Redouane Borsali

• Phd, Research Professor, CNRS Director of Research
• CNRS Director of Research - Director of PolyNat Carnot Institute - Grenoble France at French National Centre for Scientific Research

Top and bottom interfaces of high-χ cylinder-forming polystyrene-block-maltoheptaose (PS-b-MH) diblock copolymer (BCP) thin films are manipulated using cross-linked copolymer underlayers and a fluorinated phase-preferential surface-active polymer (SAP) additive to direct the self-assembly (both morphology and orientation) of BCP microdomains into s...

Here we describe the design and the characterization of novel electrode materials consisting of multi-walled carbon nanotubes coated with glyconanoparticles (GNPs) functionalized with anthraquinone sulfonate. The resulting modified electrodes were characterized by scanning electron microscopy and cyclic voltammetry. Their electrochemical behavior r...

The development of third-generation photosensitizers for use in photodynamic therapy (PDT) is one of the most promising directions in current cancer therapy. Nanoparticles based on the block copolymer maltoheptaose-b-poly (methyl methacrylate) (MH-b-PMMA) containing the photosensitizer chlorine-aluminum phthalocyanine (ClAlPc) were developed for ap...

Carbohydrates are key building blocks for advanced functional materials owing to their biological functions and unique material properties. Here, we propose a star-shaped discrete block co-oligomer (BCO) platform to access carbohydrate nanostructures in bulk and thin-film states via the microphase separation of immiscible carbohydrate and hydrophob...

Owing to ever‐increasing environmental impact, nature‐inspired biomimetic electronics are key to unlock the potential of developing environmentally friendly brain‐like computing and biomimetic artificial‐intelligence systems. Thus far, the development of photosynaptic devices via green processing using biobased materials has become a major challeng...

For four decades, the functionalization of electrodes by biomaterials based on electrogenerated polymers, carbon nanotubes and / or nano-objects, was widely used in the field of analytical chemistry and energy conversion. Recently, we redesigned enzymatic bioelectrodes in order to produce original objects. An innovative concept of reagentless biose...

Metal halide perovskite nanocrystals (PVSK NCs) are generally unstable upon their transfer from colloidal dispersions to thin film devices. This has been a major obstacle limiting their widespread application. In this study, we proposed a new approach to maintain their exceptional optoelectronic properties during this transfer by dispersing brightl...

Block copolymers (BCPs) have garnered considerable interest due to their ability to form microphase-separated structures suitable for nanofabrication. For these applications, it is critical to achieve both sufficient etch selectivity and a small domain size. To meet both requirements concurrently, we propose the use of oligosaccharide and oligodime...

Nanofibrillated bacterial cellulose (NFBC) produced in the presence of hydroxypropylcellulose (HPC) (HP-NFBC) is amphiphilic and has a very long fiber length (>15 μm). In this study, polycaprolactone (PCL)-grafted HP-NFBC (HPNFBC-g-PCL) was prepared via ring-opening polymerization from the hydroxy groups on the HP-NFBC surface as initiation sites....

Background: Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. Levodopa (L-DOPA) remains the gold-standard drug available for treating PD. Curcumin has many pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anti-amyloid, and antitumor properties. Copolymers composed of Poly...

Nanofibers containing silk fibroin (SF), chondroitin sulfate (CS) and silver sulfadiazine (SSD) were made up through electrospinning technique, to produce new dressings with the potential to control the wound infections. Poly(ethylene oxide) (PEO) was added to the acidic water solution used for electrospinning to improve electrospinnability. Fibers...

We have developed a block copolymer (BCP)-based patterned electrode with a periodic structure of 80 nm and investigated their application in organic photovoltaics. The indium tin oxide (ITO) electrodes with the thicknesses of 30, 50, 70, 90, and 120 nm were sputtered onto BCP-patterned templates and the morphology and optoelectronic properties were...

Vapor phase infiltration into a self-assembled block copolymer (BCP) to create a hybrid material in one of the constituent blocks can enhance the etch selectivity for pattern transfer. Multiple pulse infiltration into carbohydrate-based high-χ BCP has previously been shown to enable sub-10 nm feature pattern transfer. By optimizing the amount of in...

Carbohydrates constitute a sustainable source of materials that has attracted growing interest due to their “green” aspects, biocompatibility, biodegradability and biorecognition properties. Their industrial applications at the macroscopic scale offer new solutions for biobased materials, and they have been applied in different sectors, such as cos...

Glyconanoparticles (GNPs) made by self‐assembly of carbohydrate‐based polystyrene‐block‐β‐cyclodextrin copolymer are used as a building block for the design of nanostructured biomaterials of electrode. The firm immobilization of GNPs is carried out on electrochemically generated polymer, poly(pyrrole‐adamantane), and copolymer, poly(pyrrole‐adamant...

We designed and synthesized high χ-low N-maltoheptaose-(triazolium⁺/N(SO2CF3)2–)-polyisoprene-(triazolium⁺/N(SO2CF3)2–)-maltoheptaose ABA triblock elastomers featuring triazolium⁺/N(SO2CF3)2– (TFSI–) counteranion ionic interfaces separating their constituting polymeric sub-blocks. Spin-coated and solvent-vapor-annealed (SVA) MH1.2k-(T⁺/TFSI–)-PI4.3...

Call for PostDoctoral Research Position in 2022* “Self-Assembly of Glycopolymers” team @ CERMAV, UGA, CNRS, Grenoble https://cermav.cnrs.fr/en/the-teams/physico-chemistry-and-self-assembly-of-glycopolymers/ Online call submitted on: December 07th , 2021 Deadline for the reception of applications and proposals: February 1st , 2022 End of pre-selec...

In-depth understanding of block copolymer (BCP) thermodynamics allows to obtain numerous self-assembled nanostructures and further extend the BCP capabilities to host additives. Therefore, different research groups have begun incorporating additives of versatile nature such as nanoparticles or electrolytes. Within BCP composite systems, additives a...

Tamoxifen citrate (TMC), a non-steroidal antiestrogen drug used for the treatment of breast cancer, was loaded in a block copolymer of maltoheptaose-b-polystyrene (MH-b-PS) nanoparticles, a potential drug delivery system to optimize oral chemotherapy. The nanoparticles were obtained from self-assembly of MH-b-PS using the standard and reverse nanop...

Polymer self-assembly in solution still constitutes a simple methodology for the preparation of elegant yet sophisticated nanomaterials. This work aims at presenting how the fine tuning of the experimental parameters of the nanoprecipitation process can lead to a variety of novel morphologies ranging from nanocorals through cubosomes to nanocubes....

Polymer self-assembly in solution still constitutes a simple methodology for the preparation of elegant yet sophisticated nanomaterials. This work aims at presenting how the fine tuning of the experimental parameters of the nanoprecipitation process can lead to a variety of novel morphologies ranging from nanocorals through cubosomes to nanocubes....

International Conf on Polymers

Background Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. Levodopa (L-DOPA) remains the standard gold drug available for the treatment of PD. Curcumin has a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anti-amyloid, antitumor properties. Copolymers com...

Industry Microelectronic Materials Conference

Sequential infiltration synthesis (SIS) into poly(styrene)-block-maltoheptaose (PS-b-MH) block copolymer using vapors of trimethyl aluminum and water was used to prepare nanostructured surface layers. Prior to the infiltration, the PS-b-MH had been self-assembled into 12 nm pattern periodicity. Scanning electron microscopy indicated that horizontal...

A series of new glyconanoparticles (GNPs) was obtained by self-assembly by direct nanoprecipitation of a mixture of two carbohydrate amphiphilic copolymers consisting of polystyrene-block-β-cyclodextrin and polystyrene-block-maltoheptaose with different mass ratios, respectively 0–100, 10–90, 50–50 and 0–100%. Characterizations for all these GNPs w...

Bulletin DERCI du CNRS - Bureau de Tokyo - très riche en information - Excellent travail de l'équipe de Jacques Maleval du Bureau de Tokyo pour l’Asie du Nord-Est, CNRS - Ambassade de France au Japon

Organic light-emitting diode (OLED) is an electroluminescent technology that relies on charge-carrier dynamics and is a potential light source for variable environmental conditions. Here, by exploiting a self-developed low-temperature testing system, we investigated the characteristics of hole/electron transport, electro-optic conversion efficiency...

A carbohydrate-based fullerene derivative (AcMal7-C61) is designed, synthesized and applied to a lamellar-forming high-χ block copolymer system, poly(3-hexylthiophene)-block-peracetylated maltoheptaose (P3HT-b-AcMal7), to actualize an ordered donor/acceptor (D/A) network. A well-defined D/A lamellar structure of the P3HT-b-AcMal7:AcMal7-C61 blend w...

Discrete block co-oligomers (BCOs) are gaining considerable attention due to their potential to form highly ordered ultrasmall nanostructures suitable for lithographic templates. However, laborious synthetic routes present a major hurdle to the practical application. Herein, we report a readily available discrete BCO system that is capable of formi...

Block copolymers (BCPs) with a high Flory–Huggins interaction parameter (χ) are promising alternatives to conventional nanopatterning materials for future nanolithography and nanotechnology applications. Herein, we described AB- and ABA-type BCPs comprising oligosaccharides (maltoheptaose, maltotriose, and maltose as the A block) and poly(propylene...

We report the resistive electrical memory characteristics controlled by the self-assembled nanostructures of maltoheptaose-block-polystyrene (MH-b-PS) block copolymers, where the MH and PS blocks provide the charge-trapping and insulating tunneling layer, respectively. A simple solvent annealing process, with various annealing conditions, were intr...

CsPbBr3 is a promising light-emitting material due to its wet solution processability, high photoluminescence quantum yield (PLQY), narrow color spectrum, and cost-effectiveness. Despite such advantages, the morphological defects, unsatisfactory carrier injection, and stability issues retard its widespread applications in light-emitting devices (LE...

Controlled self-assembly of polymeric systems behave according to their composition and physical-chemical properties. Inclusion of a guest molecule may influence interactions and response to the media and to other surfaces and bodies, for example, cells. Hence, loading the polymeric system with curcumin (CUR), a natural drug, confer interesting fea...

To date, most skin-like pressure sensors largely depend on the conventional lithography technique for fabricating microstructures, limited by chemical-intensive with time-consuming manufacturing processes that have limited the implementation scalability. Herein, we present the nano-resistors alongside the fibrous interlocked microstructures (FIMs)...

The exploitation of the effortless self‐assembly behavior of biomass‐based bricks can be seen as a promising route toward the innovative architectures. Here, a straightforward approach is presented where carbohydrate‐based diblock copolymer, polystyrene‐block‐maltoheptaose (PS‐b‐MH), is organized either on a rigid ultrathin film or on a flexible se...

The clean production of electrical energy from renewable resources has received recently a growing attention from the research community. A way to achieve this goal is the use of biological catalysts to catalyze the oxidation of renewable fuels. One of the streamlines on the research dealing with green electrical energy production is represented by...

Organic-inorganic halide perovskites were emerging as promising light emitters due to the high photoluminescence quantum efficiency (PLQE), narrow color spectrum, and facile bandgap tunability. However, the morphological issues of this class of materials remain as a bottleneck in generating high-performance light-emitting devices (LED). In this wor...

The sorption of oil from crude oil-in-saline water emulsions was studied using chitosan as biosorbent. The main parameters investigated were chitosan dosage, contact time, and initial crude oil concentration at fixed initial pH. The results showed that the sorption equilibrium was reached within 120 min at oil content as low as 20 mg L⁻¹. Sorption...

The promising carbohydrate-based block copolymer maltoheptaose-block-polystyrene (MH-b-PS) has been used for high-performance memory transistors and next generation nanolithography. In order to realize the potential of MH-b-PS especially in microelectronic applications, we firstly improved its synthetic method for obtaining large amount of copper-f...

Block copolymers (BCPs) with high Flory-Huggins interaction parameter (χ) and low degree of polymerization (N) are being investigated to create microphase-separated structures with sub-10 nm periodicity (d). However, the lowered N value also leads to undesirable properties. In this paper, we demonstrate that use of star-block architecture is an eff...

Silver nanowire (AgNW) networks have attracted considerable attention as transparent electrodes for emerging flexible optoelectronics. However, transference of such networks onto diverse arbitrary substrates with high conductivity remains a challenge because of the possibility of detaching and sliding occurring at the interface. Therefore, we devel...

Full details of reagents, materials, and experimental methods, further optical, electrochemical, and electronic characterization, results from control tests, as well as calculations comparing systems with immobilized versus solubilized biocatalysts.

Enzymatic biofuel cells are eco-friendly power sources that can deliver µW-mW outputs from renewable substrates, but their stability is a major issue owing to enzyme fragility. The vast majority of reported biofuel cells can only generate power continuously for relatively short periods of time. Here we report a novel “solubilized enzymatic fuel cel...

Microphase-separated structures of block copolymers (BCPs) have attracted much attention as template materials for bottom-up nanofabrication. At the same time, chain-end modification has become a leading facile and efficient technique for fine-tuning the morphologies of microphase-separated structures generated from BCPs. Herein, we describe the pr...

Background Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems. Materials and methods In the present study, we analyzed the potential b...

This study investigated the morphology, structural transformation, and electric properties of organic thin-film transistors (OTFTs) with silk fibroin as their dielectric layer at different annealing temperatures. Silk fibroin was employed because it can simplify the OTFT fabrication process and decrease fabrication cost. We successfully fabricated...

We synthesized a series of new intrinsically stretchable block copolymers (BCPs) in linear AB-type, ABA-type, and star-shaped architectures composed of oligosaccharide (MH) and flexible poly(n-butyl acrylate) (PBA) blocks for the application in field-effect transistor memory. The BCP thin films are used as the charge trapping layers in the memory d...

Microphase-separated structures of block copolymers (BCPs) have attracted considerable attention for their potential application in the bottom-up fabrication of 10 nm scale nanostructured materials. To realize sustainable development within this field, the creation of novel BCP materials from renewable biomass resources is of fundamental interest....

Graft copolymers based on carboxymethylcellulose (CMC) and thermosensitive polyetheramines (ethylene oxide/propylene oxide = 33/10 and 1/9) were prepared in water, at room temperature, by using a carbodiimide and N-hydroxysuccinimide as activators. SLS was applied to obtain Mw, A2 and Rg of CMC and its derivatives. Amide linkages were evidenced by...

Nanoparticles based on block copolymers of oligosaccharides [β-cyclodextrin (βCyD) and maltoheptaose (Mal7)] and poly(ε-caprolactone) (PCL) were prepared by microphase inversion method. Zeta-potential, particle size measurements and morphological analysis of drug-free and drug-loaded nanoparticles were performed by using, respectively, laser-dopple...

We demonstrate the self-assembly, characterization and bioelectrocatalysis of redox-active cyclodextrin-coated nanoparticles. The nanoparticles with host-guest functionality are easy to assemble and permit entrapment of hydrophobic redox molecules in aqueous solution. Bis-pyrene-ABTS encapsulated nanoparticles were investigated electrochemically an...

We report in this contribution that while low molecular weight hemicellulosic building blocks are known not to interact with cellulosic materials, their multivalent presentation on a polymeric scaffold significantly enhanced the binding interactions that are remarkably in the same range as those usually observed for lectin-carbohydrate interactions...

Self-assembly of block copolymers (BCPs) provides an attractive nanolithography approach, which looks especially promising for fabrication of regular structures with characteristic sizes below 10 nm. Nevertheless, directed self-assembly (DSA) and pattern transfer for BCPs with such small features remain to be a challenge. Here we demonstrate DSA of...

This work demonstrates a simple fabrication of cellulose nanofibers by direct electrospinning of dissolved cellulose solutions. The hard- and softwood pulps and the outer mantles of tunicate were dissolved in a mixture of trifluoroacetic acid and dichloroethane by stirring and ultrasonication to give highly viscoelastic, clear solutions. These solu...

Block copolymers (BCP) can self-assemble into nanoscale patterns with a wide variety of applications in the semiconductor industry. The self-assembly of BCPs is commonly accomplished by solvent vapor or thermal annealing, but generally these methods require long time (few hours) to obtain nanostructured thin films. In this contribution, a new and u...

This work describes how nanostructured thin films obtained from the self-assembly of block copolymers (BCPs) systems can be used as a nanoelectrode array (NEA) that can be programmed to specifically detect targeted molecules. Namely, poly(styrene-b-methacrylate) (PS-b-PMMA) thin films, after removal of PMMA phase, produced regular spaced 560 pores...

Amphiphilic graft copolymers composed of a methacrylate-based hydrophobic backbone with C11 pending chains end-capped by hydrophilic polyoxazoline (POx) blocks were successfully synthesized using the grafting-onto method by associating reverse addition fragmentation chain transfer (RAFT) polymerization with azide-alkyne Huisgen’s cycloaddition (CuA...

A series of amphiphilic photo-responsive heterografted copolymers has been successfully synthesized. The random copolymers were composed of a methacrylate backbone, with various compositions of hydrophilic oligomeric 2-methyl-2-oxazoline side chain (OMOx) and hydrophobic long alkyl chain terminated by a coumarin moiety (Cm). Using dynamic (DLS) and...

Novel multifunctional switchable chemosensors based on fluorescent electrospun (ES) nanofibers with sensitivity toward magnetism, temperature, and mercury ions (Hg²⁺) were prepared using blends of poly(N-isopropylacrylamide)-co-(N-methylolacrylamide)-co-(Acrylic acid), the fluorescent probe 1-benzoyl-3-[2-(2-allyl-1,3-dioxo-2,3-dihydro-1Hbenzo[de]i...

We here report the synthesis of a new class of carbohydrate-based block copolymers, poly(3-hexylthiophene)-block-peracetylated maltoheptaose (P3HT-b-AcMal7) and poly(3-hexylthiophene)-block-maltoheptaose (P3HT-b-Mal7), and their bulk and self-assembled thin films morphological characterizations by atomic force microscopy, transmission electron micr...

This paper describes the self-assembly of oligosaccharide-based hybrid block copolymers (BCPs) consisting of maltoheptaose (MH) and poly(methyl methacrylate) (PMMA) into 10 nm scale lamellar and cylindrical phases depending on the volume fractions of MH (ϕMH) and the annealing process. Time resolved SAXS study of the BCP bulk samples during thermal...

It is discovered that the memory-type behaviors of novel carbohydrate-block-polyisoprene (MH-b-PI) block copolymers-based devices, including write-once-read-many-times, Flash, and dynamic-random-access-memory, can be easily controlled by the self-assembly nanostructures (vertical cylinder, horizontal cylinder, and order-packed sphere), in which the...

Nanoparticles comprised of the poly(ethylene oxide)-b-poly (lactic acid) diblock copolymer (PEO-b-PLA) with and without the incorporation of lavender oil were prepared by nanoprecipitation. Diblock copolymers based on a fixed PEO block (5KDa) and two different PLA segments (4.5 or 10KDa) were used. The morphology, encapsulation eficiency, essential...

The controlled self-assembly of precise and well-defined photochemically and electrochemically active carbohydrate-coated nanoparticles offers the exiting prospect of biocompatible catalysts for energy storage/conversion and biolabeling applications. Here an aqueous nanoparticle system has been developed with a versatile outer layer for host-guest...

ligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with different responsiveness. This distinguishing feature...

Thiosemicarbazones are an important class of compounds that have been extensively studied in recent years, mainly because of their broad profile of pharmacological activity. A new 4-nitrobenzaldehyde thiosemicarbazone compound (BZTS) that was derived from S-limonene has been demonstrated to have significant antiprotozoan activity. However, the hydr...

This paper describes the systematic investigation into the aqueous self-assembly of a series of block copolymers (BCPs) consisting of maltoheptaose (MH; as the A block) and poly(μ-caprolactone) (PCL; as the B block), i.e., linear AB-type diblock copolymers with varied PCL molecular weights (MH-b-PCL(2.5k,3.3k,5k,10k)), ABy-type (y = 2, MH-b-(PCL5k)...

This paper discusses the self-assembly of oligosaccharide-containing block copolymer and the use of ultraviolet (UV) to obtain nano-porous glyco-nanoparticles by photo-degradation of the synthetic polymer block. Those glyco-nanoparticles consisting of oligosaccharide-based shell and a photo-degradable core domain were obtained from the self-assembl...

This volume is a new follow-up volume that complements Dynamic Light Scattering (1993) by the same author. The volume is directed to the recent development in the light scattering technique and to describing a wide spectrum of its applications. Both the theoretical development and utilization are traced by authors who are expert in their fields. De...

The present review summarizes our recent results regarding the synthesis and morphological characterization of sugar-based hybrid block copolymers (BCPs) consisting of maltoheptaose (MH) and poly(ε-caprolactone) (PCL). The AB-, AB2-, AB3-, ABA-, and A2B-type BCPs, in which the A and B blocks are MH and PCL, respectively, were synthesized by combini...

Mucoadhesive nanoparticles loaded with curcumin were developed as a new approach to deliver curcumin for the local treatment of oral cancer. PCL nanoparticles coated with chitosan displaying different molar masses were prepared by using the nanoprecipitation technique. The mucoadhesive properties of nanoparticle suspensions were demonstrated by the...

Oligosaccharides are one of the most promising biomaterials because they are abundant, renewable, diversified, and biosourced. The use of oligo- or polysaccharides for high-performance non-volatile organic field-effect-transistor memory is demonstrated herein. The charge-storage mechanism is attributed to charged hydroxyl groups that induce stronge...

Photosensitive amphiphilic linear polyoxazolines (CoumC11-POxn) bearing alkyl chain decorated by a UV-active coumarin end group have been synthesized by cationic ring-opening polymerization (CROP). Using DLS and DOSY NMR experiments, their self-assemblies in water were compared with those of homologous photo-unreactive amphiphilic polyoxazolines (C...

Amphiphilic oligosaccharide-based block copolymers (OBCPs) are able to self-assemble either into nanoparticles with biocompatible oligosaccharides corona in aqueous solution or in sub-nanopatterned thin-films originating from the high incompatibility between the different blocks. For these reasons, these biosourced OBCPs are valuable structures for...

Xyloglucan-block-polycaprolactone (XGO-PCL) copolymer nanoparticles have been proposed as nanocarriers for drug delivery. However, the possible harmful effects of exposure to nanoparticles still remain a concern. Therefore, the aim of this study is to evaluate the potential toxicity of XGO-PCL nanoparticles using in vitro and in vivo assays. Cytoto...