Renaud Jardri

Renaud Jardri
Université de Lille · Faculty of Medicine

MD, PhD/ HDR
Head of the perinatal psychiatry dept + head of the CHESS clinic devoted to children hearing voices, CHU Lille, France

About

240
Publications
120,474
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5,032
Citations
Introduction
I am professor of child & adolescent psychiatry at the Lille university school of medicine and senior member of the Institut Universitaire de France (IUF 2021 - 2026). My main interests are in the exploration of the underlying neural mechanisms of hallucinations in children, adolescents and adults. My research currently focuses on hallucinations and delusional beliefs, using behavioral, computational, brain imaging and developmental approaches. orcid.org/0000-0003-4596-1502
Additional affiliations
January 2020 - present
Université de Lille/ CHU de Lille, France
Position
  • Professor (Full)
Description
  • Head of the Plasticity & SubjectivitY (PSY) team, Lille Neurosci & Cognit Centre (LiNC, INSERM U-1172) Director of the research platform CURE (CIC-Psy) Director of the CHESS clinic for young people with hallucinations Head of the Perinatal Psychiatry Dpt.
September 2014 - December 2019
UFR Med - Université de Lille/ CHRU de Lille
Position
  • Professor (Full)
Description
  • Head of the hallucinations group at the SCA-Lab (Lille University) and Medical Director of the research platform CURE (Fontan Hospital, CHRU Lille, France)/ Head of the Perinatal Psychiatry Dpt. (CHRU Lille, France).
September 2012 - September 2014
Centre Hospitalier Régional Universitaire de Lille
Position
  • Professor (Associate)
Description
  • Head of the hallucinations group at the SCA-Lab (Lille University) and Medical Director of the research platform CURE (Fontan Hospital, CHRU Lille)

Publications

Publications (240)
Article
Full-text available
Background Aripiprazole is a second-generation antipsychotic, efficacious in patients with schizophrenia during acute episodes. Due to its pharmacological profile, aripiprazole may be of interest in patients with specific clinical profiles who have not been studied extensively in randomised clinical trials. Objectives To capture experience with ar...
Article
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Background: One of the core features of posttraumatic stress disorder (PTSD) is re-experiencing trauma. The anterior insula (AI) has been proposed to play a crucial role in these intrusive experiences. However, the dynamic function of the AI in re-experiencing trauma and its putative modulation by effective therapy need to be specified. Methods: T...
Article
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Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to p...
Article
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Background One out of three patients with schizophrenia failed to respond adequately to antipsychotics and continue to experience debilitating symptoms such as auditory hallucinations and negative symptoms. The development of additional therapeutic approaches for these persistent symptoms constitutes a major goal for patients. Here, we develop a ra...
Preprint
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An analysis of an internationally shared functional magnetic resonance imaging (fMRI) data involving healthy participants and schizophrenia patients extracted brain networks involved in listening to radio speech and capture hallucination experiences. A multidimensional analysis technique demonstrated that for radio-speech sound files, a brain netwo...
Article
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Autism spectrum disorders have been proposed to arise from impairments in the probabilistic integration of prior knowledge with sensory inputs. Circular inference is one such possible impairment, in which excitation-to-inhibition imbalances in the cerebral cortex cause the reverberation and amplification of prior beliefs and sensory information. Re...
Article
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Growing evidence supports that prenatal processes play an important role for cognitive ability in normal and clinical conditions. In this context, several neuroimaging studies searched for features in postnatal life that could serve as a proxy for earlier developmental events. A very interesting candidate is the sulcal, or sulco-gyral, patterns, ma...
Article
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In the current literature, two distinct and opposite models are suggested to explain the consciousness disorders in schizophrenia. The first one suggests that consciousness disorders rely on a low-level processing deficit, when the second model suggests that consciousness disorders rely on disruption in the ability to consciously access information...
Preprint
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BACKGROUND Functional magnetic resonance imaging (fMRI) capture aims at detecting auditory-verbal hallucinations (AVHs) from continuously recorded brain activity. Establishing efficient capture methods with low computational cost that easily generalize between patients remains a key objective in precision psychiatry. To address this issue, we devel...
Preprint
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Psychedelics are known to distort perception and induce visual and multimodal hallucinations as well as synaesthesia. This is in contradiction with the high prevalence of distressing voices in schizophrenia. Here we introduce a unifying account of unimodal and multimodal erroneous percepts based on circular inference. We show that amplification of...
Preprint
Full-text available
Autism spectrum disorders have been proposed to arise from impairments in the probabilistic integration of prior knowledge with sensory inputs. Circular inference is one such possible impairment, in which excitation-to-inhibition imbalances in the cerebral cortex cause the reverberation and amplification of prior beliefs and sensory information. Re...
Article
Full-text available
A wide homology between human and macaque striatum is often assumed as in both the striatum is involved in cognition, emotion and executive functions. However, differences in functional and structural organization between human and macaque striatum may reveal evolutionary divergence and shed light on human vulnerability to neuropsychiatric diseases...
Article
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Inherited metabolic disorders (IMDs) can present with psychiatric signs that vary widely from one disease to another. This picture is further complicated by the fact that these features occur at very different illness time points, which may further delay appropriate diagnosis and treatment. In this case series of 62 children and adolescents sufferi...
Preprint
Full-text available
Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to p...
Article
Full-text available
Formal thought disorder (FTD) is a core symptom cluster of schizophrenia, but its neurobiological substrates remain poorly understood. Here we collected resting-state fMRI data from 276 subjects at seven sites and employed machine-learning to investigate the neurobiological correlates of FTD along positive and negative symptom dimensions in schizop...
Article
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When we face ambiguous images, the brain cannot commit to a single percept; instead, it switches between mutually exclusive interpretations every few seconds, a phenomenon known as bistable perception. While neuromechanistic models, e.g., adapting neural populations with lateral inhibition, may account for the dynamics of bistability, a larger ques...
Article
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Background: Despite the marked inter-individual variability in the clinical presentation of schizophrenia, it remains unclear the extent to which individual dimensions of psychopathology relate to the functional variability in brain networks among patients. Here, we address this question using network-based predictive modeling of individual psychop...
Article
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The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putt...
Article
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Hallucinations can occur in different sensory modalities, both simultaneously and serially in time. They have typically been studied in clinical populations as phenomena occurring in a single sensory modality. Hallucinatory experiences occurring in multiple sensory systems-multimodal hallucinations (MMHs)-are more prevalent than previously thought...
Article
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Auditory-verbal hallucinations (AVH) are often associated with high levels of distress and disability in individuals with schizophrenia-spectrum disorders. In around 30% of individuals with distressing AVH and diagnosed with schizophrenia, traditional antipsychotic drugs have little or no effect. Thus, it is important to develop mechanistic models...
Article
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The human striatum is essential for both low and high-level functions and has been implicated in the pathophysiology of various prevalent disorders, including Parkinson’s disease (PD) and schizophrenia (SCZ). It is known to consist of structurally and functionally divergent subdivisions. However, previous parcellations are based on a single neuroim...
Preprint
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Background: Despite the marked inter-individual variability in the clinical presentation of schizophrenia, it remains unclear the extent to which individual dimensions of psychopathology may be reflected in variability across the collective set of functional brain connections. Here, we address this question using network-based predictive modeling o...
Article
Objectives Patients with autoimmune encephalitis (AE) are likely to exhibit an acute onset of severe psychiatric features, including psychosis and/or catatonia. Based on the high prevalence of catatonia in AE and our clinical experience, we hypothesized that catatonia might be a marker of severity requiring more aggressive treatment approaches. Me...
Article
La psychiatrie computationnelle est une approche théorique utilisant des modèles mathématiques pour éclairer les liens entre symptômes et anomalies neurobiologiques observées dans les troubles mentaux. Cette introduction passe en revue trois champs d'application principaux : les modèles issus de l'apprentissage par renforcement, les modèles issus d...
Article
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When facing ambiguous images, the brain switches between mutually exclusive interpretations, a phenomenon known as bistable perception. Despite years of research, a consensus on whether bistability is driven primarily by bottom-up or top-down mechanisms has not been achieved. Here, we adopted a Bayesian approach to reconcile these two theories. Fif...
Article
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Résumé Les effets psychologiques de l’isolement ont déjà été décrits dans la littérature (expéditions polaires, sous-marins, prison). Néanmoins l’échelle du confinement mis en œuvre à l’occasion de la pandémie à COVID-19 est inédite. Il nous faut non seulement relire les études publiées, mais aussi anticiper les problèmes psychologiques qui pourrai...
Article
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Auditory hallucinations (AHs) are certainly the most emblematic experiences in schizophrenia, but visual hallucinations (VHs) are also commonly observed in this developmental psychiatric disorder. Notably, several studies have suggested a possible relationship between the clinical variability in hallucinations′ phenomenology and differences in brai...
Preprint
Hallucinations can occur in different sensory modalities within an individual, both simultaneously and serially in time. Historically, they have typically been studied in clinical populations as phenomena occurring in a single sensory modality. Yet, hallucinatory experiences that occur in two or more sensory systems - multimodal hallucinations (MMH...
Article
Reward processing impairments have been linked with positive and negative symptoms of schizophrenia. Here, we performed a coordinate-based meta-analysis that combined eleven BOLD-fMRI studies comparing reward anticipation signals between schizophrenia patients and healthy controls. We observed a reduced difference in activation in schizophrenia pat...
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Introduction: Repetitive transcranial magnetic stimulation (rTMS) has been widely tested and promoted for use in multiple neuropsychiatric conditions, but as for many other medical devices, some gaps may exist in the literature and the evidence base for the clinical efficacy of rTMS remains under debate. Objective: We aimed to test for an excess...
Article
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Background: Disentangling psychopathological heterogeneity in schizophrenia is challenging, and previous results remain inconclusive. We employed advanced machine learning to identify a stable and generalizable factorization of the Positive and Negative Syndrome Scale and used it to identify psychopathological subtypes as well as their neurobiolog...
Article
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With disease progression, patients with Parkinson’s disease (PD) may have chronic visual hallucinations (VH). The mechanisms behind this invalidating non-motor symptom remain largely unknown, namely because it is extremely difficult to capture hallucination events. This study aimed to describe the patterns of brain functional changes when VH occur...
Article
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Ethanol disrupts the balance between the excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmission systems. We aimed to assess how acute ethanol intoxication in rats affects the levels of GABA, glutamate and other cerebral metabolites after injection of two different doses of ethanol. One in vivo magnetic resonance spectrum of the pr...
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Introduction: We investigated the relationship between visual hallucinations and vividness of visual imagery in patients with Alzheimer's disease (AD). Method: We recruited 28 patients with AD and 30 healthy control participants, matched for age and education. We evaluated proneness towards hallucinations with the Launay–Slade Hallucinations Scale,...
Article
editorPromoting psychiatrist-pediatrician collaborations onpostnatal depression preventionFor most women, having a baby is a very exciting and happyperiod of life, but it is also known as a time of increased vul-nerability. Although under-diagnosed, postnatal depression (PND)remains the most frequent complication after giving birth nowa-days, and c...
Article
Résumé La stimulation magnétique transcrânienne répétée (rTMS) est un outil thérapeutique d’utilisation encore récente en psychiatrie. Cet article a pour objectif d’actualiser l’état des connaissances sur la rTMS dans le traitement des troubles de l’humeur. La rTMS possède une efficacité certaine (niveau de preuve de grade 1) dans le traitement ini...
Preprint
Full-text available
Introduction: Repetitive transcranial magnetic stimulation (rTMS) has been widely tested and promoted for use in multiple neuropsychiatric conditions, but as for many other medical devices, some gaps may exist in the literature and the evidence base for rTMS clinical efficacy remains under debate. We aimed to empirically test for an excess number o...
Article
Over the last three decades there has been an accumulation of Magnetic Resonance Imaging (MRI) studies reporting that aberrant functional networks may underlie cognitive deficits and other symptoms across a range of psychiatric diagnoses. The use of pharmacological MRI and 1H-Magnetic Resonance Spectroscopy (1H-MRS) has allowed researchers to inves...
Article
Healthcare recommendations for people with disorders of sexual development (DSDs)include mental health attention and active participation of psychiatrists and psychologists in dedicated multidisciplinary teams. Therefore, it seems crucial for them to improve knowledge about specific difficulties and needs of these patients. The aim of this article...
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The clinical efficacy of neurofeedback is still a matter of debate. This paper analyzes the factors that should be taken into account in a transdisciplinary approach to evaluate the use of EEG NFB as a therapeutic tool in psychiatry. Neurofeedback is a neurocognitive therapy based on human–computer interaction that enables subjects to train volunta...
Article
The field of digital mental health is rapidly expanding with digital tools being used in assessment, intervention , and supporting self-help. The application of digital mental health to hallucinations is, however, at a very early stage. This report from a working group of the International Consortium on Hallucinations Research considers particular...
Article
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Hallucinations in children and adolescents are now known to occur on a continuum from healthy to psychopathology-related phenomena. Although hallucinations in young populations are mostly transient, they can cause substantial distress. Despite hallucinations being widely investigated, research so far has had limited implications for clinical practi...
Preprint
Full-text available
When facing fully ambiguous images, the brain cannot commit to a single percept and instead switches between mutually exclusive interpretations every few seconds, a phenomenon known as bistable perception. Despite years of research, there is still no consensus on whether bistability, and perception in general, is driven primarily by bottom-up or to...