Ravi Kant Upadhyay

Ravi Kant Upadhyay
Deen Dayal Upadhyay Gorakhpur University | DDUGU · Department of Zoology

M.Sc. Ph. D

About

208
Publications
408,404
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Citations
Introduction
Presently I am working on immunocytochemical localiuzation of sterol binding proteins in latex. With this I am also trying to observe the latex proteins and their role in cell signalling in insects, mainly in hemipteran and homopteran insects. Besides, I am also engaged in latex generated toxicity in mammals.
Additional affiliations
July 2017 - present
Immunology and molecular biology
Position
  • Deen Dayal Upadhyay Gorakhpur University
Description
  • I am teaching U. G and P.G Classes and involved in research in immunobiological and microbiological research
October 2000 - April 2001
National Research Centre on Plant Biotechnology
Position
  • Research Associate
Description
  • Sequenced rice genome contigs for chrmosome number 11 Nipobare cultivar
Education
January 1991 - October 1997
University of Delhi
Field of study
  • Insect Biochemistry

Publications

Publications (208)
Article
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Laboratory experiments were conducted to evaluate the bio - insecticidal activity of solvent extracts of latex from , Thevetia nerifolia ( Apocynaceae) , Artocarpus heterophyllus (Moraceae), Ficus glomerata ( Moraceae) , Calotropis procera ( Asclepiadaceae). on neonate larvae of Spodopetra litura (Lepidoptera :Noctuidae) a major pest of Indian agri...
Article
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In the present investigation nectar feeding and ovipositional responses were observed in various pollen collecting insect vectors belong to different orders in vegetable garden. Flower-visiting and nectar feeding behavoiur in insects from three orders of class insect Lepidoptera, hymenoptera and diptera was observed. Both form and function of mouth...
Article
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JE is a flavivirus generated dreadful CNS disease which causes high mortality in various pediatric groups. JE disease is currently diagnosed by measuring the level of viral antigens and virus neutralization IgM antibodies in blood serum and CSF by ELISA. However, it is not possible to measure various disease-identifying molecules, structural and mo...
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In the present investigation various bioassays were conducted to evaluate the anti-termite ef-ficacy of plant latex based formulations to con-trol population of Indian white termite in sub-tropical soil. Results reveal that crude latex, its fractions and combinatorial fractions have shown very high toxicity against O. obesus. The LD 50 values for d...
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In the pr esent investigation insecticidal potential and oviposition inhibition efficacy of stem, root and flower extracts of Capparis decidua was evaluated against the rice weevil Sitophilous oryzae . For this purpose different bioassays were conducted and adult in sects were exposed with varying doses of each extract. In bioassays on an average 9...
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The present review article explains venoms from various centipede species with their biomedical and pharmacological properties. Centipede venom is a natural source of bioactive proteins, peptides and other small molecules. These use venoms as defense arsenals to paralyze prey. This review paper sketch out important physiological effects like platel...
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The present review article describes invertebrate venoms and various toxins secreted by them. Animal venoms are stores of novel peptides which exhibit a wide variety of biological effects and actively interact with pathogen and parasites. Animal toxins selectively bind to ion channels and receptors and display show hemolytic, cytolytic, proteolytic...
Article
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In present research study paper wasp Ropalidia marginata Venom toxins were purified on Sepharose CL 6B 200 gel column at a constant flow rate of 5 mL/minute in 121 regular fractions. Elution pattern of venom shows presence of low molecular weight toxic peptides ranging from 12-60 kDa. Eluted fractions were pooled lyophilized and its LD50 was determ...
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In present investigation Tagetes erecta and its combinatorial formulations were evaluated to observe the anti-termite efficacy against Indian white termite Odontotermes obesus. These have shown very high termiticidal activity and repellency against present termite species. It was proved by very low LD 50 values obtained i.e. B-AST-A 261.930 and S-A...
Research
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In the present study experimental bioassays were conducted determine the toxicity and repellency of plant essential oil based formulations in Indian white termite. In anti-termite assays crude oil and extracts were used in different combinatorial mixtures for treatment of termites. In subsequent bioassays crude essential oils, and combinatorial mix...
Article
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The present article explains the effect of plant latex and its formulations on termite control. Latex is natural plant polymer secreted by highly specialized cells known as laticifers. It is a milky white thick complex mixture of proteins, alkaloids, starch, sugars, oils, tannins, resins, and gums. Both latex and its components show multiple delete...
Article
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This review article explains the use of various plant essential oils (EOs) and its formulations in termite control. Plant EOs and its components show multiple deleterious effects such as toxic, antifeedant, repellent, growth, and reproductive inhibitory activity in number of insect pest species. These active components delay egg maturation and deve...
Article
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Present article describes therapeutic and insecticidal activities of plant terpenes. Volatile terpenes and terpenophenolics were found highly active against protozoa, viruses, bacteria, and helminthes. Terpenes also display bacteriostatic, bactericidal, and virucidal activities. These potentially function like promising natural insecticides and wer...
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ins major non communicable disease and complications of various CVDs i.e. strokes, arterial diseases, stress, alcoholism, narcotics, hypertension, cancer and blood pressure and other life style diseases. NCDs do clinical, mental, physical impairments in users, and these become either permanent or temporary. But most of them impose residual disabili...
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Present review article explains the dietary and nutritional value of various fish derived natural food products. Fish is a good source of important nutrients such as proteins, fats, vitamins and minerals. Fish oil contains polyunsaturated fatty acids (PUFAs) mainly omega-3 fatty acids, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and ei...
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Present review article explains the dietary and nutritional value of various fish derived natural food products. Dietary use of fish is a good source of important nutrients such as proteins, fats, vitamins and minerals.. Fish oil possesses polyunsaturated fatty acids (PUFAs) mainly omega-3 fatty acids, eicosapentaenoic acid (EPA), docosahexaenoic a...
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The present review article describes anti-tick efficacy of various plant natural products, that is, plant extracts, pure bioorganic compounds, essential oils (EOs), and its components. This review indicates rising problem of resistance to chemical acaricides in ticks and environmental toxicity due to its residual effects. Both EOs and pure molecule...
Article
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This review emphasizes the immune responses to tick infestation and the administration of vaccine to save the life of man and his livestock. There are so many vaccines in operation in various parts of the world. These vaccines have been developed by using tick saliva toxins or recombinant antigens synthesized. This article explains the use of moder...
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Present review article explains tick-borne diseases, transmission, host immune responses, diagnosis and control in relation to climatic variations. Ticks are hematophagous ectoparasites which suck large volumes of blood from livestock and humans. They release large numbers of protozoans, bacteria, rickettsia and viral pathogens during blood feeding...
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This review article describes anti-cancer activity of various animal toxins belongs to different animal groups. Cancer is a dreadful disease that is responsible for millions of deaths worldwide. For its treatment various chemotherapeutics have been used but these are costlier and show side effects. Animal toxins are noble and unique therapeutic eff...
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Present review article emphasizes species specific coelenterate toxins, its pharmaceutical and therapeutic effects. Most of the coelenterates inflict venom accidently by using nematocysts found on arms. These animals very quickly do massive and multiple inflictions of venom which causes cardiotoxicity that leads to the death of human beings. Coelen...
Article
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Present review article explains ant venom components and its allergic and biological effects in man and animals. Red ants or small fire ants secrete and inject venom very swiftly to defend their nest against predators, microbial pathogens, and competitors and to hunt the prey. Ant venom is a mixture of various organic compounds, including peptides,...
Article
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Colostrum is naturally secreted nutritionally rich thick biological fluid that contains various bioactive molecules such as proteins, carbohydrates, fats, hormones, growth factors, vitamins, lectoferrins, and good repertoire of immunoglobulins which play important role in innate immune defense in new born infants. It contains disease protective and...
Article
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Present review article describes causes of resurgence, pathogenesis and prevention of serious and potentially life-threatening bacterial diseases i.e. typhoid, cholera, tuberculosis, leptospirosis, Brucellosis, pertussis, shigellosis, leprosy, anthrax, and plague occur in human. This article high lights effect of climatic and weather conditions on...
Article
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Ticks are the most important ancient group of obligate blood-sucking ectoparasites of terrestrial vertebrates mainly of livestock. These small-sized animals are found in tropical and subtropical regions of the world. These act as vectors and transmit a wide range of protozoa, bacteria and viruses tick-borne diseases. These attach to host skin for b...
Article
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Present article explains major threats generated by bioterrorism, risks, and its devastation impact on human life. This article also highlights different bio-weapons or genetically modified micro-organisms, methods of bio-defense, bio-security, surveillance and other strategies to counter attack the bio-weapon dissemination. Terrorists can dissemin...
Article
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This paper explains recently emerged climate induced opportunistic nosocomial infections in detail with its prevention and control. All these fungal infections have been emerged all of a sudden in hospitalized patients those who are under clinical care, recovered and in home isolation. Recent corona virus pandemic raised this problem as the high do...
Article
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Present case report describes real time situation and observations of four members of a family infected with Covid-19. They have started taking all drug regimens just after evoking of initial symptoms of Covid-19 without any delay just after consultation seek from two physicians. In this case report patients followed Ayurvedic and herbal treatments...
Article
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In the present review article human diseases caused by various groups of pathogens have been explained with its etiology, epidemiology and treatment. In addition, effect of climatic changes on parasites and pathogens has been demarcated with rising incidences of diseases. In response to environmental changes, mainly external and internal microenvir...
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The present review article explains antihyperlipidemic and cardioprotective effects of various plant natural products. These are antioxidants which found in vegetable oils, fruits, seeds, plant leaves, stem, and plant roots. This article emphasizes therapeutic potential of sulfur-containing compounds, anthraquinones, thiosulfinates and ajoenes, tri...
Article
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Present review article explains antiviral potential of essential oils more especially as an alternative treatment of coronavirus infection. This article emphasizes biological activity of major essential oil constituents and their future prospects for development of low toxic highly effective broad spectrum drugs. These could specifically inhibit vi...
Article
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Present review article explains antivirus activity of animal venom toxins against various virus pathogens of important human diseases. Venom toxins are highly specific defense molecules, which are secreted from basic glandular structures and used as arsenals to protect territory, food and mate selection. Few venomous animals secrete antimicrobial p...
Article
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Upadhyay. The main purpose of artificial immunity is to provide protection cover or shield against particular pathogenic diseases. For this purpose, individuals have been intentionally exposed to small quantities of denatured antigen and administer with attenuated strain or a live virus to evoke immunity. Artificial induction of immunity makes peop...
Article
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The present review article explains the salient features of hornet venom toxins, their physiological, biological and pharmacological effect on animals and man. Hornets sting very fast and inflict venom, which is more dangerous than those of bees. Hornet venom contains both proteinaceous and non-proteinaceous peptides i.e. scapin, adolapin, mellitin...
Article
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The present review article presents various methods for termite control in the high humidity climatic zone of Eastern Uttar Pradesh. It emphasizes the use of various plant latexes as insecticides to control forest, household and garden termite population. Plant latex is a milky white complex mixture of proteins, alkaloids, starch, sugars, oils, tan...
Article
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Present article explains insect toxins, its immune allergic, pharmaceutical and therapeutic effects. Insect venom glands generate enzymatic and non-enzymatic toxins and are inflicted by the stings. Insect's envenomation are highly painful, inflamed and life-threatening. It causes breathing difficulties, bronchospasm, hypotension and arrhythmia, car...
Article
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The present review article emphasizes anti-termite efficacy of various plant natural products for control of Indian white termite and its associating species. The Indian white termite, Odontotermes obesus (Rambur) (Isoptera: Odontotermitidae), is highly destructive polyphagous insect pest in Eastern Uttar Pradesh. It damages commercial wood, food c...
Article
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The present review article emphasizes anti-termite potential of various natural plant products against various termite species, i.e. subterranean termites, dry wood termite, and dampwood termites. Termites invade standing crops wood clothes, paper orchard vegataion and cause heavy damage to vegetable plants, seeds, bark, stems and stired grain prod...
Article
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The present review article, explain the use of plant latexes and other plant natural products for control of termites. Termites are polyphagous, highly destructive pests which cause significant loss to agricultural crops, food, fibres, wood materials and other house hold materials. However, for termite control different synthetic highly toxic chemi...
Article
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The present review article explains fish toxins from different species with their pharmaceutical and therapeutic uses. Fish stinging is a major problem in coastal areas as it exerts severe toxic effects mainly in fishermen, locals, and tourists. Fish toxins cause severe pain that radiates up in the limbs and regional lymphatics. These also impose v...
Article
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The present review article emphasized the pharmaceutical, insecticidal, and therapeutic role of Cassia fistula and its associating species. This is an ornamental plant grown in all parts of India and has a long traditional use in Ayurvedic medicines for the treatment of cough, cold, and sneezing. Plant is a good depository of chemical constituents...
Article
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Present review explains different modes of transmission of coronavirus, facts and challenges people have faced at global level. Anthropogenic activities such as trade, transport, travel, business, tourism and religious are responsible for transmission of this virus. It is noticeable that among all modes of transmission human mistakes have increased...
Article
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In the present investigation, in vivo effects of wasp toxin were evaluated on lactic dehydrogenase (LDH) and acetyl cholinesterase (AChE) enzyme activity in serum, liver and gastrocnemius muscles of albino mice. A significant elevation was observed in LDH activity in serum, liver and muscles, while the activity of AChE was decreased in serum, liver...
Article
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Present research article explains a composite thermal-aroma-organic-carbon fusion therapy to instantly fight against flu virus/human corona virus. The key concept behind this therapy is to kill invisible virus/enemy by using highly active untraceable /unrecognizable carbon and drug molecules. However, for making a cumulative defense against flu vir...
Article
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Present article explains clinical issues related to organ transplants mainly their safe procurement from donor, successes and failures. It also sketches important factors such as need, procurement, reasons of rejection, storage, transportation, and bioethical, legislative and hospital management to find solutions for highly morbid patients. It also...
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This article explains dire need of highly effective drugs as most of the antibiotics are either failed to do action as microbes have developed multiple resistance. This article pertains with new innovative methods of synthesis or development of new drug, its delivery, biological interactions and safety measurements. It also sketches out important v...
Article
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In this study biological effects of purified wasp venom toxins were evaluated on phosphatase enzyme activity in blood serum, liver and gastrocnemius muscle tissue of albino mice. A significant elevation was observed in serum acid phosphatase, alkaline phosphatase in serum, liver and gastrocnemius muscles in albino mice after injection of sub-lethal...
Article
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Animal venoms possess variety of toxins/proteins/peptides which act as ionic channel inhibitors and target vital physiological processes. Toxin peptides isolated from honey bee, wasp and scorpion show membrane binding, growth inhibition and strong cytolytic properties. These also inhibit angiogenesis and induce caspase-dependent apoptosis in melano...
Article
Present review article explains hydrophobic interactions that form during binding of toxin or toxin peptides to ion channels or activated ionic pumps which actively maintain ionic concentration across the plasma membranes. Wasps venom toxins mainly, anoplin a short peptides after binding with a receptor proteins, changes its confirmatory structure....
Article
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In present investigation hematological effects of Yellow wasp Polistes flavus were determined in albino mice. Venom gland extract was purified on a Sepharose CL 6B 200 gel column at a constant flow rate in regular fractions. Pooled fractions were lyophilized and subsequently LD50 was determined. The LD 50 of the yellow wasp Polistes flavus venom pr...
Article
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Present article aims to explain use of stem cells for management of pancreatitis a sever disorder that is prevailing in millions of people around the globe. This article emphasizes use of mesenchymal stem cells (MSCs) as treatment tools. These are most popular therapeutic agents and can be derived from bone marrow, adipose tissue, umbilical cord, h...
Article
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Present article focuses on various lipoprotein based drug delivery vehicles used in cancer and tumor therapeutics. Starting from aqueous phase delivery through liposomes or unilamellar vesicles, biomimetic HDL nanoparticles, discoidal recombinant high-density lipoproteins (d-rHDLs) are favorably used to deliver anticancer agents. LDL based carrier...
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Present review article explains the dietary use of plant pigments and therapeutic effects against cancer. Important plant pigments such as anthocyanins, lycopene, carotenoids, chlorophyll, and betalains are explained for their anticancer effects. Plant pigments are secondary metabolites which obstruct cancer cell proliferation; stop growth and cell...
Article
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Purification of spider venom Crossopriza lyoni toxins on a Sepharose CL-6B 200 column and evaluation of antimicrobial susceptibility in infectious bacterial pathogenic strains. Materials and Methods: Solubilization of spider venom toxins in Triton X-100 (0.1%), phosphate-buffered saline, and trichloroacetic acid.For obtaining purified toxins/ pepti...
Article
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The present review explains therapeutic and pharmaceutical potential of Aloe vera a well-known plant grows in semi-arid climate of tropical and subtropical regions. This article emphasizes important uses of A. vera constituents as dietary nutraceutical, medicinal, and therapeutic potential. Plant is cultivated for agricultural and medicinal and dec...
Article
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Present review article explains use of animal venom derived toxins as analgesics of the treatment of chronic pain and inflammation occurs in arthritis. It is a progressive degenerative joint disease that put major impact on joint function and quality of life. Patients face prolonged inappropriate inflammatory responses and bone erosion. Longer pers...
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The present review explains therapeutic and pharmaceutical potential of Cinnamomum tamala a well-known plant grows in high altitude areas of tropical and subtropical regions. This article emphasizes important uses of C. tamala constituents as spice, drug, and drug carrier with its therapeutic potential. Plant is a good depository of chemical consti...
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This review article explains major optic nerve disorders and cell replacement therapy. This article also signifies new innovative methods, biopharmaceuticals, im-plantable biomaterials, devices and diagnostic tools developed for restoration of vision. It asserts notable technological advancements made for regeneration of neurons and restoration of...
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Present review article emphasize role of biominerals in regenerative medicine and tissue engineering. Among all biominerals calcium is essential for body growth and development. It also performs many fundamental functions in cellular metabolism. Inside cell organic matrix is calcified by calcium phosphate minerals. It also embeds bone cells which p...
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Allium vegetables are highly nutritional, its dietary use improves digestion and mental health and lower down cholesterol level. Use of onions, garlic, scallions, chives and leeks show therapeutic efficacy against cardiovascular disease, hyperglycemia, and stomach cancer, Onions contain allylsulfides and flavonoids particularly quercetin that is an...
Article
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The present review explains nutritional, therapeutic, and pharmaceutical potential of plant gum that is commonly applied to water-soluble, non-starch polysaccharides of commerce. This article also emphasizes commercial and domestic uses of important products of gum such as chicle and jelutong mainly non-elastic gums or chewing gums. These are also...
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The present review explains nutritional, therapeutic, and pharmaceutical potential of plant gum that is commonly applied to water-soluble, non-starch polysaccharides of commerce. This article also emphasizes commercial and domestic uses of important products of gum such as chicle and jelutong mainly non-elastic gums or chewing gums. These are also...
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The present review article explains medicinal and therapeutic uses of Tulsi plant in traditional medicine. Tulsi (Ocimum sanctum [OS] Linn.) is an aromatic plant belongs to family Lamiaceae. It is traditionally used for preparation of various Ayurvedic formulations for treatment of bronchitis, influenza, and asthma. Hot concoction of Tulsi leaves i...
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Present review article aims to explain use of injectable hydrogels and microspheres derived from natural polysaccharides as drug delivery systems and cell scaffolds. Polysaccharides isolated from natural sources are proved much better than synthetic polymers for making single and composite hydrogels. This paper emphasizes recent developments occurr...
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Present review article emphasizes role of biological scaffolds, hydrogels and stem cells in tissue engineering mainly in regeneration or repairing of damaged tissues. Highly porous scaffold biomaterials are developed which act as templates for tissue regeneration and potentially guide the growth of new tissue. Present article also describes de-cell...
Article
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Present review article elucidate radiation generated effects on blood brain barrier, tissues, cells and organ systems of human body. Radiation is used to finish brain metastasis and tumor ablation but repetitive exposure of radiation induces multiple deformities almost in all tissues or organs. Low physiological dosage of radiation is provided to i...
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Present review article elucidate radiation generated effects on blood brain barrier, tissues, cells and organ systems of human body. Radiation is used to finish brain metastasis and tumor ablation but repetitive exposure of radiation induces multiple deformities almost in all tissues or organs. Low physiological dosage of radiation is provided to i...
Article
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Present review article elucidate radiation generated effects on blood brain barrier, tissues, cells and organ systems of human body. Radiation is used to finish brain metastasis and tumor ablation but repetitive exposure of radiation induces multiple deformities almost in all tissues or organs. Low physiological dosage of radiation is provided to i...
Article
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Present review article describing effects of garlic components on induction of apoptosis, cell cycle check points and inhibition of cancer cell proliferation. Garlic derived organic compounds hold unique therapeutic potential and induces apoptotic signaling pathways; do cell cycle arrest, and show cytotoxic and anti-invasive activity to a variety o...
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Present review article explains various causes of acute liver diseases and their therapeutics. This article describes major reasons of hepatic pathophysiological conditions and diseases including hepatitis, cholestasis, alcoholic and non-alcoholic steatohepatitis, jaundice, liver cirrhosis, carcinogenesis and many others. This article emphasizes us...