Rekha Rao

Rekha Rao
Guru Jambheshwar University of Science & Technology · Department of Pharmaceutical Sciences

M.PHARM., PHD

About

66
Publications
42,727
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Additional affiliations
October 1995 - February 2012
Maharishi Markandeshwar University, Mullana
Position
  • Professor (Assistant)
Education
September 2003 - October 2005
m.d.u, rohtak
Field of study

Publications

Publications (66)
Article
Full-text available
Background Quercetin is one of the most critical endogenous anti-oxidants used widely in cosmetics, nutraceuticals, and pharmaceuticals products for skincare and therapeutics due to its protective character against oxidants and inflammation. Although low hydrophilicity and poor percutaneous absorption of quercetin make it an untrustworthy entrant f...
Article
Full-text available
Reactive oxygen species triggered oxidative stress contributes to the pathogenesis of numerous ailments such as myocardial infraction, inflammation, atherosclerosis, and pigmentation disorders. ROS scavengers, particularly natural bioactives are one of the possible options to reduce this stress. However, these bioactives possess certain formulation...
Article
Full-text available
Bergenin (BER), a key constituent of Bergenia crassifolia (Saxifragaceae), has gained extensive attention, owing to its array of pharmacological actions, including anti-infective, anti-cancer, anti-diabetic, neuroprotective, hepatoprotective, anti-urolithiatic, anti-hyperuricemic, and anti-bradykinin properties. Despite ever-intensifying support fo...
Article
Full-text available
Dermal disorders such as psoriasis and eczema are associated with modifications in the chemical and molecular composition of the skin. Clobetasol propionate (CP), a superpotent topical glucocorticoid, is widely used for the therapeutic management of various skin conditions, owing to its strong anti-inflammatory, antipruritic, vasoconstrictive, and...
Chapter
By definition, drug targeting and delivery is the process of delivering a drug molecule to a specific site where the pharmacological effect is desired. A targeted release may simplify the drug administration protocols and reduce the amount of drug necessary, thus improving the cost-effectiveness and reducing the side effects. A drug administered by...
Article
Full-text available
Azelaic acid (AA), a promising agent for acne and hyperpigmentation disorders, is associated with side effects viz. rashes, skin irritation, dryness, burning and stinging. Its poor solubility also pose challenge in the development of suitable formulation. Therefore, this research was aimed to design cyclodextrin nanosponges (CDNS) of AA to address...
Article
Background Psoriasis, a chronic autoimmune disease, involves the integration of biological and molecular events by hyperproliferation of the epidermal keratinocytes and generation of inflammation markers. Due to severe complications of synthetic corticosteroids, there is a strong need for potential and safe alternative . Babchi oil (natural essenti...
Article
Sesamol (SES), a natural phenolic bioactive, is endowed with benefits in food and pharmaceuticals. However, its utility is compromised by certain unfavorable physicochemical characteristics, particularly poor stability. Therefore, present work is aimed at formulating novel SES loaded cyclodextrin nanosponges (CDNS) to protect the drug from degradat...
Article
Ellagic acid (EA) is a polyphenolic bioactive with a wide range of pharmacological activities. Regrettably, it possesses poor solubility, stability and permeability (in the gastrointestinal tract); and first-pass metabolism. Therefore, to address these challenges, the present research was aimed to encapsulate EA in cyclodextrin nanosponges (CDNS)....
Article
Full-text available
Alzheimer’s disease (AD) is a gradually growing irreversible illness of the brain that almost affects every fifth person (aged > 80 years) in the world. World Health Organization (WHO) also revealed that the prevalence of this disease will enhance (upto double) significantly upto 2030. The poor cholinergic transmission at the synapse is considered...
Article
Clobetasol propionate (CP), a superpotent topical corticosteroid, holds great promise for psoriasis treatment. However, common side effects like skin atrophy, steroidal acne, hypopigmentation and allergic contact dermatitis associated with it, hamper its utility for topical application. Taking this into consideration, the current work was aimed to...
Article
Background Drug loaded β-cyclodextrin based nanosponges (CDNS) are of special interest for the entrapment of moieties with the view to address their physicochemical challenges, and to improve their delivery characteristics and utility. Dithranol (DTH), the standard drug for psoriasis, has poor stability and solubility, which limits its pharmaceutic...
Article
Citronella oil has been frequently used as an insect repellant and antibacterial agent for management of vector borne diseases. In this study, the fabrication of citronella oil microsponge loaded hydrogel (HG-COMS) was conceptualized in order to provide future insight for developing delayed release formulation. The hydrogel was characterized for dr...
Chapter
The global incidence of skin cancer has increased dramatically in recent years. It is viewed as the most widespread form of malignant disease in the world, particularly in the United States. Surgery or radiotherapy has taken the first place among the treatment modalities for skin tumors. However, to improve patient compliance and to lessen undesira...
Article
Full-text available
Several pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmaco...
Article
Background Acne vulgaris is a chronic inflammatory disorder involving P. acnes (Propionibacterium acnes) and activation of lymphocytes and neutrophils. Dapsone (sulfone drug) possesses potent antimicrobial activities and hence, used to cure multiple inflamed acne lesions. Howbeit, its therapeutic utility is hampered, owing to its poor solubility an...
Article
Objective Dithranol (DTH) is a promising well known moiety that has long been used to impede and treat skin disorders, particularly psoriasis. Now a days, a rekindled interest in the use of DTH for this disorder has been observed. Side effects associated with conventional topical formulations of this moiety have aroused interest of scientific commu...
Article
Introduction The inception of nanosctructured lipid carriers (NLCs) proved to be a revolutionary step towards the treatment of dermatological disorders. To uncover its true potential, it is imperative that the system be characterized and evaluated comprehensively. Areas covered The present review has been written to furnish an in-depth account of...
Book
Full-text available
A theory-cum-practical book for teaching and learning of Pharmaceutics (B. Pharm as well as M. Pharm), as per the new syllabus prescribed by PCI
Article
Introduction: From a biopharmaceutical standpoint, the skin is recognized as an interesting route for drug delivery. In general, small molecules are able to penetrate the stratum corneum, the outermost layer of the skin. In contrast, the delivery of larger molecules, such as peptides and proteins, remains a challenge. Nanoparticles have been exploi...
Article
Background: Citronella Oil (CO) was used by the Indian army as mosquito repellant to repel mosquitoes at the beginning of the 20th century and later in 1948, it was registered in the USA for commercial purposes. Due to its ecofriendly nature, CO possesses immense potential as a mosquito repellent. Methods: Citronella oil is a valuable alternativ...
Article
Clobetasol propionate (CP), a super potent dihalogenated topical corticosteroid for psoriasis, displays common side effects like allergic contact dermatitis, steroid acne, skin atrophy, hypo-pigmentation and systemic absorption, on topical application. Hence, entrapment of CP in an appropriate carrier system could minimise the aforementioned side e...
Article
Azelaic acid (AA) is a naturally occurring 9-carbon straight chain saturated dicarboxylic acid widely found in wheat, ryes, and barley. It has been shown to possess biochemical activities, such as anti-inflammatory, anti microbial, antioxidant, anticomedolytic and anticancer. This therapeutic agent was approved by US food Drug Administration for tr...
Article
Full-text available
Dermatological disorders have a huge psychosocial impact, causing significant impairment of patient's life. Topical therapy plays a pivotal role in management of such disorders. Conventional topical delivery systems result in overmedication/undermedication, leading to adverse effects and reduction in therapeutic efficacy. Consequently, researchers...
Article
Full-text available
With the growing popularity of the nanomedicine-based pharmaceutical market, active molecules from chemical and natural origin are encapsulated in various nanocarriers enhancing their therapeutic efficacy. Depending upon the fabricated functionality, cyclodextrin based nanosponges has become a potential vehicle to encapsulate the active molecules....
Article
Psoriasis is a proliferative inflammatory skin disorder with relapsing episodes. Herein, the efficacy of babchi oil (BO) loaded nanostructure gel was evaluated for antipsoriatic activity and oxidative stress biomarkers assessment using mouse tail model. BO was entrapped into cyclodextrin-based nanocarriers (360.9 ± 19.55 nm), followed by incorporat...
Article
Full-text available
Babchi (Psoralea corylifolia) oil is an important essential oil used in several traditional medicines to cure various disorders. This phytotherapeutic agent possesses a number of pharmacological activities including antibacterial, antifungal, antioxidant, anti-inflammatory, immunomodulatory, and antitumor factors. However, volatile nature, poor sta...
Article
Full-text available
Babchi essential oil (BEO) is a valuable essential oil reported to possess a variety of biological activities such as antitumor, anti inflammatory, immunomodulatory, antioxidant, antifungal and antibacterial properties. Due to its anti-microbial properties, this oil possesses an immense potential for the treatment of dermatological disorders. Furth...
Article
Mosquito borne diseases such as malaria, filariasis, chikunguniya, yellow fever, dengue and Japanese encephalitis are the major cause of remarkable morbidity and mortality in livestock and humans worldwide. Since ancient times, aromatic plants are used for their medicinal value. Essential oils derived from these plants may be used as effective alte...
Article
Objective Tea Tree Oil (TTO), derived from Melaleuca alternifolia possesses broad spectrum antimicrobial potential. However, its therapeutic utility is impaired due to its high volatility, poor aqueous solubility and low stability in the presence of light, oxygen and temperature. The present study was attempted to investigate Ethyl Cellulose (EC) m...
Chapter
The tremendous impact of nanotechnology in the arena of healthcare has virtually revolutionized the outlook on health and disease management. Dermatological and skin care products constitute an expansive segment, and with the advent of nanotechnological revolution, several innovative carrier systems have emerged. Lipid-based carriers are particular...
Article
In recent years nanotechnology has revolutionized the healthcare strategies and envisioned to have a tremendous impact to offer better health facilities. In this context, medical nanotechnology involves design, fabrication , regulation, and application of therapeutic drugs and devices having a size in nano-range (1-100 nm). Owing to the revolutiona...
Article
Full-text available
Cyclodextrins, degradation product of carbohydrates, have been extensively exploited by food, pharmaceutical and cosmetic industry by virtue of their ease of availability and their ability to entrap guest moieties. Various cyclodextrin derivatives have been granted generally recognized as safe (GRAS) status by several countries. The most noteworthy...
Article
Full-text available
Background: Viruses are the most devastating pathogens of almost all life forms including humans and animals. Viruses can replicate very fast and may affect any metabolic and physiological function of the host cell. Therefore, it has been a challenge to develop a universal and common treatment against viral pathogens, in contrast to bacterial path...
Article
Full-text available
Pain is the major symptom associated with many diseases and disorders. Whether acute or chronic, pain causes much distress to the patient and can be debilitating in many cases. The quest for safe and effective pain management has driven the research efforts of the scientists for several decades. These ongoing efforts to come up with optimum therape...
Article
The use of essential oils (EOs) in the perfumery, agriculture, food industry and cosmetics is quite common owing to their aromatic properties. Tea tree oil is an EO with immense potential for the treatment of dermatological disorders due to its antimicrobial properties against broad spectrum of micro-organisms. It has minimal tendency to develop re...
Article
Background: Coenzyme Q10, a natural yellow benzoquinone, is a vitamin-like substance commonly found in blood and inner mitochondrial and cellular membranes. It is a natural antioxidant principle which plays an essential role in maintaining several biochemical pathways of body. It has exhibited many pharmacological activities in chronic heart failu...
Article
Diabetes mellitus, an endocrine disorder affecting glucose metabolism, has been crippling mankind for the past two centuries. Despite the advancements in the understanding pertaining to its pathogenesis and treatment, the currently available therapeutic options are far from satisfactory. The growing diabetic population increases the gravity of the...
Article
Full-text available
The present study was taken up with the objective of formulating emulgels to facilitate topical delivery of loratadine in the treatment of localized skin allergy. It was attempted to prepare the emulgels using three different types of surfactants, i.e. cationic, non-ionic and anionic. Further, the aim was to compare the formulations for their drug...
Article
Full-text available
The present investigation was carried out with the objective of formulating a gellified emulsion of benzoyl peroxide, an anti-acne agent. The formulations were prepared using four different vegetable oils, viz. almond oil, jojoba oil, sesame oil, and wheat germ oil, owing to their emollient properties. The idea was to overcome the skin irritation a...
Article
The effect of ultrasound energy on transdermal permeation of Losartan Potassium (LP) across albino rat skin was studied in vitro. Experiments were performed using therapeutic ultrasound (1MHz) at different intensities (0.5 and 2.5 W/cm2) for 10 and 30 minutes in continuous and pulsed (1:1) modes. Ultrasound variables used in present investigation w...
Article
Background and the Purpose of the study: Losartan potassium (LP) is an antihypertensive drug already used by oral route administration. As chemical penetration enhancers are widely used in transdermal pharmaceuticals as well as cosmetic products. Therefore, in present study, the effect of chemical enhancers on the transdermal absorption of Losartan...
Article
The purpose of present study was to design non ionic surfactant vesicles containing ramipril with different spans. The vesicles known as niosomes with a small particle size and good sphericity were prepared by thin film hydration method. Ramipril niosomes were analyzed for their morphological aspects, vesicle size and drug entrapment efficiency. Tr...
Article
Amoxicillin though originally introduced in the early 1970's for oral use in U.K., has found a gradually regular place as broad spectrum antibacterial to treat the infections of various diseases. Amoxicillin has been found to be more effective against gram positive than gram negative microorganisms and demonstrated greater efficacy to penicillin an...
Article
Non-ionic surfactant vesicles of valsartan, an angiotensin II inhibitor, were prepared by coacervation phase separation method. The prepared systems were characterised for encapsulation efficiency, shape, size and in vitro drug release. Stability study was carried out to investigate the leaching of drug from the proniosomal system during storage. T...
Article
Orally disintegrating tablets (ODTs) are gaining popularity over conventional tablets due to their convenience in administration and suitability for patients having dysphagia (difficulty in swallowing). In the present study, an attempt was made to compare the disintegration efficiency of mucilage isolated from natural source, Plantago ovata with wi...
Article
Full-text available
A number of novel drug delivery systems have emerged encompassing various routes of administration to achieve controlled and targeted drug delivery. Encapsulation of the drug in vesicular structures is one such system, which can be predicted to prolong the existence of the drug in systemic circulation and reduce the toxicity, if selective uptake ca...
Article
Full-text available
Use of ultrasound in therapeutics and drug delivery has gained importance in recent years, evident by the increase in patents filed and new commercial devices launched. The present review discusses new advancements in sonophoretic drug delivery in the last two decades, and highlights important challenges still to be met to make this technology of m...
Article
Hormone replacement therapy involves restoring estrogen (female hormone) to body when levels are diminished. Menopause is the most common cause of low estrogen levels. During menopause ovaries (glands that produce eggs and hormones) stop producing estrogen and body no longer menstruate. Women who have had their ovaries surgically removed have decre...
Article
Full-text available
A new series of (Z)-N-(substitutedphenyl)-2 -(2-((4-oxo-2- thiazolidin-5-ylidine) methyl)phenoxy)acetamides (d1-8) have been synthesized by reaction of 2-thioxo-4-thiazolidinone(a) with salicyldehyde and vanilline, which upon O-alkylation with different chloro - acetamides (c1-4) form the final derivatives (d1-8). The physical and spectral data of...
Article
Full-text available
2,5 – disubstituted 1,3,4 –oxadiazoles are synthesized from hydrazine and the corresponding aromatic acids both in the presence and in the absence of clay catalyst.
Article
To overcome the difficulties of poor skin permeability, recently ethosomes have been reported for enhanced transdermal delivery of drugs. Ethosomes are soft, malleable vesicles composed mainly of phospholipids, ethanol and water and are meant for enhanced delivery of active agents. This article reviews methods of preparation and characterization, m...
Article
The objective of the present study was to prepare and evaluate gastroretentive floating drug delivery system containing famotidine as a model drug. Famotidine tablets were prepared by wet granulation method using two different grades of hydroxypropylmethyl cellulose-HPMC K4M and HPMC K100M by effervescent technique. Sodium bicarbonate (SB) and citr...

Questions

Questions (2)
Question
can any body tell me how to select drug dose in donor cell in transdermal delivery if we have to take
drug suspension in donor cell
Question
HI GUYS, CAN WE IMPROVE DRUG PERMEATION THROUGH RAT SKIN BY INCREASING LOADING DOSE IN TRANSDERMAL DELIVERY