Rebecca Handley

Rebecca Handley
London School of Hygiene and Tropical Medicine | LSHTM · Department of Infectious Disease

Medical Parasitology

About

11
Publications
359
Reads
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29
Citations
Citations since 2017
11 Research Items
29 Citations
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Introduction
I am currently working on the FIEBRE (Febrile Illness Evaluation in a Broad Range of Endemicities) project, a prospective study of infectious causes of fever, and of antibiotic resistance, in inpatients and outpatients of all ages at multiple sites in Africa and Asia. Prior to this I was working within the trachoma group.

Publications

Publications (11)
Article
Full-text available
Background Yaws, caused by Treponema pallidum subsp. pertenue , is a skin neglected tropical disease. It is targeted for eradication by 2030, primarily using mass drug administration (MDA) with azithromycin. Traditionally, diagnosis of yaws has relied on clinical examination and serological testing. However, these approaches have poor diagnostic pe...
Article
Full-text available
Background Yaws is targeted for eradication by 2030, using a strategy based on mass drug administration (MDA) with azithromycin. New diagnostics are needed to aid eradication. Serology is currently the mainstay for yaws diagnosis; however, inaccuracies associated with current serological tests makes it difficult to fully assess the need for and imp...
Article
Full-text available
Background: In the Solomon Islands and Vanuatu, the sign trachomatous inflammation-follicular (TF) is common, but ocular infection with Chlamydia trachomatis is not. It is therefore debatable whether azithromycin mass drug administration (MDA), the recommended antibiotic treatment strategy for trachoma's elimination as a public health problem, is...
Article
Full-text available
Introduction: In the peri-elimination setting, the positive predictive value of trachomatous inflammation-follicular (TF), the primary marker used to determine need for antibiotics for trachoma, is suboptimal. Here, three non-TF measures are used to compare two regions where TF prevalence exceeds the threshold for intervention, but where the Chlam...
Article
Background: Yaws is a neglected tropical disease and results in lesions of skin, soft tissues and bones. PCR plays an important part in surveillance. Methods: Children suspected to have yaws were enrolled. From the largest lesion, paired swabs were collected, one in transport medium and one as a dry swab. In children with multiple lesions we col...
Preprint
Full-text available
Introduction Yaws is a neglected tropical disease and results in lesions of skin, soft tissues and bones. PCR plays an important part in surveillance. Methods Children suspected to have yaws were enrolled. From the largest lesion paired swabs were collected; one into transport medium and one as a dry swab. In children with multiple lesions we coll...
Article
Yaws is a neglected tropical disease targeted for eradication by 2020. Kiribati, a Pacific Island nation, was previously endemic for yaws but lacks recent data from which its current endemicity status could be determined. This study tested antibody responses to Treponema pallidum to determine if transmission of yaws is taking place among children i...
Article
Full-text available
Introduction Trachoma is endemic in several Pacific Island countries. The aims of this study were to (a) identify future trachoma mapping needs in the Pacific and (b) to examine whether any temporal trends in trachoma prevalence could be ascertained from the historical literature on trachoma in the Pacific Islands. Methods Human studies of trachom...
Data
PRISMA checklist required by journal publication guidelines. (DOC)
Data
Quality control questions used in the evaluation of trachoma studies. (DOCX)
Data
A summary of all the articles included in this review. This table includes the quality control assessment used on the prevalence studies. (DOC)

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Projects

Project (1)
Project
To determine trachoma prevalence in the Pacific