design: Observational study. Setting: Eight European natural family planning clinics. Patient(s): Ninety-nine women contributing 266 menstrual cycles. Intervention(s): The participants collected first morning u...
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Objective: Examine whether a Rasch analysis is sufficient to establish the construct validity of the Motor Function Measure (MFM) and discuss whether weighting the MFM item scores would improve the MFM construct validity. Design: Observational cross-sectional multicenter study. Setting: 23 physical medicine departments, neurology departments,...
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Objectives To estimate the transferability of processes of care from general practitioners (GPs) to allied healthcare professionals and the determinants of such transferability. Design French national cross-sectional multicentre study Setting 128 family practices providing supervised training for residents in general practice. Participants All p...
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Objective To study the best possible luteinizing hormone (LH) threshold to predict ovulation within the 24, 48, and 72 h. Design Observational study. Setting Multicenter collaborative study. Patients A total of 107 women. Interventions Women collected daily first morning urine for hormonal assessment and underwent serial ovarian ultrasound. Thi...
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Background Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings. Our aim was to assess the potential short-term impact of combined interventions on HIV spreading in the adult population of Mbongolwane and Eshowe (KwaZulu-Natal, South Africa) using sex-...
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Objective To characterize the variability of hormonal profiles during the luteal phase in normal cycles. Design Observational study. Setting Not applicable. Patient(s) Ninety-nine women contributing 266 menstrual cycles. Intervention(s) The women collected first morning urine samples that were analyzed for estrone-3-glucuronide, pregnanediol-3-...
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Introduction Even in normally cycling women, the shapes of hormone levels may widely vary between cycles and between women. Over the last decades, finding ways to characterize and compare the cycle hormone waves has shown to be a very difficult task and most answers, in particular polynomials or splines, do not refer to physiologically meaningful p...
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Objective: ADHD is one of the most frequent neurodevelopmental disorders. In addition to clinical assessment, its diagnosis requires the use of validated and reliable behavior questionnaires such as the Conners' Parent Rating Scale-Revised: Short Form (CPRS-R:S). Though various French versions of the CPRS-R:S have been already put to use in clinic...
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This study modeled the presence of Ebola virus RNA in the semen of male Ebola survivors participating in the Postebogui study in Guinea. The median time of reverse-transcription polymerase chain reaction negativity was 46.4 days after symptom onset (95% confidence interval, 11-82.6). The results emphasize the importance of the World Health Organiza...
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Introduction Les voies aériennes distales (VAD) sont responsables de moins de 25 % des résistances totales chez un sujet sain et sont le principal site d’obstruction chez l’asthmatique (plus de 50 % des résistances totales). L’asthme est une maladie hétérogène et plusieurs phénotypes ont été décrits. À ce jour, l’exploration fonctionnelle respirato...
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Background and aims: A major limitation to liver transplantation is organ shortage, leading to the use of non-optimal liver grafts. The Donor Risk Index has been validated and recommended to select donors/organs. The Eurotransplant Donor Risk Index was derived from the Donor Risk Index. The objective of our study was to perform an external validat...
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Background: The restricted mean survival time (RMST) estimates life expectancy up to a given time horizon and can thus express the impact of a disease. The aim of this study was to estimate the 15-year RMST of a hypothetical cohort of incident patients starting renal replacement therapy (RRT), according to their age, gender and diabetes status, an...
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Objectifs Dès 1996, les hospices civils de Lyon (HCL) ont établi un recueil des accidents d’exposition au sang (AES) auprès de 24 000 professionnels de santé. Un système sentinelle était nécessaire pour détecter les variations de ces AES. Méthodes Divers paramètres (geste, matériel en cause, etc.) sont saisis sur CHIMED (logiciel de santé au trava...
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ObjectifTester la non-infériorité de la cryothérapie (Froid Sec Alkantis®, Lyon, France) seule ou en association avec un traitement antalgique vs un traitement antalgique seul de palier supérieur, pour permettre de diminuer d’un palier la puissance des antalgiques utilisés en traumatologie. MéthodesCette étude prospective randomisée de non-inférior...
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The potential spread of nosocomial Ebola virus disease (EVD) in non-outbreak areas is not known. The objective was to use detailed contact data on patients and healthcare workers (HCW) to estimate emergence probability and secondary incident cases (SIC) of EVD after hospitalization of an index case with undetected EVD. Contact data were collected t...
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Objectives: Estimating HIV incidence is critical for identifying groups at risk for HIV infection, planning and targeting interventions, and evaluating these interventions over time. The use of reliable estimation methods for HIV incidence is thus of high importance. The aim of this study was to compare methods for estimating HIV incidence in a po...