Ravindra Patil

• M.Pharm Ph.D
• VNU University of Science

Diabetes mellitus is a chronic metabolic disorder and rapidly increasing cases of diabetes throughout the world are major concerns in both developed and developing countries. Currently available oral antidiabetic medicines have limitations in efficacy and safety, which in conjunction with the emergence of diabetes mellitus as a global epidemic have...

Introduction: Many modern medicines used today based on plants and plant products. Piper betle is generally known as the betle vine, it is an important medicinal and recreational plant. High performance thin layer chromatography (HPTLC) is an advanced powerful analytical method with more separation power, high performance and superior reproducibili...

Objective: To study the Effect of Solanum melongena Linn. leaves extracts on Clonidine induced catalepsy and milk induced Leukocytosis and Eosinophilia in mice. Methods: Methanolic and chloroform extracts of Solanum melongena Linn. leaves were prepared. Preliminary phytochemical screening of the prepared extracts was carried out. Effects of prepare...

Objective: The objective of the study was to evaluate the effect of Piper betle L. leaves extract against clonidine-induced catalepsy and milk-induced leukocytosis and eosinophilia in mice. Methods: Methanolic extract of P. betle L. leaves was prepared using Soxhlet apparatus. Preliminary phytochemical screening of the prepared extract was carried...

Pharmacognostic and preliminary phytochemical investigation on bark of Ficus bengalensis was carried out to determine macroscopic, microscopic, physical parameters and chemical constituents. A macroscopic study showed that bark is about 5 to 12 mm in thick outer surface is rough due to lenticel with channel shaped. Microscopic studies indicated pre...

Objective: Asthma is a multifaceted inflammatory disorder which results into narrowing of airway with broncho-constriction and spasm. As the complex pathophysilogy of asthma, various animal models are generally used to investigate the immunological and physiological pathogenesis of disease. Abrus precatorius Linn (Fabacease) is a climbing shrub. Th...

Objective To evaluate the effect of ethanol extract of Abrus precatorius (A. precatorius) for the management of asthma.Methods In the present study, ethanol extract of A. precatorius leaves at doses of 100-150 mg/kg i.p. was evaluated for the management of asthma using milk induced leukocytosis and eosinophilia in mice.ResultsThe results of the pre...

Asthma is a common disease that is rising in prevalence worldwide with the highest prevalence in industrialized countries. Asthma affect about 300 million people worldwide and it has been estimated that a further 100 million will be affected by 2025. Since the ancient times, plants have been exemplary sources of medicine. Current asthma therapy lac...

In India, indigenous remedies have been used in the treatment of diabetes mellitus since the time of Charaka and Sushruta. Plants have always been an exemplary source of drugs and many of the currently available drugs have been derived directly or indirectly from them. The ethnobotanical information reports that about 800 plants may possess anti-di...

Coccinia grandis Linn (Curcubitaceae) is a climber herb cultivated throughout India. In traditional medicine fruits have been used to treat leprosy, fever, asthma, bronchitis and jaundice. In present study, ethanol extract of C. grandis fruit (ECGF) at 100, 125 and 150 mg·kg−1, i.p., was evaluated for mast cell stabilizing, antianaphylactic and ant...

Objective To evaluate the antiasthmatic activity of Ricinus communis (R. communis) Linn (Euphorbiaceae) to validate its traditional use.Methods The antiasthmatic activity of ethanol extract of R. communis (ERCR) root was evaluated on milk induced leucocytosis and eosinophilia in mice, mast cell degranulations in mice and passive cutaneous anaphylax...

Clonidine, an α 2 adrenoreceptor agonist, induces dose dependent catalepsy in mice, which releases histamine from mast cells which is responsible for different asthmatic conditions. Ricinus communis Linn (Euphorbiaceae) is a medicinal plant; root is sweetish and has been used traditionally in the treatment of inflammation, pain fever, asthma, bronc...

Clitoria ternatea L. (Family: Fabaceae) is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antiasthmatic activity of ethanol extract of Clitoria ternatea roots. In the present study ethanol extract of Clitoria ternatea root (ECTR) was evaluated for preliminary phytochemical s...

To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL). Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw. The results indicated that MRCL exhibited considerable antinocicepti...

To isolate and characterize antidiabetic component (bioactivity-guided fractionation) from hydro alcoholic extract of Ocimum sanctum (O. sanctum) aerial part. Ten fractions (F1-F10) were isolated from hydro alcoholic extract of O. sanctum aerial part by column chromatography. All the fractions F1 to F10 were screened for antidiabetic activity in al...

Abrus precatorius Linn (Fabaceae) is a climbing shrub; leaves are pinnate with many pairs of leaflets. Leaves 5–10 cm long, leaflets 10–20 pairs, opposite, flowers are pink clustered. The roots, stems, and leaves contain glycyrrhizin, sweet in taste. Leaves are traditionally have been used in the treatment of fever, asthma and caries of teeth. Clon...

To evaluate antidiabetic activity of chloroform extracts of Acacia arabica bark, Benincasa hispida fruit, Tinispora cordifolia stem, Ocimum sanctum areal parts and Jatropha curcus leaves. The chloroform extracts of Acacia arabica bark, Benincasa hispida fruit, Tinospora cordifolia stem, aerial part of Ocimum sanctum and Jatropha curcus leaves were...

To investigate effects of ethanol extract of Abrus precatorius leaves (EAPL) on egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats. In present study ethanol extract of Abrus precatorius leaves (EAPL) at doses of 100, 125, 150 mg/kg i.p were evaluated for preliminary phytochemical screening, acute toxicity...

Clonidine, a α2 adrenoreceptor agonist induces dose dependent catalepsy in mice, which was inhibited by histamine H1 receptor antagonists but not by H2 receptor antagonist. Clonidine releases histamine from mast cells which is responsible for different asthmatic conditions. Clitoria ternatea L. (Family: Fabaceae) is a perimial twing herb. The roots...

Clonidine, a a2adrenoreceptor agonistinduces dose dependent catalepsy in mice, which was inhibited by histamine H1 receptor antagonists but not by H2receptor antagonist. Clonidine releases histamine from mast cells which is responsible for different asthmatic conditions. Roots of Beta vulgaris are sweet, expectorant and tonic, and are useful in psy...

Clitoria ternatea L. (Family: Fabaceae) a perennial twing herb, steams are terete, more or less pubescent. Root is bitter in taste used to cure sever bronchitis, asthma. In Kokan root juice s given in cold milk to remove the phlegm in chronic bronchitis. C. ternatea have reported number of pharmacological activities such as nootropic, anxiolytic, a...

In world Helminthes infections are the most widespread of all the infections in humans. The morbidity due to parasitic diseases has been increasing in our population. The gastrointestinal helminthes become resistant to the currently available anthelmintic drugs. Anthelmintic substances having considerable toxicity to human beings are present in foo...

Clitoria ternatea L. (Family: Fabaceae) a perennial twing herb, steams are terete, more or less pubescent. Root is bitter in taste used to cure sever bronchitis, asthma. In Kokan root juice s given in cold milk to remove the phlegm in chronic bronchitis.C. ternatea have reported number of pharmacological activities such as nootropic, anxiolytic, an...

Now a day’s asthma has grown to be one of the leading chronic diseases throughout the world Mast cells, are important mediators of inflammatory responses such as allergic inflammation and hypersensitivity in asthma. An imbalance between reactive oxygen and nitrogen species and antioxidants are also main cause of asthma. Ficus bengalensis Linn. (Mor...

The antidiabetic effects of hydroalcohiolic extracts of Acacia Arabica, Benincasa hispida , Tinispora cordifolia and Ocimum sanctum were investigated in diabetic rats. The Alloxan monohydrate was used to induce the diabetes in normal rats. The tolbutamide 80 mg/kg p.o. was used the standard antidiabetic throughout the study. Our results indicated t...

Catalepsy is a condition in which the animal maintains imposed posture for long time before regaining normal posture. Clonidine, a a2- adrenoceptor agonist, induces dose dependent catalepsy in mice, which is inhibited by histamine H1 receptor antagonists but not by H2 receptor antagonist. Hence this screening is useful to evaluate antihistaminic ac...

Gynandropsis gynandra (Capparidaceae) leaves are traditionally used in the treatment of pain. In order to evaluate the scientific validity of this, leaves were extracted successively to produce various extracts. These extracts were screened for antinociceptive activity using the hot plate test and acetic acid-induced writhing test in mice at a dose...

Aerial parts of the plant Sida rhombifolia Linn. (Malvaceae) were extracted successively to produce various extracts. These extracts were screened for various parameters of anti-arthritic activity, such as adjuvant-induced arthritis, motor performance, mean distance travelled, and histopathological study. Results showed that the polar constituents...

Clitoria ternatea L. (Family: Fabaceae) is a perimial twing herb. The roots have a sharp bitter taste and cooling, laxative, diuretic, anthelmintic, anti-inflammatory properties; they are useful in severe bronchitis, asthma and fever. Stem and flower are recommended for treatment of snake bites. The seeds are Cathartic and the root is diuretic. The...

Clitoria ternatea L. (Family: Fabaceae) is a perimial twing herb. The roots have a sharp bitter taste and cooling, laxative, diuretic, anthelmintic, anti-inflammatory properties; they are useful in severe bronchitis, asthma and hectic fever Stem and flower are recommended for treatment of snake bite. The seed are Cathartic and the root is diuretic....

Various extracts of Ficus bengalensis bark was screened for it's antiallergic and antistress potential in asthma by milk-induced leucocytosis and milk-induced eosinophilia. Aqueous, ethanol, and ethyl acetate extracts showed significant decrease in leucocytes and eosinophils in the order given while petroleum ether and chloroform extracts were inac...

Various extracts of Ficus bengalensis bark were evaluated for anti cataleptic activity as the plant is having antiasthamatic activity. Aqueous extract (50 mg/kg, i.p.) of the plant significantly inhibited clonidine-induced catalepsy but not inhibited haloperidol-induced catalepsy. Thus the antihistaminic activity of F. bengalensis may be due to pol...

Asthma is disease of the human respiratory system in which the airways constrict and become narrow, often in response to a "trigger" such as exposure to an allergen, cold air, exercise or emotional stress. Due to rapid industrialization and urbanization, asthma prevalence is predicted to increase more rapidly in the coming years. Despite the availa...