Rassoul Dinarvand

Tehran University of Medical Sciences | TUMS · School of Pharmacy

L-asparaginase (ASNase) enzyme has limited therapeutic use due to its poor pharmacokinetics and immunogenicity. To overcome these obstacles, we immobilized ASNase in biocompatible poly hydroxypropyl methacrylamide (P(HPMA))-based nanogels simply formed through the host-guest inclusion complex of ASNase-conjugated random copolymer of HPMA and polyet...

Purpose: This research intended to fabricate the thiolated chitosan-dextran nanoparticles (NPs) containing topotecan (TPH-CMD-TCS-NPs) to assess the ability of NPs in improving the efficacy of intravitreal chemotherapy of retinoblastoma in a rabbit xenograft model. Methods: The coacervation process was used to produce the NPs. The cellular uptak...

Poly(lactide-co-glycolide) (PLGA)-based formulation is one of the most often used parenteral extended-release forms to deliver various therapeutics. VIVITROL® as a commercialized PLGA microsphere formulation encapsulates naltrexone, a narcotic antagonist for opioid addiction and alcohol dependency. However, no U.S. Food and Drug Administration-appr...

The newly-emerged pathological conditions and increased rates of drug resistance necessitate application of the state-of-the-art technologies for accelerated discovery of the therapeutic candidates and obtaining comprehensive knowledge about their targets, action mechanisms, and interactions within the body including those between the receptors and...

Despite advances in bone tissue engineering, fabricating a scaffold which can be used as an implant for large bone defects remains challenge. One of the great importance in fabricating a biomimetic bone implant is considering the possibility of the integration of the structure and function of implants with hierarchical structure of bone. Herein, we...

This corrects the article "Brain targeted delivery of rapamycin using transferrin decorated nanostructured lipid carriers published in 2022: Volume 12, Issue 1, Pages 21-32 (doi: 10.34172/bi.2021.23389). The original version of this article contained an error in Fig. 3. The confocal images for cellular uptake of coumarin-6 loaded bare NLCs (B-NLC),...

IntroductionSuper-paramagnetic iron oxide nanoparticles (SPIONs) are known as promising theranostic nano-drug carriers with magnetic resonance imaging (MRI) properties. Applying the herbaceous components with cytotoxic effects as cargos can suggest a new approach in the field of cancer-therapy. In this study mesoporous silica coated SPIONs (mSiO2@S...

Nanocarriers of different origins that respond to stimuli have been synthesized and used in various biomedical applications, such as intracellular drug delivery. To develop highly efficient nanocarriers, novel clickable and cleavable soybean oil-based polyurethane nanomicelles (CPUM), and polyurethane-hyaluronic acid nanomicelles (CPUM-HA) were pre...

Primary liver cancer is among the most common fatal solid cancers, ranking as the fourth most frequent cause of cancer-related mortality worldwide. Hepatocellular carcinoma (HCC) is the most prevalent histological type of primary liver cancers, which accounts for up to 90% of cases and is resistant to a large percentage of currently available anti-...

Yousefpour P, Atyabi F, Vasheghani-Farahani E, Movahedi M, Dinarvand R. Int J Nanomedicine. 2011;6:1977—1990. The authors have advised Figure 9D on page 1986 is incorrect. Due to an error at the time of figure assembly Figure 9B and D were duplicated. The correct Figure 9 is shown below. Figure 9 Fluorescence microscopy of cellular uptake of (A)...

The aim of the present study was to investigate the therapeutic potential of budesonide- (BDS-) loaded hyaluronic acid nanoparticles (HANPs) for treatment of inflammatory bowel disease (IBD) using an acute model of colitis in rats. The therapeutic efficacy of BDS-loaded HANPs in comparison with an aqueous suspension of the drug with the same dose (...

Background: Stimuli-responsive drug delivery systems have been proven to be a promising strategy to enhance tumor localization, overcome multidrug resistance (MDR), and reduce the side effects of chemotherapy agents. Objectives: In this study, a temperature and redox dual stimuli-responsive system using mesoporous silica nanoparticles (MSNs) for...

Background Recently biodegradable nanoparticles are the center of attention for the development of drug delivery systems. Molecularly imprinted polymer (MIP) is an interesting candidate for designing drug nano-carriers. MIP-based nanoparticles could be used for cancer treatment and exhibited the potential to fill gaps regarding to ligand-based nano...

Introduction: Breast cancer is a leading cause of death among females. Multifunctional nano-carriers are recognized as promising platforms for targeted delivery of therapeutic to the tumor sites, while having contrast agents (e.g., magnetic nanoparticles) for monitoring the tumor microenvironment. Recently, many different systems have been develope...

Introduction: Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a modern technique/technology, which makes it possible to construct 3D objects from computer-aided design (CAD) digital models. This technology can be used in the progress of drug delivery systems, where porosity has played important role in attaining an a...

Here, we assessed the efficacy and safety of Nano lipid carrier (NLC) drug delivery system containing tretinoin (NLC-TRE) in comparison with the conventional 0.05% tretinoin cream (TRE cream) in mild to moderate acne vulgaris. A stable and appropriate NLC-TRE formulation was prepared using a high-pressure homogenizer and particle characterization a...

In this study, electrospun Poly(vinyl alcohol)/Chitosan-g-Poly (N-vinyl imidazole) (PVA/CS-g-PNVIM) wound dressing containing Titanium dioxide/Curcumin (CUR) was prepared as a novel wound healing system with multifunctional properties, including wound closure, drug release, and antibacterial activity. The wound dressing nanofibers system's mechanic...

Talaie F, Azizi E, Dinarvand R, Atyabi F. Int J Nanomedicine. 2011;6:1963‒1975. The Editor and Publisher of International Journal of Nanomedicine wish to retract the published article. Concerns were raised regarding the alleged duplication of images in Figures 3 and 7. Specifically, Figure 3A, chitosan nanoparticles, appears to have been duplicate...

IntroductionTeriflunomide (TFN), an immunomodulatory drug, has demonstrated cytotoxic effects in recent studies. This potential can be combined with nano-drug delivery to achieve an improved anticancer formulation.MethodsIn this study, super paramagnetic iron oxide nanoparticles (SPIONs) were coated with polydopamine (PD-SPIONs) and used to deliver...

Infectious diseases (ID) are serious threats against the global health and socio-economic conditions. Vaccination usually plays a key role in disease prevention, however, insufficient efficiency or immunogenicity may be quite challenging. Using the advanced vectors for delivery of vaccines with suitable efficiency, safety, and immune-modulatory act...

Biomaterials that have capacities to simultaneously induce bone regeneration and kill bacteria are in high demand because bone defects face risks of severe infection in clinical therapy. The aim of this study was to investigate the use of gelatin methacryloyl (GelMA), alginate, gelatin hydrogels containing levofloxacin loaded poly (lactic-co-glycol...

For effective treatment of infected bone, it is essential to use local drug delivery systems with the ability to deliver both antibiotics and osteoinductive factors. Herein, a pH-sensitive silk fibroin (SF)/sodium alginate (SA) hydrogel scaffolds containing teicoplanin (TEC) and phenamil (PM) loaded SF nanoparticles (PMSFNPS) are introduced for tre...

In this study, hyaluronic acid-functionalized disulfide hollow mesoporous silica nanoparticles (HMSN-NH2-HA) were synthesized as an anticancer drug delivery system. In this regard, hyaluronic acid, a natural ligand for cluster of differentiation-44 (CD44) receptors overexpressed on the surface of tumor cells, was covalently grafted onto the HMSNs....

Although stem cell therapy is a major area of interest in tissue engineering, providing proper oxygen tension, good viability, and cell differentiation remain challenges in tissue-engineered scaffolds. In this study, an osteogenic scaffold was fabricated using the 3D bio-printing technique. The bio-ink contained alginate hydrogel, encapsulated huma...

Breast cancer is the most prevalent type of cancer in women; hence, many researches have been focused on developing effective treatment protocols. In this study, a novel nanocarrier was fabricated for gene and photothermal combination cancer therapy by conjugating histone methyltransferase complex subunit SET1 (hSET1) on reduced polydopamine coated...

This is an Erratum to "Biodistribution of Cy5-labeled Thiolated and Methylated Chitosan-Carboxymethyl Dextran Nanoparticles in an Animal Model of Retinoblastoma" [J Ophthalmic Vis Res 2021;17(1):58–68] and does not have an abstract. Please download the PDF or view the article HTML.

Stimuli-responsive drug delivery systems have been proven to be a promising strategy in order to enhance tumour localization, overcome multidrug resistance (MDR), and reduce the side effects of chemotherapy agents. In this study, a temperature and redox dual stimuli-responsive system using mesoporous silica nanoparticles (MSNs) for targeted deliver...

Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by progressive cognitive impairment and memory loss. The mammalian target of rapamycin (mTOR) signaling pathway could regulate learning and memory. The effect of rapamycin (Rapa) on mTOR activity could slow or prevent the progression of AD by affecting various es...

Ocular disorders comprising various diseases of the anterior and posterior segments are considered as the main reasons for blindness. Natural products have been identified as potential treatments for ocular diseases due to their anti-oxidative, antiangiogenic, and anti-inflammatory effects. Unfortunately, most of these beneficial compounds are char...

Combination chemotherapy has become a treatment modality for breast cancer. However, serious side effects and high cytotoxicity associated with this combination therapy make it a high-risk method for breast cancer treatment. This study evaluated the anticancer effect of decorated niosomal nanocarriers loaded with cisplatin (CIS) and epirubicin (EPI...

Fast, efficient, and accurate detection of SARS-CoV-2 spike antigen is pivotal to control the spread and reduce the mortality of COVID-19. Nevertheless, the sensitivity of available nanobiosensors to detect recombinant SARS-CoV-2 spike antigen seems insufficient. As a proof-of-concept, MOF-5/CoNi2S4 is developed as a low-cost, safe, and bioactive h...

Purpose: The use of more potent medicine for local chemotherapy of retinoblastoma in order to minimize local and systemic adverse effects is essential. The main goal of this investigation was to assess the biodistribution of thiolated and methylated chitosan-carboxymethyl dextran nanoparticles (CMD-TCs-NPs and CMD-TMC-NPs) following intravitreal (...

Synthesis of a self-assembled supramolecular network was achieved through host-guest chemistry between the inter-molecularly crosslinked α-cyclodextrin with cystamine linker (bisCD) and random copolymer of poly HPMA and PEG acrylate (P(HPMA-MPEGA) synthesized by the RAFT polymerization. Compared to α-CD, bisCD caused strong PEG chain aggregation, r...

Metal–organic frameworks (MOFs) have been widely used as porous nanomaterials for different applications ranging from industrial to biomedicals. An unpredictable one-pot method is introduced to synthesize NH2-MIL-53 assisted by high-gravity in a greener media for the first time. Then, porphyrins were deployed to adorn the surface of MOF to increase...

Introduction: Recent studies showed that rapamycin, as a mammalian target of rapamycin (mTOR) inhibitor, could have beneficial therapeutic effects for the central nervous system (CNS) related diseases. However, the immunosuppressive effect of rapamycin as an adverse effect, the low water solubility, and the rapid in vivo degradation along with the...

The objective of this study was to investigate the loading capacity and release profiles of curcumin (CUR), as a hydrophobic drug molecule, and doxorubicin hydrochloride (DOX), as a hydrophilic drug molecule, into hollow mesoporous silica nanoparticles (HMSNs) through a co-delivery system. The drug loading and release studies were conducted and ana...

Gene therapy is regarded as a valuable strategy for efficient cancer treatment. However, the design of effective delivery systems that can deliver gene materials such as siRNA specifically to the tumour tissues plays a pivotal role in cancer therapy. For this reason, a targeted cationic liposome for melanoma treatment was developed. This system con...

SN38 is the active metabolite of irinotecan with 1000-fold greater cytotoxicity compared to the parent drug. Despite the potential, its application as a drug is still seriously limited due to its stability concerns and low solubility in acceptable pharmaceutical solvents. To address these drawbacks here nanostructured lipid carrier (NLC) containing...

Hybrid bioactive inorganic–organic carbon-based nanocomposites of reduced graphene oxide (rGO) nanosheets enlarged with multi-walled carbon nanotubes (MWCNTs) were decorated to provide a suitable space for in situ growth of CoNi2S4 and green-synthesized ZnO nanoparticles. The ensuing nanocarrier supplied π–π interactions between the DOX drug and a...

Indirubin can be applied as an anti-cancer drug for inhibition of brain tumors. However, its performance is reduced due to hydrophobicity. In this study, we synthesized cationic human serum albumin (CHSA) nanoparticle by a new hybrid approach for improvement the surface chemistry of albumin and investigate the amount of indirubin loaded CHSA nanopa...

Background Punica granatum L. (pomegranate) with astringent activities and Matricaria chamomilla L. (chamomile) with anti-inflammatory and antioxidant properties are natural remedies used for various skin disorders, including wound healing.Objectives This study was conducted to evaluate the individual and combined wound healing activity of the meth...

Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNi 2 S 4 , and the porphyrins were incorporated into the layers as well to increase the sensitivity of the prepared nanostructure. The prepared nanocomposite can es...

The novel coronavirus pandemic has rapidly spread around the world since December 2019. Various techniques have been applied in identification of SARS-CoV-2 or COVID-19 infection including computed tomography imaging, whole genome sequencing, and molecular methods such as reverse transcription polymerase chain reaction (RT-PCR). This review article...

Almost 13% of all death in the world is related to cancer. One of the major reasons for failing cancer treatment is the late diagnosis of the tumors. Thus, diagnosis at the early stages could be vital for the treatment. Serum autoantibodies, as tumor markers, are becoming interesting targets due to their medical and biological relevance. Among them...

Herein, the NH 2-UiO-66 metal organic framework (MOF) has been green synthesized with the assistance of high gravity to provide a suitable and safe platform for drug loading. The NH 2-UiO-66 MOF was characterized using a field-emission scanning electron microscope, transmission electron microscope (TEM), X-ray diffrac-tion, and zeta potential analy...

Here, polyethylenimine (PEI) modified silk fibroin nanoparticles (SFNPs) were prepared for codelivery of doxorubicin (DOX) and survivin siRNA. The prepared NPs were characterized in terms of stability and structural, functional, and physicochemical properties. Moreover, the ability of the conjugate to escape from the endosome and cellular uptake we...

Targeted drug delivery is a tool to make treatment more specific, selective, and effective and to prevent unwanted complications. Prostate specific membrane antigen (PSMA) is a useful biomarker in order to monitor and control prostate cancer. Glutamate-Urea-R (Glu-Urea-R) is a PSMA enzyme inhibitor capable of binding to this surface marker of prost...

Zn-rich (GaN)1-x(ZnO)x nanostructure was synthesized in assistance of high-gravity technique in order to reduce the time of reaction and the temperature. The synthesized inorganic nanomaterial has been applied in both drug/gene delivery system, and as the first fully-inorganic nanomaterial, was investigated in a comprehensive cellular investigation...

With significant advancements in research technologies, and an increasing global population, microfluidic and nanofluidic systems (such as point-of-care, lab-on-a-chip, organ-on-a-chip, etc) have started to revolutionize medicine. Devices that combine micron and nanotechnologies have increased sensitivity, precision and versatility for numerous med...

Retinoblastoma (Rb) is the most common intraocular malignancy in children that accounts for approximately 4% of all pediatric malignancies. Since chemotherapy is a widely practiced treatment for Rb, there is a growing interest in developing new and effective drugs to overcome systemic and local side effects of chemotherapy to improve the quality of...

Today, researches have been extended to prepare multifunctional scaffolds capable of regulating cellular behaviors, including human Adipose-derived mesenchymal stem cells (hASCs) differentiation to bone tissues. In the present study, an aniline trimer (AT)-based self-healable conductive polyurethane scaffold (PU-AT scaffold) with body temperature‐r...

The therapeutic effects of carotenoids as dietary supplements to control or even treat some specific diseases including diabetic retinopathy, cardiovascular diseases, bacterial infections, as well as breast, prostate, and skin cancer are discussed in this review and also thoughts on future research for their widespread use are emphasized. From the...

In this study, the actinidin enzyme that was extracted from kiwi fruit was immobilized on a scaffold based on electrospun chitosan nanofibers, and its ability to treat burn wounds was investigated. Afterward, cytotoxicity of the nanofibrous patch and nanofibers with actinidin enzyme was evaluated by MTT test separately on skin fibroblast cells (AGO...

In this work, three different samples of molybdenum disulfide (MoS2) nanoflakes, carbon nanoparticles and molybdenum disulfide/carbon (MoS2/C) nanocomposite were synthesized by one step hydrothermal method. The structural and optical properties of the samples were characterized by X-ray diffraction, transmission electron microscopy, energy-dispersi...

Currently, Alzheimer's disease (AD) accounts for more than half of all dementia cases. Although genetics, age, and environmental factors affect the disease, the cause of AD is not yet fully known. Various drugs have been proposed for the prevention and treatment of AD, but the delivery of these therapeutic agents to the brain is difficult. The bloo...

The cell-extracellular matrix (ECM) interactions are known to have a strong impact on cell behaviors in neural tissues. Due to complex physiology system and limited regenerative capacity of nervous system, neural tissue engineering has attracted attention as a promising strategy. In this study, we designed a hydrogel loaded by poly (lactic-co-glyco...

Aims Exosomes hold great promise as bio-inspired delivery vehicles. Mesenchymal stem cells (MSCs) are recognized for their potential to yield huge quantities of exosomes. We aimed to investigate the potential use of modified exosomes derived from genetically modified dental pulp MSCs (DPSCs) as a carrier to deliver tumor suppressor miR-34a to repre...

Anastrozole (ANZ) is considered constitute of the fourth-generation of Non-steroidal aromatase blockage which uses in treatment of hormone receptor positive breast cancer in postmenopausal women used for 5 years. Nanostructured lipid carriers have recently emerged as a multifunctional platform for drug delivery in cancer therapy. In this study, we...

Abstract Evaluation of the effect of different parameters for designing a non-viral vector in gene delivery systems has great importance. In this manner, 2D crystals, precisely layered double hydroxides, have attracted the attention of scientists due to their significant adjustability and low-toxicity and low-cost preparation procedure. In this wor...

Decorating photocatalysts with noble metal nanoparticles (e.g., Pt) often increases the catalysts' photocatalytic activity and biomedical properties. Here, a simple and inexpensive method has been developed to prepare a Pt-Ag 3 PO 4 /CdS/chitosan composite, which was characterized and used for the visible light-induced photocatalytic and antibacter...