Rebecca L. Glaser

Wright State University | WSU · Department of Surgery

Although numerous studies have demonstrated that sentinel lymph node (SLN) biopsy can accurately determine the axillary nodal status for early breast cancer some studies have suggested that SLN biopsy may be less reliable for tumors >2 cm in size. This analysis was performed to determine whether tumor size affects the accuracy of SLN biopsy. The Un...

Impact of testosterone therapy on breast cancer specific survival

Testosterone (T) is the most abundant biologically active hormone in women. It has a direct effect at the andro-gen receptor in every major organ system. Local aromatization of T is a major source of bioavailable estradiol. Adequate amounts of bioavailable T are essential for optimal health, immune function, and disease prevention. More than 80% of...

Introduction: High dose testosterone (T) has been used for treating hormone-sensitive breast cancers for many years. However, a drawback to T therapy is its propensity to convert to estradiol (E2) via aromatase, which can override the growth inhibitory effects of T and stimulate estrogen sensitive tumors. Aromatase is higher in some women than othe...

Introduction: Androgens, including subcutaneous testosterone implants have been used to treat breast cancer since 1937. Testosterone is antiproliferative and proapoptotic in the breast. However, testosterone aromatizes to estradiol, which can stimulate estrogen receptor (ER) positive breast cancers. Active tumors display increased aromatase activit...

PurposeTo evaluate the efficacy of testosterone supplementation for improving aromatase inhibitor musculoskeletal symptoms (AIMSS).Methods Postmenopausal women experiencing moderate-to-severe arthralgias while taking adjuvant aromatase inhibitors for breast cancer were enrolled in this trial. Initially, patients were randomly allocated to receive e...

Background: Testosterone implants have been used for over eighty years to treat symptoms of hormone deficiency in pre and postmenopausal women. Evidence supports that androgens are breast protective. However, there is a lack of data on the long-term effect of testosterone therapy on the incidence of invasive breast cancer (IBC). This study was spe...

This analysis was designed to determine the efficacy of anastrozole, an aromatase inhibitor, combined with testosterone in a subcutaneous implant in preventing elevated estradiol levels and the subsequent side effects of excess estrogen associated with testosterone therapy. It also allowed for the establishment of normative ranges of serum testoste...

This analysis was designed to determine the efficacy of anastrozole, an aromatase inhibitor, combined with testosterone in a subcutaneous implant in preventing elevated estradiol levels and the subsequent side effects of excess estrogen associated with testosterone therapy. It also allowed for the establishment of normative ranges of serum testoste...

Background: Aromatase inhibitors are a mainstay hormone receptor-positive breast cancer treatment. AIA occur in up to 50% of patients (pts), adversely affecting quality of life and treatment compliance. A small phase II clinical trial of oral testosterone unedeconate appeared to improve AIA over placebo (P), with no significant androgenic side effe...

Introduction: There is evidence that androgens are breast protective and that testosterone (T) therapy treats many symptoms of hormone deficiency in both pre and postmenopausal patients. However, there is a lack of data on the effect of long-term T therapy on the incidence of breast cancer. Methods: A ten-year prospective, IRB approved study (Dayto...

Breast cancer treatment in women over the age of 80 remains a complex issue due to pre-existing comorbidities, therapy-related toxicities, and the lack of evidence-based data in this population, leading to both overtreatment and under treatment. The average life expectancy of an 80-year-old woman is 9.7 years and chronologic age alone should not be...

Background: Some studies have shown that testosterone (T) therapy is associated with an increase in venous thrombotic events,particularly in men at high risk. This may be due to aromatization of T and subsequent estrogen induced thrombophilia. Subcutaneous (SC) T implants bypass the liver and do not adversely affect the clotting system. However, T...

Constantine Dimitrakakis1,2, Rebecca Glaser3,4,∗ 1 Athens University Medical School, 1st Department of Ob/Gyn, Athens, Greece 2 National Institutes of Health, NICHD, Bethesda, United States 3 Wright State University Boonshoft School of Medicine, Department of Surgery, Dayton, United States 4 Millennium Wellness Center, Dayton, United States Objecti...

P137 Critical role of testosterone in both sexes Adrian Valeriu Neacs¸ u1,∗, Rebecca L. Glaser2, Iuliana Ceaus¸ u1 1 UMF ‘Carol Davila’, Clinical Hospital Dr. I. Cantacuzino, Obstetrics & Gynecology, Bucharest, Romania 2 Wright State University Boonshoft School of Medicine, Department of Surgery, Department of Surgery, Dayton, United States The lo...

Late breaking abstract, oral presentation European Menopause and Andropause Society. 11’th European Conference on Menopause and Andropause, Amsterdam, The Netherlands, 22.05.2017.

Objective Hormone receptor-positive breast cancers respond favorably to subcutaneous testosterone combined with an aromatase inhibitor. However, the effect of testosterone combined with an aromatase inhibitor on tumor response to chemotherapy was unknown. This study investigated the effect of testosterone-letrozole implants on breast cancer tumor r...

Objectives This prospective study was designed to investigate the effect of testosterone, delivered by subcutaneous implants, on the female voice. Methods Ten women who had opted for testosterone therapy were recruited for voice analysis. Voices were recorded prior to treatment and at 3 months, 6 months, and 12 months while on testosterone therapy....

Testosterone (T) is the most abundant biologically active hormone in women. Androgen receptors (AR) are located throughout the body including the breast where T decreases tissue proliferation. However, T can be aromatized to estradiol (E2), which increases proliferation and hence, breast cancer (BCA) risk. Increased aromatase expression and an imba...

Background Testosterone (T), the most abundant biologically active hormone in women, is essential for mental and physical health. Androgen receptors (AR) are located throughout the body, in every major organ system including the breast where T decreases proliferation and increases apoptosis. However, T is aromatized to estradiol, which stimulates...

A 10-year prospective IRB study, approved March of 2008, was designed to follow pre and postmenopausal women with symptoms of hormone deficiency, treated with testosterone (T) or testosterone combined with anastrozole (T + A) subcutaneous implants for the occurrence of breast cancer (BCA). In January 2015, an 82-month interim analysis was performed...

109 Background: Menopausal symptoms can be severe in breast cancer survivors in whom estrogen therapy is contraindicated. Our previous pilot trial demonstrated that testosterone (T) combined with anastrozole (A) in subcutaneous implants provided therapeutic T levels without elevating estradiol. Our current goal was to document the clinical effect o...

Background: Menopausal symptoms can be severe in breast cancer survivors in whom estrogen therapy is contraindicated. Our previous pilot trial demonstrated that testosterone (T) combined with anastrozole (A) in subcutaneous implants provided therapeutic T levels without elevating estradiol. Our current goal was to document the clinical effect of T+...

Objective Experimental and clinical data support the inhibitory effect of testosterone on breast tissue and breast cancer. However, testosterone is aromatized to estradiol, which exerts the opposite effect. The aim of this study was to determine the effect of testosterone, combined with the aromatase inhibitor anastrozole, on a hormone receptor pos...

There is evidence that androgens are breast protective and that testosterone therapy treats many symptoms of hormone deficiency in both pre and postmenopausal patients. However, unlike estrogen and progestins, there is a paucity of data regarding the incidence of breast cancer in women treated with testosterone therapy. This study was designed to i...

Although testosterone therapy is being increasingly prescribed for men, there remain many questions and concerns about testosterone (T) and in particular, T therapy in women. A literature search was performed to elucidate the origin of, and scientific basis behind many of the concerns and assumptions about T and T therapy in women. This paper refut...

Objectives: The objectives of this study were to determine therapeutic serum testosterone (T) levels/ranges and inter-individual variance in women treated with subcutaneous T implants. Study design: In study group 1, T levels were measured at two separate time intervals in pre- and post-menopausal women treated with subcutaneous T for symptoms o...

Abstract 48 Subgroups of patients treated with an aromatase inhibitor (anastrozole) delivered subcutaneously in combination with testosterone R. Glaser1, C. Dimitrakakis2,3 1Department of Surgery, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA, 2Department of Ob/Gyn, Athens University Medical School, Athens, Greece, 3NICHD,...

Background Androgens are thought to have an adverse effect on female scalp hair growth. However, our clinical experience of androgen replacement therapy in women with androgen deficiency, in which hair loss was seldom reported, led us to question this concept. Objectives To evaluate the effect of subcutaneous testosterone therapy on scalp hair grow...

Text: This study was designed to evaluate the effect of subcutaneous testosterone implant therapy on lipid profiles in female patients. As part of a 10-year IRB approved trial on the effect of testosterone implant therapy on the incidence of breast cancer, testosterone levels and lipid profiles were examined in 154 women treated at the clinic Febru...

Androgens are thought to have an adverse effect on female scalp hair growth. However, our clinical experience of androgen replacement therapy in women with androgen deficiency, in which hair loss was seldom reported, led us to question this concept. To evaluate the effect of subcutaneous testosterone therapy on scalp hair growth in female patients....

This study was designed to measure the beneficial effects of continuous testosterone therapy, delivered by subcutaneous implant, in the relief of somatic, psychological and urogenital symptoms in both pre- and post-menopausal patients, utilizing the validated Health Related Quality of Life (HRQOL), Menopause Rating Scale (MRS). 300 pre- and post-me...

Background Correlation between circulating sex steroid levels and breast cancer has been controversial, with measurement of free, or bioavailable hormone rarely available. Salivary hormone levels represent the bioavailable fraction. To further elucidate the role of endogenous hormones in breast cancer, we aimed to assess correlation between salivar...

Background: Breast cancer survivors commonly experience severe symptoms of hormone deficiency that can adversely affect their health and quality of life. Beneficial effects of subcutaneous testosterone therapy include relief of hot flashes, heart discomfort, insomnia, depression, irritability, anxiety, fatigue, memory loss, sexual problems, inconti...

This article is an adaptation of an abstract/poster presentaton made at the 13th International Congress on Steroidal Hormones and Hormones and Cancer, Quebec City, Canada (September 2008), concerning the topic of breast feeding as a contraindication to testosterone therapy. The purpose of the presentation and this article is to provide a summary of...

This article is an adaptation of an abstract/poster presentation made at the 13th International Congress on Steroidal Hormones and Hormones & Cancer, Quebec City, Canada (September 2008), concerning the topic of breast feeding as a contraindication to testosterone therapy. The purpose of the presentation and this article is to provide a summary of...

There is a lack of evidence in the literature supporting vaginal application of a combination hormone-containing cream for local and systemic symptom relief. This pilot study examined the extent of absorption of a single cream containing estriol, estradiol, progesterone, DHEA, and testosterone. A combination cream was administered to 12 postmenopau...

It has been suggested that sentinel lymph node (SLN) biopsy for breast cancer may be less accurate after excisional biopsy of the primary tumor compared with core needle biopsy. Furthermore, some have suggested an improved ability to identify the SLN when total mastectomy is performed compared with lumpectomy. This analysis was performed to determi...

To determine the optimal experience required to minimize the false-negative rate of sentinel lymph node (SLN) biopsy for breast cancer. Before abandoning routine axillary dissection in favor of SLN biopsy for breast cancer, each surgeon and institution must document acceptable SLN identification and false-negative rates. Although some studies have...

Although numerous studies have demonstrated that sentinel lymph node (SLN) biopsy can accurately determine the axillary nodal status for early breast cancer some studies have suggested that SLN biopsy may be less reliable for tumors >2 cm in size. This analysis was performed to determine whether tumor size affects the accuracy of SLN biopsy. The Un...

To determine the optimal radioactive colloid injection technique for sentinel lymph node (SLN) biopsy for breast cancer. The optimal radioactive colloid injection technique for breast cancer SLN biopsy has not yet been defined. Peritumoral injection of radioactive colloid has been used in most studies. Although dermal injection of radioactive collo...

Multiple radioactive lymph nodes are often removed during the course of sentinel lymph node (SLN) biopsy for breast cancer when both blue dye and radioactive colloid injection are used. Some of the less radioactive lymph nodes are second echelon nodes, not true SLNs. The purpose of this analysis was to determine whether harvesting these less radioa...

Previous studies have demonstrated the feasibility of sentinel lymph node (SLN) biopsy for nodal staging of patients with breast cancer. However, unacceptably high false-negative rates have been reported in several studies, raising doubt about the applicability of this technique in widespread surgical practice. Controversy persists regarding the op...

Introduction:Multiple radioactive lymph nodes are often removed during the course of sentinel lymph node (SLN) biopsy for breast cancer when both blue dye and radioactive colloid injection are used. Some of the less radioactive lymph nodes are second echelon nodes, not true SLNs. The purpose of this analysis was to determine whether harvesting thes...

To evaluate the role of preoperative lymphoscintigraphy in sentinel lymph node (SLN) biopsy for breast cancer. Numerous studies have demonstrated that SLN biopsy can be used to stage axillary lymph nodes for breast cancer. SLN biopsy is performed using injection of radioactive colloid, blue dye, or both. When radioactive colloid is used, a preopera...

• In a review of five Dayton, Ohio, area hospitals during a six-year period, seven patients who were treated for an acquired arteriovenous (A-V) fistula after cardiac catheterization were identified. Four patients had undergone cardiac studies in area hospitals, while three were studied elsewhere. The four A-V fistulas after 23 291 cardiac catheter...