Reggie Gaudino

Reggie Gaudino
Front Range Biosciences · R&D

Ph.D

About

20
Publications
7,310
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344
Citations
Additional affiliations
January 1992 - January 1996
Washington University in St. Louis
Position
  • PostDoc Position

Publications

Publications (20)
Patent
Full-text available
This technology relates in part to methods of identifying plant cultivars based on the terpene synthase genes that are identified and/ or quantified (e.g., copy number, ploidy) in the cultivars. The methods provided herein permit plant cultivars with desired characteristics/ phenotypes, e.g., a desired terpene production profile, to be selected for...
Patent
Full-text available
The technology relates in part to methods and compositions for detecting one or more pathogens in plants. In some aspects, the technology relates to methods and compositions for detecting hops latent viroid in plants. In some aspects, the technology relates to methods and compositions for detecting hops latent viroid in cannabis plants. In some asp...
Article
Full-text available
The widespread legalization of Cannabis has opened the industry to using contemporary analytical techniques for chemotype analysis. Chemotypic data has been collected on a large variety of oil profiles inherent to the cultivars that are commercially available. The unknown gene regulation and pharmacokinetics of dozens of cannabinoids offer opportun...
Preprint
Full-text available
The accelerating legalization of Cannabis has opened the industry to using contemporary analytical techniques. The gene regulation and pharmacokinetics of dozens of cannabinoids remain poorly understood. Because retailers in many medical and recreational jurisdictions are required to report chemical concentrations of cannabinoids, commercial labora...
Article
Full-text available
Gene copy number (CN) variation is known to be important in nearly every species where it has been examined. Alterations in gene CN may provide a fast way of acquiring diversity, allowing rapid adaptation under strong selective pressures, and may also be a key component of standing genetic variation within species. Cannabis sativa plants produce a...
Article
Full-text available
Terpenes are responsible for most or all of the odor and flavor properties of Cannabis sativa, and may also impact effects users experience either directly or indirectly. We report the diversity of terpene profiles across samples bound for the Washington dispensary market. The remarkable degree of variation in terpene profiles ultimately results fr...
Preprint
Full-text available
Gene copy number variation is known to be important in nearly every species where it has been examined. Alterations in gene copy number may provide a fast way of acquiring diversity, allowing rapid adaptation under strong selective pressures, and may also be a key component of standing genetic variation within species. Cannabis sativa plants produc...
Poster
Full-text available
This poster describes our team's work into analyzing whole genome shotgun data towards various breeding applications.
Poster
Full-text available
Describes Steep Hill Genetics Team's work into cloning the cannabinoid synthase family and functionally identifying the product profiles of each variant we studied.
Patent
Full-text available
Compositions and methods for providing desired cannabinoid content in Cannabis plants. More particularly, the invention relates to compositions and methods for using cannabinoid synthase paralogs as guidance for breeding Cannabis plants with a desired cannabinoid content, including but not limited to cultivars, varieties, lines, and methods of bree...
Article
Full-text available
As the most widely used illicit drug worldwide, and as a source of numerous under-studied pharmacologically-active compounds, a precise understanding of variability in psychological and physiological effects of Cannabis varieties is essential. The National Institute on Drug Abuse (NIDA) is designated as the sole legal producer of Cannabis for use i...
Preprint
Full-text available
As the most widely used illicit drug, the basis of the fastest growing major industry in the US, and as a source of numerous under-studied psychoactive compounds, understanding the psychological and physiological effects of Cannabis is essential. The National Institute on Drug Abuse (NIDA) is designated as the sole legal producer of Cannabis for us...
Article
Full-text available
RNA polymerase I (pol I) transcribes the repeated genes that encode the precursor of 17-18, 5.8, and 25-28 S ribosomal RNA (rRNA). Pol I transcription is up-regulated in growing cells and down-regulated in quiescent cells, presumably reflecting the demand for ribosomes and protein synthesis. However, the signal transduction pathways responsible for...
Article
Full-text available
In eukaryotes, RNA polymerase I transcription is controlled by DNA elements located within the spacers that separate the tandemly arranged rRNA genes. Unlike rRNA coding sequences, the intergenic spacers evolve rapidly and have little sequence similarity even among closely related species. Nonetheless, the arrangement of functional elements, such a...
Chapter
Full-text available
Termination of transcription by the RNA polymerase of E. coli is generally assumed to be quite limited in the absence of deliberate transcription termination signals. However, the inherent termination rate of RNA polymerase in the absence of deliberate termination signals (what we will refer to as the processivity of RNA polymerase) has not been ca...
Article
Full-text available
Thesis (Ph. D.)--State University of New York at Buffalo, 1993. Includes bibliographical references (leaves 233-250). Photocopy of typescript.

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