Reed A. Davis

Northeast Ohio Medical University | NEOMED · Department of Pharmaceutical Sciences

Iron formations display some of the oldest and most enigmatic landforms on Earth, presently restricted to few areas of the planet. The original rock, the Banded Iron Formation (BIF) was formed in the Proterozoic and has been continuously weathered through a complex interplay of chemical and biological processes involving the massive mobilization of...

Due to the high prevalence of opioid prescription following orthopedic procedures, there is a growing need to establish an animal model system to evaluate the effects of opioids on bone remodeling. Rabbits have been employed as model organisms in orthopedic research as they exhibit well-defined cortical bone remodeling similar to humans. Existing r...

Bats are the only mammals to have achieved powered flight. A key innovation allowing for bats to conquer the skies was a forelimb modified into a flexible wing. The wing bones of bats are exceptionally long and dynamically bend with wingbeats. Bone microarchitectural features supporting these novel performance attributes are still largely unknown....

Bone is a dynamic and mechanically active tissue that changes in structure over the human lifespan. The products of the bone remodeling process have been studied substantially using traditional two-dimensional techniques. Recent advancements in X-ray imaging technology via desktop micro-computed tomography (µCT) and synchrotron radiation micro-comp...

The optimum skeletal element and bone tissue type to select for maximum nuclear DNA yield has been recently investigated. We employed X-ray photoelectron spectroscopy (XPS) to evaluate the elemental composition (atomic percentage) of cancellous and cortical bone tissue types to: (1) evaluate the use of XPS for surface chemistry analysis of cancello...

Osteocytes are believed to play a central role in the sustained health of bone, thus a decline in their numbers is detrimental and alterations in the lacunar-canalicular network (LCN) may be linked to accelerated bone remodeling and subsequent bone loss. Due to the preferential bias of particular bone diseases in females, such as osteoporosis, the...

The gross similarities between human hand and foot bones and bear paws have been well documented. Macroscopic skeletal analyses provide insight into species origin when whole bones are recovered but are frequently rendered inapplicable when bones are fragmented. In these scenarios, histological techniques are often applied. However, specific resear...

Krüppel-like factors (KLFs) are zinc finger proteins which bind to promoter or enhancer regions of genes in order to regulate their transcription. They are involved in many functions including the regeneration of retinal axons following optic nerve damage. However, studies involving optic nerve regeneration in zebrafish have only surveyed Klfs expr...