Raquel Mayordomo

Universidad de Extremadura, Plasencia, Cáceres, Spain · Anatomy, Celullar Biology and Zoology

Onychomycosis is a common fungal infection that affects the nails and accounts for approximately 50% of all nail diseases. The main pathogens involved include dermatophytes, such as Trichophyton rubrum, members of the T. mentagrophytes complex, and emerging pathogens in this infection, T. schoenleinii and T. tonsurans. Tea tree (Melaleuca alternifo...

Background: There are evidence indicating that some metabolites of arachidonic acid produced by cytochromes P450 (CYP) and epoxide hydroxylase (EPHX2), such as hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) or dihydroxyeicosatrienoic acids (DHETEs), play an important role in blood pressure regulation and they could contrib...

The toenail unit, commonly called the nail, is one of the most frequently examined and treated structures in clinical podiatry. Ultrasound is a standard clinical technique because it is a noninvasive, painless, and rapid diagnostic tool. The main objective of this study was to obtain morphometric data of the healthy toenail unit by ultrasound for c...

Human papillomavirus is the ethological agent of various tumors, including plantar warts as one of the most frequent clinical presentations. Diagnosis of these warts continues to be mainly clinical, and a significant incidence of misdiagnosis leads to inadequate treatment. The aim of this study is to implement and validate a multiplex PCR detection...

Purpose Obesity is a growing health problem that affects a high percentage of the population. In podiatry context, few studies have addressed obesity because most pedobarographic systems are unable to bear the weight of patients with obesity, making it difficult to examine and manage these patients. The objective of this study was analyzed the soci...

Onychomycosis is usually diagnosed symptomatically due to the very clear signs caused by the fungus on the nail surface and structure, although the growth of the infecting agent must also be verified by culture in an enriched medium. This procedure is normally lengthy (four weeks), and samples can be contaminated, delaying the prescription of appro...

Anthropometry and kinanthropometry are sciences that measure variations in the physical dimensions and composition of the human body. There are studies that analyze these parameters individually, but we believe that it is much better to analyze them globally. We realized a multivar-iate analysis, to determine which variables could explain the profi...

The use of photogrammetry provides an inexpensive, alternative method that can simplify the processes traditionally carried out in the orthotics workshop. The objectives of this study are to develop a method based on photogrammetry to obtain 3D-printed positive foot casts for fabricating thermoconformed orthoses from a negative cast in phenolic foa...

Nail consistency is a little studied characteristic of the nail plate. Numerous factors can influence its determination, including the anatomy of the nail apparatus, the structure of the nail plate, and the type and quantity of keratins present. To study the relationship between nail consistency and the expression level of type I keratins, a sample...

Background: Onychomycosis, or fungal nail infection, is the cause of 50% of onychopathies seen by podiatric physicians. This pathology is accompanied by a negative psychosocial component because of its effect on self-image, which is an essential part of social relations. Conventional pharmacologic treatment based on antifungal agents is lengthy and...

Aims: This work examines the available scientific evidence about the efficiency of essential oils (EO) as an alternative therapy to traditional treatment of fungal infections, including onychomycosis, assessing the effect of the three EO most frequently studied for their antifungal activity (thyme, cinnamon and tea tree EO) against three causative...

Abstract: The nail plate is one of the essential structures of the nail apparatus and is highly keratinized, making it difficult to handle this tissue experimentally. Different types of nail consistency were identified by applying distal pressure to the nail plate. To analyze the relationship between the keratins expressed in the nail plate and nai...

Onychomycosis and human papillomavirus (HPV) plantar warts are common in clinical practice. Clinical diagnosis is based on searching for pathognomonic signs and symptoms. However, due to misdiagnosis, podiatrists may unnecessarily prescribe antifungal treatments or burn lesions with chemical agents. The objective of this study was to assess podiatr...

Personal hygiene is one of the basic activities in the care of our body. Parents are responsible for their children’s hygiene to prevent infections and keep them healthy. However, children must acquire hygiene habits correctly and independently. This study examines the sociodemographic profile, hygiene habits and knowledge, and level of autonomy of...

Onychomycosis is the main cause of toenail disorders and is produced by a fungal infection. It is becoming more prevalent because of new lifestyles and immunosuppression statuses. The therapeutic approach to onychomycosis is under considerable study because of the lengthy treatments that require strong patient commitment, the limited efficacy of tr...

Introduction Human papillomavirus has been reported as the etiological cause of most cervical cancers and other potentially malignant lesions. It also affects other areas, producing benign tumors on the skin. Plantar warts are a common problem found in clinical practice and share signs and symptoms with other dermatological conditions. Diagnosis of...

During confinement, each University student has dealt with their emotions and what this entails in the best possible way: stress, anxiety, seeing how their performance decreases, sedentary lifestyle, etc... At the University Center of Plasencia, from the Student Orientation Plan and from the GIDUBEX we have carried out a study in which 321 students...

Background Maintaining autonomy is one of the principal objectives for seniors and people with psychiatric disorders. Podiatric medical care can help them maintain autonomy. This work aimed to characterize and quantify the support of the toes in a psychiatric population by analyzing the influence of psychotropic medications and toe and foot support...

Onychomycosis is one of the most frequent reasons for visiting podiatrist clinics. Complementary tests and the accurate identification of the infectious agents are key issues for a successful treatment of onychomycosis. This is particularly important when lifestyle, age and immunodepressed patients increase the prevalence of non-dermatophyte fungal...

Nail disorders are the most frequent reason for visits to the podiatry clinic. Although they are not a severe health problem, these types of pathologies have a psychosocial impact on patients, affecting their self-esteem and leading to social and professional self-isolation that can cause anxiety and depression. Laser therapy is considered a potent...

Introduction Onychomycosis is the main cause of nail alteration. Hepatotoxicity, interference and low adherence to pharmacological treatment are associated. Therefore, our objective was to assess the in vitro effectiveness of tea tree essential oil (less harmful) against main causative agents of these infections. Material and methods Thrichophyton...

DESARROLLO DE UN MOLDE POSITIVO DEL PIE EN IMPRESIÓN 3D PARA SU USO EN PRÁCTICAS DE PODOLOGÍA La obtención de moldes de los pies para la elaboración de ortesis plantares, es una de las competencias específicas que todo estudiante de podología debe adquirir durante su formación universitaria. El estudiante, debe adquirir las habilidades prácticas pa...

RECURSOS 3D PARA EL APRENDIZAJE PRECLÍNICO EN PODOLOGÍA CON MODELOS DE UÑA El podólogo es un profesional sanitario autónomo con conocimientos, habilidades y aptitudes para realizar la prevención, el diagnóstico y el tratamiento de las afecciones de los pies, mediante procedimientos propios de su disciplina. Para ejercer la Podología es necesario re...

Kinanthropometry allows us to analyze variations in physical dimensions and body composition. This study’s objective was to evaluate the kinanthropometric differences based on physical activity performance, depending on whether the lower body or the whole body is more or less potent and the differences with a sedentary population. We analyzed 131 i...

Dispositivo para la obtención de medidas para la determinación de la consistencia de una lámina ungueal de una uña de un usuario "in vivo". La lámina ungueal comprende un borde libre y está asociada a un lecho ungueal, caracterizado porque el dispositivo comprende un mecanismo de presión adaptado para aplicar fuerza puntual sobre el borde libre de...

This work presents an identification procedure of flexural behavior of toenail plates in twenty subjects with no history of feet or nails injury as of in-vivo measurements. In particular, four different mechanical models are considered to describe such properties, ranging from the pure elastic to viscoelastic, the latter from the classical and frac...

Simple Summary: Scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS) is a useful technique to analyse elemental composition in the nail plate. The dorsal, intermediate, and ventral layers are differentiated by the levels of the elements present in each layer. The level of calcium in the dorsal layer is the main predictiv...

Human anatomy is a core subject that students of all health degrees are required to pass. Practical classes with human cadavers are a widely used educational resource in medicine, but are less frequent in other health degrees. Determining how first-year podiatry, nursing, and physiotherapy students cope with human anatomy practical classes and iden...

Introduction: Onychomycosis is the main cause of nail alteration. Hepatotoxicity, interference and low adherence to pharmacological treatment are associated. Therefore, our objective was to assess the in vitro effectiveness of tea tree essential oil (less harmful) against main causative agents of these infections. Material and methods: Trichophy...

Chronic kidney disease (CKD) is a major health problem worldwide and, in Spain, it is present in 15.1% of individuals. CKD is frequently associated with some comorbidities and patients need to be prescribed multiple medications. Polypharmacy increases the risk of adverse drug reactions (ADRs). There are no published studies evaluating the prevalenc...

Background Chronic kidney disease (CKD) is a public health disease that affects 15.1% of the adult population. Although a high prevalence (94.1%) of skin disorders has been detected in people on haemodialysis or with advanced CKD, few studies have analysed foot disorders at initial CKD stages. Objectives To analyse the prevalence of foot disorders...

Introducción: Para el correcto diagnóstico de la onicomicosis es fundamental realizar una adecuada toma de muestra. Objetivo: Evaluar la competencia de los alumnos del grado en Podología en la realización de la toma de muestra ungueal como experiencia preclínica y clínica. Métodos: Estudio observacional, descriptivo y transversal, realizado sobre...

Background: There are various treatment protocols to manage the increased bacterial load in plantar ulcers. Recently, Controlled-Flux Electrolyzed Acidic Solution (CFEAS), with a pH less than 3, has appeared to be an effective option since its antimicrobial effect could help in the healing of those ulcers. In order to evaluate its potential in thi...

Background and objectives: Foot lesions can be developed during hiking because of external factors. This makes it important to study the effect of hiking equipment on lesion development. Materials and Methods: Technical and non-technical socks were given to 109 hikers to wear during a short hike. Participants were examined at three stages of the hi...

Abstract Hiking has become very popular due to the physical and mental health benefits it provides. Skin lesions may occur with hiking and various factors contribute to their development. Although some lesions may appear to have little importance, something as simple as chaffing can cause serious ulcers in people with at-risk feet. Few studies have...

Few studies have focused on the relation between the use and characteristics of footwear and the presence of foot lesions in people with psychiatric disorders. This work analyzes the influence of different footwear habits on the presence of deformities and ungueal and dermal pathologies of the foot of institutionalized people with psychiatric disor...

Introduction: Forefoot morphology is determined by toe length. It is hereditary and unlikely to change during a person’s lifetime, although certain factors may lead to modifications. This study examines whether extrinsic factors such as footwear or deformities are associated with changes in the morphology of the forefoot and its pathologies. Materi...

Introducción: Las tendinopatías crónicas son patologías degenerativas frecuentes en la extremidad inferior y en personas que realizan deporte. Este trabajo revisa la bibliografía existente sobre la eficacia de la técnica de electrolisis percutánea, como uno de los tratamientos más novedosos en cuanto a la regeneración de tendones, para resolver sus...

Background: This study examines the possible influence of factors such as nail shape and consistency, sex, and sports activity on the development of the most common nail disorders in a population of young people. Methods: The nail plates of 140 young people (66 females and 74 males) were studied. Of these 140 participants, 72 were runners who tr...

Abstract Objective: The aim of this study is to analyze different foot type in a young population and its relation to pathologies of the forefoot and other factors as age and sex. Material and Methods: we conducted a descriptive study of 103 participants and determined the foot type and the presence of digital deformity. Results: We can say in our...

Background: Dermatomycoses are a group of pathologic abnormalities frequently seen in clinical practice, and their prevalence has increased in recent decades. Diagnostic confirmation of mycotic infection in nails is essential because there are several pathologic conditions with similar clinical manifestations. The classical method for confirming t...

Orchestrated proliferation, differentiation, and cell death contribute to the generation of the complex cytoarchitecture of the central nervous system, including that of the neuroretina. However, few studies have comprehensively compared the spatiotemporal patterns of these 3 processes, or their relative magnitudes. We performed a parallel study in...

This study has focused on describing the relationship between the presence of Os peroneum and the development of peroneal tendinopathy caused by the existence of a friction syndrome between the sesamoid bone and the peroneus longus muscle. The subject studied was a young athlete who has diffuse burning pain in the side of the right leg. The differe...

Programmed cell death is a genuine developmental process of the nervous system, affecting not only projecting neurons but also proliferative neuroepithelial cells and young neuroblasts. The embryonic chick retina has been employed to correlate in vivo and in vitro studies on cell death regulation. We characterize here the role of two major signalin...

El Liquen Plano es una dermatopatía caracterizada por la aparición de pápulas pruriginosas extendidas por todo el cuerpo incluyendo la afectación a nivel del pie y de las uñas. El presente artículo además de hacer una revisión de la epidemiología, etiología, el diagnóstico diferencial, las enfermedades asociadas, la histología, la evolución y el tr...

Este articulo presenta una serie de terapias complementarias en relación con diferentes patologías del pie. Estas terapias nos serán de gran ayuda como coadyuvantes en los tratamientos podológicos de afecciones frecuentes como papilomavirus, dermatofitosis y onicomicosis.

Programmed cell death occurs during both early and late neural development. The mechanisms for the regulation and execution of the early cell death as well as its developmental role are still not fully understood. In this work we have studied the early programmed cell death in the retinal neuroepithelium. Apoptotic cells were selectively located ar...

GDNF and the GDNF receptors, c-Ret, GFR alpha 1 and 2 mRNA is expressed in the developing chicken retina. GDNF labelling was mainly found in embryonic day 4-5 retina but weak labelling could also be found over scattered retinal cells at later stages. c-ret labelling was found over ganglion cells, amacrine and horizontal cells; the preferred GDNF re...

GDNF and the GDNF receptors, c-Ret, GFRalpha1 and 2 mRNA is expressed in the developing chicken retina. GDNF labelling was mainly found in embryonic day 4-5 retina but weak labelling could also be found over scattered retinal cells at later stages, c-ret labelling was found over ganglion cells, amacrine and horizontal cells; the preferred GDNF rece...

Proliferation, cell death and differentiation occur simultaneously in developing retina and are precisely orchestrated. We have studied the effects of biotin (vitamin H) on early retinal development. In vivo administration of biotin to early embryonic chick eyes at moderately elevated levels induced malformations, affecting retina and lens structur...

Cell death in the developing retina is regulated, but so far little is known about what factors regulate the cell death. Several neurotrophic factors and receptors, including the neurotrophins and Trk receptors, are expressed during the critical time. We have studied the developing avian retina with respect to the role of nerve growth factor (NGF)...

Natural occurring cell death has been recognised as a feature of normal vertebrate development (Glucksman, 1951; Saunders, 1966). We have studied the temporal and cellular patterns of cell death in the developing chicken retina using the terminal transferase dUTP nick end-labelling (TUNEL) technique. This technique was combined with other methods t...

Best macular dystrophy is an autosomal dominant disease leading to macular degeneration and subsequent impaired vision. The disease has juvenile onset and affects the retinal pigment epithelium and adjacent photoreceptors. There are histopathological similarities between Best macular dystrophy (BMD) and age-related macular degeneration (AMD) with a...

The formation of the midbrain region depends mainly on the activity of a signalling center located in the isthmus region, on the border between the prospective mesencephalon and metencephalon. FGF-8 has been proposed as a signalling molecule responsible for this specification because of its expression pattern and its ability to elicit duplication o...

In a previous study, a monoclonal antibody (MAB) named GL1 was identified that is expressed in a precise pattern during gastrulation and early neurulation stages in chick embryos. In this article we have further investigated the expression pattern of this MAB in the chick embryo. GL1 antigen is present in several organs that seem not to be related...

Careful histological observation of the development of the anlage of the inner ear in chicken embryos led us to question the traditional view of otic placode (OP) formation. First, morphological studies in the cephalic region carried out on stages preceding the appearance of the placodal epithelium revealed that the medial placodal cells are contin...

Careful histological observation of the development of the anlage of the inner ear in chicken embryos led us to question the traditional view of otic placode (OP) formation. First, morphological studies in the cephalic region carried out on stages preceding the appearance of the placodal epithelium revealed that the medial placodal cells are contin...