Renaud Tissier

Renaud Tissier
Netherlands Cancer Institute · Division of Psychosocial Research and Epidemiology

PhD

About

22
Publications
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74
Citations

Publications

Publications (22)
Article
Full-text available
In conventional flowcytometry one detector (primary) is dedicated for one fluorochrome. However, photons usually end up in other detectors too (fluorescence spillover). ‘Compensation’ is a process that corrects the spillover signal from all detectors except the primary detector. Post ‘compensation’, the photon counting error of spillover signals be...
Preprint
In flow cytometers, ideally each detector receives photons from one specific fluorochrome. However, photons usually end up in different detectors too (fluorescence spillover). ‘Compensation’ is a process that removes this extra signal from all detectors other than the primary detector dedicated to that fluorochrome. Post ‘compensation’, the measure...
Article
Full-text available
Background: Social anxiety disorder (SAD) is an incapacitating disorder running in families. Previous work associated social fearfulness with a failure to habituate, but the habituation response to neutral faces has, as of yet, not been investigated in patients with SAD and their family members concurrently. Here, we examined whether impaired habit...
Article
Background Patients with social anxiety disorder (SAD) fear negative evaluation in social situations. Specifically, previous work indicated that social anxiety is associated with increased medial prefrontal cortex activation in response to unintentional social norm (SN) transgressions, accompanied by increased embarrassment ratings for such SN viol...
Data
Relationship between indices of social anxiety and gray matter characteristics, corrected for level of depressive symptoms (sensitivity analysis 2)
Data
Detailed statistics of effects of social anxiety on, and heritability estimates of parameters of interest: general imaging phenotypes (tab 1); subcortical volumes (tab 2); cortical thickness (tab 3); cortical surface area (tab 4).
Data
Detailed statistics of effects of social anxiety on parameters of interest in sample without comorbidity (sensitivity analysis 1): subcortical volumes (tab 1); cortical thickness (tab 2); cortical surface area (tab 3).
Data
Relationship between indices of social anxiety and gray matter characteristics in selection of LFLSAD sample: participants with (comorbid) psychopathology other than (sub)clinical SAD were excluded (sensitivity analysis 1)
Data
Detailed statistics of effects of social anxiety on parameters of interest, corrected for level of depressive symptoms (sensitivity analysis 2): subcortical volumes (tab 1); cortical thickness (tab 2); cortical surface area (tab 3).
Data
Detailed statistics of effects of social anxiety on, and heritability estimates of non-ROIs: subcortical volumes (tab 1); cortical thickness (tab 2); cortical surface area (tab 3).
Article
Full-text available
Abstract The main goal of this paper is to estimate the effect of triglyceride levels on methylation of cytosine-phosphate-guanine (CpG) sites in multiple-case families. These families are selected because they have 2 or more cases of metabolic syndrome (primary phenotype). The methylations at the CpG sites are the secondary phenotypes. Ascertainme...
Data
Prediction accuracy results for n = 100 individuals. Results in terms of predictive ability for simulated datasets of 100 individuals for 200 variables and 1000 variables. (PDF)
Data
Complete variable selection results. Boxplots of estimated effects of each of the p variables of X and the distribution of the average estimated regression coefficients for all the combinations of network an group penalization prediction methods. (PDF)
Data
List of metabolites used in the DILGOM analysis. Detailed description and acronyms of the 57 metabolites studied in the DILGOM study. (PDF)
Article
Full-text available
Building prediction models based on complex omics datasets such as transcriptomics, proteomics, metabolomics remains a challenge in bioinformatics and biostatistics. Regularized regression techniques are typically used to deal with the high dimensionality of these datasets. However, due to the presence of correlation in the datasets, it is difficul...
Article
Full-text available
Social anxiety disorder is an invalidating psychiatric disorder characterized by extreme fear and avoidance of one or more social situations in which patients might experience scrutiny by others. The goal of this two-generation family study was to delineate behavioral and electrocortical endophenotypes of social anxiety disorder related to social e...
Data
Table S1: Simulations results obtained on 500 datasets with 400 families of size 5 with at least 2 cases of a rare disease (prevalence around 1%) and α1=0.1. Into brackets are respectively standard deviations, root mean square errors and the coverage probabilities. Table S2: Simulations results obtained on 500 datasets with 400 families of size 5 w...
Article
Full-text available
The case-control design is often used to test associations between the case-control status and genetic variants. In addition to this primary phenotype a number of additional traits, known as secondary phenotypes, are routinely recorded and typically associations between genetic factors and these secondary traits are studied too. Analysing secondary...
Article
Full-text available
For a better understanding of the biological mechanisms involved in complex traits or diseases, networks are often useful tools in genetic studies: coexpression networks based on pairwise correlations between genes are commonly used. In case of a family-based design, it can be problematic when there is a large between-family variation in expression...

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