Regina Sepsiova

Regina Sepsiova
Comenius University Bratislava · Department of Genetics

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16
Publications
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67
Citations

Publications

Publications (16)
Article
CRISPR-Cas9 is a genome-editing technique that has been widely adopted thanks to its simplicity, efficiency, and broad application potential. Due to its advantages and pervasive use, there have been attempts to include this method in the existing curricula for students majoring in various disciplines of biology. In this perspective, we summarize th...
Article
Full-text available
The Phl p 5 allergen of the plant species Phleum pratense is considered one of the most crucial grass pollen allergenic molecules inducing respiratory allergies. In this study, we evaluated seasonal variation in the concentration of both grass pollen and Phl p 5 allergens as well as the ratio allergen/pollen (pollen potency) in the air of Bratislav...
Article
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In virtually every eukaryotic species, the ends of nuclear chromosomes are protected by telomeres, nucleoprotein structures counteracting the end-replication problem and suppressing recombination and undue DNA repair. Although in most cases, the primary structure of telomeric DNA is conserved, there are several exceptions to this rule. One is repre...
Article
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Poaceae pollen and Phl p 5 allergen concentrations to determine whether airborne pollen concentrations alone are sufficient to reflect the actual allergenic potential of the air. The relationships between the mentioned pollen and allergen concentrations and associated environmental variables were also examined. The airborne particles were collected...
Poster
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The ends of linear chromosomes are protected by telomeres, which are primarily maintained by the RNA-protein complex telomerase. Environmental stressors were previously shown to affect telomere length [1]. Even though some yeast produce ethanol, it inhibits cell growth and survival in higher concentrations [2]. Formaldehyde (FA) is a simple, very r...
Conference Paper
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During each cell division, telomere length in wild-type yeasts is maintained within a defined interval to protect their genome integrity. Various environmental stress factors can influence telomere length, which can be assessed by terminal restriction fragment (TRF) analysis. High concentrations of ethanol inhibit cell replication, survival and alc...
Article
Telomeric sequences constitute only a small fraction of the whole genome yet they are crucial for ensuring genomic stability. This function is in large part mediated by protein complexes recruited to telomeric sequences by specific telomere-binding proteins (TBPs). Although the principal tasks of nuclear telomeres are the same in all eukaryotes, TB...
Article
Full-text available
Telomeres of nuclear chromosomes are usually composed of an array of tandemly repeated sequences that are recognized by specific Myb domain containing DNA-binding proteins (telomere-binding proteins, TBPs). Whereas in many eukaryotes the length and sequence of the telomeric repeat is relatively conserved, telomeric sequences in various yeasts are h...
Data
Scheme for construction of vectors used to express (A) Teb1p and (B) Taz1p in Escherichia coli. For detailed description see Materials and Methods. Sequences of the primers used for PCR are listed in S1 Table. (PDF)
Article
Full-text available
Double-stranded regions of the telomeres are recognized by proteins containing Myb-like domains conferring specificity toward telomeric repeats. Although biochemical and structural studies revealed basic molecular principles involved in DNA binding, relatively little is known about evolutionary pathways leading to various types of Myb domain-contai...

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