Raquel O. Rodrigues

Raquel O. Rodrigues
International Iberian Nanotechnology Laboratory

Ph.D. in Chemical and Biological Engineering

About

39
Publications
10,238
Reads
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719
Citations
Citations since 2016
28 Research Items
697 Citations
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2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Additional affiliations
June 2018 - December 2018
NASA Ames Research Center, Mountain View, United States
Position
  • Internship NASA-FCT
October 2017 - March 2018
Massachusetts Institute of Technology
Position
  • Fulbright Research Grant
September 2014 - present
University of Porto
Position
  • PhD Student

Publications

Publications (39)
Article
Every year, cancer causes millions of deaths around the globe, and researchers have been engaged to provide novel therapies for this threatening disease. However, this process is commonly hampered by failures in clinical trials. For this reason, efforts have been made to develop in vitro models capable of modelling the complex and heterogeneous tum...
Article
Organ-on-chip (OoC) platforms are a new class of advanced microfluidic devices that have been attracting significant attention for drug development since they can allow a faster and more patient specific evaluation of the effects of drugs due to the mimicking of organ human models. As most microfluidic devices, the great majority of the OoC is made...
Article
Full-text available
The development of cancer models that rectify the simplicity of monolayer or static cell cultures physiologic microenvironment and, at the same time, replicate the human system more accurately than animal models has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are a solution that has been explored over the last decade. The...
Article
The nanofluids (NFs) are known as a colloidal suspension where nanoparticles (NPs) are dispersed in conventional base fluids (BFs). This suspension has been frequently used to augment the heat transfer (HT) capacity of a fluid by studying their thermophysical properties. This review outlines the most recent advances on the NFs thermal properties an...
Article
Full-text available
Numerical simulations have revolutionized research in several engineering areas by contributing to the understanding and improvement of several processes, being biomedical engineering one of them. Due to their potential, computational tools have gained visibility and have been increasingly used by several research groups as a supporting tool for th...
Article
Full-text available
Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system. Hence, they have been increasingly used for biomed...
Article
Full-text available
This paper presents the design, fabrication and characterization of temperature microsensors based on Resistance Temperature Detectors (RTDs) with a meander-shaped geometry. Numerical simulations were performed for studying the sensitivity of the RTDs according to their windings numbers as well as for optimizing their layout. These RTDs were fabric...
Article
Full-text available
The combination of diagnostics and therapy (theranostic) is one of the most complex, yet promising strategies envisioned for nanoengineered multifunctional systems in nanomedicine. From the various multimodal nanosystems proposed, a number of works have established the potential of Graphene-based Magnetic Nanoparticles (GbMNPs) as theranostic platf...
Article
Full-text available
In article number 2004258, Ali Khademhosseini, Su Ryon Shin, and co‐workers develop a model for investigating chemotherapy‐induced cardiotoxicity where induced pluripotent stem cell‐derived cardiac tissues are interacted with breast cancer tissues on a dual‐organ platform. Using electrochemical immuno‐aptasensors to monitor cell‐secreted multiple b...
Article
Despite the progress achieved in nanomedicine during the last decade, the translation of new nanotechnology‐based therapeutic systems into clinical applications has been slow, especially due to the lack of robust preclinical tissue culture platforms able to mimic the in vivo conditions found in the human body and to predict the performance and biot...
Article
Full-text available
Cardiotoxicity is one of the most serious side effects of cancer chemotherapy. Current approaches to monitoring of chemotherapy‐induced cardiotoxicity (CIC) as well as model systems that develop in vivo or in vitro CIC platforms fail to notice early signs of CIC. Moreover, breast cancer (BC) patients with preexisting cardiac dysfunctions may lead t...
Research Proposal
Dear all, I am glad to announce that I am currently co-editing a Special Issue on Cancers journal (IF= 6.162) with the theme Cancer-on-a-chip: applications and challenges. In this Special Issue, we invite contributions (original research papers, review articles, and short communications) that focus on the latest advances and challenges in cancer-o...
Article
Full-text available
The loss of the red blood cells (RBCs) deformability is related with many human diseases, such as malaria, hereditary spherocytosis, sickle cell disease, or renal diseases. Hence, during the last years, a variety of technologies have been proposed to gain insights into the factors affecting the RBCs deformability and their possible direct associati...
Article
Full-text available
Since the first microfluidic device was developed more than three decades ago, microfluidics is seen as a technology that exhibits unique features to provide a significant change in the way that modern biology is performed. Blood and blood cells are recognized as important biomarkers of many diseases. Taken advantage of microfluidics assets, change...
Chapter
Cancer incidence and mortality are growing worldwide at an alarming pace, emphasizing the urgent need for new strategies to combat this disease. One of the frontiers of cancer research is currently focused on the design of multifunctional magnetic nanoparticles capable to achieve the synergistic cancer theranostics (both diagnosis and therapy). Alt...
Article
Herein, we introduce a flexible, biocompatible, robust and conductive electrospun fiber mat as a substrate for flexible and stretchable electronic devices for various biomedical applications. To impart the electrospun fiber mats with electrical conductivity, poly(3,4‐ethylenedioxythiophene) (PEDOT), a conductive polymer, was interpenetrated into ni...
Article
Full-text available
In this study, hydrophilic magnetic nanoparticles were synthesized by green routes using a methanolic extract of Rubus ulmifolius Schott flowers. The prepared magnetic nanoparticles were coated with carbon-based shell for drug delivery application. The nanocomposites were further chemically functionalized with nitric acid and, sequentially, with Pl...
Article
Full-text available
A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests...
Article
The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery⁠. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act a...
Article
Full-text available
Techniques, such as micropipette aspiration and optical tweezers, are widely used to measure cell mechanical properties, but are generally labor-intensive and time-consuming, typically involving a difficult process of manipulation. In the past two decades, a large number of microfluidic devices have been developed due to the advantages they offer o...
Article
Full-text available
The amount of applications associated with microfluidic devices is increasing since the introduction of Lab-on-a-chip devices in the 1990s, especially regarding biomedical and clinical fields. However, in order for this technology to leave the fundamental research and become a day-life technology (e.g., as point-of-care testing), it needs to be dis...
Article
Magnetite, nickel and cobalt ferrites were prepared and encapsulated within graphitic shells, resulting in three hybrid magnetic graphitic nanocomposites. Screening experiments with a 4-nitrophenol aqueous model system (5 g L⁻¹) allowed to select the best performing catalyst, which was object of additional studies with the liquid effluent resulting...
Article
Full-text available
The poor heating efficiency of the most reported magnetic nanoparticles (MNPs), allied to the lack of comprehensive biocompatibility and haemodynamic studies, hampers the spread of multifunctional nanoparticles as the next generation of therapeutic bio-agents in medicine. The present work reports the synthesis and characterization, with special foc...
Article
Intracranial aneurysm is a local dilatation of an intracranial artery with high risk of rupture and death. Although it is generally accepted that the weakening of the arterial wall is the main cause for the rupture of an aneurysm, it still no consensus about the reasons for its creation, expansion and rupture. In particular, what is the role played...
Article
The cell-free layer (CFL) is a hemodynamic phenomenon that has an important contribution to the rheological properties of blood flowing in microvessels. The present work aims to find the closest function describing RBCs flowing around the cell depleted layer in a polydimethysiloxane (PDMS) microchannel with a diverging and a converging bifurcation....
Conference Paper
Full-text available
Magnetic fluid hyperthermia (MFH) is considered a promising therapeutic technique for the treatment of cancer cells, in which magnetic nanoparticles (MNPs) with superparamagnetic behavior generate mild-temperatures under an AC magnetic field to selectively destroy the abnormal cancer cells, in detriment of the healthy ones. However, the poor heatin...
Article
Full-text available
Red blood cells (RBCs) in microchannels has tendency to undergo axial migration due to the parabolic velocity profile, which results in a high shear stress around wall that forces the RBC to move towards the centre induced by the tank treading motion of the RBC membrane. As a result there is a formation of a cell free layer (CFL) with extremely low...
Article
The behavior of suspensions of individual blood cells, such as red blood cells (RBCs), flowing through microvessels and microfluidic systems depend strongly on the hematocrit (Hct), microvessel topology and cell properties. Although it is well known that blood rheological properties are temperature dependent, to the best of our knowledge no work ha...
Article
Full-text available
Blood flow presents several interesting phenomena in microcirculation that can be used to develop microfluidic devices capable to promote blood cells separation and analysis in continuous flow. In the last decade there have been numerous microfluidic studies focused on the deformation of red blood cells (RBCs) flowing through geometries mimicking m...
Data
Trajectories of both RBC and PBMC flowing around the cross-flow pillars. RBCs deform and pass through the pillars into the branch channel whereas a PBMC rolls along the pillars in the direction of the primary flow.
Article
In the last years, there has been an increasing interest in evaluating possible relations between fatty acid (FA) patterns and the risk for chronic diseases. Due to the long life span (120 days) of red blood cells (RBCs), their FA profile reflects a longer term dietary intake and was recently suggested to be used as an appropriate biomarker to inve...
Article
Several studies have already demonstrated that it is possible to perform blood flow studies in microfluidic systems fabricated by using low-cost techniques. However, most of these techniques do not produce microchannels smaller than 100 microns and as a result they have several limitations related to blood cell separation. Recently, manufacturers h...
Article
Full-text available
Microfluidic devices are electrical/mechanical systems that offer the ability to work with minimal sample volumes, short reactions times, and have the possibility to perform massive parallel operations. An important application of microfluidics is blood rheology in microdevices, which has played a key role in recent developments of lab-on-chip devi...
Conference Paper
Studies of in vitro blood flow behaviour in stenosis are essential not only as an attempt to understand this phenomenon, but also to develop microfluidic devices, as an alternative clinical methodology to detect blood diseases. Regarding a better understanding of the role that rigid Red Blood Cells (rRBCs) play in the blood flow behaviour, we have...
Article
A separação e a identificação de células são essenciais em várias aplicações biomédicas, incluindo a biologia celular e os métodos de diagnóstico e terapêuticos. O sangue é um fluido não-Newtoniano contendo inúmeras informações preciosas sobre o estado fisiológico e patológico do corpo humano. No entanto, devido à sua complexidade, existem actualme...

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Projects

Projects (6)
Project
Currently, there are limited and ineffective treatments against neurological and neurodegenerative diseases. This is mainly due to the complexity of the brain and the inability of most drugs to cross the blood–brain barrier. The EU-funded BrainChip4MED project aims to develop an in vitro model for studying brain-targeting nanocarriers as drug vehicles to the brain. Researchers will employ brain-on-a-chip (BoC) technology to generate a microfluidic-based model and combine it with multiplex biosensors to screen various drugs in real time. The project will focus on drug leads for the treatment of Alzheimer’s disease. More information: https://cordis.europa.eu/project/id/101032481
Project
The goal of SensBrain4Med is to address the current challenges by developing an efficient Blood Brain Barrier-Brain model, equipped with a monitoring multiplexed biosensing system that allows the accurate, automatic and continuous measurement of key-biomarkers secreted by the brain models (both healthy and diseased), during nanotherapeutic studies. The strategy goes through incorporating a multiarray of biosensors within Brain-on-a-chip, putting this project at the forefront of the most advanced technological solutions to provide truthful analytical information of new nanoformulations developed for neurodegenerative diseases, particularly Alzheimer.
Project
The RTChip4Theranostics’s vision is to improve the clinical translation of drug delivery nanocarriers for cancer theranostics, providing magnetic resonance imaging and lowering the amount of anticancer drug needed for a therapeutic effect, so minimizing the common side effects of chemotherapy. Its focus is the development of an organ-on-a-chip, being the liver its first target, with integrated pH and temperature micro(bio)sensors, capable to assess the efficacy of drug delivery nanocarrier systems designed for cancer therapy. These micro(bio)sensors will add essential diagnostic and therapeutic information, allowing real-time and long-term biostudies. In parallel GBMNPs will be optimized as intelligent and on-demand drug delivery systems with pH-dependent controlled release. Additionally, the developed liver-on-a-chip with integrated micro(bio)sensors will be used to evaluate the toxicity and efficacy of the graphene-based magnetic nanoparticles (GBMNPs) screened as dual pH- and thermo- responsive drug delivery nanocarriers.