Regina Becker

Regina Becker
University of Luxembourg · Luxembourg Centre for Systems Biomedicine (LCSB)

About

21
Publications
1,371
Reads
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202
Citations
Citations since 2017
13 Research Items
118 Citations
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Introduction

Publications

Publications (21)
Article
Full-text available
Several phenotypic differences observed in Parkinson’s disease (PD) patients have been linked to age at onset (AAO). We endeavoured to find out whether these differences are due to the ageing process itself by using a combined dataset of idiopathic PD (n = 430) and healthy controls (HC; n = 556) excluding carriers of known PD-linked genetic mutatio...
Article
Full-text available
Contemporary biomedical research heavily relies on secondary use of personal health data that were obtained in a different clinical or research setting. Under the European Union’s General Data Protection Regulation ( GDPR ), data controllers processing personal data must comply with the principle of purpose limitation, which restricts further proce...
Article
Full-text available
Unstructured: Researchers must collaborate globally in order to rapidly respond to the COVID-19 pandemic. In Europe, the General Data Protection Regulation (GDPR) regulates the processing of personal data, including health data of value to researchers. Even during a pandemic, research still requires 1) a legal basis for the processing, 2) an addit...
Preprint
UNSTRUCTURED Researchers must collaborate globally to rapidly respond to the COVID-19 pandemic. In Europe, the General Data Protection Regulation (GDPR) regulates the processing of personal data, including health data of value to researchers. Even during a pandemic, research still requires a legal basis for the processing of sensitive data, additio...
Article
Full-text available
Background The new European legislation on data protection, namely, the General Data Protection Regulation (GDPR), has introduced comprehensive requirements for the documentation about the processing of personal data as well as informing the data subjects of its use. GDPR’s accountability principle requires institutions, projects, and data hubs to...
Article
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
Full-text available
Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition...
Chapter
Within life-science research the upcoming EU General Data Protection Regulation has a significant operational impact on organisations that use and exchange controlled-access Human Data. One implication of the GDPR is data bookkeeping. In this poster we describe a software tool, the Data Information System (DAISY), designed to record data protection...
Article
Tremendous progress has been made in biomedical research in genomics, proteomics and metabolomics, which has led to an increasing insight into molecular mechanisms related to diseases. Yet the output of disease prevention, diagnosis and treatment solutions remains low. It is against this background that several European countries have gathered to t...
Article
Full-text available
NB, Peltonen L (2009) Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet. 41(1):35-46. 6. Yuille M, van Ommen GJ, Bréchot C, Cambon-Thomsen A, Dagher G, Landegren U, Litton JE, Pasterk M, Peltonen L, Taussig M, Wichmann HE, Zatloukal K (2008) Biobanking for Europe. Briefings in Bioinformatics...
Article
The KFA programme to gather the necessary dosimetric and biophysical information to develop optimal dose calculation routines for conformal proton radiation therapy is introduced. First experiments in a water phantom and with a plastic phantom are presented for incident protons of 175.5 MeV. Furthermore, the first detailed biophysical investigation...
Article
For the treatment of several tumour types, calculated proton dose distributions predict an improvement in tumour response compared to conformal photon and electron radiotherapy. The dose can be delivered with much higher precision due to the limited proton range and the sharp distal fall-offs. For tumour treatment and dosimetric purposes, it is nec...
Article
The microdosimetric weighting function approach is used widely for beam comparison studies. The suitability of this model to predict the relative biological effectiveness (RBE) of therapeutic proton beams was studied. The RBE(alpha) (i.e., linear approximation) dependence on the type of biological end point, initial proton energy, energy spread of...

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