Remy Durand

Remy Durand
Assistance Publique – Hôpitaux de Paris | AP-HP · Hôpital Avicenne

PharmD, PhD, HDR

About

236
Publications
25,251
Reads
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3,495
Citations
Additional affiliations
September 2004 - present
Assistance Publique – Hôpitaux de Paris
Position
  • MCU-PH
September 2004 - March 2015
Université Paris 13 Nord
Position
  • Research Assistant
September 2004 - May 2015
Université Paris 13 Nord, Bobigny, France
Position
  • Research Assistant

Publications

Publications (236)
Article
Full-text available
The mite Sarcoptes scabiei is responsible for scabies, a pruritic and contagious skin disease in humans. S. scabiei is also responsible for mange in a wide range of animal species. The treatment of S. scabiei infection is hampered by an under-effectiveness of the few available drugs. The objective of this work was to evaluate the in vitro acaricide...
Article
Full-text available
There is a need for new, cost-effective drugs to treat leishmaniasis. A strategy based on traditional medicine practiced in Bolivia led to the discovery of the 2-substituted quinoline series as a source of molecules with antileishmanial activity and low toxicity. This review documents the development of the series from the first isolated natural co...
Article
Full-text available
We used molecular tools to identify an autochthonous case of gnathostomiasis in Madagascar. This severe ocular infection, caused by Gnathostoma spinigerum nematodes, led to vision loss in the patient's left eye. Clinicians should be aware of this parasitosis in Madagascar and other countries in Africa.
Article
Full-text available
The bed bugs (Cimex lectularius and C. hemipterus) have undergone a significant resurgence worldwide since the 1990s. A compilation of findings from a database, including 2650 scientific publications from seven major medical databases, allowed us to document main evolutionary events, from fossil evidence, dating from 11,000 years ago, until the pre...
Article
Pediculosis is a prevalent ectoparasite infestation caused by lice. The head louse (Pediculus humanus capitis) and body louse (Pediculus humanus humanus) are obligatory parasites whose only known hosts are humans. Pediculosis is probably the most common ectoparasitic infestation, affecting up to 80% of the population in several countries, and parti...
Article
Full-text available
Background: With less than one severe case per year in average, Plasmodium vivax is very rarely associated with severe imported malaria in France. Two cases of P. vivax severe malaria occurred in patients with no evident co-morbidity. Interestingly, both cases did not occur at the primary infection but during relapses. Case presentations: Patien...
Preprint
Background: With less than one severe case per year in average, P. vivax is very rarely associated with severe imported malaria in France. We report two cases of P. vivax severe malaria in patients with no evident co-morbidity. Interestingly, both cases did not occur at the primary infection but during relapses. Case presentations Patient 1 A 27-y...
Preprint
Full-text available
Background With less than one severe case per year in average, Plasmodium vivax is very rarely associated with severe imported malaria in France. Two cases of P. vivax severe malaria occurred in patients with no evident co-morbidity. Interestingly, both cases did not occur at the primary infection but during relapses. Case presentations Patient 1:...
Article
Full-text available
Human lice, Pediculus humanus, are obligate blood-sucking parasites. Phylogenetically, they belong to several mitochondrial clades exhibiting some geographic differences. Currently, the body louse is the only recognized disease vector, with the head louse being proposed as an additional vector. In this article, we study the genetic diversity of hea...
Article
Full-text available
Chemical, physical, and mechanical methods are used to control human lice. Attempts have been made to eradicate head lice Pediculus humanus capitis by hot air, soaking in various fluids or asphyxiation using occlusive treatments. In this study, we assessed the maximum time that head lice can survive anoxia (oxygen deprivation) and their ability to...
Article
Full-text available
Treatment of head lice has relied mainly on the use of topical insecticides. Today, conventional topical pediculicides have suffered considerable loss of activity worldwide. There is increasing interest in the use of natural products such as essential oils for head louse control, and many of them are now incorporated into various over-the-counter p...
Article
Full-text available
The members of the Palurea Study Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for this error and is pleased to list the members of the group here.
Article
Full-text available
Background The development of alternative approaches in ectoparasite management is currently required. Essential oils have been demonstrated to exhibit fumigant and topical toxicity to a number of arthropods. The aim of the present study was to assess the potential efficacy of ten essential oils against Sarcoptes scabiei. Methods The major chemica...
Article
Purpose Prospective data on potential factors associated with severity of imported Plasmodium falciparum malaria are lacking. We evaluated whether several host- and parasite-related biomarkers may improve early severity evaluation. Methods Prospective multicenter observational study comparing uncomplicated and severe imported falciparum malaria in...
Article
Full-text available
Scabies, or mange as it is called in animals, is an ectoparasitic contagious infestation caused by the mite Sarcoptes scabiei. Sarcoptic mange is an important veterinary disease leading to significant morbidity and mortality in wild and domestic animals. A widely accepted hypothesis, though never substantiated by factual data, suggests that humans...
Article
Full-text available
Sarcoptes scabiei infection is a contagious disease affecting both humans and animals. The transmission occurs either by direct contact or from the environment where mites could survive several days remaining infective. The number of products available for environmental control of S. scabiei is very limited. The objective of the present study was t...
Article
Full-text available
Introduction La gale est régulièrement à l’origine de foyers épidémiques difficile à maîtriser (e.g. collectivités). À température ambiante, S. scabiei, semble capable de survivre 24 à 36 heures dans l’environnement. Des produits de désinfection de l’environnement sont conseillés mais aucune preuve de leur efficacité n’a été apportée à ce jour. L’o...
Article
Scabies is an ectoparasitic infestation caused by the mite Sarcoptes scabiei. Currently, S. scabiei is taxonomically divided into different varieties based on host origin. Genetics-based research on scabies has been conducted but the data on genetic diversity of populations of this mite in humans in Europe is lacking. We evaluated the genetic diver...
Article
Full-text available
The three members of the ring-infected erythrocyte surface antigen (RESA) proteins family share high sequence homologies, which impair the detection and assignment to one or another protein of some pathogenic processes inherent to Plasmodium falciparum malaria. The present study was intended to determine if the antibody and inflammatory responses o...
Article
Full-text available
Native to temperate regions of North America, Corythucha ciliata, orlace bug, is an invasive insect that is spreading from relatively cold regions to relatively hot regions and is now distributed throughout the temperate and subtropical zones.¹ Until recently, lace bugs were not reported in the scientific literature as biting or stinging humans. Ar...
Article
Full-text available
According to previous studies, Sarcoptes mites of wombats were relatively recently introduced into Australia by colonizers and/or their dogs. However, that affirmation has been called into question due to apparent flaws in the design of the phylogenetic studies. With the aim of providing a definitive answer to this question, a part of the mitochond...
Article
Full-text available
Numerous studies have indicated a strong association between amplification of the multidrug resistance-1 gene and in vivo and in vitro mefloquine resistance of Plasmodium falciparum. Although falciparum infection usually is not treated with mefloquine, incorrect diagnosis, high frequency of undetected mixed infections, or relapses of P. vivax infec...
Data
Evaluation of the number of Plasmodium vivax mdr-1 copies by using a standard curve of 6 standards of mixed plasmids (from the standard-1, 1:1 ratio of Pvmdr-1 and β-tubulin to the standard-6, 6:1 ratio of Pvmdr-1 and β-tubulin) by the ΔCT method.
Article
There are growing concerns about the emergence of resistance of Sarcoptes scabiei to permethrin and other pyrethroid derivatives. Sarcoptes scabiei mites collected from 40 patients visiting two hospitals near Paris, France, were genotypically characterized considering two parts of their voltage-sensitive sodium channel gene. No nucleotide polymorph...
Article
Full-text available
Background: Plasmodium vivax is the most prevalent human malaria parasite, causing serious public health problems in malaria-endemic countries. Until recently the Duffy-negative blood group phenotype was considered to confer resistance to vivax malaria for most African ethnicities. We and others have reported that P. vivax strains in African count...
Article
There are growing concerns about the emergence of resistance of Sarcoptes scabiei to permethrin and other pyrethroid derivatives. Sarcoptes scabiei mites collected from 40 patients visiting two hospitals near Paris, France, were genotypically characterized considering two parts of their voltage-sensitive sodium channel gene. No nucleotide polymorph...
Article
Full-text available
To date, 11 studies conducted in different countries to test the association between Plasmodium falciparum Na(+)/H(+) exchanger gene (Pfnhe; PF13_0019) polymorphisms and in vitro susceptibility to quinine have generated conflicting data. In this context and to extend our knowledge of the genetic polymorphism of Pfnhe gene, we have sequenced the ms4...
Article
Full-text available
Bed bugs are hematophagous insects responsible for a re-emerging and challenging indoor pest in many countries. Bed bugs infestations may have health consequences including nuisance biting, cutaneous and systemic reactions. This resurgence can probably be attributed to factors such as increased international travel and development of resistance aga...
Article
Full-text available
The aim of this study was to provide a comprehensive analysis of the worldwide genetic polymorphism of ms4760 alleles of the pfnhe-1 gene and to discuss their usefulness as molecular marker of quinine resistance (QNR). A new numbering of ms4760 allele, classification grouping ms4760 alleles according to the number of DNNND and DDNHNDNHNND repeat mo...
Article
Insecticide treatment resistance is considered to be a major factor in the increasing number of infestations by head lice. The large insecticide selection pressure induced by conventional topical pediculicides has led to the emergence and spread of resistance in many parts of the world. Possible mechanisms of resistance include accelerated detoxifi...
Data
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Article
Background: Treatment of head lice infestation relies on the application of topical insecticides. Overuse of these products has led to the emergence of resistance to pyrethroids and malathion worldwide. Permethrin resistance in head lice is mostly conferred by the knockdown resistance (kdr) trait. Objective: To evaluate the occurrence of permeth...
Article
Full-text available
Plasmodium falciparum exports proteins that remodel the erythrocyte membrane. One such protein, called Pf155/RESA (RESA1) contributes to parasite fitness, optimizing parasite survival during febrile episodes. Resa1 gene is a member of a small family comprising three highly related genes. Preliminary evidence led to a search for clues indicating the...
Data
Characteristics of 30 Senegalese patients presenting with uncomplicated P. falciparum malaria.
Data
Characteristics of 54 Beninese patients presenting with severe P. falciparum malaria.
Data
Characteristics of 47 Beninese patients presenting with uncomplicated P. falciparum malaria.
Data
Characteristics of 39 Senegalese patients presenting with severe P. falciparum malaria.
Article
Clin Microbiol Infect 2012; 18: 338–344 Insecticide treatment resistance is considered to be a major factor in the increasing number of infestations by head lice. The large insecticide selection pressure induced by conventional topical pediculicides has led to the emergence and spread of resistance in many parts of the world. Possible mechanisms of...
Article
The human body louse is the only known vector of Bartonella quintana. However, the presence of this bacterium has recently been detected in the head lice of homeless individuals and Nepalese slum children. Previous studies have reported the isolation of Acinetobacter baumannii from the body lice of homeless individuals. An epidemiological survey in...
Article
Full-text available
Molecular investigations performed following the emergence of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum have allowed the identification of the dihydrofolate reductase (DHFR) enzyme as the target of pyrimethamine. Although clinical cases of Plasmodium malariae are not usually treated with antifolate therapy, incorrect diagno...
Article
Full-text available
Recently, Plasmodium falciparum parasites bearing Pfdhfr I164L single mutation were found in Madagascar. These new mutants may challenge the use of antifolates for the intermittent preventive treatment of malaria during pregnancy (IPTp). Assays with transgenic bacteria suggested that I164L parasites have a wild-type phenotype for pyrimethamine but...
Article
Full-text available
The purpose of this review was to provide up-to-date information on the resistance of Plasmodium falciparum to the main antimalarials used in Madagascar and to assist implementation of the malaria control and elimination program. In 2006, the failure rate for chloroquine treatment was 44% (n = 300) and was comparable to the rate observed in contine...
Data
Members of the National Reference Center Study Group for Imported Malaria in Metropolitan France.
Article
Full-text available
Little is known about severe imported Plasmodium falciparum malaria in industrialized countries where the disease is not endemic because most studies have been case reports or have included <200 patients. To identify factors independently associated with the severity of P. falciparum, we conducted a retrospective study using surveillance data obtai...
Article
Full-text available
Resistance of head lice to pyrethroids induces difficult therapeutic problems. Previous studies demonstrated that this resistance was present in a French urban area, but its prevalence needed to be more precisely evaluated in terms of genotyping lice collected from more infested children over a certain period of time. We monitored the presence of t...