Rassoul DinarvandTehran University of Medical Sciences | TUMS · School of Pharmacy
Rassoul Dinarvand
Professor of Pharmaceutics
About
530
Publications
205,789
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Introduction
Rassoul Dinarvand currently works at the School of Pharmacy, Tehran University of Medical Sciences. Rassoul does research in Nanotechnology, Controlled Drug Delivery. His research group is currently focusing on Nanostructures as targeted drug delivery systems for cancer treatment.
Additional affiliations
Education
January 1991 - December 1993
May 1989 - September 1990
April 1983 - September 1988
Publications
Publications (530)
Paclitaxel (PTX), an antimitotic drug from the taxanes group, prevents the proliferation of breast cancer cells through mitosis arrest and activation by a cascade of signaling pathways that lead to apoptosis. Mitochondria is one of the important signaling routes for inducing apoptosis. For mitochondria targeting, triphenylphosphonium (TPP) with a d...
Neurodegenerative disorders are complex, progressive, and life-threatening. They cause mortality and disability for millions of people worldwide. Appropriate treatment for neurodegenerative diseases (NDs) is still clinically lacking due to the presence of the blood-brain barrier (BBB). Developing an effective transport system that can cross the BBB...
Purpose
Recent studies have reported the promising effect of intravitreal propranolol on retinal neovascularization. However, rapid clearance and short half-life of the drug in the vitreous are the main drawbacks of this therapeutic approach. This study investigates the extension of the residence time of propranolol in the vitreous by polymeric nan...
Zinc protoporphyrin (ZnPP), known as a heme-oxygenase inhibitor, acts as an anticancer agent mainly by increasing free radical levels in the target cells and inducing cell death. However, its efficacy is restricted due to its poor solubility and numerous adverse reactions. To address this issues, nanopolymeric micelles have shown promising potentia...
Prostate cancer is the most common cancer in men. Approximately 80 % of people with advanced prostate cancer reportedly develop bone metastasis. Common treatments of bone metastasis of prostate cancer (BM-PC) cause severe adverse effects. Besides, there is a high probability of metastatic bone tumor recurrence after tumor resection surgery. Thus, l...
Our study aimed to introduce a novel double-cross-linked and thermoresponsive hydrogel with remarkable potential for accelerating third-degree burn wound healing. Burn injuries are recognized as challenging, critical wounds. Especially in third-degree burns, treatment is demanding due to extended wounds, irregular shapes, significant exudation, and...
One of the most common types of bone cancer is osteosarcoma. Currently a combination of therapies including surgery, chemotherapy, and radiation therapy is used. Bone defects, re-formation of the tumor, or remaining tumor cells after the surgery are the main challenges of osteosarcoma treatments. Scaffolds can be used to overcome the bone defects p...
The efficacy of injectable micellar carriers is hindered due to the disassembly of micelles into free surfactants in the body, resulting in their dilution below the critical micelle concentration (CMC). Copolymer micelles were developed to address this issue, containing a superhydrophilic zwitterionic block and a superhydrophobic block with a disul...
Three-dimensional (3D) printing has transformed tissue engineering, enabling the creation of intricate structures with precise measurements and controlled porosity. Bioprinting, which deposits live cells into a 3D matrix to produce functional tissues, has gained significant attention. However, a major challenge in bioprinting is developing bioink t...
Drug delivery strategies aim to maximize a drug's therapeutic efficiency by increasing the drug's concentration at the target site while minimizing delivery to off-target tissues. There is a great deal of interest in using magnetic nanoparticles in combination with applied magnetic fields to selectively control drug accumulation and release in targ...
Background:
To have a better and longer effect, botulinum neurotoxin (BoNT) is injected several times in a treatment course, which could increase side effects and cost. Some of the most cutting-edge strategies being investigated for proteins to their physiologic targets involve the reformulation of BoNT based on peptide-based delivery systems. For...
L-asparaginase (ASNase) enzyme has limited therapeutic use due to its poor pharmacokinetics and immunogenicity. To overcome these obstacles, we immobilized ASNase in biocompatible poly hydroxypropyl methacrylamide (P(HPMA))-based nanogels simply formed through the host-guest inclusion complex of ASNase-conjugated random copolymer of HPMA and polyet...
Purpose:
This research intended to fabricate the thiolated chitosan-dextran nanoparticles (NPs) containing topotecan (TPH-CMD-TCS-NPs) to assess the ability of NPs in improving the efficacy of intravitreal chemotherapy of retinoblastoma in a rabbit xenograft model.
Methods:
The coacervation process was used to produce the NPs. The cellular uptak...
Poly(lactide-co-glycolide) (PLGA)-based formulation is one of the most often used parenteral extended-release forms to deliver various therapeutics. VIVITROL® as a commercialized PLGA microsphere formulation encapsulates naltrexone, a narcotic antagonist for opioid addiction and alcohol dependency. However, no U.S. Food and Drug Administration-appr...
The newly-emerged pathological conditions and increased rates of drug resistance necessitate application of the state-of-the-art technologies for accelerated discovery of the therapeutic candidates and obtaining comprehensive knowledge about their targets, action mechanisms, and interactions within the body including those between the receptors and...
Despite advances in bone tissue engineering, fabricating a scaffold which can be used as an implant for large bone defects remains challenge. One of the great importance in fabricating a biomimetic bone implant is considering the possibility of the integration of the structure and function of implants with hierarchical structure of bone. Herein, we...
This paper presents the fabrication of a biocompatible supramolecular nanogel containing immobilized L-asparaginase (ASNase), an anti-leukemic therapeutic agent, to improve the enzyme's physicochemical stability. The ASNase-conjugated random copolymer of N-(2-Hydroxypropyl)methacrylamide (HPMA) and polyethylene glycol (PEG) acrylate was simply comb...
Note
This corrects the article "Brain targeted delivery of rapamycin using transferrin decorated nanostructured lipid carriers published in 2022: Volume 12, Issue 1, Pages 21-32 (doi: 10.34172/bi.2021.23389). The original version of this article contained an error in Fig. 3. The confocal images for cellular uptake of coumarin-6 loaded bare NLCs (B-...
IntroductionSuper-paramagnetic iron oxide nanoparticles (SPIONs) are known as promising theranostic nano-drug carriers with magnetic resonance imaging (MRI) properties. Applying the herbaceous components with cytotoxic effects as cargos can suggest a new approach in the field of cancer-therapy. In this study mesoporous silica coated SPIONs (mSiO2@S...
Nanocarriers of different origins that respond to stimuli have been synthesized and used in various biomedical applications, such as intracellular drug delivery. To develop highly efficient nanocarriers, novel clickable and cleavable soybean oil-based polyurethane nanomicelles (CPUM), and polyurethane-hyaluronic acid nanomicelles (CPUM-HA) were pre...
Primary liver cancer is among the most common fatal solid cancers, ranking as the fourth most frequent cause of cancer-related mortality worldwide. Hepatocellular carcinoma (HCC) is the most prevalent histological type of primary liver cancers, which accounts for up to 90% of cases and is resistant to a large percentage of currently available anti-...
Yousefpour P, Atyabi F, Vasheghani-Farahani E, Movahedi M, Dinarvand R. Int J Nanomedicine. 2011;6:1977—1990.
The authors have advised Figure 9D on page 1986 is incorrect. Due to an error at the time of figure assembly Figure 9B and D were duplicated. The correct Figure 9 is shown below.
Figure 9 Fluorescence microscopy of cellular uptake of (A)...
The aim of the present study was to investigate the therapeutic potential of budesonide- (BDS-) loaded hyaluronic acid nanoparticles (HANPs) for treatment of inflammatory bowel disease (IBD) using an acute model of colitis in rats. The therapeutic efficacy of BDS-loaded HANPs in comparison with an aqueous suspension of the drug with the same dose (...
Background:
Stimuli-responsive drug delivery systems have been proven to be a promising strategy to enhance tumor localization, overcome multidrug resistance (MDR), and reduce the side effects of chemotherapy agents.
Objectives:
In this study, a temperature and redox dual stimuli-responsive system using mesoporous silica nanoparticles (MSNs) for...
Background
Recently biodegradable nanoparticles are the center of attention for the development of drug delivery systems. Molecularly imprinted polymer (MIP) is an interesting candidate for designing drug nano-carriers. MIP-based nanoparticles could be used for cancer treatment and exhibited the potential to fill gaps regarding to ligand-based nano...
Introduction: Breast cancer is a leading cause of death among females. Multifunctional nano-carriers are recognized as promising platforms for targeted delivery of therapeutic to the tumor sites, while having contrast agents (e.g., magnetic nanoparticles) for monitoring the tumor microenvironment. Recently, many different systems have been develope...
Introduction:
Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a modern technique/technology, which makes it possible to construct 3D objects from computer-aided design (CAD) digital models. This technology can be used in the progress of drug delivery systems, where porosity has played important role in attaining an a...
Here, we assessed the efficacy and safety of Nano lipid carrier (NLC) drug delivery system containing tretinoin (NLC-TRE) in comparison with the conventional 0.05% tretinoin cream (TRE cream) in mild to moderate acne vulgaris. A stable and appropriate NLC-TRE formulation was prepared using a high-pressure homogenizer and particle characterization a...
In this study, electrospun Poly(vinyl alcohol)/Chitosan-g-Poly (N-vinyl imidazole) (PVA/CS-g-PNVIM) wound dressing containing Titanium dioxide/Curcumin (CUR) was prepared as a novel wound healing system with multifunctional properties, including wound closure, drug release, and antibacterial activity. The wound dressing nanofibers system's mechanic...
Talaie F, Azizi E, Dinarvand R, Atyabi F. Int J Nanomedicine. 2011;6:1963‒1975.
The Editor and Publisher of International Journal of Nanomedicine wish to retract the published article. Concerns were raised regarding the alleged duplication of images in Figures 3 and 7. Specifically,
Figure 3A, chitosan nanoparticles, appears to have been duplicate...
IntroductionTeriflunomide (TFN), an immunomodulatory drug, has demonstrated cytotoxic effects in recent studies. This potential can be combined with nano-drug delivery to achieve an improved anticancer formulation.MethodsIn this study, super paramagnetic iron oxide nanoparticles (SPIONs) were coated with polydopamine (PD-SPIONs) and used to deliver...
Infectious diseases (ID) are serious threats against the global health and socio-economic conditions. Vaccination usually plays a key role in disease prevention, however, insufficient efficiency or immunogenicity may be quite challenging. Using the advanced vectors for delivery of vaccines with suitable efficiency, safety, and immune-modulatory act...
Biomaterials that have capacities to simultaneously induce bone regeneration and kill bacteria are in high demand because bone defects face risks of severe infection in clinical therapy. The aim of this study was to investigate the use of gelatin methacryloyl (GelMA), alginate, gelatin hydrogels containing levofloxacin loaded poly (lactic-co-glycol...
For effective treatment of infected bone, it is essential to use local drug delivery systems with the ability to deliver both antibiotics and osteoinductive factors. Herein, a pH-sensitive silk fibroin (SF)/sodium alginate (SA) hydrogel scaffolds containing teicoplanin (TEC) and phenamil (PM) loaded SF nanoparticles (PMSFNPS) are introduced for tre...
In this study, hyaluronic acid-functionalized disulfide hollow mesoporous silica nanoparticles (HMSN-NH2-HA) were synthesized as an anticancer drug delivery system. In this regard, hyaluronic acid, a natural ligand for cluster of differentiation-44 (CD44) receptors overexpressed on the surface of tumor cells, was covalently grafted onto the HMSNs....
Although stem cell therapy is a major area of interest in tissue engineering, providing proper oxygen tension, good viability, and cell differentiation remain challenges in tissue-engineered scaffolds. In this study, an osteogenic scaffold was fabricated using the 3D bio-printing technique. The bio-ink contained alginate hydrogel, encapsulated huma...
Breast cancer is the most prevalent type of cancer in women; hence, many researches have been focused on developing effective treatment protocols. In this study, a novel nanocarrier was fabricated for gene and photothermal combination cancer therapy by conjugating histone methyltransferase complex subunit SET1 (hSET1) on reduced polydopamine coated...
This is an Erratum to "Biodistribution of Cy5-labeled Thiolated and Methylated Chitosan-Carboxymethyl Dextran Nanoparticles in an Animal Model of Retinoblastoma" [J Ophthalmic Vis Res 2021;17(1):58–68] and does not have an abstract. Please download the PDF or view the article HTML.
Ocular disorders comprising various diseases of the anterior and posterior segments are considered as the main reasons for blindness. Natural products have been identified as potential treatments for ocular diseases due to their anti-oxidative, antiangiogenic, and anti-inflammatory effects. Unfortunately, most of these beneficial compounds are char...
Stimuli-responsive drug delivery systems have been proven to be a promising strategy in order to enhance tumour localization, overcome multidrug resistance (MDR), and reduce the side effects of chemotherapy agents. In this study, a temperature and redox dual stimuli-responsive system using mesoporous silica nanoparticles (MSNs) for targeted deliver...
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by progressive cognitive impairment and memory loss. The mammalian target of rapamycin (mTOR) signaling pathway could regulate learning and memory. The effect of rapamycin (Rapa) on mTOR activity could slow or prevent the progression of AD by affecting various es...
Combination chemotherapy has become a treatment modality for breast cancer. However, serious side effects and high cytotoxicity associated with this combination therapy make it a high-risk method for breast cancer treatment. This study evaluated the anticancer effect of decorated niosomal nanocarriers loaded with cisplatin (CIS) and epirubicin (EPI...
Fast, efficient, and accurate detection of SARS-CoV-2 spike antigen is pivotal to control the spread and reduce the mortality of COVID-19. Nevertheless, the sensitivity of available nanobiosensors to detect recombinant SARS-CoV-2 spike antigen seems insufficient. As a proof-of-concept, MOF-5/CoNi2S4 is developed as a low-cost, safe, and bioactive h...
Purpose:
The use of more potent medicine for local chemotherapy of retinoblastoma in order to minimize local and systemic adverse effects is essential. The main goal of this investigation was to assess the biodistribution of thiolated and methylated chitosan-carboxymethyl dextran nanoparticles (CMD-TCs-NPs and CMD-TMC-NPs) following intravitreal (...
Synthesis of a self-assembled supramolecular network was achieved through host-guest chemistry between the inter-molecularly crosslinked α-cyclodextrin with cystamine linker (bisCD) and random copolymer of poly HPMA and PEG acrylate (P(HPMA-MPEGA) synthesized by the RAFT polymerization. Compared to α-CD, bisCD caused strong PEG chain aggregation, r...
Metal–organic frameworks (MOFs) have been widely used as porous nanomaterials for different applications ranging from industrial to biomedicals. An unpredictable one-pot method is introduced to synthesize NH2-MIL-53 assisted by high-gravity in a greener media for the first time. Then, porphyrins were deployed to adorn the surface of MOF to increase...
Introduction: Recent studies showed that rapamycin, as a mammalian target of rapamycin (mTOR) inhibitor, could have beneficial therapeutic effects for the central nervous system (CNS) related diseases. However, the immunosuppressive effect of rapamycin as an adverse effect, the low water solubility, and the rapid in vivo degradation along with the...
The objective of this study was to investigate the loading capacity and release profiles of curcumin (CUR), as a hydrophobic drug molecule, and doxorubicin hydrochloride (DOX), as a hydrophilic drug molecule, into hollow mesoporous silica nanoparticles (HMSNs) through a co-delivery system. The drug loading and release studies were conducted and ana...
Gene therapy is regarded as a valuable strategy for efficient cancer treatment. However, the design of effective delivery systems that can deliver gene materials such as siRNA specifically to the tumour tissues plays a pivotal role in cancer therapy. For this reason, a targeted cationic liposome for melanoma treatment was developed. This system con...
SN38 is the active metabolite of irinotecan with 1000-fold greater cytotoxicity compared to the parent drug. Despite the potential, its application as a drug is still seriously limited due to its stability concerns and low solubility in acceptable pharmaceutical solvents. To address these drawbacks here nanostructured lipid carrier (NLC) containing...
Hybrid bioactive inorganic–organic carbon-based nanocomposites of reduced graphene oxide (rGO) nanosheets enlarged with multi-walled carbon nanotubes (MWCNTs) were decorated to provide a suitable space for in situ growth of CoNi2S4 and green-synthesized ZnO nanoparticles. The ensuing nanocarrier supplied π–π interactions between the DOX drug and a...
Indirubin can be applied as an anti-cancer drug for inhibition of brain tumors. However, its performance is reduced due to hydrophobicity. In this study, we synthesized cationic human serum albumin (CHSA) nanoparticle by a new hybrid approach for improvement the surface chemistry of albumin and investigate the amount of indirubin loaded CHSA nanopa...
Background
Punica granatum L. (pomegranate) with astringent activities and Matricaria chamomilla L. (chamomile) with anti-inflammatory and antioxidant properties are natural remedies used for various skin disorders, including wound healing.Objectives
This study was conducted to evaluate the individual and combined wound healing activity of the meth...
Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNi 2 S 4 , and the porphyrins were incorporated into the layers as well to increase the sensitivity of the prepared nanostructure. The prepared nanocomposite can es...