Rasheda Akter

BCSIR Rajshahi Laboratories, Bangladesh Council of Scientific & Industrial Research

Aims: Increased oxidative stress in diabetes mellitus may lead to splenic damage, contributing to decreased immunity. This study aims to evaluate the potential of vitamin E supplements as a protective agent against spleen injury by examining physiological, hematological, biochemical, and histological changes in diabetic rat model. Methods: Diabet...

This study focused on Stevia rebaudiana, a plant known for its sweet taste and unique medicinal properties in managing diabetes complications. The research aimed to evaluate the antihyperglycemic potential of crude ethanolic and aqueous extracts from Stevia rebaudiana leaves, utilizing the Oral Glucose Tolerance Test (OGTT) on albino rats subjected...

Background Nyctanthes arbor-tristis Linn. (Oleaceae) is a traditional therapeutic plant, highly used in Ayurveda for a wide range of activities, such as anthelmintic, antipyretic, laxative, rheumatism, skin ailments, and sedative. Aims of the review This review aims to furnish up-to-date details on botanical characterization, geographical distribu...

Proline specific serine protease enzyme, dipeptidyl peptidase IV (DPP-4) has become a promising target for diabetes, as it stops glucagon-like peptide 1 (GLP-1) from becoming inactive, resulting in higher levels of active GLP-1. This lowers glucose levels by increasing insulin secretion and decreasing glucagon secretion. DPP-4 is also linked to a h...

Aims One of the most important resources for the development of new drugs is a biologically active lead compound from natural sources. Biomedical researchers and pharmaceutical companies have a high interest in plant-derived molecules that can be used for drug development. Background: The collective knowledge of plants and their phytoconstituents w...

Background Menthol-rich essential oil of Mentha arvensis L. (Japanese mint) have been identified as a valuable and new source of natural bioactive compounds with applications not only in industry but also in our daily life. Objective The present study aimed to assess the cytotoxicity, acute toxicity, antidepressant and antioxidant activities of Ja...

Garlic is used as an essential ingredient for culinary and medicinal purposes all over the world. Therefore, the improvement of garlic quality is continuous. Bangladesh has developed some high yielding garlic varieties with the better quality like low disease and infestation rate, high storage capacity. The antimicrobial and bioactive properties of...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus, identified in December 2019 in Wuhan city of China. Because of its rapid human to human transmission the World Health Organization (WHO) declared the novel coronavirus outbreak a global pandemic in March 2020. Despite rigorous global containment and quarantine...

Astragalin is a biologically active flavonoid compound with various pharmacological activities, including anti-inflammatory, antioxidant, neuroprotective activity, cardioprotective activity, anti-obesity, antiulcer, antidiabetic, antifibrotic, anti-osteoporotic, anticancer, etc. This natural compound has been found in almost all medicinal plants an...

Background: Adhatoda vasica (Nees.) of family Acanthaceae has been used in the Southeast tropical zone as it is efficacious against headache, colds, cough, whooping cough, fever, asthma, dyspnea, phthisis, jaundice, chronic bronchitis and diarrhea and exhibits commendable pharmacological activities. Objective The aim of the review is to provide a...

Background: Linum usitatissimum or flax has been broadly utilized in numerous milieus world-wide as a primeval medicinal plant because of its health benefits in diverse types of diseases. Objective: The objective of this review is to assemble the latest information on the botanical description, distribution, conventional uses, and biochemical const...

Ethnopharmacological relevance Functional disability associated with rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease is a challenging concern in healthcare systems. Along with environmental factors and epigenetic disorders, multiple pathways are reported as prominent mechanism for the progression of RA symptoms including; pain,...

Background: Brassica oleracea var. Capitata F. Alba (white cabbage) is a cruciferous vegetable which used as a vegetable and traditional medicine all over the world. Different preparation from several parts of the plant - roots, shoots, leaves and the whole plant are used to treat a wide range of diseases including diabetes, cancer, gastric, inflam...

Background: Enhydra fluctuans Lour, a tropical herb, commonly known as helencha or harkuch, belonging to family Asteraceae, and is an edible semi-aquatic herbaceous vegetable plant with serrate leaves, grows commonly in different parts of the world. Enhydra fluctuans possesses potential pharmacological role against inflammation, cancer, diarrhea,...

Objective:To explore the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Cynodon dactylonPers. aerial parts (EECA) in Wistar rats. Methods: To assess the antidiabetic activity of EECA, oral glucose tolerance test(OGTT) model, and alloxan-induced diabetic test (AIDT) model were performed. The EECA was used at the doses of 2 g/kg...

The present study scrutinizes the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Ficus racemosa L. stem barks (EEFB) in Wistar rats. Oral glucose tolerance test (OGTT) model and alloxan induced diabetic model (AIDM) were performed to assess antidiabetic activity of EEFB at doses of 750mg/kg, 500 mg/kg and 250 mg/kg, and 2g/ kg...

Lactobacillus and Lactococcus species found in the yogurt of different sources are most widely assayed and used all over the world as a probiotic agent. This study aimed to isolate and identify novel probiotic agents with therapeutic value against diarrhea. Initially, the probiotic properties of the isolated lactic acid bacteria from the yogurt sam...

Saurauia roxburghii Wall. is an interesting plant, found growing chiefly along the eastern and south-eastern countries of Asia. The various ethnic groups of these regions use the plant as a medication for relieving a wide spectrum of diseases and conditions, including indigestion, boils, fever, gout, piles, eczema, asthma, ulcers, bronchitis, epile...

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders showing slow progressive cognitive decline. Focusing on acetylcholinesterase (AChE) is one of the significant tactics for AD therapeutics, as cholinergic pathways in the cerebral cortex and basal forebrain are undermined. Propolis, a substance naturally produced by bees...

Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders showing slow progressive cognitive decline. Focusing on acetylcholinesterase (AChE) is one of the significant tactics for AD therapeutics, as cholinergic pathways in the cerebral cortex and basal forebrain are undermined. Propolis, a substance naturally produced by bees...

Skin cancer encompass the primary and second most frequent form of carcinogenesis in the United States. In current decades, CYP1A1, (encodes a member of the cytochrome P450 superfamily of enzymes) has become a major interest in skin cancer research. Enzymes belong to the Cytochrome P450 (CYP) superfamily are considered as the most important and fun...

Colorectal is one of the most incident and deadliest cancer worldwide, accounting for a million new cases every year. Various scientific studies has demonstrated that inhibition of cyclooxygenase-2 (COX-2) signaling by COX-2 inhibitors is an effective strategy for controlling colorectal carcinogenesis. COX-2 belongs to the family of myeloperoxidase...

Background : The objective of the present study was to evaluate the sub-acute toxic effects of ethanol extract of fenugreek seeds on kidney tissues of albino rats. Materials and methods: The present study was conducted on 30 albino rats divided into Group A, B, C, D and R. Group A (Control group) was treated with distilled water. Group B, Group C a...

Tyrosine kinases (KDR) have been considered as a potential targets for the design of new anticancer agents. Recently, a series of N-4-chlorophenylnaphthamides has been reported with KDR inhibitory activity. In order to demonstrate the pharmacokinetics and the relationship between the structures and their inhibition of KDR, 3D-QSAR and in silico ADM...

Moringa Oleifera Lam (Called Shajna in Bengali) is a plant which has a long history of uses in liver disorders in this subcontinent. This study was done to evaluate the hepatoprotective effects of ethanol extract of leaf of this plant on paracetamol induced hepatotoxicity in albino rats. The total experiments were designed as follows I) Experiment-...

To assure the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Acacia nilotica L. stem barks (EANB) in Wistar rats were carried out in the present studies. Acute toxicity study of EANB was implemented in Swiss albino mice to determine its doses for theantidiabetic and antidiarrhoeal study. Oral glucose tolerance model (OGTM) and...

Our study was undertaken to assess the protective effect of Spirodela polyrhiza against sodium arseniteinduced toxicity in experimental model. Animals were divided into six groups. The first group was used as control group while the other groups were treated with S. polyrhiza, sodium arsenite (10 ppm), 10 ppm As plus S. polyrhiza, sodium arsenite (...

Bangladesh is a rich store house of medicinal plants. Catharanthus roseus is administered as a cooling medicine. It is used for the treatment of diabetes, cancer, fever, malaria, cancer, throat infection and chest complaints. Taking all these things into consideration, it creates sufficient interest to carry out proximate analysis and amino acid co...

This study investigated the quantitative phytochemical contents, total phenolics, total flavonoids, total carotenoids, antioxidative capacity, tannin, proanthocyanidins, lycopene, chlorophyll a, and chlorophyll b of the Stephania japonica extract. Comprehensive antioxidative effects of the extract were also investigated. Quantitative assays were co...

Chenopodium album Linn (Called Bathua in Bengali) is a plant which has a long history of uses in liver disorders in this subcontinent. This study was done to evaluate the hepatoprotective effects of ethanol extract of this plant on paracetamol induced hepatotoxicity in albino rats. The total experiments were designed as follows (I) Experiment (part...

Objective: To evaluate the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Psidium guajava leave (EEPGL) in Wister rats to support its traditional uses. Methods: Oral glucose tolerance test model and alloxan induced diabetic test model were performed to evaluate antidiabetic activity of EEPGL at doses of 1.00, 0.50 and 0.75 g/k...

This study investigated the quantitative phytochemical contents, total phenolics, total flavonoids, total carotenoids, total antioxidative capacity, tannin, proanthocyanidins, lycopene, chlorophyll a and chlorophyll b of the Stephania japonica extract. Comprehensive antioxidative effects of the extract were also investigated. Quantitative assays we...

The present study was undertaken to evaluate the antidiabetic properties with phytochemical screening of the ethanol leaves extracts of two common indigenous medicinal plants of Bangladesh -Azadirachta indica (Neem) and Andrographis peniculata (Kalomegh) on experimental animal model. Hypoglycemic activity of the concentrated ethanolic (90%) extract...

The present study was undertaken to evaluate the antidiabetic properties with phytochemical screening of the ethanol leaves extracts of two common indigenous medicinal plants of Bangladesh -Azadirachta indica (Neem) and Andrographis peniculata (Kalomegh) on experimental animal model. Hypoglycemic activity of the concentrated ethanolic (90%) extract...

The present study was carried out to investigate the antidiabetic and antioxidant effect with phytochemical screening of ethanol extract of Saurauia roxburghii. The ethanol extract of Saurauia roxburghii was evaluated for its antidiabetic activities in alloxan induced diabetic rats. The significant reduction in blood glucose levels of the ethanol e...

The hypocholesterolemic effects of the ethanol extract of Ananas comosas (L.) Merr. (Pineapple) was investigated in 5 groups of albino rats, 7 in each group. Group I rat received only distilled water and served as normal control. Groups II, III, IV and V were made hypercholesterolemic by feeding cholesterol orally suspended in 2% cholic acid mixed...

This study was subjected to investigate antioxidant, cytotoxic and antimicrobial (antibacterial and antifungal) properties of Eclipta alba ethanol extract. The antioxidant and cytotoxic properties of the extract were assessed by DPPH free radical scavenging method and brine shrimp lethality bioassay, respectively. Disc diffusion technique and food...

The present study was carried out to investigate the anti-inflammatory, antinociceptive and antipyretic activities of the crude ethanol extract of Azadirachta indica leaves on experimental animal model at three different dose level- 1g/kg, 500 mg/kg and 100 mg/kg. For evaluation of the anti-inflammatory property carrageenan induced paw edema served...

The ethanolic bark extract of Mitragyna diversifolia showed significant (p<0.05) antidiarrheal activity on gastrointestinal motility with barium sulfate milk model and castor oil- induced diarrheal model in rats. These results revealed that the bark extract possess pharmacological activity against diarrhea and may possibly explain the use of the pl...