Raul Felipe Palma-Álvarez

Raul Felipe Palma-Álvarez
University Hospital Vall d'Hebron · Department of Psychiatry

MD. PhD

About

74
Publications
6,329
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372
Citations
Introduction
Raul Felipe Palma-Alvarez is graduated as medical physician from the University of Rosario (Colombia) and specialized as Psychiatrist at Vall d’Hebron University Hospital (Spain). His Doctorate Degree was on addiction, dual diagnosis, and alexithymia. He currently works at the Addiction and Dual Diagnosis Unit of the Department of Psychiatry of Vall d’Hebron University Hospital. He has focused his clinical practice and research on addictions, mental disorders, and dual diagnosis.
Additional affiliations
May 2016 - present
University Hospital Vall d'Hebron
Position
  • Psychiatrist
May 2012 - May 2016
University Hospital Vall d'Hebron
Position
  • Medical Doctor
Education
September 2017 - January 2022
Autonomous University of Barcelona
Field of study
  • Substance Use Disorsers, Dual Diagnosis, and Alexithymia
January 2013 - September 2014
University of Murcia
Field of study
  • Master in Neuroscience
May 2012 - May 2016
University Hospital Vall d'Hebron
Field of study
  • Psychiatry

Publications

Publications (74)
Article
Full-text available
Objective: Agitation in patients diagnosed with personality disorders (PD) is one of the most frequent crises in emergency departments (ED). Although many medications have been tested, their effectiveness has been small or non-significant, and no specific drugs are supported by the available evidence. This study aimed to evaluate the efficacy of In...
Article
Objective COVID-19 and lockdown measures impacted mental health globally and had a particular impact on patients with substance use disorders (SUD). However, the impact of gender, age, and dual diagnosis on consumption patterns and mental health during COVID-19 lockdown among patients with SUD has not been analyzed in depth. Therefore, this study a...
Article
Background and objectives : The longitudinal relationship between insomnia disorder and adult attention-deficit/hyperactivity disorder (ADHD) has been scarcely investigated. This study aimed to evaluate the relationship between the remission of insomnia disorder and adult ADHD clinical severity, psychiatric and medical comorbidities, and the health...
Article
Full-text available
Introduction: COVID-19 has had a great impact on mental health in the general population. However, few studies have focused on patients with substance use disorders (SUDs). This research aimed to compare the clinical status and substance use patterns of SUD outpatients, before and during confinement due to the COVID-19 pandemic. Methods: This mu...
Article
Full-text available
Background Hepatitis C virus (HCV) management is a challenge in patients with substance use disorder (SUD). This study aimed to describe an HCV screening and linkage to care program in SUD patients, and analyze the characteristics of this population in relation to HCV infection, particularly the impact of psychiatric comorbidities (dual diagnosis)....
Article
Full-text available
Introduction: Several investigations have been performed on insomnia symptoms in adult attention-deficit/hyperactivity disorder (ADHD). However, the relationship between insomnia disorder and adult ADHD has been neglected in research. The main objective of the current study is to analyze the differences between adult ADHD patients with and without...
Article
Introduction: Lamotrigine is an antiepileptic medication approved as a mood stabilizer for the prevention of depressive episodes in bipolar disorder. Among its adverse reactions, it may present maniac symptoms, despite being an idiosyncratic adverse effect and low incidence. Case report: We present the case of a 58-year-old patient, diagnosed with...
Article
Objective: Cannabis and synthetic cannabinoids (SC) are related to several neuropsychiatric symptoms and disorders, especially psychotic symptoms and disorders. Interestingly, catatonia-like symptoms associated with cannabis and SC have been generally neglected in research and scarcely described despite the clinical repercussions. Hence, this revi...
Article
Full-text available
Background: Alexithymia frequently correlates with several psychiatric disorders, including substance use disorder (SUD). However, most studies reporting the associations between alexithymia and psychiatric disorders have been performed in populations without SUD. This research, therefore, evaluates alexithymia in Spanish patients with SUD and the...
Conference Paper
Introduction Patients with substance use disorders (SUD) have higher alexithymia levels and present frequently suicidal ideation (SI) and suicide (SA) [1,2]. Beside, alexithymia has been related to suicidal behaviors in several psychiatric disorders[3]. Although, there are some studies on alexithymia and suicidality in SUD patients, to our knowledg...
Conference Paper
Introduction Insomnia has been related to a more severe substance use disorder presentation (1). There are few longitudinal studies in outpatients center for SUD treatment that evaluate how insomnia impacts on relapses. Objectives To analyze how insomnia impacts on the time of the first substance relapse in SUD outpatients after the onset of addic...
Article
A B S T R A C T Ayahuasca is a psychotropic infusion prepared by boiling the bark of Amazonian plants and has many psychopharmacological effects not fully understood. Some of those effects are used as treatment for different diseases. However, the side effects of ayahuasca, including ayahuasca-induced psychosis, are an important issue. Here we repo...
Article
Introduction The impact of psychiatric comorbidity and addiction features throughout the course of addiction has been widely studied. This is a naturalistic study conducted in an outpatient unit, where treatment follow-up studies are scarce compared to studies including inpatients or those under experimental conditions. Therefore, this follow-up st...
Article
Ayahuasca is a psychotropic infusion prepared by boiling the bark of Amazonian plants and has many psychopharmacological effects not fully understood. Some of those effects are used as treatment for different diseases. However, the side effects of ayahuasca, including ayahuasca-induced psychosis, are an important issue. Here we report the case of a...
Conference Paper
INTRODUCCIÓN La alexitimia es prevalente en pacientes con trastorno por uso de sustancias (TUS); sin embargo, su impacto en la adherencia y las recaídas no se ha establecido de forma clara. Además, el instrumento Gold Estándar para la medicación de alexitimia (Escala de Alexitimia de Toronto de 20 ítems – TAS-20) no ha sido validada para población...
Article
Full-text available
Background: Insomnia is highly prevalent in patients with substance use disorders (SUD), and it has been related to a worse course of addiction. Insomnia during detoxification in a hospital has not been adequately studied. This study aims to compare sociodemographic, clinical, and psychopathological characteristics of SUD patients undergoing a deto...
Article
Alexithymia is related to a higher severity of substance use disorders (SUD); however, few longitudinal studies have been performed on how alexithymia impacts treatment outcomes. This study aims to evaluate alexithymia as a factor that could influence retention and the time of the first relapse in a one-year follow-up in an outpatient treatment cen...
Article
Full-text available
Introduction: Improving the knowledge and attitudes of people facing an opioid overdose is one of the key prevention measures for reducing overdose occurrence and severity. In this respect, the Opioid Overdose Knowledge (OOKS) and Attitudes (OOAS) Scales have been developed and validated in English to assess and improve knowledge and attitudes of o...
Article
Drug dependence is a neuropsychiatric condition that involves genetic, epigenetic and environmental factors. Allele-specific methylation (ASM) is a common and stable epigenetic mechanism that involves genetic variants correlating with differential levels of methylation at CpG sites. We selected 182 single-nucleotide polymorphisms (SNPs) described t...
Article
Full-text available
Objective This study aims to assess the validity of the ADHD module of the Mini-International Neuropsychiatric Interview (MINI-Plus) in patients with substance use disorders (SUD), using the Conners’ Adult ADHD Diagnostic Interview for DSM-IV (CAADID) as the external criterion. Method A cross sectional international multi-center study in 10 countr...
Article
Quinolones are an antibiotic group widely used due to their antimicrobial action and security profile, however, it has been described neuropsychiatric adverse effects, being induced-psychotic episodes one of the most clinically relevant. Nevertheless, this secondary effect has been scarcely studied. A literature search using PRISMA guidelines was p...
Article
Ayahuasca is a psychotropic infusion prepared by boiling the bark of Amazonian plants and has many psychopharmacological effects not fully understood. Some of those effects are used as treatment for different diseases. However, the side effects of ayahuasca, including ayahuasca-induced psychosis, are an important issue. Here we report the case of a...
Conference Paper
Objetivos: Estudiar las diferencias en la gravedad de la adicción, variables clínicas y afectación en la calidad de vida en personas con Trastorno por Consumo de Cannabis en función de si presentan o no un Trastorno de Ansiedad comórbido. Métodos y materiales: Se realizó una evaluación psicológica completa siguiendo un protocolo estandarizado a los...
Conference Paper
Introducción Hay pocos estudios sobre uso de antipsicóticos en pacientes que presentan trastornos psicóticos y uso de sustancias comórbidos (psicosis duales) a pesar de ser una presentación frecuente en los centros de atención de estos pacientes (1). En relación a antipsicóticos modernos, la literatura científica es escasa a pesar que los nuevos an...
Conference Paper
Objetivos Identificar la prevalencia y evaluar las características clínicas del insomnio en una muestra de pacientes TDAH adultos con Patología Dual. Material y métodos La muestra la forman 252 pacientes adultos con TDAH remitidos para evaluación diagnóstica al Programa de TDAH del Hospital Universitari Vall d’Hebron. Se realizó una evaluación clín...
Conference Paper
INTRODUCTION Impulsivity and Alexithymia are related to substance use disorders (SUD) as risk factors (1,2), several cognitive skills are implied in both traits (1,2). However, few researches are published on their mutual relationship in SUD patients. OBJECTIVES To describe the correlations between alexithymia and impulsivity in SUD patients. METHO...
Conference Paper
OBJETIVOS Analizar diferencias sociodemográficas y clínicas entre consumo de cocaína vs. speedball (cocaína+heroína) en pacientes de una sala de consumo de drogas inyectadas. MÉTODOS Estudio transversal realizado en una sala de consumo de drogas inyectadas admnistrándose una entrevista semiestructarada a todos los pacientes. Se recogían datos socio...
Article
Objective: The objective of this study was to compare psychiatric comorbidity and consumption-related variables in ADHD patients seeking treatment for cocaine, cannabis, or both. Method: Assessment was conducted using European Addiction Severity Index (EuropASI), Conners’ Adult ADHD Diagnostic Interview (CAADID), Structured Clinical Interview for D...
Article
Full-text available
Background: Alcohol dependence is highly prevalent in the general population; some differences in alcohol use and dependence between women and men have been described, including outcomes and ranging from biological to social variables. This study aims to compare the severity of alcohol dependence with clinical and psychopathological characteristics...
Article
Psychiatric comorbidity can negatively impact the course of addictions. Psychiatric features of patients who continued treatment after the first stage of an addiction program have not been sufficiently analysed. Therefore, only these patients were included in order to compare psychiatric comorbidity and clinical factors between patients who were ab...
Article
Full-text available
Objectives: To compare alcohol and other drugs abuse, state impulsivity, craving and the relationship between craving and impulsivity in alcohol-dependent patients with or without dual disorder attending to an alcohol treatment center in Cadiz town. Method: An observational, descriptive and transversal study performed on 112 alcohol dependent pa...
Article
Full-text available
Introduction: Cocaine dependence is a disorder where relapses are frequently presented and many factors are involved. Furthermore, cocaine dependence is associated with poor health-related quality of life (HRQoL) outcomes. This study aims to explore perceived HRQoL as an indicator of drug relapse in cocaine-dependent patients (CDP). Subjects and...
Article
Cocaine-induced psychotic disorder (CIPD) is one of the most serious consequences of cocaine use. Despite the high frequency of CIPD, specific treatment for CIPD has been scarcely researched. Although supportive measures are the first approach, antipsychotic use is often necessary due to clinical severity and CIPD consequences. We report a 38-years...
Article
Full-text available
AIM The objective of the study is to evaluate the differences in health outcomes as well as treatment satisfaction and functionality, focusing particularly in cognitive deficits and perceived disability among stable psychotic patients with therapeutic adherence treated with oral antipsychotics (OA) vs Aripiprazole Long Acting Inyectable (A-LAI). M...
Article
Background Drug dependence is a complex neuropsychiatric disorder that results from the interaction of genetic and environmental factors. MicroRNAs (miRNAs) are very abundant in the central nervous system and seem to play key roles in the drug-induced plasticity of the brain that likely drives the emergence of addiction. Some studies suggest that S...
Article
Background Drug addiction is a neuropsychiatric disorder where long-lasting changes in gene expression within particular regions of the brain play an important role. Work over the past decade has demonstrated a crucial role for epigenetic mechanisms in driving stable changes in gene expression in several tissues, including the brain. Allele-specifi...
Article
Full-text available
Objectives People with a history of injecting drugs have high prevalence of hepatitis C virus (HCV) infection, and many have opioid use disorder (OUD). Modern HCV therapies with improved efficacy and tolerability are available, but access is often limited for this group, who may be underserved for health care and face social inequity. This work dev...
Article
Objective: Adverse health effects including cognitive impairment have been described in older adults with benzodiazepine misuse, although the literature about this issue is scarce. The present study aimed to assess cognitive decline in older adults with benzodiazepine use disorder and changes in cognitive state at the 6-month follow-up, as well as...
Article
Substance use disorder (SUD) is a worldwide concern that has its own particularities regarding age and sex. This study aims to assess the differences between old SUD women and men regarding socio-demographics, clinical factors and outcomes. A 6-months follow-up longitudinal study was conducted in an outpatient center, on a convenience sample of 115...
Presentation
Full-text available
HCV is a blood-borne virus easily transmitted via injections. People with a history of injecting drugs (PWID) are at high risk of HCV infection, many have opioid use disorder (OUD). Many are involved in OUD treatment, including opioid agonist therapy (OAT)/ opioid substitution therapy (OST). Modern therapy of direct-acting antivirals (DAAs) is effe...
Article
Methadone maintenance programs (MMP) for opioid dependence treatment have been widely used due to their effective therapeutic outcomes. Harm reduction programs (HRP) are complementary programs for severe patients with high risk behaviors and when abstinence is not possible. This study aims to compare patients in MMP that use HRP (MMP-HRP) and patie...
Article
There has been little research about deleterious effects, including cognitive impairment, related to hazardous long-term alcohol use in old adults. This study aims to assess cognitive decline in old patients with alcohol use disorder and changes in cognitive state at 6 months follow-up, achieving or not abstinence. A six-month follow-up study was c...
Article
Full-text available
Background: Cannabis is the most widely used illegal drug in the world. Both an early cannabis use onset and the amount used contribute to the risk of suffering mental disorders in adulthood. Objective: Review longitudinal studies conducted on adolescents associating early cannabis use with the subsequent occurrence of mental disorders. Method: A...
Article
Full-text available
Genetic factors involved in the susceptibility to drug addiction still remain largely unknown. MiRNAs seem to play key roles in the drug-induced plasticity of the brain that likely drives the emergence of addiction. In this work we explored the role of miRNAs in drug addiction. With this aim, we selected 62 SNPs located in the 3’UTR of target genes...
Article
Background and objective Dual diagnosis is the coexistence of an addictive disorder and another mental disorder. The objective is to estimate cravings and self-reported quality of life in a sample of patients with alcoholic dependence, with or without dual pathology, who attend an outpatient treatment centre. Patients and method A cross-sectional...
Article
Introduction: Pharmacological treatment of insomnia in patients with addictions has been hardly investigated and there are few researches about it in an inpatient detoxification. The aim of this study was to describe the outcomes of the pharmacological treatment of insomnia in SUD patients admitted to a detoxification unit in Spain, with a focus o...
Article
Full-text available
Objectives Episodes of agitation are frequent in intoxicated patients who have a substance use disorder, a psychiatric disorder or both (dual diagnosis). For managing the agitation, it is necessary to act promptly in a safe environment and addressing any underlying etiology. Inhaled loxapine improves symptoms of agitation in adults with psychiatric...
Article
Risks factors for suicide are multiple and highly prevalent in addicted patients (previous suicide attempts, substance abuse, impulsivity, history of sexual abuse and other factors). The aim of this study is to identify and to compare the clinical and socio-demographic profile of SUD outpatients with lifetime suicidal behavior (previous suicidal id...
Article
Background and objective: Dual diagnosis is the coexistence of an addictive disorder and another mental disorder. The objective is to estimate cravings and self-reported quality of life in a sample of patients with alcoholic dependence, with or without dual pathology, who attend an outpatient treatment centre. Patients and method: A cross-sectio...
Article
Vitamin D deficiency has been linked with schizophrenia. We aimed to determine whether patients with a first episode of psychosis (FEP) had lower vitamin D levels compared with controls considering their final diagnosis. We conducted a cross-sectional study determining 25-hydroxyvitamin D blood levels. 25-Hydroxyvitamin D levels were considered opt...
Article
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) are prevalent infections in opiate-dependent patients. Opiate replacement treatment (ORT) with methadone or buprenorphine is associated with several important outcomes among patients with opiate dependence. However, little is known about outcomes in patients with HIV and/or HCV infectio...
Article
Introduction Pain medication misuse is commonly found in patients under headache treatment and may produce co-morbid anxiety and depressive symptomatology. Management of this issue requires a comprehensive and integrative treatment including psychotherapy. Group interventions have been scarcely studied in addictive disorders, those interventions ai...
Article
Substance Use Disorders (SUD) and Attention Deficit Hyperactive Disorder (ADHD) are frequent conditions in out drug treatment centers. There are evidences about the high prevalence of ADHD in SUD patients (20%) compared with just ADHD in general population (1–7.3%). Both disorders and psychiatric comorbidity are important in the diagnosis proceedin...
Article
Introduction Substance use disorder is a growing phenomenon among old adults. It is usually significantly undervalued, misidentified, under diagnosed and poorly treated. It has been related to cognitive impairment but there are few studies focused on the elderly. Aim To evaluate the relationship between drug use and cognitive impairment in old adu...
Poster
First World Congress of the World Association on Dual Disorders (WADD) & Fifth International Congress of the Spanish Society on Dual Disorders (SEPD)
Poster
First World Congress of the World Association on Dual Disorders (WADD) & Fifth International Congress of the Spanish Society on Dual Disorders (SEPD)
Article
Several neurobiological factors are related to opiate-use disorder (OUD), and among them, neurotrophins have a relevant role. Brain-derived neurotrophic factor (BDNF) is a central neurotrophin involved in many neuronal processes, and it has been related to several psychiatric diseases and addictive disorders. BDNF can be measured in plasma and seru...
Article
Background: The aim of this study is to describe the features of cocaine-dependent patients who have had cocaine-induced tactile/somatic hallucinations (CITSH), and to analyze the association with addiction-related variables and psychiatric comorbidity, comparing patients with CITSH, patients with cocaine psychotic symptoms (CIP) and no CITSH, and...
Article
Objective: The aim of this study was to assess for the first time the criterion validity of the semi-structured Diagnostic Interview for ADHD in adults (DIVA 2.0), and its concurrent validity in comparison with the Conners' Adult ADHD Diagnostic Interview for DSM-IV (CAADID) and other ADHD severity scales, following the Diagnostic and Statistical...
Poster
First World Congress of the World Association on Dual Disorders (WADD) & Fifth International Congress of the Spanish Society on Dual Disorders (SEPD)
Article
Introduction Legal and illegal drugs can cause psychotic symptoms, in cocaine-dependent patients the prevalence of these symptoms may reach 86% (Vorspan, 2012). It is estimated that 13–32% of cocaine-dependent patients have kinaesthetic hallucinations (Siegel, 1978; Mahoney, 2008; Roncero, 2012). Objectives To compare the prevalence of substance-i...
Article
Introduction Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric chronic disorder of childhood that persists into adolescence and adulthood in the most part of cases. There are various ways of treating ADHD. Objectives Assess the effectiveness and tolerability of atomoxetine long-term and routine clinical practice in adult ADHD treatm...
Article
Introduction Attention Deficit Hyperactivity Disorder (ADHD) prevalence in the general adult population is estimated to be between 2–4%. Despite the high prevalence, until recently there was only one validated semi-structured interview available for the accurate diagnostic assessment of ADHD within the adult population: the Conners Adult ADHD Diagn...
Article
Full-text available
Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipita...
Article
Full-text available
INTRODUCTION: Although impairment in the quality of life is common among cocaine dependent patients, there are but a few researches about the interaction between addiction and quality of life. OBJECTIVE: To study different parameters of quality of life in a sample of cocaine dependent patients and to compare patients with or without dual diagnosis...