Ranjit K Harwansh

GLA University · Institute of Pharmaceutical Research

Background This study developed a UV spectrophotometric method for quantifying allopurinol and lycopene in both bulk and dosage forms, aiming for simplicity and practicality. Materials and Methods The method was developed and validated using methanol and lyco-pene in phosphate buffer saline at various pH levels (7.4, 6.8, 1.2, 5.5). Validation par...

Introduction Mangiferin shows great promise as a potent drug for a wide variety of diseases. Its low bioavailability and poor water solubility, however, restrict its therapeutic use. Methods The aim of the study goal was to systematically design a UV-spectroscopy method for mangiferin quantification in analytical samples that is quick, easy, and v...

Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from...

Cancer is a serious health problem and one of the leading causes of death in humans in both developing and underdeveloped countries. Researchers are using nanotechnology to improve the specificity and effectiveness of cancer therapy as the number of cancer cases worldwide increases daily. The aim of this bibliometric analysis is to examine current...

Since the earliest days, people have been employing herbal treatments extensively around the world. The development of phytochemical and phytopharmacological sciences has made it possible to understand the chemical composition and biological properties of a number of medicinal plant products. Due to certain challenges like large molecular weight an...

Among the primary causes of mortality in today's world is cancer. Many drugs are employed to give lengthy and severe chemotherapy and radiation therapy, like nitrosoureas (Cisplatin, Oxaliplatin), Antimetabolites (5-fluorouracil, Methotrexate), Topoisomerase inhibitors (Etoposide), Mitotic inhibitors (Doxorubicin); such treatment is associated with...

Rheumatoid arthritis, in short called as RA, is a severe auto-immune condition characterized by thickening of the synovium joints, inflammation and soreness of joints, which subsequently destroys the articular structures. The drug used to treat RA requires the delivery of a formulation in intact form to synovial joints and release of a whole amount...

Citation: Deshmukh, R.; Singh, V.; Harwansh, R.K.; Agrawal, R.; Garg, A.; Singh, S.; Elossaily, G.M.; Ansari, M.N.; Ali, N.; Prajapati, B.G. Emerging Trends of Nanomedicines in the Management of Prostate Cancer: Perspectives and Potential Applications. Pharmaceutics 2024, 16, 297. https://doi. Abstract: Prostate cancer is one of the most life-threa...

SARS-CoV-2 is a highly contagious and transmissible viral infection that first emerged in 2019 and since then has sparked an epidemic of severe respiratory problems identified as “coronavirus disease 2019” (COVID-19) that causes a hazard to human life and safety. The virus developed mainly from bats. The current epidemic has presented a significant...

Ulcerative colitis (UC) is a multifactorial disorder of the large intestine, especially the colon, and has become a challenge globally. Allopathic medicines are primarily available for the treatment and prevention of UC. However, their uses are limited due to several side effects. Hence, an alternative therapy is of utmost importance in this regard...

Malaria is still a major endemic disease transmitted in humans via Plasmodium-infected mosquitoes. The eradication of malarial parasites and the control measures have been rigorously and extensively deployed by local and international health organizations. Malaria's recurrence is a result of the failure to entirely eradicate it. The drawbacks relat...

Inflammatory bowel disease (IBD) is a life-threatening complex disease. It causes chronic intestinal inflammation in GIT. IBD significantly affects people’s lifestyles and carries a high risk of colon cancer. IBD involves the rectum, ileum, and colon, with clinical manifestations of bloody stools, weight loss, diarrhea, and abdominal pain. The prev...

Resveratrol (RSV) is a polyphenolic phytoalexin, and belongs to the stilbene family. RSV has several therapeutic activities such as cardioprotective, anticancer, and antioxidant. Apart from its therapeutic benefits, its pharmacological uses are limited due to low solubility, poor bioavailability, and short biological halflife. A researcher continuo...

Cancer is the deadliest and most serious health problem. The mortality rate of cancer patients has increased significantly worldwide in recent years. There are several treatments available, but these treatments have many limitations, such as non-specific targeting, toxicity, bioavailability, solubility and permeability problems, serious side effect...

Colorectal cancer (CRC) is a complex and multifactorial disorder in middle-aged people. Several modern medicines are available for treating and preventing it. However, their therapeutic uses are limited due to drawbacks, such as gastric perforation, diarrhea, intestinal bleeding, abdominal cramps, hair loss, nausea, vomiting, weight loss, and adver...

Curcumin is a potent bioactive compound of Curcuma longa. Curcumin comprises a broad spectrum of biological activities, including hepatoprotective, anticancer, antimicrobial, anti-inflammatory, antitumor, anti-oxidant, etc. However, its low aqueous solubility, rapid excretion, and poor bioavailability restricted its therapeutic uses. To resolve the...

Oral and injectable drug administration have recently been replaced with transdermal drug delivery (TDD) approaches, which are less intrusive, less likely to be rejected by patients, and easier to administer. There is still room for improvement in the treatment of gout with the use of a TDD system. Gout has become a worldwide epidemic and a severe...

A peptic ulcer is a disease that affects the stomach lining caused by Helicobacter pylori. The present research aimed to formulate and evaluate the mucoadhesive microsphere of ofloxacin for the effective and safe treatment of peptic ulcers. The mucoadhesive microspheres were developed using natural polymers like Guar gum, Sodium alginate, and Chito...

Skin is a defensive barrier that protects the body against sun rays and other harmful environmental elements. Sun rays contain ultraviolet rays, UVA (320-400 nm) and UVB (280-320 nm), which are highly harmful to the skin, leading to photoaging. Nowadays, sunscreen products are being utilized to protect the skin against photodamage. Conventional sun...

Colorectal cancers are among the most commonly found cancers over the world. In spite of the recent advancements in diagnosis and prognosis, the management of this metastatic condition remains a challenge. The utility of monoclonal antibodies in the healing of patients with colorectal cancer has opened a new chapter in the quest for newer therapies...

Drug-loaded, brain-targeted nanocarriers could be a promising tool in overcoming the challenges associated with Alzheimer's disease therapy. These nanocargoes are enormously flexible to functionalize and facilitate the delivery of drugs to brain cells by bridging the blood-brain barrier and into brain cells. To date, modifications have included nan...

Cancer is one of the deadliest illnesses of the 21st century. Chemotherapy and radiation therapies both have considerable side effects. Antitumor antibiotics are one of them. Coughs, common colds, fevers, laryngitis, and infectious disorders have all been treated with Andrographis paniculata for centuries. Extracts of Andrographiseffectively treat...

The goal of current research was to develop a new form of effective drug, curcumin-loaded solid lipid nanoparticles (Cur-SLNs) and test its efficacy in the treatment of lung cancer. Different batches of SLNs were prepared by the emulsification–ultrasonication method. For the optimization of formulation, each batch was evaluated for particle size, p...

Plants are used by almost 80% of the world's population for health and healing, and medicinal and aromatic plants account for 25% of all integrated pharmaceuticals. Moringa oleifera is a multi-purpose herbal plant that is utilized as a portion of human food and a therapeutic alternative all over the world. According to studies, it has been discover...

COVID-19 was caused by a novel coronavirus known as SARS-CoV-2. The COVID-19 disease outbreak has been avowed as a global pandemic by the World Health Organization at the end of March 2020. It leads to the global economic crash, resulting in the starvation of a large population belonging to economically backward countries. Hence, the development of...

Background: β-artemether (BAT) and lumefantrine (LFT) combination therapies are well recognized for the treatment of malaria. However, the current conventional formulations have several drawbacks. Objective: The study aims to develop novel lipid nanoparticles (LNP) for efficient delivery of BAT and LFT. Methods: The LNP were prepared by solven...

Burn injuries are extremely debilitating, resulting in high morbidity and mortality rates around the world. The risk of infection escalates in correlation with impairment of skin integrity, creating a barrier to healing and possibly leading to sepsis. With its numerous advantages over traditional treatment methods, nanomaterial-based wound healing...

The coronavirus disease outbreak towards the end of 2019 was caused by a novel coronavirus known as SARS-CoV-2. The COVID-19 disease outbreak has been avowed as a global pandemic by the World Health Organization by the end of March 2020. The COVID-19 pandemic was responsible for the crash of the global economy, resulting in the starvation of a larg...

Skin aging is the result of programmed senescence and prolonged environmental injury to skin. Human skin is continuously exposed to environmental influences and is therefore subjected to both intrinsic as well as extrinsic aging processes. Aged skin is characterized by loss of skin tone and resilience, increased roughness and dryness, irregular pig...

World population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA vir...

Co-trimoxazole appropriates to category of broad-spectrum antimicrobial. They are active upon administration in vitro against an extensive collection of microorganisms. Their application in medical field has roughly spanned over decade now. There are numerous approaches that were progressed for improving their effectiveness towards their antimicrob...

Methotrexate (MTX) is famous for its therapeutic potential against different cancers including colorectal cancer. Goal of the present investigation was to formulate MTX loaded mucoadhesive microparticles for colon targeting. The optimized formulation (MTX-MS2) was composed of mucoadhesive polymers (sodium alginate, guar gum and carbopol 940) in an...

In the last decades, gasotransmitters have gained attention for their crucial role in pathophysiological and cellular functions. Gasotransmitters are gaseous mediators of the cellular signaling and biological responses from one end to the other. The isoform of these gaseous signaling molecules includes NO (nitric oxide), CO (carbon monoxide), and H...

Cancer is a heterogeneous disease, occurs due to transcriptional changes in genetic and epigenetic including numerous genes and proteins. Worldwide, breast cancer (BC) is the life-threatening malignancies in women, is characterized by the occurrence of more than one molecular alteration. The incidence and mortality of BC are growing every day becau...

Nasal drug delivery has been used from the prehistoric times for the treatment of neurological disorders like Alzheimer's disease (AD). AD is a neurodegenerative disease and prime cause of dementia. AD has become most common disease worldwide and its treatment remains challengeable. For delivering a drug to the brain, blood brain barrier is a major...

Inflammatory bowel disease (IBD) is a common colonic disorder affecting most of the world population. In order to overcome the IBD, present study was aimed to fabricate the sulfasalazine loaded amidated pectin microparticles by ionic gelation technique. The microparticles were filled in Eudragit S 100 coated hard gelatin capsules for pH and time de...

Breast cancer (BC) is a multifactorial disease and becoming a major health issue in women throughout the globe. BC is a malignant type cancer resulted after transcriptional changes in proteins and genes. Besides the availability of modern medicines and detection tools, BC become topmost deadly disease and its cure still remains challengeable. Nanot...

Quality assessment and scientific validation of medicinal plants are essential parameters to be considered in ensuring the quality, efficacy, and safety of herbal products at large. In search of newer therapeutic leads, enzymes are considered to be an attractive target for drug development due to their essential catalytic roles in many physiologica...

Multidrug resistance (MDR) is a major health issue for the treatment of infectious diseases throughout the world. Staphylococcus aureus (S. aureus) is a Gram-positive bacteria, responsible for various local and systemic infections in humans. The continuous and abrupt use of antibiotics against bacteria such as S. aureus results in the development o...

Objective To circumvent the aforementioned problems and for the successful delivery of those newly discovered poorly soluble compounds, researchers have focused on the feasibility of biocompatible lipids such as Solid lipid nanoparticles (SLN) as carrier system. Background Sertraline (SRT) is commercially available as hydrochloride salt. Poor bioa...

Smart nanosystems (SNs) have the potential to revolutionize drug delivery. Conventional drug delivery systems have poor drug-loading, early burst release, limited therapeutic effects etc. Thus, to conquer these problems, researchers have taken advantage of the host-guest interactions as bioinspired nanosystems that could be delivered nanocarriers m...

A simple, rapid, quantitative, and validated high-performance thin-layer chromatographic (HPTLC) method has been developed for the simultaneous estimation of quercetin (QU), rutin (RU), and gallic acid (GA) in the methanolic extract of Amaranthus tricolor L. aerial parts. Densitometric analysis of QU, RU, and GA were carried out in the absorbance m...

The herbal medicines have been popularized throughout the globe since time immemorial. Several plant based therapeutic leads have been produced through integrated approaches. Many herbal bioactives have several health benefits but limited therapeutic potential due to short half-life and low bioavailability profile. Plant derived molecules are eithe...

Objective: To prepare and characterize an optimized phospholipid complex of Ursolic acid (UA) to overcome the poor pharmacokinetic properties and to investigate the impact of the complex on hepatoprotective activity and bioavailability in animal model. Significance: UA is a potential phytoconstituent obtained from several plant sources, which has b...

The development of traditional medicine with the perspectives of safety, efficacy and quality would help not only to preserve the traditional heritage but also to rationalize the use of herbal medicine in the human healthcare. Nature is considered as a compendium for templates of new chemical entities. The medicinal plants mentioned in the differen...

Evidence-based validation of the ethno-pharmacological claims on traditional medicine (TM) is the need of the day for its globalisation and reinforcement. Combining the unique features of identifying biomarkers that are highly conserved across species, this can offer an innovative approach to biomarker-driven drug discovery and development. TMs are...

Betulinic acid (BA) is a potent bioactive compound and well known for its therapeutic activity. However, its efficacy is restricted due to low solubility as well as poor bioavailability. The aim of the study was to develop a BA loaded nanoemulsions for enhanced bioavailability and hepatoprotective activity. The optimized nanoemulsion (BA-NE1) was c...

The development of functional food (medicinal plants, marine sources, vitamins, minerals, fish oils, plant-based oils, amino acids, etc.) as nutraceutical and dietary supplements are gaining momentum with the perspectives of safety, efficacy, and quality for promotion of health of human beings. Nutraceuticals are diet supplements that deliver an en...

Secondary metabolites from plants provide lead molecules for drug development. Metabolomics is a modern omic-technique for comprehensive analysis of phytochemicals. Advances in mass spectrometry (MS) based platforms like GC-MS and LC-MS, helped in separation and identification of several metabolites. Such analysis can be a valuable tool for identif...

Ethnopharmacological relevance: Ayurveda entails a scientific tradition of harmonious living and its origin can be traced from ancient knowledge in Rigveda and Atharvaveda. Ayurveda is a traditional healthcare system of Indian medicine since ancient times. Several Ayurvedic medicines have been exploiting for treatment and management of various dis...

Objective Tinospora cordifolia is used for treatment of several diseases in Indian system of medicine. In the present study, the inhibition potential of T. cordifolia extracts and its constituent tinosporaside to cause herb-drug interactions through rat and human liver cytochrome enzymes was evaluated. Materials and Methods Bioactive compound was...

Ethnopharmacological relevance: Ayurveda (Sanskrit: Ayus - life + Veda - knowledge) means the "True knowledge of life". Ayurveda deals with a complete self-sustainable system of medicine. The Government of India through its Ministry of AYUSH is responsible for policy formulation, development and implementation of programs for the growth, developme...

Abstract Ethnopharmacological relevance ‘Ubtan’ is a traditional herbal formulation in the Indian system of medicine being used in India and its subcontinent for a long time. Several commercial skin care formulations are marketed throughout this region as the name of Ubtan. Therefore, it is worthwhile to evaluate Ubtan in respect of its efficacy a...

Evidence based validation of the ethno-pharmacological claims on traditional medicine (TM) is the need of the day for its globalization and reinforcement. Combining the unique features of identifying biomarkers that are highly conserved across species, this can offer an innovative approach to biomarker-driven drug discovery and development. TMs are...

Stereospermum suaveolens (Roxb.) DC. is used in folk medicine for the treatment of diabetes, pain, fever, inflammations and asthma. The major phytoconstituents found in the plant bark are lapachol and apigenin exhibit various pharmacological activities. To ensure the content of uniformity of biomarkers, the aim of the present study was to develop a...

Ferulic acid (FA) is a potent dietary antioxidant compound present in the bran of some dietary sources, such as wheat, rice, barley and oats, coffee, various citrus fruits, tomatoes, vegetables etc. The aim of the present study was to develop a FA-loaded nanoemulsion gel to ensure the maximum therapeutic profile. The pseudo ternary phase diagrams o...

Herbal products and their formulations have been prescribed for the cure, mitigation, and therapy of several ailments associated with human beings since time immortal. Drugs of natural origin suffer from poor physicochemical properties, which are related to their poor pharmacokinetics and bioavailability in the human body diminishing their therapeu...

Skin aging is the result of programed senescence and prolonged environmental injury to skin. Human skin is continuously exposed to environmental influences and is therefore subjected to both intrinsic as well as extrinsic aging processes. Aged skin is characterized by the loss of skin tone and resilience, increased roughness and dryness, irregular...

Carissa spinarum is a well-known medicinal plant which has been reported for its anthelmintic, antipyretic, antiviral, antimicrobial and antitumour activities. In this study, a reverse-phase high-performance liquid chromatographic method was developed for the simultaneous estimation of betulinic acid (BA) and ursolic acid (UA) in the methanol extra...

The use of herbal drugs for the prevention and treatment of various health ailments has been in practice from time immemorial. Scientific validation and documentation of indigenous knowledge to work on patenting and research based on literature are necessary for the growth of Indian system of medicine. The Indian government has taken several initia...

Aloe vera (L.) Burm. f. (Family Liliaceae) is an evergreen perennial succulent plant widely used from antiquity. Aloe vera contains various carbohydrate polymers, notably glucomannans, along with a range of other organic and inorganic components. Phenolic compounds have been identified so far as chromone, anthraquinone or anthrone derivatives. Thre...

Nanotechnology is the study, design, creation, synthesis, manipulation, and application of functional materials, devices, and delivery systems through control of matter at the nanometer scale. These include nanovectors, nanotubes, nanosensors, nanowires and nanocantilever arrays, nanopores and nanoformulations. These advances will lead to significa...

Nanoemulsion (NE) is defined as an O/W or W/O emulsion producing a transparent product that has a droplet size from 20-200nm and does not have the tendency to coalesce. It is promising for transdermal delivery of drugs as an efficient route of drug administration. Several mechanisms have been proposed to explain the advantages of nanoemulsions for...

The preliminary phytochemical investigation was carried out on the crude extracts of the roots of Chloroxylon swietenia. The crude extracts were investigated for their anthelmintic activity against Indian earthworms (Pheretima posthuma). Three concentrations (25, 50 and 100 mg/mL) of each extract were performed in activity, which involved the evalu...

Pelletization methods like solution layering, suspension layering or powder layering and extrusion-spheronization process is the most frequently used method for producing spherical pellets which utilizes a granulating liquid such as water, requires drying steps which is time consuming. Many drugs exhibit stability problem due to the presence of wat...

Buchanania lanzan Spreng plant is well known for its medicinal and therapeutic values in Indian folk medicine. However, to be clinically useful, more scientific data are needed. Therefore, in the present study, we investigated the effects of root of Buchanania lanzan Spreng. methanolic extract (MBL) on pain and acute inflammation. To assess the ana...

The present investigation aims to evaluate an isotropic and thermodynamically stable nanoemulsion formulation for transdermal delivery of glycyrrhizin (GZ), with minimum surfactant and cosurfactant (Smix) concentrations that could improve its solubility, permeation enhancement, and stability. Pseudo-ternary phase diagrams were developed and various...

Glycyrrhiza glabra, also known as liquorice and sweetwood, is native to the Mediterranean and certain areas of Asia. Historically, the dried rhizome and root of this plant were used medicinally by the Egyptian, Chinese, Greek, Indian and Roman civilizations as carminative, expectorant and cough remedies. It is now known that glycyrrhizic acid and i...