Rebecca Shi

Rebecca Shi
Stanford University | SU · Department of Biology

Doctor of Philosophy

About

8
Publications
601
Reads
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83
Citations
Citations since 2016
7 Research Items
83 Citations
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201620172018201920202021202205101520
Introduction
Rebecca Shi currently works at the School of Medicine, Stanford University in Kang Shen's lab. Rebecca does research in Developmental / Cell biological neuroscience studying dendritic morphogenesis.

Publications

Publications (8)
Article
Ligand-receptor interactions guide axon navigation and dendrite arborization. Mechanical forces also influence guidance choices. However, the nature of such mechanical stimulations, the mechanosensor identity, and how they interact with guidance receptors are unknown. Here, we demonstrate that mechanosensitive DEG/ENaC channels are required for den...
Preprint
Ligand-receptor interactions guide axon navigation and dendrite arborization. Mechanical forces also influence guidance choices. However, the nature of such mechanical stimulations, the mechanosensors identity and how they interact with guidance receptors are unknown. Here, we demonstrate that mechanosensitive DEG/ENaC channels are required for den...
Article
Full-text available
Background Dendrite morphogenesis plays an essential role in establishing the connectivity and receptive fields of neurons during the development of the nervous system. To generate the diverse morphologies of branched dendrites, neurons use external cues and cell surface receptors to coordinate intracellular cytoskeletal organization; however, the...
Article
Full-text available
The PSD-95-like, disc-large (DLG) membrane-associated guanylate kinase (PSD/DLG-MAGUK) family of proteins scaffold AMPAR complexes to the postsynaptic compartment, and are postulated to orchestrate activity-dependent modulation of synaptic AMPAR functions. SAP102 is a key member of this family, present from early development, prior to PSD-95 and PS...
Article
Proper morphogenesis of dendrites plays a fundamental role in the establishment of neural circuits. The molecular mechanism by which dendrites grow highly complex branches is not well understood. Here, using the Caenorhabditis elegans PVD neuron, we demonstrate that high-order dendritic branching requires actin polymerization driven by coordinated...
Article
Full-text available
Shank proteins, one of the principal scaffolds in the postsynaptic density (PSD) of the glutamatergic synapses, have been associated with autism spectrum disorders and neuropsychiatric diseases. However, it is not known whether different Shank family proteins have distinct functions in regulating synaptic transmission, and how they differ from othe...
Article
Full-text available
PSD-95-like, disc-large (DLG) family membrane associated guanylate kinase proteins (PSD/DLG-MAGUKs) are essential for regulating synaptic AMPA receptor (AMPAR) function and activity-dependent trafficking of AMPARs. Using a molecular replacement strategy to replace endogenous PSD-95 with SAP97β, we show that the prototypic β-isoform of PSD-MAGUK, SA...

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