Rashmi Kaul

Rashmi Kaul
Oklahoma State University - Center for Health Sciences · Biochemistry and Microbiology

PhD

About

38
Publications
2,119
Reads
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1,066
Citations
Citations since 2016
10 Research Items
391 Citations
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Introduction
Rashmi Kaul currently works at the Biochemistry and Microbiology, Oklahoma State University - Center for Health Sciences. Rashmi does research in Cancer Research, Cell Biology and Immunology. Their current project is 'Antibiotic Drug Delivery Platforms based on Nanodiamond Particles'.

Publications

Publications (38)
Article
The bladder epithelial cells elicit robust innate immune responses against urinary tract infections (UTIs) for preventing the bacterial colonization. Physiological fluctuations in circulating estrogen levels in women increase the susceptibility to UTI pathogenesis, often resulting in adverse health outcomes. Dr adhesin bearing Escherichia coli (Dr...
Preprint
The bladder epithelial cells elicit robust innate immune responses against urinary tract infections (UTIs) for preventing the bacterial colonization. Physiological fluctuations in circulating estrogen levels in women increase the susceptibility to UTI pathogenesis, often resulting in adverse health outcomes. Dr adhesin bearing Escherichia coli (Dr...
Article
Urinary tract infections (UTIs) are the second most common infectious disease in the United States, costing about $ 3.5 billion annually in treatment. As resistance to antibiotics becomes more common, a greater need for alternative treatments, including low‐dosage and cellular‐targeted antibiotic for treating UTIs, is required. Nanodiamond particle...
Article
Full-text available
The protective role of endogenous estrogen against Urinary Tract Infection (UTI) is well recognized, but the involvement of estrogen receptors (ERs) in modulating immunity in the urinary tract during UTI pathogenesis has not been investigated. The current study investigates the role of ERα in modulating immune responses and UTI outcome. Mice were p...
Article
Full-text available
Objectives: Serum carcinoembryonic antigen is a tumor marker often found to be elevated in colorectal cancer patients. Elevated carcinoembryonic antigen has been strongly associated with poor prognosis. However, little is known about the patient and tumor characteristics between carcinoembryonic antigen-secreting and non-secreting tumors. Methods:...
Poster
Serum Carcinoembryonic Antigen (CEA) is a tumor marker often found to be elevated in colorectal cancer patients. Elevated CEA has been strongly associated with poor prognosis. However, not all colon cancer tumors produce CEA, and little is known about the patient and tumor characteristics between CEA-producing and non-CEA-producing tumors. We perfo...
Article
Full-text available
About 25–44% of women will experience at least one episode of recurrent UTI and the causative agent in over 70% of UTI cases is uropathogenic Escherichia coli (UPEC). UPEC cause recurrent UTI by evading the bladder’s innate immune system through internalization into the bladder epithelium where antibiotics cannot reach or be effective. Thus, it is...
Article
Full-text available
AIM To investigate gender-specific liver estrogen receptor (ER) expression in normal subjects and patients with hepatitis C virus (HCV)-related cirrhosis and hepatocellular carcinoma (HCC). METHODS Liver tissues from normal donors and patients diagnosed with HCV-related cirrhosis and HCV-related HCC were obtained from the NIH Liver Tissue and Cell...
Article
Premature birth is one of the leading causes of newborn death, estimated 1 in 10 newborn babies. The maternal intrauterine tract infections account for 30-40% of total premature birth. The maternal intrauterine infections are treated with antibiotics, but the neonatal mortality rate has not been decreased. The tocolytic drugs only delay premature d...
Article
Urinary tract infections (UTIs) cost $0.4–0.5 billion a year in the US and is the second most common disease affecting millions of people. As resistance to antibiotics becomes more common, a greater need for alternative treatments is needed. Nanodiamond particles (NDPs) are actively researched as drug delivery platforms due to their biocompatibilit...
Article
Environmental exposure to mercury can cause a number of adverse effects in humans including the disruption of endocrine function that may result in sex-specific effects. The present study was designed to characterize sex-specific effects of chronic inorganic mercury exposure on toll-like receptor (TLR) 2 and TLR4 and inflammatory signaling in the l...
Article
Epidemiological data on bacterial translocation (BT), colonization and inflammation in normal human livers is lacking. In this study we investigated the status of bacterial colonization and inflammation in the normal, cirrhotic primary biliary cirrhosis (PBC), and nonalcoholic steatohepatitis (NASH) human liver tissues. Comparatively normal livers...
Article
Full-text available
The striking gender disparity observed in the incidence of hepatocellular carcinoma (HCC) suggests an important role of sex hormones in HCC pathogenesis. Though the studies began as early as in 1980s, the precise role of sex hormones and the significance of their receptors in HCC still remain poorly understood and perhaps contribute to current cont...
Article
We investigated the relationship between nutrition, body composition, and bone mineral density (BMD) in young adults after liver transplantation. A cross-sectional study involving bone densitometry, anthropometry, and detailed food and lifestyle questionnaires. Of 37 patients recruited, 26 were male. The mean age was 38.8 (+/-12.3) years, and the p...
Article
Full-text available
Hepatitis B (HBV) and hepatitis C (HCV) viral infection or co-infection leads to risk of development of chronic infection, cirrhosis and hepatocellular carcinoma (HCC). Immigration and globalization have added to the challenges of public health concerns regarding chronic HBV and HCV infections worldwide. The aim of this study is to review existing...
Article
Several types of aggressive cancers, including hepatocellular carcinoma (HCC), often arise as a multifocal primary tumor. This suggests a high rate of premalignant changes in noncancerous tissue before the formation of a solitary tumor. Examination of the messenger RNA expression profiles of tissue samples derived from patients with cirrhosis of va...
Article
Intestinal trefoil factor (ITF) promotes epithelial cell migration and mucosal restitution during inflammation. We used real-time quantitative PCR, in situ nucleic acid hybridization, and immunohistochemistry to study the expression of the ITF gene and protein expression in the liver of primary biliary cirrhosis (PBC) and controls. There were signi...
Article
Complement system plays an important role in host defense mechanisms against microorganisms and tumor cells. To protect themselves from autologous complement-mediated damage, normal host tissues express cell membrane-associated complement regulatory proteins (CRPs). To investigate whether neoplastic endometrial tissues overexpress these proteins to...
Article
Full-text available
Urinary tract infections (UTIs) are associated with approximately 27% of premature births. Escherichia coli is the most frequent causal agent of UTIs and expresses virulence factors, including surface adhesins that recognize specific host tissue receptors. We have reported that E. coli Dr adhesin recognizes decay-accelerating factor as the host tis...
Article
Multiple TCRBV genes have been implicated in experimental autoimmune myasthenia gravis (EAMG) pathogenesis in susceptible H-2(b) strains of mice. We studied the contribution of specific TCRBV and AV genes in EAMG pathogenesis using B10.BV8S2 transgenic mice (H-2[b]). The TCR transgenic mice predominantly have TCRBV8S2 transgene, but can use any of...
Article
Experimental autoimmune myasthenia gravis (EAMG) is an Ab-mediated autoimmune disease. The pathogenic auto-antibody production depends on the activation of CD4+ cells after their TCR interact with dominant T cell epitopes within acetylcholine receptor (AChR) in the context of the MHC class II molecule. In vitro analysis suggested that the TCRBV6 wa...
Article
Recombinant (r) human IL-2 was administered in vivo to improve homing and engraftment of rheumatoid arthritis (RA) patients' peripheral blood mononuclear cells (PBMC) into severe combined immunodeficient (SCID) mice. Human rIL-2 treatment resulted in augmented human Ig production and induced IgM rheumatoid factor (RF) of human origin in SCID-RA chi...
Article
Recombinant (r) human IL-2 was administered in vivo to improve homing and engraftment of rheumatoid arthritis (RA) patients' peripheral blood mononuclear cells (PBMC) into severe combined immunodeficient (SCID) mice. Human rIL-2 treatment resulted in augmented human Ig production and induced IgM rheumatoid factor (RF) of human origin in SCID-RA chi...
Article
Myasthenia gravis (MG) is a classical antibody-mediated autoimmune disease of the neuromuscular junction. MG-like disease could be induced in animals by immunization with acetylcholine receptor (AChR) in complete Freund’s adjuvant (CFA). We have established the mouse model of MG, experimental autoimmune myasthenia gravis (EAMG) and have characteriz...
Article
MHC class I and CD8+ cell deficiency have either prevented systemic lupus erythematosus-like disease in mice or enhanced type I diabetes in nonobese diabetic mice. To study the involvement of MHC class I and class I-restricted CD8+ T cells in the induction of a classical Ab-mediated disease, experimental autoimmune myasthenia gravis (EAMG), we immu...
Article
To analyze the impact of lack of MHC class II gene expression, and to demonstrate the direct genetic evidence for the involvement of the MHC class II gene product in the development of experimental autoimmune myasthenia gravis (EAMG), MHC class II gene-disrupted C57BL6 mutant (-/-) and EAMG-susceptible MHC class II wild-type C57BL6 mice (+/+) were...
Chapter
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and fatigue. The defective neuromuscular transmission in MG is due to a functional loss of the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane, which is the result of the effects of anti-AChR antibodies and complement (Lindstrom et al, 1988). Many...
Article
Nine multiplex RA families of North Indian origin were tissue typed to determine the segregation of parental haplotypes among sibs. The assortment of haplotypes in 18 affected sibs was not random, with seven sib pairs being HLA identical and two haploidentical with the proband (P = 0.0007). HLA-DR4 occurred in eight out of nine probands (88.8%) and...

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