Rasha M. Abu El-Khair

Alexandria University | AU · Department of Pharmacognosy

Many of the plants of genus Salsola are edible halophytes which are known for their use in treatment of inflammation as well as their nutritional content. This study aims at comprehensive chemical profiling of two Salsola species that are widely distributed in arid areas; S. imbricata and S. jordanicola, using UHPLC-QqQ-MS in an attempt to decipher...

In the current study, seven Sri Lankan tea grades; Orange Pekoe, Flowery Pekoe, Broken Orange Pekoe Fannings, Broken Orange Pekoe black tea, green tea, silver tips and golden tips white tea grades were subjected to comprehensive metabolic profiling using UPLC-MS/MS combined with chemometrics. Theasensinin C and E, theaflavin and theacitrin were the...

Anticoagulation therapy represents a mainstay of treatment and prevention of cardiovascular diseases which are the leading causes of mortality worldwide. In addition, several case reports of spontaneous bleeding occurred linking the consumption of many dietary supplements during treatment with anticoagulants or in postoperative patients. This promp...

Selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window than multitargeted anticoagulants. They have evolved as a crucial part of prevention and treatment of thromboembolic diseases and in therapeutic protocols involved in many clinical trials in coronavirus disease 2019 (COVID-19) patients. Biological...

Traditional edible natural products enclose a wealth of anticoagulants that can be prospected for new selective factor Xa inhibitors. Unlike multitargeted anticoagulants, selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window. In the present study, an in-house database comprises 3D structures of 1571...

The presented work discusses the development of a rapid and precise analytical protocol using near infrared spectroscopy combined with multivariate data analysis to authenticate, detect and quantify most of the commonly encountered plant adulterants used in fraud of saffron stigmas including safflower, pomegranate fruit peel, calendula flower, papr...

Seven compounds were isolated from the leaves and fruits of Egyptian Withania somnifera dunal, (Family: Solanaceae). The identity of the compounds based on their spectroscopic data were as follows: two withanolides; withaperuvin C (1), phyperunolideF (2) and four lipids;1,2-di-O-palmitoyl-3-O-(6´´´-sulfo-α-D-quinovopyranosyl)-glycerol (3), vaccenic...

Introduction: Species of Apiaceae are used in folk medicine as spices and in officinal medicinal preparations of drugs. They are an excellent source of phenolics exhibiting antioxidant activity, which are of great benefit to human health. Discrimination among Apiaceae medicinal herbs remains an intricate challenge due to their morphological simila...

Aims: To investigate the chemotype of the Egyptian Withania somnifera and explore the cytotoxic activity of different extracts as well as the major isolated withanolides on four cell lines of common cancer variants in Egypt, both in vitro and using computational methods. Study Design: Preparation of the different plant parts extract, determination...

A sensitive, reliable, simple and rapid thin-layer chromatographic method has been developed for routine analysis of withanolide S content for the purpose of quality control assessment of chemotype III of W. somnifera. The new method was used first to compare the accumulation of withanolide S in different parts of the plant, which was found to be t...

Poster

Objective: The present study was designed to study the effect of supplementing Silybum marianum cultures with different combinations and concentrations of growth regulators on the total phenolic content and the antioxidant activity of the produced cultures.Methods: The total polyphenolic content of 23 extracts of calli was calculated as µg of galli...

Withania somnifera popularly known as ashwaganda or Indian Ginseng is a well known plant in India. Furthermore, it is a common plant in Egypt. The objective of this study is to evaluate the effectiveness of the extracts of different parts of the plant in the protection against oxidative stress and its therapeutic potential in the treatment of Alzhe...

DPPH screening of both seed and pericarp extracts of Vicia faba L. cv. Rena Mora in fresh and dried form revealed that the 70% alcoholic extract of fresh pericarp showed maximum antioxidant activity. It was then fractionated using different organic solvents. The antioxidant activity of the different fractions was determined by DPPH method. The IC50...