Reinhard Stindl

Reinhard Stindl
Alpharm Inc., Austria · apo-med-center

M.D.

About

27
Publications
12,990
Reads
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821
Citations
Introduction
I am convinced that the most important task in science is to develop new theoretical frameworks, which better fit the existing experimental and observational data. As Richard Goldschmidt put it, already in 1940: “A good observation may lead to results which a meaningless experiment cannot achieve, and a good idea or analysis may accomplish with one stride what a thousand experiments cannot do. This truism, obvious as it is in the history of all sciences, is frequently forgotten in this era of overestimation of new techniques, which are tools of progress only when in the hands of constructive thinkers.”
Additional affiliations
July 2002 - October 2006
Medical University of Vienna
Position
  • PostDoc Position
September 1999 - February 2002
University of California, Berkeley
Position
  • Researcher
February 1996 - March 1998
University of Vienna
Position
  • University Assistant (Training in medical genetics)
Education
October 1986 - June 1994
University of Vienna
Field of study
  • Medical School

Publications

Publications (27)
Article
Full-text available
Long telomeres, the protective caps of eukaryotic chromosomes, which erode during aging, have been the symbol of youth and regenerative potential. It therefore came as a surprise, when several cross-sectional studies reported that telomeres in sperm cells of old men are longer than in young men and that paternal age is positively linked to telomere...
Article
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Charles Darwin knew that the fossil record is not overwhelmingly supportive of genetic and phenotypic gradualism; therefore, he developed the core of his theory on the basis of breeding experiments. Here, I present evidence for the existence of a cell biological mechanism that strongly points to the almost forgotten European concept of saltatory ev...
Article
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Recently, an influential sequencing study found that more than 1700 genes had non-silent mutations in either a breast or colorectal cancer, out of just 11 breast and 11 colorectal tumor samples. This is not surprising given the fact that genomic instability is the hallmark of cancer cells. The plethora of genomic alterations found in every carcinom...
Article
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There have been several reports of a significant positive correlation between paternal age and chromosome telomere length in offspring. Moreover, the telomeres in sperm cells of older men tend to be longer than in young men, and it has been concluded that telomeres lengthen in the testes during adulthood. This would be the first evidence of an incr...
Article
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The currently prevailing theory of a transmissible cancer cell lineage in Tasmanian devils was based on the discovery of apparently identical chromosomal aberrations in facial tumors of several animals. New findings of facial tumors that have no detectable cytogenetic similarities to previously published cancer karyotypes and the recent detection o...
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Correspondence re: Lapham K, Kvale MN, Lin J, et al. 2015. Automated assay of telomere length measurement and informatics for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics 200: 1061–1072.
Article
Full-text available
Longer telomeres in the somatic cells of an individual have been regarded as a marker of youth and biological fitness within a population. Yet, several research groups have reported the surprising findings of longer telomeres in the germ cells of older men, which translated into longer leukocyte telomere length in their offspring. Although all thes...
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Correspondence re: Sandler, O., S. P. Mizrahi, N. Weiss, O. Agam, I. Simon, and N. Q. Balaban. 2015. "Lineage correlations of single cell division time as a probe of cell-cycle dynamics." Nature no. 519 (7544):468-71. doi: 10.1038/nature14318.
Article
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Upon re-examination of large telomere datasets from healthy human populations, a downward secular trend in telomere length at birth was found. The authors theorized that relatively recent environmental stresses to female germ cells could have driven the observed intergenerational telomere erosion; otherwise, these trends would have pushed populatio...
Article
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Correspondence re: Hung, C. M., et al. 2014. "Drastic population fluctuations explain the rapid extinction of the passenger pigeon." Proc Natl Acad Sci U S A no. 111 (29):10636-41. doi: 10.1073/pnas.1401526111
Article
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Correspondence re: Stringer, C. (2014) Stringer, C. 2014. "Why we are not all multiregionalists now." Trends Ecol Evol no. 29 (5):248-251
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Correspondence re: Villeda et al. 2014."Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice." Nat Med no. 20 (6):659-63. doi: 10.1038/nm.3569.
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Correspondence re: Zimonjic et al. 2001. "Derivation of human tumor cells in vitro without widespread genomic instability." Cancer Res no. 61 (24):8838-44. Submitted to Cancer Research 8/19/2002, rejected 8/29/2002
Article
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Correspondence re: Forsberg, L. A., et al. 2014. "Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer." Nat Genet 46 (6):624-8. doi: 10.1038/ng.2966.
Article
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Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or meth...
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Einstein is often quoted to have said that without the bee, mankind would have but 4 years to live. It is highly unlikely that he made this comment, which was even mentioned in a Lancet article on honey bees. However, the current vanishing of the bees can have serious consequences for human health, because 35% of the human diet is thought to benefi...
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Pelizaeus-Merzbacher disease is a rare X-linked neurodegenerative disorder caused by sequence variations in the proteolipid protein 1 gene (PLP1). PLP1 gene duplications account for approximately 50%-75% of cases and point variations for approximately 15%-20% of cases; deletions and insertions occur infrequently. We used multiplex ligation-dependen...
Article
Myelodysplasia associated with a complex karyotype is usually associated with advanced stage myelodysplastic syndrome (MDS) and an enhanced risk to develop secondary leukemia. We report on a 36-year-old female patient who was first presented in 1997 because of 'Pseudo Pelger-Huet' neutrophils. The remaining blood and differential counts were normal...
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According to the fossil record, 99.9% of all species that have ever lived on Earth have disappeared. However, only about 4% died out during the five mass extinction events, whereas it seems that the majority of species vanished without any signs of significant earthbound or extraterrestrial physical threats. Clearly, biological extinction mechanism...
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The classic explanation that women outlive men solely due to hormonal and lifestyle differences, does not withstand a critical analysis. In developed countries, the average gap in life expectancy between the sexes is 7 years. It has widened over the last decades, despite the trend of women copying the 'unhealthy' lifestyle of men. Estrogen levels i...
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Cancer cells and aneuploid cell lines can acquire resistance against multiple unrelated chemotherapeutic drugs that are over 3,000-fold those of normal levels and display spontaneous resistances up to 20-fold of normal levels. Two different mechanisms were proposed for this phenotype: (i) classical mutation of drug metabolizing genes or (ii) chromo...
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The mutagenic ranges of aneuploidy, an abnormal number of chromosomes, and gene mutation are analyzed for their abilities to cause the dominant phenotypes of cancer. In the cell, activating gene mutations are buffered because virtually all gene products are kinetically linked into biochemical assembly lines and thus functionally controlled by upstr...
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The mutation rates of cancer cells to drug and multidrug resistance are paradoxically high, i.e., 10(-3) to 10(-6), compared with those altering phenotypes of recessive genes in normal diploid cells of about 10(-12). Here the hypothesis was investigated that these mutations are due to chromosome reassortments that are catalyzed by aneuploidy. Aneup...
Article
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For nearly a century, cancer has been blamed on somatic mutation. But it is still unclear whether this mutation is aneuploidy, an abnormal balance of chromosomes, or gene mutation. Despite enormous efforts, the currently popular gene mutation hypothesis has failed to identify cancer-specific mutations with transforming function and cannot explain w...
Article
A 68-year-old woman presented with profuse hemorrhage and other signs suggesting an acute leukemia. Histologic and cytogenetic evaluation of her bone marrow revealed alveolar rhabdomyosarcoma as the underlying cause of massive disseminated intravascular coagulation and hyperfibrinolysis. A review of the literature reveals that coagulopathy appears...
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Pancytopenia and fulminant disseminated intravascular coagulation in a 68-year-old woman suggested an acute hematologic malignancy. However, cytogenetic analysis on a bone marrow sample revealed a near-tetraploid karyotype with an isochromosome 1q and a translocation (2;13) (q35;q14), which was suggestive of an alveolar rhabdomyosarcoma (ARMS). Thi...

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