Rebecca Mease

Rebecca Mease
Universität Heidelberg · Institute of Physiology and Pathophysiology

PhD

About

23
Publications
4,041
Reads
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516
Citations
Additional affiliations
May 2014 - August 2014
Marine Biological Laboratory
Position
  • Grass Fellow
August 2012 - July 2014
Max Planck Institute of Neurobiology
Position
  • PostDoc Position
October 2010 - present
Technische Universität München
Position
  • PostDoc Position
Education
September 2003 - August 2010
University of Washington Seattle
Field of study
  • Neurobiology and Behavior
September 1998 - June 2002
Massachusetts Institute of Technology
Field of study
  • Brain and Cognitive Sciences

Publications

Publications (23)
Chapter
The thalamus is a key structure in the mammalian brain, providing a hub for communication within and across distributed forebrain networks. Research in this area has undergone a revolution in the last decade, with findings that suggest an expanded role for the thalamus in sensory processing, motor control, arousal regulation, and cognition. Moving...
Preprint
The primary somatosensory cortex (S1) is the hub for body sensation of both innocuous and noxious signals, yet its role in somatosensation versus pain is debated. Despite known contributions of S1 to sensory gain modulation, its causal involvement in subjective sensory experiences remains elusive. Unspecific bulk manipulations of S1 activity have n...
Article
Full-text available
Large portions of the thalamus receive strong driving input from cortical layer 5 (L5) neurons but the role of this important pathway in cortical and thalamic computations is not well understood. L5-recipient “higher-order” thalamic regions participate in cortico-thalamo-cortical (CTC) circuits that are increasingly recognized to be (1) anatomicall...
Article
Full-text available
Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-types remain unclear to a large extent. Here, we recorded spike responses upon whisker touch of anatomically identi...
Article
Full-text available
The transmission of noxious stimuli from peripheral receptors to the cortex involves multiple central ascending pathways. While projections to areas in the brainstem and diencephalon are likely involved in mediating the immediate behavioural responses to pain, the assessment of the sensory and emotional/motivational components of pain are likely pr...
Article
Full-text available
Neurons in cortical layer 5B (L5B) connect the cortex to numerous subcortical areas. Possibly the best-studied L5B cortico-subcortical connection is that between L5B neurons in the rodent barrel cortex (BC) and the posterior medial nucleus of the thalamus (POm). However, the spatial organization of L5B giant boutons in the POm and other subcortical...
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Full-text available
High-frequency “burst” clusters of spikes are a generic output pattern of many neurons. While bursting is a ubiquitous computational feature of different nervous systems across animal species, the encoding of synaptic inputs by bursts is not well understood. We find that bursting neurons in the rodent thalamus employ “multiplexing” to differentiall...
Article
Full-text available
Zusammenfassung Die Übersetzung von schmerzhaften Reizen in Schmerzempfindungen wird durch mehrere periphere und zentrale Signalwege des Nervensystems verwirklicht. Man nimmt heute an, dass die Organisation dieser Signalwege die beiden Hauptfunktionen der Schmerzwahrnehmung wiederspiegeln: die Bewertung von schmerzhaften Reizen (wo, was, wie stark)...
Article
Full-text available
The transduction of painful stimuli into the experience of pain involves several peripheral and central signaling pathways of the nervous system. The organization of these pathways parallels the main functions of pain: the assessment of noxious stimuli (where, what, how strong), and the negative emotion of unpleasantness. Multiple lines of evidence...
Article
Full-text available
Cortical layer 5B (L5B) thick-tufted pyramidal neurons have reliable responses to whisker stimulation in anesthetized rodents. These cells drive a corticothalamic pathway that evokes spikes in thalamic posterior medial nucleus (POm). While a subset of POm has been shown to integrate both cortical L5B and paralemniscal signals, the majority of POm n...
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Full-text available
The cortex connects to the thalamus via extensive corticothalamic (CT) pathways, but their function in vivo is not well understood. We investigated “top-down” signaling from cortex to thalamus via the cortical layer 5B (L5B) to posterior medial nucleus (POm) pathway in the whisker system of the anesthetized mouse. While L5B CT inputs to POm are ext...
Article
Full-text available
In the mammalian brain, thalamic signals reach the cortex via two major routes: primary and higher-order thalamocortical pathways. While primary thalamocortical nuclei transmit sensory signals from the periphery, the function of higher-order thalamocortical projections remains enigmatic, in particular their role in sensory processing in the cortex....
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Full-text available
Diverse ion channels and their dynamics endow single neurons with complex biophysical properties. These properties determine the heterogeneity of cell types that make up the brain, as constituents of neural circuits tuned to perform highly specific computations. How do biophysical properties of single neurons impact network function? We study a set...
Article
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The linear-nonlinear cascade model (LN model) has proven very useful in representing a neural system's encoding properties, but has proven less successful in reproducing the firing patterns of individual neurons whose behavior is strongly dependent on prior firing history. While the cell's behavior can still usefully be considered as feature detect...
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Full-text available
A major synaptic input to the thalamus originates from neurons in cortical layer 6 (L6); however, the function of this cortico-thalamic pathway during sensory processing is not well understood. In the mouse whisker system, we found that optogenetic stimulation of L6 in vivo results in a mixture of hyperpolarization and depolarization in the thalami...
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Adaptation is a fundamental computational motif in neural processing. To maintain stable perception in the face of rapidly shifting input, neural systems must extract relevant information from background fluctuations under many different contexts. Many neural systems are able to adjust their input-output properties such that an input's ability to t...
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Full-text available
Ascending and descending information is relayed through the thalamus via strong, “driver” pathways. According to our current knowledge, different driver pathways are organized in parallel streams and do not interact at the thalamic level. Using an electron microscopic approach combined with optogenetics and in vivo physiology, we examined whether d...
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Full-text available
Many neural systems are equipped with mechanisms to efficiently encode sensory information. To represent natural stimuli with time-varying statistical properties, neural systems should adjust their gain to the inputs' statistical distribution. Such matching of dynamic range to input statistics has been shown to maximize the information transmitted...
Article
In transforming sensory data into voltage signals, the strategies employed by neurons and neural systems have been shown to be adaptive: as the statistical properties of the environment change, the mapping from input to output also changes, often in such a way as to maximize information transmission. In large part, neuronal dynamics arise from volt...

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