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September 1989 - September 2010
Publications
Publications (383)
Skeletal ossification occurs either directly within mesenchymal tissues or indirectly through a template of hyaline cartilage. Between the epiphyses and diaphyses of long bones, hyaline cartilaginous growth plates remain and constitute the progenitor cell reservoir from which the tissue develops toward the diaphysis and determines longitudinal bone...
Aim: With the resolution from April 28, 2014, the Bavarian state government in Germany decided to found a new medical school at Augsburg University, thereby requiring the development of a competency-based medical curriculum.
Methods: Two interdisciplinary groups developed a spiral curriculum (following Harden) employing the model of Thumser-Dauth &...
Apophyses are growth zones attached to the shaft (corpus) of larger bones. They vary in size and develop their own ossification centres or form as part of an usually fibrocartilaginous tendon or ligament insertion. The structure of the cartilaginous apophyseal plate is very similar to that of an epiphyseal growth plate and like these they are adapt...
The acromioclavicular (AC) joint connects the acromion with the lateral end of the clavicle and constitutes an important load-transmitting element between the upper extremity and the skeleton of the trunk.
This review discusses functional aspects that relate the AC and the coracoclavicular (CC) ligaments to AC joint instability and lateral clavicle...
Background: While numerous anatomical institutes already worked up their Nazi history, this is not yet done for the Anatomical Institute in Innsbruck.
Results: The Chairman of the Institute during the Third Reich, Felix Sieglbauer, was professor of anatomy since 1918 and held this position until his retirement in 1946. About his person during the T...
Purpose:
To assess the use of diffusion-tensor (DT) imaging of articular cartilage to detect and grade early cartilage damage in human specimens with early signs of cartilage damage.
Materials and methods:
This study was approved by the institutional review board. Forty-three cartilage-on-bone samples drilled from 21 human patellae were examined...
While allowing the greatest range of axial rotation of the entire spine with 40° to each side, gradual restraint at the extremes of motion by the alar ligaments is of vital importance. In order for the ligaments to facilitate a gradual transition from the neutral to the elastic zone, a complex interaction of axial rotation and vertical translation...
To investigate the relationship of the different diffusion tensor imaging (DTI) parameters (ADC, FA, and first eigenvector (EV)) to the constituents (proteoglycans and collagen), the zonal arrangement of the collagen network, and mechanical loading of articular cartilage.
DTI of eight cartilage-on-bone samples of healthy human patellar cartilage wa...
To investigate changes of diffusion tensor imaging (DTI) parameters (mean apparent diffusion coefficient [ADC], fractional anisotropy [FA], and first eigenvector) with increasing proteoglycan (PG) extraction of articular cartilage.
Twelve cylindrical cartilage-on-bone samples were drilled from 4 human patellae (3 per patella). Each sample was divid...
The objective of this study was to develop a technique for analyzing spatial patterns of cartilage loss in the medial femoral condyle (MF), and to study MF cartilage loss in participants of the Osteoarthritis Initiative. Using a 0.7 mm sagittal double echo at steady state (DESS) sequence, 160 osteoarthritic knees from 80 participants with varying d...
Undefined middle foot pain among older individuals is an increasingly problem. Thereby the tarso-metatarsal joints (Lisfranc's joint, TMT joints) are particularly important for foot structure. The aim of this study was to obtain into force transmission in TMT joints by analysing degenerative morphological changes (DMC) of the articular cartilage an...
How do students use multimedia tools to support their learning during a gross anatomy dissection course? We investigated this question in the anatomic dissection course for first year medical students at the University of Munich (n=850) by giving all participating students access to an anatomical multimedia CD-ROM. The use of this multimedia learni...
The characteristic cells in tendons and ligaments are called tenocytes, which are responsible for the formation and turnover of the extracellular matrix. They react to external stimuli and facilitate the functional adaptation of the proteoglycan and collagen network to mechanical requirements. Via numerous cellular processes they form a complex com...
Ziele: Beschadigung der Kollagenfaserarchitektur (KFA) wird als Zeichen irreversibler Knorpelschaden mit spater nachfolgender Arthrose (OA) angesehen. Ziel der Arbeit war, erstmals durch direkte Korrelation mit der Rasterelekronenmikroskopie zu prufen, ob die Diffusions-Tensor-Bildgebung (DTI) die zonale KFA des Knorpels darstellen und die Dicke de...
This study evaluated a method for determining the density and distribution of bone of mandibular condyles using proprietary computerized tomography (CT) software.
Thirty-eight condylar specimens were investigated with a high-resolution multislice CT. The density was determined by using bone density analysis algorithms available within the proprieta...
Das Inkrafttreten der neuen ÄAppO 2003 war der Ausgangspunkt für tiefgreifende curriculare Veränderungen an allen bundesdeutschen medizinischen Fakultäten. Vor diesem Hintergrund wurde 2004 ein postgradueller und interfakultärer Master of Medical Education (MME)-Studiengang unter der Schirmherrschaft des Medizinischen Fakultätentages (MFT) an der U...
The implantation of total ankle prosthesis is one of the most challenging operations in orthopaedic surgery. The main problem that surgeons face is the fixation of the total ankle prosthesis on the tibial side. The subchondral bone plate of the distal tibia is considered the strongest region on the inferior tibial facies. Based on information about...
Der Verlauf des Ramus deltoideus als Ast aus der Arteria tibialis posterior kann anhand der Präparation an Sprunggelenken mit hoher Übereinstimmung dargestellt werden. In allen Fällen hatte der Ramus deltoideus in seinem Verlauf einen direkten Bezug zum Ligamentum deltoideum pars mediale, so dass bei einer Verletzung dieses Bandes eine Mitbeteiligu...
Autologous chondrocyte transplantation (ACT) has had reasonable success for repairing small articular cartilage defects. A limiting factor for ACT is, however, the in vitro cultivation of chondrocytes because it leads to dedifferentiation. Therefore, the goal of this work was to optimize the monolayer culture of chondrocytes in vitro.
Human articul...
The immunohistochemical labelling patterns of the extracellular matrix at the insertion of the flexor carpi ulnaris tendon and the entheses at both ends of the pisometacarpal and pisohamate ligaments were compared in order to relate the molecular composition of the attachment sites to their mechanical environment. Tissue was obtained from elderly d...
The role of the facet joint in low back pain has gained public attention lately. The objective of our study was to investigate whether there is any difference in the adaptation of the cancellous bone in the superior articular process depending on the specific stress condition in different levels of the spine. Therefore, the trabecular structure of...
The coracoacromial ligament forms part of the coracoacromial arch and is implicated in impingement syndrome and acromial spur formation. Here, we describe its structure and the composition of its extracellular matrix. Ligaments were obtained from 15 cadavers, nine from older people (average age 74.7 years) and six from younger individuals (average...
Hyaline cartilage is characterised by a specialised extracellular matrix. On the one hand, different proteoglycans and glycosaminoglycans increase the volume by binding water molecules, on the other hand, the three-dimensionally organised collagen network keeps the tissue together, which is the prerequisite for internal hydrostatic pressurisation....
The implementation of new medical licensing regulations (AAppO 2003) was the starting point for radical curricular changes in all German medical schools. In 2004, the postgraduate and interfaculty Master of Medical Education (MME) degree programme was established at the University of Heidelberg under the auspices of the Medical Faculty Association...
The ligaments of the knee can be divided into four groups. Ventral reinforcements are the patellar retinaculae. The posteromedial complex stabilizes the valgus stress. It consists of the medial collateral ligament, the thickened posteromedial capsule and a branch of the tendon of the semimembranosus muscle as well as the oblique popliteal ligament....
The ligaments of the knee can be divided into four groups. Ventral reinforcements are the patellar retinaculae. The posteromedial complex stabilizes the valgus stress. It consists of the medial collateral ligament, the thickened posteromedial capsule and a branch of the tendon of the semimembranosus muscle as well as the oblique popliteal ligament....
The triangular fibrocartilage complex (TFCC) transmits load from the wrist to the ulna and stabilizes the distal radioulnar joint. Damage to it is a major cause of wrist pain. Although its basic structure is well established, little is known of its molecular composition. We have analysed the immunohistochemical labelling pattern of the extracellula...
A sound knowledge of the scientific basis of medicine is a prerequisite for successful learning and understanding of clinical issues. Teachers of clinical medicine, however, often complain that their students' knowledge on the scientific basis of medicine is too low. In the clinical curricula of most medical schools in Germany, students rely on sel...
Die Füße werden von den Menschen meist wenig beachtet, sind sie doch in Strümpfen und Schuhwerk verborgen oder stehen mit dem Schmutz der Erde in Berührung. Dabei sind sie ein zentrales Element unseres Selbstverständnisses als aufrechtgehende Wesen. Sie vermitteln die Relativbewegung zum Boden, erlauben vielfältige kräftige Bewegungen vom Treten bi...
The scapholunate interosseous ligament (SLIL) connects the scaphoid and lunate bones and plays a crucial role in carpal kinematics. Its rupture leads to carpal instability and impairment of radiocarpal joint function. As the ligament is one of the first structures affected in rheumatoid arthritis, we conducted an immunohistochemical study of cadave...
Introduction Spondylolytic spondylolisthesis is an osseous discontinuity of the vertebral arch that predominantly affects the fifth lumbar vertebra. Biomechanical factors are closely related to the condition. An immunohistochemical investigation of lysis-zone tissue obtained from patients with isthmic spondylolisthesis was performed to determine th...
The effects of exercise on articular hyaline articular cartilage have traditionally been examined in animal models, but until recently little information has been available on human cartilage. Magnetic resonance imaging now permits cartilage morphology and composition to be analysed quantitatively in vivo. This review briefly describes the methodol...
Facet joints play an important role in intervertebral load transmission and are crucial for rotational kinematics. Clinically, the role of facet joints as a possible source of low back pain is seen as controversial and at present is not sufficiently investigated. In this study, human lumbar facet (zygapopyhysial) joints from donors with advanced ag...
The vertebral bodies and vertebral arches show a characteristic distribution of cortical and cancellous bone. The pedicles are loaded by uniplanar bending that is reflected by the arrangement of the cortical substance of bone. The ligaments of the vertebral column consist of longitudinal and (with the exception of the ligamentum longitudinale anter...
The composition of the extracellular matrix in tendons and ligaments is directly related to the mechanical environment. Local compression triggers functional adaptation that leads to cartilage-specific transformation of the tissue. The molecular composition of the extracellular matrix at the enthesis is related to the amount of stress and to the ge...
The composition of the extracellular matrix in tendons and ligaments is directly related to the mechanical environment. Local compression triggers functional adaptation that leads to cartilage-specific transformation of the tissue.
The molecular composition of the extracellular matrix at the enthesis is related to the amount of stress and to the ge...
The present study pursues the hypothesis that local compressive force and the occurrence of cartilage-specific transformation processes within the extracellular matrix of tendons and ligaments are directly correlated. We compare the pattern of certain marker molecules typical of (fibro)cartilage in select examples. Investigations are carried out of...
The superior tarsus is a plate of tissue that stiffens the upper eyelid, gives it support and determines its form. The purpose of the present study was to relate the composition of its extracellular matrix to its function and to report regional differences that may influence the activity of its Meibomian glands. Fourteen methanol-fixed specimens we...
The present study pursues the hypothesis that local compressive force and the occurrence of cartilage-specific transformation processes within tendons and ligaments are directly correlated.
In selected anatomical samples of human origin the distribution pattern of certain components of the extracellular matrix is assessed. Investigations are carrie...
An isolated arthrodesis of the talocalcaneonavicular joint is a common indication in cases of pain and post-traumatic arthroses.
Because of the high infection rate after surgery with the lateral incision, the authors decided to evaluate an alternative, minimally invasive procedure. Joint destruction was carried out via a posterolateral access after...
We performed an anatomic study on 20 fresh lower limbs. Resin was injected in the popliteal artery. Medial sural artery perforator flaps were sculptured according to anatomic markings. On average, length of flaps was 12.9 cm, width was 7.9 cm; all 38 perforators were musculocutaneous: 1 perforator was always found (on average, 1.9 per flap). All pe...
In higher vertebrates, the paraxial mesoderm undergoes a mesenchymal to epithelial transformation to form segmentally organised structures called somites. Experiments have shown that signals originating from the ectoderm overlying the somites or from midline structures are required for the formation of the somites, but their identity has yet to be...
Studienziel: Die Ätiologie der Supraspinatussehnenruptur ist multifaktoriell. Eine mögliche Ursache ist die mechanische Schädigung der Supraspinatussehne durch eine Einengung im subakromialen Raum. Das Ziel der vorliegenden Studie war es, verschiedene morphometrische Einflussgrößen des subakromialen Raumes auf ihre Relevanz bei vorliegender Suprasp...
At this point we may observe that problems in medical education should be sought for neither in the tutor-student ratio nor in the conditions of studies, but rather in the universities' general dilemma, in the conflict between patient care, research, and education. It is furthered by the absence of academic teaching's "market value" and of a specif...
Lipectomy is a standard procedure in plastic surgery. Until now, however, there was no definite information about the influence of different liposuction techniques (tumescent versus dry liposuction) on the integrity of lymph collectors during this procedure. To study the effect of these liposuction techniques on the incidence of lymph vessel injury...
The new curriculum for medical licensure in Germany focuses on interdisciplinary and problem-based learning. In recent years, first experiences with this learning model were gathered in several German medical schools conducting courses supplementing the traditional curriculum. This article describes the course "Nervous system and behavior" at Ludwi...
Mit der neuen Approbationsordnung sind die medizinischen Fakultäten aufgefordert, Fächer übergreifendes und problemorientiertes Lernen in den Mittelpunkt des Studienkurrikulums zu rücken. Erfahrungen mit der Anwendbarkeit dieses Lernmodells wurden in den Vorjahren bereits an verschiedenen deutschen Fakultäten in Kursen, die das traditionelle Kurrik...
Die lumbale Spinalstenose ist erst in den letzten Jahrzehnten zu einem greifbaren Krankheitsbild geworden. Sie ist dadurch definiert, dass ein Missverhältnis zwischen dem Raumbedarf für das Rückenmark in der unteren Lendenwirbelsäule und dem zur Verfügung stehenden Platz besteht. Einzelne Engstellen treten vor allem in der unteren Lendenwirbelsäule...
The etiology of rotator cuff tears is multifactorial. An important factor is the damage of the rotator cuff by narrowing of the subacromial space. The purpose of this investigation was to estimate the influence of various metrical parameters on the size of the subacromial space.
We investigated 161 human macerated scapulae, 36 of them had a known t...
Strengthening of the shoulder depressors is an important component in the treatment of impingement syndrome. However, the quantitative effect of various muscle forces on the width of the subacromial space has never been demonstrated in vivo. Therefore, the purpose of this study was to analyze the influence of adducting and abducting muscle forces o...
The distribution of the thickness of cartilage as well as of the subchondral mineralization reflects the various stresses on the joint compartments. Both long bones of the lower arm participate in load bearing. The humeroradial and humeroulnar parts of the joint are incongruent. The capitulum humeri is slightly smaller than the corresponding fovea,...
The outstanding progress achieved in MRI and arthroscopic techniques has forced orthopedic surgeons to consider the anatomy of the shoulder joint in detail. The superior labrum complex shows a broad range of variations, which is the reason for some difficulties regarding diagnostic conclusions as well as therapeutic considerations. In particular, t...
Although the hypertrophied shape of the zygapophysial joints in degenerative instability of the lumbar spine is well known, its underlying pathophysiological mechanism is unclear. The authors sought to provide evidence that there is increased fibrocartilaginous metaplasia in the posterior joint capsule resulting from greater mechanical loading; the...
To provide evidence for the existence of a wide range of molecules characteristic of fibrocartilage at normal alar ligament entheses, that may have a bearing on the pathogenesis of rheumatoid arthritis. The alar ligaments provide the mechanical restraint for head rotation and their integrity can be compromised in patients with RA and occasionally i...
Die Verteilung von Knorpeldicke und Mineralisierung
spiegelt die vielseitige Beanspruchung der Gelenkkrper des
Ellenbogengelenks wider. ber beide Unterarmknochen werden
Druckkrfte bertragen.Sowohl Humeroradial- als auch
Humeroulnargelenk sind jeweils inkongruent. Im lateralen
Gelenkabschnitt ist der konvexe Gelenkkrper geringfgig
kleiner, im medial...
The outstanding progress achieved in MRI
and arthroscopic techniques has forced orthopedic
surgeons to consider the anatomy
of the shoulder joint in detail.
The superior labrum complex shows
a broad range of variations, which is the
reason for some difficulties regarding diagnostic
conclusions as well as therapeutic
considerations. In particular, t...
Functional computed tomography for visualization and quantification of subchondral bone mineralization using CT osteoabsorptiometry (CT-OAM).
Tarsometatarsal (TMT) and metatarsophalangeal (MTP) joints of 46 human hallux valgus (HV) specimens were examined (sagittal 1/1/1 mm) on a single slice CT scanner SCT (Somatom Plus 4, Siemens AG). Subchondral...
Purpose:
Functional computed tomography for visualization and quantification of subchondral bone mineralization using CT osteoabsorptiometry (CT-OAM).
Materials and methods:
Tarsometatarsal (TMT) and metatarsophalangeal (MTP) joints of 46 human hallux valgus (HV) specimens were examined (sagittal 1/1/1 mm) on a single slice CT scanner SCT (Somat...
One of the theories as to the etiology and pathogenesis of lunatomalacia (Kienböck's disease) is based on the presentation of an osseous compartment syndrome caused by a venous block in the pedicle. This gave us cause to examine the lunate bone more closely and to investigate possible anatomical causes for the disruption. For this purpose, ten hand...
One of the theories as to the etiology and pathogenesis of lunatomalacia (Kienböck's disease) is based on the presentation of an osseous compartment syndrome caused by a venous block in the pedicle. This gave us cause to examine the lunate bone more closely and to investigate possible anatomical causes for the disruption. For this purpose, ten hand...
To assess the morphology, topography, frequency, and etiology of intraosseous carpal ganglions.
Two hundred and eighty formalin fixed cadaveric wrists (mean age 80.3 +/- 9.7 years, range 40 to 101 years) were radiographed. Fifty specimens suspicious for cyst-like bone lesions underwent magnetic resonance imaging (T1w and proton density-fat-saturate...
We tested the hypothesis that muscle cross-sectional areas (MCSAs) are more highly (and independently) correlated with cartilage morphology than are body height and weight, and that the physiological reduction of cartilage thickness with aging is associated with a proportional, age-dependent decrease in MCSAs. In 59 asymptomatic individuals (23-75...
The synovial fold of the humeroradial joint is known, and sometimes considered as a meniscus that could be injured by chronic repeated trauma related to pronation and supination. The aims of this study were to determine the gross anatomy and histological structure of this fold, and to clarify its participation in the painful lateral syndromes of th...
