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Ranjita Shegokar

Ranjita Shegokar
Capnomed GmbH and Freie Universität Berlin

PhD
www.ranjitas.com

About

75
Publications
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3,230
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Introduction
Ranjita Shegokar currently associated with Capnomed GmbH and Freie Universität Berlin. Her most recent publication is 'Lipid-Based Nanoparticles for Targeted Drug Delivery of Anticancer Drug.' visit my website - www.ranjitas.com

Publications

Publications (75)
Article
Background Icodextrin (IDX) is an antiadhesive polymer that can be used as a carrier solution for intraperitoneal (IP) delivery of chemotherapeutic drugs. Methods We investigated the suitability of IDX solution as a carrier of Cisplatin and Doxorubicin for delivery as pressurized intraperitoneal aerosol chemotherapy (PIPAC). We examined the spraya...
Article
Full-text available
Aims: To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Methods: Positively and negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine...
Article
In recent years, SLNs and NLCs are among the popular drug delivery systems studied for delivery of lipophilic drugs. Both systems have demonstrated several beneficial properties as an ideal drug-carrier, optimal drug-loading and good long-term stability. NLCs are getting popular due to their stability advantages and possibility to load various oil...
Chapter
The current progress of modern medicine is based on the resistance of malignant tumors in advanced medical treatments, as well as on the need to develop new therapeutic approaches. In the last few years, numerous studies have focused their attention on the promising use of nanomaterials, such as nanowires, zinc oxide, or mesoporous silica nanoparti...
Chapter
Current societal challenges demonstrate the added value of nanotechnology in improving several goods in a set of industries (e.g., pharmaceuticals, nutraceuticals, cosmetics, medical devices). Along with the unprecedent technological developments, ethical issues are posed to scientists, regulators, and users as new materials with new functionalitie...
Chapter
Nowadays research effort on nanotechnologies for pharmaceutical has shown that many nanodrug delivery systems (including nanocrystalline suspension, emulsion, liposomes, polymeric nanoparticles, lipid nanoparticles) can be used as enabling technologies to overcome the associated issues with hydrophobic API (poor water solubility, injection of low d...
Chapter
Preclinical testing is the link between drug discovery and availability to the patient. It takes at least 12–15 years for a drug to get from the lab to clinical use. Chemical agents are synthesized or obtained by other high-throughput methods. These compounds are then tested for their effectiveness on the biological target. Various parameters such...
Book
Full-text available
A comprehensive review of scientific and regulatory advances in the application of nanotechnology to immunology and toxicology during recent years. • Provides the reader a thorough knowledge of the safety aspects of nanopharmaceuticals which are currently under research. • Focuses on the characterization and quantification of the nanopharmaceutical...
Chapter
Lipid nanoparticles are widely explored in many therapeutic, targeting, and imaging areas. Among the various nanoplatforms, lipid-based nanostructures offer better attributes to drug delivery, such as high loading capacity, biocompatibility, improved physicochemical and long-term stability, ease of surface modification, adjustable drug release, and...
Chapter
Lipid nanoparticles offer multifaceted drug delivery to cancer. To date, various lipid nanoparticles, ranging from phospholipid-based liposomes to second generation solid lipid nanoparticles, i.e., nanostructured lipid nanoparticles are explored for drug delivery of anticancer drugs. An ample amount of research has been done on emulsions (in nano o...
Chapter
Recent years have witnessed an extraordinary increase in number of research studies on understanding fundamental and applied uses of metal nanoparticles. In all these studies, various aspects of metal nanoparticles like type of metal, nanoparticle size, and shape of nanoparticle and shape-dependent properties are studied. Metal nanoparticles are be...
Article
Nanostructured lipid carriers (NLCs) of Leonotis leonurus were successfully produced using high-pressure homogenisation (HPH) on a LAB 40 homogeniser. The particle size was determined for the formulation as well as short-term stability study. The formulation was exposed to Chang liver cells for a glucose uptake study and to INS-1 cells for a chroni...
Book
Completely dedicated to the biomedical applications of metal nanoparticles, this book covers the different toxicity problems found in healthcare situations and also provides comprehensive info on the use of metal nanoparticles in treating various diseases. Metal Nanoparticles in Pharma is the first edited volume to set up the discussion for a clini...
Chapter
Full-text available
Lipid based nano drug delivery systems have gained momentum over the decades due to their role in improving bioavailability, controlling and targeting actives, enhancing stability and also as vaccine adjuvants. Their popularity over polymeric nanoparticles has been due to their excellent biocompatibility and ease during formulation (Muchow et al. 2...
Chapter
Nanocrystals are pure drug particles stabilized by surfactants without any surrounding polymer or lipid matrix. They mainly offer an advantage over other drug-delivery systems of severalfold enhancements in solubility. It is a fast-growing industrially feasible technology and is currently flourishing in the pharma and cosmetics industries. Several...
Chapter
Nanotechnology is being widely studied in bone repair or regeneration treatments in the form of scaffolds because of improved efficacy and selective targeting in comparison to conventional approaches. Nanoparticle-based drug delivery is a choice in many conditions, such as bone infections, cancer bone metastasis, osteosarcoma, inflammatory diseases...
Chapter
Nanotechnology is a smarter way to apply a multimodal approach in biomedical science, especially in the therapeutic, targeting, and imaging areas. Among the various nanoplatforms, polymeric and lipid-based nanostructures have been of considerable interest to drug-delivery formulators due to the complementary functional advantages of both lipids and...
Article
Introduction: Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties and well-established safety profile; prime requisites considered during the selection of any excipient in formulation development. Areas covered: The individual properties and applications of...
Chapter
Cell-based drug delivery (CBDD) is explored widely to target particular organs (e.g., spleen, lungs, etc.) in cancer, tissue inflammation, or in bone injury. Highly mobile cells like mononuclear phagocytes (dendritic cells, sertoli cells, monocytes, and macrophages), neutrophils, and lymphocytes loaded drug nanocarriers are exploited as Trojan hors...
Chapter
Drug synthesis, high-throughput screening generates billions of poorly soluble drugs which are neglected in further developments due to solubility issues. In the last 20 years, nanonization by milling is being effectively used commercially to save these drugs by overcoming solubility problems in commercial way. Various labs at industry and academic...
Chapter
Proof of drug resistance and failure of antiretroviral therapy due to administration of suboptimal doses has been shown in the past. A greater understanding of HIV-1 virus, its replication, transmission, and resistance mechanisms are basic tools to fine-tune drug discovery efforts to obtain the right candidate with specific pharmacological antiretr...
Article
Full-text available
The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready availability and most importantly cost. The aim of this work was to develop affordable microbicide mucoadhesive gel formulation of synthetic anti HIV drug, stavudine and to characterise it in terms of its physical properties, mucoadhesiveness and sp...
Chapter
Electrophoresis is widely used in pharmaceutical field for multiple applications. It is mainly employed for protein separation and identification. The information obtained on protein content and composition from multiple gel electrophoresis provides basic knowledge required for drug design, biomarker, vaccine, and antibiotic research. Furthermore,...
Chapter
Full-text available
Early years are proof of nanoparticle developments and understanding basic mechanisms. With no doubt, nanotechnology based drug delivery systems are very effective to achieve improved therapeutic effects in vivo and properties in vitro. Drug discovery programs are generating pharmacologically promising drug candidates but they suffer from solubilit...
Chapter
Few last decades witnessed increasing research reports on flavonoids because of their wide range of applications. Flavonoids have been used in completely different fields ranging from the food industry to medicine. Apigenin is one of the several flavonoids being researched and reported to have relatively low toxicity compared to other flavonoids. T...
Article
Full-text available
p>The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready availability and most importantly cost. The aim of this work was to develop affordable microbicide mucoadhesive gel formulation of synthetic anti HIV drug, stavudine and to characterise it in terms of its physical properties, mucoadhesiveness a...
Article
Full-text available
Till date scientists are struggling to understand the complete mechanism of carcinogenesis. In future, the real time detection of cancer may help scientists to identify some of the complicated biological mechanisms. Certain special features of cancer cells enable researchers to deliver the drug or to develop the right drug therapy. These cell prope...
Article
Sepsis is a clinical syndrome characterized by a multisystem response to a pathogenic assault due to underlying infection involves conglomerate of interconnected biochemical, cellular, and organ-organ interaction networks. After withdrawal of recombinant human activated protein C (rAPC), researchers and physicians have been striving in search of ne...
Chapter
The unique properties of graphene are attracting a significant amount of attention from scientists for various biomedical applications. Several attempts have been already made to functionalize the surface of graphene oxide with polymers, surfactants and other chemical moieties in an attempt to increase cellular uptake, to target a particular organ,...
Chapter
Anthelmintics are commonly used to treat parasitic worm infections in human and animals. These parasitic worms infect crops, domestic pets and livestock. Helminth, being tropical infectious disease gets less attention from developed world. The main chemotherapeutic agents used in humans are mainly adapted from veterinary medicine. Among them only f...
Article
Coenzyme Q10 (Q10) has a poor bioavailability due to its very low aqueous solubility and high molecular weight. The purpose of this review is to discuss the different types of Q10 drug delivery systems (DDS) ranging from the simple oily dispersions to the nanotechnology-oriented systems such as nanocrystals, self-nanoemulsified drug delivery system...
Article
Objective: To prepare stable and easy to handle formulation of solid lipid nanoparticles (SLNs) by freeze-drying with or without cryoprotectants, as appropriate. Materials and methods: SLNs were freeze-dried without cryoprotectants or with cryoprotectants in quantities selected by freeze-thaw test (sucrose, glucose) or literature search (trehalo...
Article
Abstract Nicergoline, a poorly soluble active pharmaceutical ingredient, possesses vaso-active properties which causes peripheral and central vasodilatation. In this study, nanocrystals of nicergoline were prepared in an aqueous solution of polysorbate 80 (nanosuspension) by using four different laboratory scale size reduction techniques: high pres...
Article
Full-text available
Liposomes as a drug delivery system provides a leading approach for the systemic (intravenous) administration of drugs. Several approaches to kill tumor cells specifically have been developed, but still there is dearth in their selectivity. Among all other nano-carrier systems, liposomal formulations of cytotoxic drugs have received an appreciable...
Article
Full-text available
Most of the infectious diseases depending upon the stage of infection need treatment at least for a month to several years e.g. tuberculosis, acquired immunodeficiency syndrome. Medication by oral administration is of choice in all treatments, but unfortunately use of large doses resulting from drug poor solubility and bioavailability leads to toxi...
Article
This study aimed to examine the long-term physical stability of quercetin nanocrystals produced by three methods. Quercetin nanocrystals were prepared by high pressure homogenization, bead milling and cavi-precipitation. The nanocrystals produced by these methods were compared for particle size, saturation solubility and dissolution of the drug par...
Article
Full-text available
The feasibility of preparing lyophilized or spray dried forms for reconstitution into nanosuspension (NS) was investigated in this study. The bare and surface modified aqueous NS of nevirapine were successfully converted into an anhydrous form by both techniques. The optimization of suitable cryoprotectant is essential to obtain completely dry prod...
Article
To achieve successful delivery of drug locally as well as systematically rectal route has proved its potential. The main objective of this research work was to evaluate the in vivo performance of paracetamol Suppocire CP suppository. Initially, suppositories were prepared, evaluated for their physicochemical parameters and in vitro drug release. An...
Article
Carotenoids play a major role in scavenging singlet oxygen and peroxyl radicals in human. Several studies have shown that lutein and zeaxanthin help to protect the skin and eyes from photodamage and offer several other health benefits. The potential benefits of using lutein as nutritional or cosmetic ingredient are reviewed in this paper. Recent ad...
Article
Full-text available
Surface hydrophobicity of nanocarriers influences protein binding and subsequently fate of nanoparticles in blood circulation. Therefore, characterization of surface hydrophobicity of nanocarriers provides important preclinical information. Here, a modified classical adsorption method for the needs of characterization of cationic solid lipid nanopa...
Article
Full-text available
To achieve successful delivery of drug locally as well as systematically rectal route has proved its potential. The main objective of this research work was to evaluate the in vivo performance of paracetamol Suppocire CP suppository. Initially, suppositories were prepared, evaluated for their physicochemical parameters and in vitro drug release. An...
Article
Full-text available
Lipospheres of stavudine were prepared by melt dispersion technique using trimyristin, tripalmitin and triastearin, stearic acid, Compritol® 888 ATO and Precirol® ATO 5 as lipid matrix in the various drug-lipid ratios. Drug entrapped free flowing solid lipospheres of triglycerides and glyceryl behenate were characterized for surface morphology, par...
Article
Cationic solid lipid nanoparticles (cSLN) are promising lipid nanocarriers for intracellular gene delivery based on well-known and widely accepted materials. cSLN containing single-chained cationic lipid cetyltrimethylammonium bromide were produced by high pressure homogenization and characterized in terms of (a) particle size distribution by photo...
Article
The main aim of this study was to prepare quercetin nanocrystals using three fabrication methods, viz. high-pressure homogenization, bead milling, and cavi-precipitation. The three fabrication methods were compared in terms of particle size, saturation solubility, and dissolution of the products obtained. The average particle size of the coarse que...
Article
Lutein is a well known antioxidant and anti-free radical used in cosmetic, nutraceutical industry with potential application in pharmaceutics as supportive antioxidant in treatments. As lipophilic molecule it is poorly soluble in water and has a low bioavailability. Lutein nanosuspension was prepared to enhance dissolution velocity, saturation solu...
Article
Flavonoids have many positive effects on various cell layers of the skin (e.g. anti-oxidant, anti-allergic and anti-inflammatory effects). However, the limiting factor of the use of flavonoids is their low water solubility. To overcome the poor solubility, apigenin nanosuspensions were prepared using the combination technology (CT), i.e. bead milli...
Article
Full-text available
Increasing number of antiretroviral drugs coming from high throughput screening besides their high dose has poor solubility profile. Formulation development of these drugs is a major obstacle to their clinical application. To overcome extremely low water solubility and associated poor bioavailability they can be formu-lated as nanosuspensions. This...
Article
Full-text available
In this paper we discuss, production, characterization and in-vivo evaluation of nevirapine nanosuspensions. Laser diffraction showed that the average particles size was 457 nm. Following single-dose administration, the plasma gamma concentration profiles showed fast release. Macrophage uptake studies confirmed enhanced cellular uptake for nanonize...
Article
Topical application of lutein as an innovative antioxidant, anti-stress and blue light filter, which is able to protect skin from photo damage, has got a special cosmetic and pharmaceutical interest in the last decade. Lutein is poorly soluble, and was therefore incorporated into nanocarriers for dermal delivery: solid lipid nanoparticles (SLN), na...
Article
Full-text available
Gene silencing by RNA interference is a rapidly growing therapeutic area for managing diseases. Despite research advances in this direction, the poor cellular uptake of synthetic small interfering RNAs is a major impediment to their clinical applications. Polymer and lipid-based systems are attractive carrier systems for delivery of siRNA and provi...
Chapter
Drug nanocrystals are a formulation principle for systemic and also intracellular delivery of poorly soluble drugs. Their production by bottom up tech­iques (precipitation – hydrosols, Nanomorph) and by top down techniques (bead milling – NanoCrystal®, high pressure homogenization – DissoCubes®, NANOEDGE®) is briefly described, representing the fir...
Article
Full-text available
Nanotechnology has offered enormous improvement in field of therapeutics by means of designing of drug delivery systems and opened the possibility of controlling infections at the molecular level. Nanocarriers can cross biological barriers and are able to target cellular reservoirs of Mycobacterium tuberculosis (M. tuberculosis). Nanoparticle-based...
Article
Full-text available
The main objective of present research study was to evaluate the potential of lipid nanoparticles for active delivery of an antiretroviral drug to lymphatic tissues. Stavudine entrapped drug loaded solid lipid nanoparticles (SLNs) were prepared and characterized for a variety of physicochemical parameters such as appearance, particle size, polydisp...
Article
In 1990, the lipid nanoparticles were invented in the laboratories, the first patent filings took place in 1991. The lipid nanoparticles were developed as alternative to traditional carriers such as polymeric nanoparticles and liposomes. After 20 years of lipid nanoparticles, the present state of development is reviewed - academic progress but also...
Article
Freeze-drying has been considered as an advanced and reliable technique to improve the long-term stability of colloidal nanoparticles. Stavudine loaded solid lipid nanoparticles (SLN) suitable for parenteral administration were converted into dry product. The lipid matrix Trimyristin (2.0 w/w %) was stabilized using combination surfactant system. T...
Article
Freeze-drying has been considered as an advanced and reliable technique to improve the long-term stability of colloidal nanoparticles. Stavudine loaded solid lipid nanoparticles (SLN) suitable for parenteral administration were converted into dry product. The lipid matrix Trimyristin (2.0 w/w %) was stabilized using combination surfactant system. T...
Article
Full-text available
The production of nanocrystals was scaled up from lab scale (20 g) to pilot scale (3 kg), scale up factor 150. The flavonoid apigenin was used as model compound, with potential for pharma, cosmetic and nutraceutical products. Lab scale production was performed by high pressure homogenization (HPH), pilot scale by applying the smartCrystal combinati...
Article
Poor solubility of new drugs and their related low oral bioavailability and general delivery problems are becoming a major challenge. Nanocrystals being a kind of "universal" formulation approach for these molecules are reviewed in this paper regarding the industrial feasibility, i.e. industrially available production processes (bottom-up and top-d...
Article
Full-text available
The purpose of this article was to investigate the feasibility of incorporating didanosine (DDI) into nanostructured lipid carriers (NLC) for potential treatment of AIDS dementia complex. Aqueous DDI-free and DDI-loaded NLC were manufactured using hot high-pressure homogenization. The lipid matrix contained a mixture of Precirol® ATO 5 and Transcut...
Article
Full-text available
Paracetamol is commercially available in oral and rectal dosage forms for geriatric and pediatric patients. Limitation of oral drug delivery for pediatric patient is inconvenience to swallow the tablet, capsule and oral suspension; in such case suppositories are effective and often used. To achieve successful delivery of drug locally as well as sys...

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Projects (2)
Project
Background: Manuscripts/write ups are invited on innovative drug delivery systems (academics/industry/collaboration). Selected authors will be contacted personally. Kindly send write up along with email id. Goal: To bring together all novel ideas on DD
Archived project
Nanopharmaceuticals in immunology- Screen various DDS