Ravi Shankaran Dhesingh

Ravi Shankaran Dhesingh
University of Madras | UMadras · Centre for Nanosciences and Nanotechnology

Ph.D.

About

78
Publications
10,211
Reads
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2,587
Citations
Citations since 2016
25 Research Items
1148 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Introduction
My research interest is on Nano-Bio Materials and Sensors. The research involves the integration of nanotechnology and biotechnology to develop novel multifunctional materials and devices that address various challenges of diagnosis and drug delivery. Special interest is on flexible optoelectronics, bio-inspired nanomaterials and multifunctional coatings for affordable and point-of-care (POC) health care products.
Additional affiliations
January 2011 - January 2015
PSG Institute of Advanced Studies
Position
  • Principal Investigator, NanoBIo Materials and Sensors Laboratory
April 2010 - November 2010
University of Missouri
Position
  • Researcher
Description
  • Multifunctional coating for medical and defence applications
December 2007 - March 2009
Kyushu University
Position
  • Professor (Associate)
Description
  • Biosensors and microdevices for biomedical and defence applications.

Publications

Publications (78)
Article
ABSTRACT In this study, we have investigated the colorimetric sensing of heavy metal ions, especially copper ions (Cu2+) for multiple analyses using gelatin functionalized silver nanoparticles (AgNPs) and AgNPs loaded gelatin hydrogels. Gelatin functionalized AgNPs were prepared by chemical reduction of silver nitrate. The gelatin functionalized Ag...
Article
Full-text available
Low-cost flexible thin-films exhibiting stimuli-responsive properties were fabricated on poly(methyl methacrylate) (PMMA) as the base supporting material. Labeling of this transparent thermoplastic with Congo red diazo dye revealed its simultaneous pH-responsive and temperature-responsive abilities. UV, FT-IR, and film stability studies identified...
Article
Full-text available
Immunosensors based on surface plasmon resonance (SPR) have become a promising tool in sensor technology for biomedical, food, environmental, industrial and homeland security applications. SPR is a surface sensitive optical technique, suitable for real-time and label-free analysis of biorecognition events at functional transducer surfaces. Fabricat...
Article
Interest in the development of surface plasmon resonance (SPR) based immunosensors for detection and monitoring of low-molecular-weight analytes of biomedical, food and environmental fields has been rapidly increasing over the last 10 years. By combining the advantages of the specific antigen–antibody immunoreaction and the high sensitivity and rel...
Article
We present a new approach for fabricating robust, regenerable antimicrobial coatings containing an ionic liquid (IL) phase incorporating silver nanoparticles (AgNPs) as a reservoir for Ag(0)/Ag(+) species within sol-gel-derived nanocomposite films integrating organosilicate nanoparticles. The IL serves as an ultralow volatility (vacuum-compatible)...
Article
Development of shape dependent interaction of silver nanostructures (Nanoparticles, Nanowires, and Nanocubes) with mercury (Hg²⁺) for its sensing applications has been accounted earlier by our group. For the continuation of our work, we have studied the effect on shape dependent interaction of silver nanotriangles (AgNTs) with mercury by simple col...
Article
Development of effective nanoformulations is one of the captivated attentions in the area of healthcare applications. Drug encapsulated metal nanoparticles (AuNPs) is an impressive nanoformulations, which reduces the side effects, enrich the pharmacokinetic and enables the targeted drug delivery. Gold nanoformulations (FA‐AuNFs) receiving much cons...
Article
Cellulose based nanoplasmonic sensors gained immense attention for various applications due to their advantageous physicochemical characteristics such as ease of fabrication, low density, chirality, surface functionalization and disposal. Herein, a hydrogel based nanoplasmonic sensor probe was fabricated and evaluated for the detection of melamine...
Article
A simple, low-cost and highly selective nanosensor was developed for naked-eye detection of mercury ions (Hg2+) based on Eosin/silver nanocubes (Eosin/AgNCbs). Silver nanocubes (AgNCbs) were synthesized by polyol assisted chemical method. HR-TEM result shows the formed AgNCbs have a mean diameter of 84±0.005 nM (diagonally measured) and edge length...
Article
This work aims at the development of curcumin loaded poly(methyl methacrylate) (CC-PMMA) fluorescent nanofiber membrane and the evaluation of its multifunctional characteristics. The nanofibers were created by electrospinning method. The conditions of the spinning were optimized to obtain beadless and smooth nanofibers. The physico-chemical charact...
Article
Full-text available
Nanoformulation based drug delivery is one of the most important research areas in the field of nanomedicine, which provides promising alternatives to the limitations of conventional chemotherapy. Nano drug delivery enables improved pharmacokinetic profile, bioavailability and therapeutic efficiency compared to the regular chemotherapeutic drugs. H...
Article
The effective use of the gold nanoparticle (AuNPs) conjugated drugs for targeted drug delivery applications is one of the most promising research areas in the field of cancer. Herein, we aimed to establish a nano drug conjugated with docetaxel as a possible therapy option. Gold nanoparticles were synthesized by chemical reduction method. This is fo...
Article
Cancer is the second leading causes of death worldwide and it is one of the fatal diseases that kill millions of people every year. It is characterized by uncontrolled proliferation of cells and loss of apoptosis that generates an abnormal mass of cells or tumors. Prostate cancer (PCa) is one of the most common cancers in men and the risk is higher...
Article
Introduction: Fast dissolving films have received great attention in pharmaceutical industry because of their unique properties and advantages. The drug loaded films undergo quick disintegration in the salivary fluids of the oral cavity and release the drug. The purpose of this study is to fabricate tuberculosis (TB) drugs such as Isoniazid and Rif...
Article
The present work investigates fabrication and characterization of graphene/ poly (methyl methacrylate) (PMMA) composite flexible films. Graphene/PMMA flexible films were fabricated by one-pot alternate stirring sonication (OPASS) process. The method relies on the alternate high speed stirring and ultrasonication of graphite and its blending with PM...
Article
Background: Carcinoma of the prostate gland (PCa) is one of the most commonly diagnosed cancer diseases among men around the world. PCa has become the major considerable health and epidemic problem which causes death in men with a high prevalence and relatively lower mortality risk. The inability of conventional diagnosis tools to detect cancer at...
Article
We aimed to develop a simple and low-cost method for the production of high-performance cellulose nanomaterials from renewable and sustainable resources. Here, cellulose microcrystals (CMCs) were prepared by controlled acidic and basic hydrolysis of cotton from textile industry wastes. The resulted CMCs were further converted into cellulose nanocry...
Article
Full-text available
In this work, we have investigated the uses of herbal extract of Terminalia bellerica (T.bellerica) as an efficient reducing as well as capping agent for reliable green synthesis of silver nanoparticles (AgNPs) at room temperature. HR-TEM results of AgNPs confirmed that, the nanoparticles are spherical in shape with an average diameter of ~30 ± 6 n...
Article
Background: Glaucoma, a chronic eye condition caused by progressive degeneration of retinal ganglion cells may result in permanent blindness. The restricted efficiency of currently available glaucoma treatments has awakened a global need for designing a novel anti-glaucoma drug delivery mechanism that targets the drug to the site of action in a su...
Article
In this study, we aimed to establish a new and simple method for colorimetric sensing of lead (Pb²⁺ using curcumin nanoparticles (CC NPs) impregnated nanofibers. The CC NPs with high aqueous solubility was prepared by simple grinding and sonication methods. CC NPs were spherical in shape with an average particle size of 8 nm and was used for the pr...
Article
Carbon quantum dots (CQDs) have great potential due to its advantageous characteristics of highly fluorescent nature and good stability. In this study, we aimed to develop a simple and efficient method for the green synthesis of fluorescent CQDs from sugarcane bagasse, a renewable and sustainable resource. The process involves the top down approach...
Article
A new rhodamine based cellulose acetate nanofibers were fabricated for the colorimetric detection of picric acid without any surface modification of nanofibers. Rhodamine loaded cellulose acetate nanofibers were electrospun using electrospinning method. This sensing membrane was selective to picric acid compared to other nitro compounds. The nanofi...
Article
We have investigated the chemical synthesis of gelatin functionalized silver nanoparticles (AgNPs) and its physico-chemical characteristics for sensing of mercury (II) ions (Hg2+). Gelatin functionalized AgNPs were prepared by chemical reduction method. The colorimetric sensing of Hg2+ was carried out in three different phases including solution, h...
Article
The aim of the present work is to develop a simple, rapid and highly selective colorimetric sensor for Hg2+ based on 1D silver nanowires (AgNWs) ink. AgNWs were synthesized through polyol assisted method and systematic characterization was done by various techniques such as high resolution-transmission electron microscope (HR-TEM), X-ray photoelect...
Article
Smart flexible films are of its kind which can be used for multitudinal purposes with enhanced performance and comfortness. The incorporation of pH-sensitive dyes into polymer materials leads to flexible and easy-to-handle pH-sensors which are able to give immediate visible signal. The present study explores the in-situ low-cost fabrication of halo...
Article
We have developed a new and simple strategy for colorimetric sensing of formaldehyde (HCHO) using a nanofiber based functional strip. Transparent Poly(methyl methacrylate) (PMMA) nanofibers were fabricated by electrospinning method. All experimental conditions are optimized for the production of nanfibers with a diameter of 119 ± 0.05 nm. Various t...
Article
In this study, we aimed to develop a simple, biocompatible and selective colorimetric sensor strip for detection of lead (Pb2+) using curcumin loaded cellulose acetate (CC-CA) nanofibers. The nanofibers were fabricated by electrospinning method. Curcumin functionalized nanofibers were characterized by various techniques such as polarizing optical m...
Conference Paper
The plasmonic response of noble metal nanoparticles due to their unique physical and optical properties serves as building blocks for a variety of applications in nanophotonics, nanodevices and nanomedicine. The plasmonic nanomaterials exhibit strong UV-visible absorption bands that are not present in the bulk metal. This provides the brilliant...
Conference Paper
The plasmonic response of noble metal nanoparticles due to their unique physical and optical properties serves as building blocks for a variety of applications in nanophotonics, nanodevices and nanomedicine. The plasmonic nanomaterials exhibit strong UV-visible absorption bands that are not present in the bulk metal. This provides the brilliant...
Conference Paper
Silver nanoparticles have wide spread application in bio-medical, defense and opto-electronic areas owing their unique optical and electronic properties. Over the years, large number studies are being carried out on the use silver nanopartices in various formulations for sensor applications. In this study, we aimed to use silver nanoparticles (AgNP...
Article
Development of high performance analytical methods for identification and quantification of small molecules is an ever increasing global issue in the enhancement of the quality and longevity of human life. SPR based optical immunoassay is one of the promising analytical tools for rapid and real-time analysis of chemical and biological substances in...
Article
Surface plasmon resonance (SPR) based immunosensor for rapid and sensitive determination of thyroxine (T4), which is one of major thyroid hormones, has been investigated. Here, a mixed self-assembled monolayer (SAM) of poly(ethylene) glycols (PEG) aromatic dialkanethiols was employed for fabricating sensor surface. As a methodology for low-molecula...
Article
In order to develop the fully integrated portable surface plasmon resonance (SPR) system for detection of explosives, the amplification strategy of SPR signal was investigated. Indirect competitive inhibition method allowed the middle-sized SPR sensor to detect trinitrotoluene (TNT) at ppt level. However, this enhanced SPR signal was not high enoug...
Article
In modern biomedical technology, development of high performance sensing methods for dopamine (DA) is a critical issue because of its vital role in human metabolism. We report here, a new kind of bioaffinity sensor for DA based on surface plasmon resonance (SPR) using a D(3) dopamine receptor (DA-RC) as a recognition element. A conjugate of DA was...
Article
Recent concern on international terrorism and weapons of mass destruction demands the development of novel analytical methods for identification and quantification of explosive molecules. In this article, we describe the development of high-performance immunosensors for detection of 2,4,6-trinitrotoluene (TNT), a prime component of the landmines an...
Article
We have developed a new immunosensor based on self-assembly chemistry for highly sensitive and label-free detection of 2,4,6-trinitrotoluene (TNT) using surface plasmon resonance (SPR). A monolayer of amine terminated poly(ethylene glycol) hydrazinehydrochloride (PEG-NH2) thiolate was constructed on an activated gold surface and immobilized with tr...
Article
Nanotechnology offers exciting opportunities and unprecedented compatibilities in manipulating chemical and biological materials at the atomic or molecular scale for the development of novel functional materials with enhanced capabilities. It plays a central role in the recent technological advances in biomedical technology, especially in the areas...
Article
Detection of 2,4,6-trinitrotoluene (TNT) is an important environmental, security and health concern for the global community. TNT is a prime constituent of most of the landmines and bombs and is highly toxic and mutagenic. Various military and terrorist activities (e.g., manufacturing, waste discharge, testing and training) have resulted in extensi...
Article
Full-text available
Detection of TNT is an important environmental and security concern all over the world. We herein report the performance and comparison of four immunoassays for rapid and label-free detection of 2,4,6-trinitrotoluene (TNT) based on surface plasmon resonance (SPR). The immunosensor surface was constructed by immobilization of a home-made 2,4,6-trini...
Article
We have established a new surtace-plasmon-resonance (SPR) based affinity biosensor for highly sensitive and selective detection of dopamine (DA) employing a D3 dopamine receptor (D-RC) and a home-made DA-bovine serum albumin (DA-BSA) conjugate. The proposed biosensor is simple, reproducible and exhibit excellent sensitivity for DA (detection limit...
Article
This paper presents the sensing characteristics of a new, versatile and portable surface plasmon resonance (SPR) immunosensor for detecting 2-hydroxybiphenyl (HBP) employing an indirect competitive immunoreaction principle. The HBP–bovine serum albumin (HBP–BSA) conjugate prepared by covalent binding of HBP with BSA using an aliphatic chain spacer...
Article
This paper describes the development and comparison of two immunoassays for the detection of 2,4,6-trinitrotoluene (TNT) based on competitive inhibition. Two polyclonal antibodies were used in the immunoassay; one was prepared from 2,4,6-trinitrophenol–bovine serum albumin conjugate (anti-TNP-BSA Ab, goat IgG) and another from 2,4,6-trinitrophenyl–...
Article
A simple and highly sensitive surface-plasmon-resonance (SPR) immunoassay has been demonstrated for rapid and label-free detection of 2,4,6- trinitrotoluene (TNT). The immunoreaction between a home-made polyclonal anti-2,4,6-trinitrophenyl-keyhole-limpet-hemocyanine antibody (P-TNPh-KLH Ab) with a physically immobilized TNPh-ovalbumin (TNPh-OVA) co...
Chapter
Explosive molecules that leak out of a landmine may have extremely low concentrations in soil or air. This chapter aims at the development of a highly sensitive biosensor to detect explosive molecules for landmine detection. A highly sensitive surface plasmon resonance-based immunosensor for detection of trisenitrophenol (TNP) functioning with indi...
Article
Square-wave voltammetric detection of dopamine was studied at a copper (Cu)-(3-mercaptopropyl) trimethoxy silane (MPS)-complex modified electrode (Cu-MPS). The modification of the electrode was based on the attachment of MPS onto an electrochemically activated glassy carbon electrode (GCE) by the interaction between methoxy silane groups of MPS and...
Article
A surface plasmon resonance (SPR) immunosensor for the determination of 2,4,6-trinitrotoluene (TNT) has been developed based on the principle of indirect competitive immunoreaction. 2,4,6-trinitrophenol-bovine serum albumin (TNP-BSA) conjugate was immobilized onto a SPR gold chip by means of simple physical adsorption. Binding of anti-TNP antibody...
Article
We have examined the sensing characteristics of a surface plasmon resonance (SPR) immunoassay for the detection of 2,4,6-trinitrotoluene (TNT) using an immunoreaction between 2,4,6-trinitrophenol-ovalbumin (TNP-OVA) conjugate and anti-2,4,6-trinitrophenol antibody (anti-TNP antibody). TNP-OVA conjugate was attached to a SPR-gold sensing surface by...
Article
A new surface plasmon resonance (SPR) immunosensor has been demonstrated for the determination of 2,4,6-trinitrophenol (TNP) based on the principle of indirect competitive immunoreaction using trinitrophenol–bovine serum albumin (TNP–BSA) conjugate and anti-TNP antibody. TNP–BSA conjugate was immobilized on a SPR chip by physical adsorption. TNP in...
Article
A new sol-gel derived composite sensor has been developed for the determination of sulfite and sulfur dioxide using 3-aminopropyltrimethoxysilane, ferrous sulfate and graphite powder by sol-gel process. Cyclic voltammetry and amperometry studies revealed that the modified iron dispersed sol-gel derived ceramic composite electrode exhibited excellen...
Article
Full-text available
A novel biosensor based on surface plasmon resonance (SPR) immunoassay has been developed for the determination of 2,4,6-trinitrotoluene (TNT) and its derivative nitroaromatic explosive compounds. A conjugate immobilized SPR gold sensing surface was used as a solid phase immunoassay and the quantification of TNT was carried out based on the princip...
Article
A new iron immobilized (3-mercaptopropyl)trimethoxysilane (MPS) self-assembled layer has been developed over a gold electrode surface by a combined sol–gel and self-assembly techniques. The sensor exhibited excellent sensing characteristics for the catalytic reduction as well as oxidation of hydrogen peroxide (H2O2) at the potentials of +0.1 and +0...
Article
A new sol–gel composite electrode containing dispersed copper was fabricated using (3-mercaptopropyl)trimethoxysilane (MPS) and copper nitrate. The sensor exhibited excellent characteristics for simultaneous determination of ascorbic acid and dopamine owing to its combined features of sol–gel composite and copper catalysis. The peaks for the oxidat...
Article
A new glucose biosensor has been fabricated by immobilizing glucose oxidase into a copper dispersed sol-gel derived ceramic-graphite composite. The copper in the biocomposite offers excellent electrocatalytic activity towards the reduction (at -0.2 V) as well as oxidation (at +0.45 V) of hydrogen peroxide liberated in the enzymatic reaction enablin...
Article
A new silver dispersed composite electrode made of sol–gel derived ceramic–graphite has been demonstrated for the determination of dopamine. Silver has been immobilized within the porous and rigid silicate network in the composite by the specific interaction with (3-mercaptopropyl)trimethoxysilane (MPS). The modified composite electrode coated with...
Article
A new and simple amperometric sensor for sulfur dioxide (SO2) has been constructed based on the self-assembly of (3-mercaptopropyl)trimethoxysilane (MPS) over a glassy carbon (GC) electrode followed by the complexation with silver. The silver dispersed onto the self-assembled surface exhibited excellent electrocatalytic activity for the determinati...
Article
A new copper dispersed ceramic-graphite composite electrode was fabricated by the initial mixing of copper nitrate and (3-mercaptopropyl)trimethoxy silane (MPS) followed by stirring with graphite powder. The combination of the metal catalysis and the advantages of the ceramic composite favored the electrocatalytic reduction of hydrogen peroxide (H2...
Article
A chemically modified amperometric sensor was constructed by mechanically immobilizing cobalt hexacyanoferrate onto the surface of a paraffin impregnated graphite electrode (PIGE). The cyclic voltammogram of the electrode exhibited two reversible redox peaks corresponding to Co2+/Co3+ and Fe(CN)64−/Fe(CN)63− reactions. Thiosulphate was found to und...
Article
A new modified electrode constructed by self-assembly of (3- mercaptopropyl)trimethoxysilane on a gold electrode followed by immobilization with hydrazine exhibits excellent electrocatalytic activity for the reduction of hydrogen peroxide at a reduced overpotential of - 0.15 V. Immobilization of hydrazine in the sol-gel layer formed on the electrod...
Article
A mechanically immobilized cobalt hexacyanoferrate modified electrode has been constructed. The modified electrode exhibits two reversible redox peaks in a 0.1 M NaC1 medium, and can be used for the amperometric determination of glutathione. The modified electrode facilitates the catalytic oxidation of glutathione at a reduced overpotential compare...
Article
A graphite electrode modified with cobalt hexacyanoferrate by mechanical immobilization was used for amperometric determination of hydrazine. The modified electrode exhibits good catalytic activity for the oxidation of hydrazine at a reduced overpotential with remarkable sensitivity. The modified electrode showed a linear response for hydrazine in...
Article
An amperometric sensor constructed by mechanical immobilization of nickel hexacyanoferrate onto the paraffin impregnated graphite electrode is reported. The modified electrode exhibits a reversible redox peak, which corresponds to surface-confined Fe(CN)4- 6/Fe(CN)3- 6reaction. Electrocatalytic oxidation of hydrazine is effective on the modified el...
Article
A new copper hexacyanoferrate modified electrode was constructed by mechanical immobilization. The modified electrode was characterised by cyclic voltammetric experiments. Electrocatalytic oxidation of glutathione was effective at the modified electrode at a significantly reduced overpotential and at broader pH range. The modified electrode shows a...
Article
A chemically modified electrode constructed by mechanical immobilisation of nickel hexacyanoferrate onto a paraffin impregnated graphite electrode is described. The modified electrode is stable over hundreds of cycles when scanned between 0.0 to 1.0 V at 100 mV/s in 0.1 M NaNO3 in the pH range 2 to 8. The modified electrode catalyses the oxidation...
Article
Full-text available
A nickel hexacyanoferrate modified electrode was constructed by mechanical immobilization. A reversible peak with midpoint potential of 0.38 V was observed in cyclic voltammetry with 0.1 M NaNO3. Electrocatalytic oxidation of thiosulfate was effective on the modified electrode at a significantly reduced overpotential of 0.5 V and at broad pH range....
Article
A newly modified electrode was prepared by mechanical immobilization of copper hexacyanoferrate (CuHCF) on a graphite electrode. The modified electrode was characterized by cyclic voltammetric experiments. The effect of different background electrolytes, pHs and scan rates on the electrochemical behaviour of the electrode has been evaluated. In NH4...
Article
Copper hexacyanoferrate (CuHCF) modified graphite electrode prepared by mechanical immobilisation method has been used for the amperometric determination of sulphite, which can be extended for the determination of SO2 in air after absorbing the pollutant in sodium hydroxide solution. This method is based upon the electrocatalytic oxidation of sulph...
Article
A novel copper hexacyanoferrate (CuHCF) modified electrode is constructed. A thin film of CuHCF is transferred onto the carbon working electrode by mechanical immobilisation. The modified electrode has been characterised by cyclic voltammetric experiments. The effect of different background electrolytes, pH and scan rates on the electrochemical beh...

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Projects

Projects (3)
Project
Development of nano-bio chip for clinical diagnosis DST project
Project
On the development of gold based nanocarrier for targeted drug delivery to prostate cancer DBT Project