
Ream LangheRoyal College of Surgeons in Ireland | RCSI · Department of Obstetrics & Gynaecology
Ream Langhe
MB ChB, Dipl(Stat), DRCOG, Dip (clin ed) MSc, PhD, ABHSOG, MRCPI
About
66
Publications
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Introduction
Research Experience
January 2010 - September 2013
St. James's Hospital
Position
- PhD Student
Publications
Publications (66)
Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Su...
Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study
aimed to inform their prioritization by modelling.
Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs
were based on postoperative SARS-CoV-2 rates an...
Experience of medical students about induction day of obstetrics and gynaecology rotation.
AbstractBackgroundMaternal obesity is a significant risk factor for unfavourable outcomes during pregnancy. However, the extent ofthis relationship is poorly defined in Irish mothers.AimsThis study was to compare maternal and perinatal outcomes between obese and non-obese mothers in an Irish population.MethodsA retrospective comparative study was c...
Background: Overweight maternal pre-pregnancy, obesity and excessive gestational weight gain are significant risk
factors for unfavorable maternal and perinatal outcomes during pregnancy. The association of obesity with maternal
and perinatal outcomes is poorly understood in Jabal Akhdar region of Libya. This study was to examine maternal
and perin...
A retrospective audit of Consent Form in Our Lady of Lourdes Hospital
Background: Maternal obesity is a significant risk factor for unfavorable outcomes during pregnancy. However, the extent of this relationship is poorly defined in Irish mothers. The aim of this study was to compare maternal and perinatal outcomes between obese and non-obese mothers in an Irish population.
Methods: A retrospective comparative stud...
Advanced maternal age (AMA) is identified as childbearing of women aged 35 years old and above. AMA has shown to be associated with economic, social and health complications affecting the mother and the foetus. These include intrauterine growth restriction, pre-eclampsia, preterm birth, stillbirth and caesarean section risk.
This study examines t...
The authors report a case of a retained foreign body in a vagina for an uncertain period of time. The child presented with vaginal discharge but no other symptoms. The foreign body was removed under general anaesthesia with no complications.
Case presentation: A 19-year old primigravida was admitted to the hospital for induction of labour due to postdates. Her pregnancy was categorised as low risk. She had a forceps delivery due to a prolonged second stage. Placenta was delivered by controlled cord traction. She suffered from a primary postpartum haemorrhage and was transferred to thea...
A retrospective audit of LLETZ procedure in Louth County Hospital
An audit on the management of ectopic pregnancy in OLOH
Audit on the management of PPROM in OLOH
A case report of unusual cause of postmenopausal bleeding
Audit on management of VBAC in Portlaoise Hospital
Audit on management of primary major postpartum haemorrhage
The classic features of molar pregnancy are irregular vaginal bleeding, hyperemesis, enlarged uterus for gestational age and early failed pregnancy. Less common presentations include hyperthyroidism, early onset pre-eclampsia or abdominal distension due to theca lutein cysts. Here, we present a case of molar pregnancy where a woman presented to the...
A 32-year-old woman presented at 15 weeks and 6 days with vague abdominal pains of one day duration. All information were obtained from the maternal chart. Tumour markers were elevated; CEA: 39, CA125: 226 U/ml and CA19.9: 46723. Abdominal-pelvic ultrasound was performed and revealed an intrauterine pregnancy and a well-defined fluid collection wit...
A figure illustrates rupture uterus and lower uterine segment before repair
A figure shows repaired ruptured uterus and lower uterine segment
Epidemiology study of cervical cancer in Louth County hospital
A study to evaluate the efficacy of cold coagulation treatment for the eradication of CIN and HPV at 6 months follow up
Uterine Sacculation in Pregnancy
A Case of Postpartum HELLP Syndrome
Review of gynacological laparoscopic surgeries in Mullingar Hospital over a period of one year
Background:Uterine rupture in pregnancy is a rare and catastrophic complication with a high incidence of fetal and maternal morbidity. Very few cases have been reported in the literature.
Case presentation: A 28-year-old fifth gravid woman with a history of one caesarean section presented to our department at 39 weeks and 6 days gestation with com...
This project explored the differences in prevalence of a number of risk factors associated with the main types of cervical cancer (adenocarcinoma and squamous cell carcinoma) in a cohort of women referred to Tallaght hospital colposcopy clinic. This is a retrospective study (n=148) looking at cervical cancer patients with a new referral to Tallaght...
Management of 3rd and 4th degree tears plays a vital role in preventing complications, such as bowel incontinence. The aim of this audit examines clinical practices used by Mullingar Midlands Regional Hospital (MRHM) obstetric deparmtment, in management of 3rd and 4th degree perineal tears as per Royal College of Obstetric and Gynaecology (RCOG) gu...
INTRODUCTION: Cervical cancer holds significant social and financial implications not only on Irish society, but across the globe, as it is the fourth most common cancer affecting women worldwide (IARC). This project identified the incidence, presentation, time to diagnosis and association of risk factors with cervical cancer in women referred to c...
Ovarian cancer is the fifth most common cancer in women and the leading cause of death from gynaecological malignancy in the Western world. The majority of ovarian cancers are diagnosed at an advanced stage and this is due to lack of a reliable screening test and the vagueness of symptoms. Early diagnosis is key as the 5-year survival rate for wome...
Objectives
Cervical cancer is the seventh most prevalent cancer diagnosed in Irish women and therefore holds both significant social and financial implications on Irish society. The main aims of this project were to identify the incidence, time to identification , and risk factors associated with cervical cancer in a cohort of women referred to col...
According to WHO Female Genital Mutation (FGM) refers to all procedures which involve the partial or total removal of the external genitalia or injury to the female genital organs whether for cultural or any other non- therapeutic reasons. It is classified into four distinct types: Type 1 or Clitoridectomy comprises of the partial or total removal...
Ovarian cancer is the seventh most common cancer in women and the most frequent cause of gynaecological malignancy-related mortality in women. Currently, no standardized reliable screening test exists. MicroRNA profiling has allowed the identification of signatures associated with diagnosis, prognosis and response to treatment of human tumours. The...
Ovarian cancer incidences and mortality rates in Ireland are among the highest worldwide. Biomarkers, including human epididymis protein 4 (HE4) and risk of malignancy (ROMA) index, may have utility in preoperative ovarian mass diagnosis. More accurate differentiation between benign and malignant masses would prevent fertility impairing surgery in...
Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant) and A2780 (cisplatin-sensitive) ovarian carcinoma cell lines were used. The cytotoxic effect of MMP-9/MMP-2 inhibitor, (2...






































