Renata Bitar

Renata Bitar
Université de Fribourg · Department of Medicine

MD, PhD

About

35
Publications
4,466
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538
Citations
Introduction
Focus on Optical Methods and in their application for Biological Imaging. R&D/Business expertise in bringing to the market an Optical Biopsy as a highly accurate tool for skin cancer screening. CEO & Founder at DERMiSCAN/Switzerland - is an easy-to-use portable cloud-based device to provide non-invasive, real-time skin cancer and scars screening with the same level of accuracy as that performed by dermatologists. It will allow many people to have easy access to a first skin evaluation, held out of hospital environment, avoiding surgery, overbooking, waiting time at specialists and high costs of all process.
Additional affiliations
September 2013 - October 2016
Université de Fribourg
Position
  • PostDoc Position

Publications

Publications (35)
Article
Early-stage detection of cutaneous melanoma can vastly increase the chances of cure. Excision biopsy followed by histological examination is considered the gold standard for diagnosing the disease, but requires long high-cost processing time, and may be biased, as it involves qualitative assessment by a professional. In this paper, we present a new...
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Although there are many articles focused on in vivo or ex vivo Raman analysis for cancer diagnosis, to the best of our knowledge its potential to predict the aggressiveness of tumor has not been fully explored yet. In this work Raman spectra in the finger print region of ex vivo breast tissues of both healthy mice (normal) and mice with induced mam...
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In this work, Raman spectra in the 900-1,800 cm-1 wavenumber region of in vivo and ex vivo breast tissues of both healthy mice (normal) and mice with induced mammary gland tumors (abnormal) were measured. In the case of the in vivo tissues, the Raman spectra were collected for both transcutaneous (with skin) and skin-removed tissues. To identify th...
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The identification of normal and cancer breast tissue of rats was investigated using high-frequency (HF) FT-Raman spectroscopy with a near-infrared excitation source on in vivo and ex vivo measurements. Significant differences in the Raman intensities of prominent Raman bands of lipids and proteins structures (2,800–3,100cm−1) as well as in the bro...
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To qualify the FT-Raman spectral data of primary and metastatic cutaneous melanoma in order to obtain a differential diagnosis. Ten normal human skin samples without any clinical or histopathological alterations, ten cutaneous melanoma fragments, and nine lymph node metastasis samples were used; 105, 140 and 126 spectra were obtained respectively....
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Cutaneous melanoma is the most aggressive type of skin cancer and Ft-Raman spectroscopy has been studied as a potential method that could be a real alternative for early diagnosis of neoplasms. To qualify the spectral FT-Raman data, in order to differentiate cutaneous melanoma and pigmented nevus. For this study, 10 samples of cutaneous melanoma, 9...
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The biochemical alterations between inflammatory fibrous hyperplasia (IFH) and normal tissues of buccal mucosa were probed by using the FT-Raman spectroscopy technique. The aim was to find the minimal set of Raman bands that would furnish the best discrimination. Raman-based optical biopsy is a widely recognized potential technique for noninvasive...
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The aim of this study was to evaluate the vibrational modes of malignant and benign breast tissues with the following diagnosis: fibroadenoma, invasive ductal carcinoma, ductal carcinoma in situ, and fibrocystic condition. Quadratic discriminate analysis, a multivariate statistical method of analysis, showed 98.5% separation between normal and alte...
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Breast cancer is the most frequent cancer type in women Worldwide. Sensitivity and specificity of clinical breast examinations have been estimated from clinical trials to be approximately 54 % and 94 %, respectively. Further, approximately 95 % of all positive breast cancer screenings turn out to be false-positive. The optimal method for early dete...
Article
Thyroid gland is a small gland in the neck consisting of two lobes connected by an isthmus. Thyroid's main function is to produce the hormones thyroxine (T4), triiodothyronine (T3) and calcitonin. Thyroid disorders can disturb the production of these hormones, which will affect numerous processes within the body such as: regulating metabolism and i...
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Fourier transform infrared (FT-IR) spectroscopy is a potential tool for noninvasive optical tissue diagnosis. Applications of this technique for non-clinical purposes have increased since it has been shown that it can also provide the identification of functional groups, bonding types, and molecular conformations. Moreover, the spectral bands are m...
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The diagnosis of thyroid pathologies is usually made by cytologic analysis of the fine needle aspiration (FNA) material. However, this procedure has a low sensitivity at times, presenting a variation of 2-37%. The application of optical spectroscopy in the characterization of alterations could result in the development of a minimally invasive and n...
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FT-Raman Spectroscopy was applied to identify biochemical alterations existing between inflammatory fibrous hyperplasia (IFH) and normal tissues of buccal mucosa. One important implication of this study is related to the cancer lesion border. In fact, the cancerous normal border line is characterized by the presence of inflammation and its correct...
Article
The Raman-based optical diagnosis of normal cervix, inflammative cervix (cervicitis), and cervical intraepithelial neoplasia was investigated on samples of 63 patients. The main alterations were found in the 857 cm(-1) (CCH deformation aromatic); 925 cm(-1) (C-C stretching); approximately 1247 cm(-1) (CN stretch, NH bending of Amide III); 1370 cm(-...
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Study of genetic material allows the comprehension the origin of the many biochemical changes that follow diseases, like cancer, promoting the development of early preventive inquiry and more efficient individual treatments. Raman spectroscopy can be an important tool in DNA study, since it allows probe molecular vibrations of genetic material in a...
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Raman spectroscopy has been well established as a powerful method for studying biological tissues and diagnosing diseases. In this study we have developed a breast cancer animal model and collected in vivo Raman spectra of mammary glands of 27 Sprague-Dawley female rats treated with DMBA and 5 non-treated used as control group. A dispersive Raman s...
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The histogenesis of the breast Paget's disease was investigated by the optical diagnosis technique using Raman spectroscopy. A total of 15 spectra of the associated breast lesion, 21 spectra of the eczematoid skin lesion and 396 spectra of invasive breast cancer not otherwise specified were compared by clustering the spectral data between 800 - 180...
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Photodynamic Therapy (PDT) is an emerging and promising therapeutic modality for treatment of a wide variety of malignant and nononcologic tumors, as well as in the treatment of infected skin ulcers. This study evaluated the effectiveness of the PDT to treat a chronic skin wound that had been already subjected to several clinical and surgical type...
Article
The dentin quality of primary and permanent teeth was inspected by Fourier transformed Raman spectroscopy (FT-Raman); scanning electron microscopy/energy-dispersive spectroscopy (SEM/EDS) and hardness test. Middle dentin of crowns were reached by carbide bur abrading providing a uniform smear layer. Phosphoric acid was applied in order to simulate...
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The characterization of the FT-Raman spectra of the borders of lesions is of great importance in guiding the surgeon during surgical intervention. The main goals of this study were to investigate spectra of the borders of lesions of samples of infiltrating ductal carcinoma (IDC) and to determine the characteristics of these spectra. A total of 93 s...
Article
FT-Raman spectroscopy was employed to study normal human colorectal tissues in vitro with the aim of evaluating the spectral differences of the complex colon mucous in order to establish a characteristic Raman spectrum. The samples were collected from 39 patients, providing 144 spectra for the statistical analysis. The results enable one to establi...
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Melanoma is the most aggressive skin cancer and is invariably fatal if left untreated. Melanoma removal at early stages is almost always curative and therefore early detection is essential. Removal of every pigmented lesion is unacceptable for the patient, especially in the case of multiple skin lesions or lesions localized in cosmetically importan...
Article
This study evaluated the molecular and morphological changes on dentin elements after the Er:YAG laser irradiation. Six human third molars were selected and the occlusal one-third of the crown was removed. The dentin surface was schematically divided into areas corresponding to four surface treatments groups: Control (Group C): 37% phosphoric acid...
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We employ Fourier-transform Raman spectroscopy to study normal and tumoral human breast tissues, including several subtypes of cancers. We analyzed 194 Raman spectra from breast tissues that were separated into 9 groups according to their corresponding histopathological diagnosis. The assignment of the relevant Raman bands enabled us to connect the...
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FT-Raman spectroscopy was employed to study (in-vitro) non-altered human colorectal tissues aiming evaluate their spectral differences. The samples were collected from 39 patients, adding 144 spectra. The results enable one estabilish 3 well defined spectroscopic groups of what was consistently checked by statistical (clustering) and biological (hi...
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Fourier-transform (FT)-Raman spectroscopy has been used to explore the changes in the vibrational bands of normal, dysplastic (DE) and squamous cell carcinoma (SCC) tissues. Raman spectroscopy has been applied as a diagnostic tool for the detection of cancers, due to its sensitivity to the changes in molecular composition and conformation that occu...
Article
In this work we employ the Fourier Transform Raman Spectroscopy to study the human breast tissues, both normal and pathological. In the present study we analyze 194 Raman spectra from breast tissues that were separated into 9 groups according to their corresponding histopathological diagnosis, which are as follows: Normal breast tissue, Fibrocystic...
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Full-text available
In this study FT-RAMAN spectra of breast tissue from 35 patients were obtained and separated into nine groups for histopathologic analysis, which are as follows: normal breast tissue, fibrocystic condition, in situ ductal carcinoma, in situ ductal carcinoma with necrosis, infiltrate ductal carcinoma, infiltrate inflammatory ductal carcinoma, infilt...
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Optical spectroscopy has been extensively studied as a potential in vivo diagnostic tool to provide information about the chemical and morphologic structure of tissue. Raman Spectroscopy is an inelastic scattering process that can provide a wealth of spectral features that can be related to the specific molecular structure of the sample. This artic...
Article
FT-Raman spectroscopy is a modern analytical tool and it is believed that its use for skin cancer diagnosis will lead to several advantages for patients, e.g., faster results and a minimization of invasivity. This article reports results of an ex Vivo study of the FT-Raman spectra regarding differentiation between non-diseased and malignant human s...
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Resumo -FT-Raman spectroscopy was employed to study (in-vitro) normal and neoplasic human colorectal tissues aiming to evaluate their spectral differences. The samples were collected from 59 patients, adding 227 spectra for the statistical analysis. The spectra were previously separated in clusters by Cluster analysis and compared to the histopatho...
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Resumo -Atualmente a espectroscopia Raman é uma das áreas mais ativas de pesquisa, podendo vir a ser utilizada na concepção de equipamentos para análise de tecidos biológicos fornecendo diagnósticos precisos e em tempo real. O objetivo deste trabalho foi processar espectros Raman, de mama humana, utilizando redes neurais artificiais, com a finalida...

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