Ravindra Gujar

La Jolla Institute for Allergy & Immunology · Division of Vaccine Discovery

High numbers of tissue-resident memory T (T RM ) cells are associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, single-cell and bulk transcriptomic analysis of T RM and non-T RM cells present in tumor and normal lung tiss...

p>Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2, cause reduced gene expression and are linked to rheumatoid arthritis (RA) and other autoimmune diseases. PTPN2 inhibits signaling through the T cell and cytokine receptors and loss of PTPN2 promotes T cell expansion and CD4 and CD8-driven autoimmunity. However, it...

Background: Elevated levels of inflammatory molecules are the key players in muscle wasting/atrophy leading to human morbidity. TNFα is a well-known pro-inflammatory cytokine implicated in the pathogenesis of muscle wasting under diverse clinical settings. S-allyl cysteine (SAC), an active component of garlic (Allium sativum), has established anti...

Calpain, a proteolytic enzyme plays critical role in the skeletal muscle physiology by maintaining the protein metabolism. Up-regulation in the activity of such enzyme under diverse clinical settings (i.e. diabetes, cancer, AIDS, chronic heart failure, immobilization, aging etc) leads to loss in muscle proteins and causes atrophy/cachexia/sarcopeni...

Calpain, a proteolytic enzyme plays critical role in the skeletal muscle physiology by maintaining the protein metabolism. Up-regulation in the activity of such enzyme under diverse clinical settings (i.e. diabetes, cancer, AIDS, chronic heart failure, immobilization, aging etc) leads to loss in muscle proteins and causes atrophy/ cachexia/sarcopen...