Rémi Thomasson

Claude Bernard University Lyon 1 | UCBL · Centre de soins d'enseignement et de recherche dentaire

Autosomal Emery-Dreifuss muscular dystrophy (EDMD) is caused by mutations in the lamin A/C gene (LMNA) encoding A-type nuclear lamins, intermediate filament proteins of the nuclear envelope. Classically, the disease manifests as scapulo-humero-peroneal muscle wasting and weakness, early joint contractures and dilated cardiomyopathy with conduction...

Background: The heart is 1 of the organs most affected by hereditary hemochromatosis (HH). The clinical impact of cardiomyopathy in patients with HH requires a particular diagnosis and less invasive treatments. We developed a model of cardiomyopathy in knockout (KO) mice for the high-Fe (HFE) gene and assessed left ventricular (LV) function and st...

Introduction et but de l’étude Le fer est un oligoélément essentiel, impliqué dans des processus physiologiques et métaboliques fondamentaux comme le transport de l’oxygène et la protection contre l’oxydation. L’hémochromatose héréditaire (HH) est une pathologie principalement due à une mutation du gène codant pour la protéine humaine de l’hémochro...

Introduction: The effect of constitutive inactivation of the gene encoding myostatin on the gain in muscle performance during postnatal growth hsa not been well characterized. Methods: We analyzed 2 murine myostatin knockout (KO) models: i) the Lee model (KO(Lee) ) and ii) the Grobet model (KO(Grobet) ), and measured the contraction of tibialis...

Background Despite the well-known impact of exercise training in the prevention of cardiovascular diseases, few studies have been made to clarify the effects of exercise training in non-ischemic cardiomyopathies. In this study, we focused on the role of voluntary exercise training in a murine model of dilated cardiomyopathy (αMHC-MerCreMer:Sf/Sf) i...

Introduction Mechanisms involved in cardiac dysfunction induced by iron overload are not fully elucidated. The goal of our study is to evaluate cardiac function in HFE gene knock-out mice and determine the potential mechanisms involved in cardiac dysfunction. Material and methods Male wild type (WT, n=9), HFE gene knock-out (KO, n=8) and HFE heter...

Individual's one-repetition maximum (1-RM) is required to calculate and prescribe intensity for resistance training, while testing protocols enhance the risk of injuries and are time-consuming. The aim of the present study was to assess the accuracy of 1-RM prediction from ratings of perceived exertion (RPE) of resistance exercises performed at sub...

Glucocorticoids are widely used as therapeutic substances, but sometimes diverted from their primary use by athletes. The ergogenic effect of short-term glucocorticoid administration was previously demonstrated in men subjects but its effect in women as well as the mechanisms involved remain unknown. In a first study, we investigated the effects of...

The aim of the study was to evaluate the effects of short-term glucocorticoid treatment on plasma amino acids, free fatty acids, blood glucose, and several hormones in healthy volunteers performing long-lasting exercise. 9 young female subjects exercised 2 h at 50-55% VO₂ max twice, once after placebo (Pla) ingestion and once after prednisone (Cor,...

This study examined the relationships between plasma and saliva adrenocortical hormones in response to long-duration submaximal exercise. In nine healthy, physically active, female volunteers, blood and saliva samples were taken at rest and every 30 min during a 120-min cycling trial at 50-55% VO(2max) for cortisol and dehydroepiandrosterone (DHEA)...

The aim of this study was to evaluate serum and saliva adrenocortical hormones and their relationships at rest and during submaximal exercise and recovery in 9 obese diabetic middle-aged men (BMI: 35.2 ± 1.6 kg/m (2)). Blood and saliva samples were taken at rest, every 10 min of a 30-min cycling exercise at 70% of maximal heart rate, and after 10 m...

Given the high correlation between the serum and saliva hormone values demonstrated at rest, saliva provides a convenient non-invasive way to determine dehydroepiandrosterone (DHEA) and cortisol concentrations. However, to our knowledge, pituitary adrenal recovery following short-term suppression with corticosteroids has never been investigated in...

The present study investigated whether short-term oral administration of glucocorticoid would modify performance and selected hormonal and metabolic parameters during submaximal exercise in healthy women. Nine recreational female athletes completed cycling trials at 70-75% VO(2) max until exhaustion after either placebo (Pla, gelatin) or oral predn...

In order to test the hypothesis that salbutamol would change substrate oxidation during submaximal exercise, eight recreationally trained men twice performed 1 h at 60% VO(2) peak after ingestion of placebo or 4 mg of salbutamol. Gas exchange was monitored and blood samples were collected during exercise for GH, ACTH, insulin, and blood glucose and...