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Raspail Carrel Founou Zangue

Raspail Carrel Founou Zangue

BSc., MSc., PhD

About

45
Publications
7,093
Reads
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1,019
Citations

Publications

Publications (45)
Article
Full-text available
The resistome, virulome and mobilome of extended spectrum ß-lactamase (ESBL)-producing Escherichia coli (ESBL-Ec) isolated from pigs in Cameroon and South Africa were assessed using whole genome sequencing (WGS). Eleven clonally related phenotypic ESBL-Ec isolates were subjected to WGS. The prediction of antibiotic resistance genes, virulence facto...
Article
Full-text available
The exacerbation of antimicrobial resistance (AMR) is a major public health threat worldwide. In sub-Saharan Africa, there is a scarcity of data regarding multidrug-resistant (resistance to at least one antibiotic of three or more families of antibiotics) as well as extended spectrum β-lactamase-producing Enterobacterales (ESBL-PE), isolated among...
Preprint
Background: Extended-spectrum β-lactamase-producing E. coli (ESBL-Ec) harbouring virulence genes in the microbiome of food animals could likely threaten human health but is poorly understood in Cameroon and South Africa. Here, we assessed the resistome, virulome and mobilome of ESBL-Ec isolated from swine microbiomes in these countries, using whole...
Article
Full-text available
As of 23 April 2021, the outbreak of COVID-19 claimed around 150 million confirmed cases with over 3 million deaths worldwide. Yet, an even more serious but silent pandemic, that of antimicrobial resistance (AMR), is likely complicating the outcome of COVID-19 patients. This study discusses the current knowledge on the emergence of the SARS-CoV-2 a...
Article
Full-text available
As of 23 April 2021, the outbreak of respiratory coronavirus disease (COVID-19) had resulted in around 150 million confirmed cases with over 3 million deaths worldwide. Yet, an even more serious but silent pandemic, that of antimicrobial resistance (AMR), is likely complicating the outcome of COVID-19 patients. Here we review the current knowledge...
Article
Objective: Effective family planning services (FPs) use significantly improves both women and men sexual and reproductive health. Recently, the Chinese government has launched the two-child policy allowing families to have additional child. This study aimed to explore the population interest for FPs, unmet needs and the populations' expectations....
Article
Full-text available
Antimicrobial resistance (AMR) threatens to reverse the essential benefits of antibiotics, not only in humans, where decades of advancements in healthcare outcomes are endangered, but also in the food production industry. As the world moves toward Sustainable Development Goals, food safety is a critical element to improve and strengthen global heal...
Article
Full-text available
Aim: To determine the prevalence and describe the antimicrobial resistance patterns of circulating methicillin-resistant staphylococci (MRS) isolated from clinical specimens during a 3-year period in Yaoundé, Cameroon. Materials & methods: From January 2017 to December 2019, 1683 clinical samples were plated onto Mannitol salt agar. Bacterial id...
Poster
Background: In a multicentre comparative study conducted in pig abattoirs in Cameroon and South Africa, extended spectrum beta-lactamase producing Enterobacterales (ESBL-PE) were screened from pooled nasal and rectal samples of 432 pigs and nasal and hand swabs of 82 humans. An overall high ESBL-PE prevalence (>70%) was observed in both sample type...
Preprint
Full-text available
Antimicrobial resistance (AMR) threatens to reverse the essential benefits of antibiotics not only in humans, where decades of advancements in healthcare outcomes are endangered but also in the food production industry. The emergence of AMR in the pre- and post-harvest systems presents a serious risk of contamination or infection directly by antibi...
Article
Full-text available
Objective: The draft genome sequence of a clinical Acinetobacter haemolyticus A109R1B4 isolated from a rectal swab of a hospitalised patient is described here. Methods: Genomic DNA was sequenced using an Illumina MiSeq platform. Generated reads were de novo assembled using the Qiagen CLC Genomics Workbench. The assembled contigs were annotated a...
Article
Full-text available
Background and objectives: Extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae is a serious public health issue globally. In this study, the antibiotic resistance genes, virulence factors, mobile genetic elements, and genetic lineages of circulating ESBL-producing K. pneumoniae strains isolated from pigs and humans in Cameroonian a...
Preprint
Background Evidences in sub-Saharan Africa including Cameroon indicate that most of HIV discordant couples want more children despite their HIV status. Investigate and establish contraception preferences among HIV infected individuals are fundamental and crucial to provide effective reproductive healthcare.Methods We performed a cross-sectional stu...
Article
Full-text available
Food animals are considered reservoirs of methicillin‐resistant Staphylococcus aureus (MRSA) and are implicated in their zoonotic transmission in the farm‐to‐plate continuum. LA‐MRSA has been reported as a zoonotic agent that has the potential to spread to humans and may cause infections in at‐risk groups. In this study, whole genome sequencing was...
Article
Full-text available
Extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae remain a critical clinical concern worldwide. The aim of this study was to characterize ESBL-producing K. pneumoniae detected within and between two hospitals in uMgungundlovu district, South Africa, using whole genome sequencing (WGS). An observational period prevalence study on...
Article
Full-text available
Chronic Lymphocytic Leukemia (CLL) is an acquired monoclonal disorder characterized by a gradual accumulation of functionally incompetent lymphocytes. It generally presents a clonal B cells arrested in the B-cell differentiation pathway that resemble morphologically to mature lymphocytes in the peripheral blood. There is a scarcity of CLL data amon...
Article
Full-text available
Extended spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) represent a significant public health concern globally and are recognized by the World Health Organization as pathogens of critical priority. However, the prevalence of ESBL-PE in food animals and humans across the farm-to-plate continuum is yet to be elucidated in Sub-Saharan cou...
Article
Full-text available
Genomic characterisation of Klebsiella michiganensis co-producing OXA-181and NDM-1 carbapenemases isolated from a cancer patient in uMgungundlovu District, KwaZulu-Natal Province, South Africa
Article
Full-text available
Background Gram-negative ESKAPE bacteria are increasingly implicated in several difficult-to-treat infections in developed and developing countries. They are listed by the World Health Organization as resistant bacteria of critical priority in research. Objectives To determine the risk factors, prevalence, phenotypic profiles, genetic diversity an...
Article
Objectives: Here we report the draft genome sequence of a methicillin-resistant Staphylococcus epidermidis strain (sequence type 59) isolated from a pooled rectal sample from pigs collected in an abattoir in South Africa. Methods: Genomic DNA of S. epidermidis PR246B0 was sequenced using an Illumina MiSeq platform. Generated reads were de novo a...
Conference Paper
Background and objectives: Extended spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) represent a significant public health concern globally and are recognized by the World Health Organization as pathogens of critical priority in research. However, the prevalence of ESBL-PE in food animals and humans across the farm-to-plate continuum...
Article
Objectives: The draft genome sequences of two Enterobacter aerogenes HN503E2II and PN108E5IIB isolated from two Cameroonian abattoirs, are reported here. Methods: Genomic DNA of these isolates was sequenced using an Illumina MiSeq platform. Generated reads were de novo assembled using the Qiagen CLC Genomics Workbench. The assembled contigs were...
Article
Objectives: We report here the draft genome sequence of E. coli strain HN503E1II isolated from a nasal sample of an abattoir worker in Cameroon. Methods: Genomic DNA of E. coli was sequenced using an Illumina MiSeq platform. Generated reads were de novo assembled using the Qiagen CLC Genomics Workbench. The assembled contigs were annotated and a...
Article
Full-text available
Objectives: This study critically reviewed the published literature and performed a meta-analysis to determine the overall burden of antibiotic-resistant bacteria in food animals in Africa. Methods: English and French published articles indexed in EBSCOhost, PubMed, Web of Science, and African Journals Online were retrieved, with searches being...
Article
Full-text available
Background and objectives: Extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae is a serious public health issue globally. In this study, the antibiotic resistance genes, virulence factors, mobile genetic elements and genetic lineages of circulating ESBL-producing K. pneumoniae strains isolated from pigs and humans in Cameroonian ab...
Data
Search strategy performed in PubMed and Web of Science. (DOCX)
Article
Full-text available
Introduction Despite evidence of the high prevalence of antibiotic resistant infections in developing countries, studies on the clinical and economic impact of antibiotic resistance (ABR) to inform interventions to contain its emergence and spread are limited. The aim of this study was to analyze the published literature on the clinical and economi...
Article
Full-text available
Antibiotics are now “endangered species” facing extinction due to the worldwide emergence of antibiotic resistance (ABR). Food animals are considered as key reservoirs of antibiotic-resistant bacteria with the use of antibiotics in the food production industry having contributed to the actual global challenge of ABR. There are no geographic boundar...

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Projects

Projects (5)
Project
This project aim to provide a Real time baseline data of the genetic diversity of bacteria strains circulating in Africa continent to address the new therapeutic approachs based on evidence of the impact of Zoonotic bacteria as a real threat.
Project
The overarching goal of the project is to contribute to the containment of antibiotic resistance (ABR) and reduction of maternal, neonatal and infant mortality in Cameroon. More specifically, the project seeks to investigate Streptococcus agalactiae (aka Group B streptococcus [GBS]) in the microbiome of pregnant women and neonates in Cameroon. Moreover, other important bacteria such as Escherichia coli, Staphylococcus aureus, Clostridium perfringens, Streptococcus pneumoniae, etc., that can be involved in serious life-threatening infections among parturient, neonates and infants, are investigated in carriage and clinical specimens.