Ramón Enrique Robles Zepeda

University of Sonora · Department of Chemical Biological and Agricultural Sciences

Ganoderma species have been studied for their pharmacological approaches, such as anticancer, antitumor, antiproliferative, and antioxidant activity. Elicitors are used to increase Ganoderma bioactive composite production. This study aims to evaluate the antiproliferative activity of ethanolic extracts from mycelium of Ganoderma tuberculosum (G. tu...

Cucurbitacin IIb, a triterpene obtained from the Ibervillea sonorae plant, reduces tumour development in a preclinical model of cervical cancer. Acetison and Etanison, phytopreparations made from I. sonorae, present biological activity analogous to CIIb in HeLa. This research evaluated the tumour growth inhibitory effect of these phytopreparations...

Loxosceles spp. spiders can cause serious public health issues. Chemical control is commonly used, leading to health and environmental problems. Identifying molecular targets and using them with natural compounds can help develop safer and eco-friendlier biopesticides. We studied the kinetics and predicted structural characteristics of arginine kin...

Ticks are ectoparasites that affect humans, companion animals and production animals and are vectors of bacterial and viral pathogens. Rhipicephalus sanguineus, commonly known as the brown tick, is the most widely distributed ectoparasite in Mexico and throughout the world. Dogs are part of the tick´s life cycle, being of interest in public and vet...

The objective of the present study was to determine the chemical profile, and the antimicrobial and antibiofilm effect of the Lophocereus schottii extract against uropathogenic Escherichia coli. A methanolic extract of L. schottii was analyzed by mass spectrometry (ESI-IT-MSn and APCI-IT-MSⁿ) to determine the profile of bioactive compounds. The ant...

Ethnopharmacology relevance Ibervillea sonorae (S. Watson) Greene is a plant from northwestern Mexico, known as “Wereke” or “Guareque”, used by the Mayo ethnic group to treat diabetes and cancer. Cucurbitacin IIb (CIIb), isolated from I. sonorae has apoptotic and antitumor activity in a model of cervical cancer with the HeLa cell line. One pathway...

Litsea glaucescens is a native plant from Mexico and Central America known as laurel, and they leaves are commonly used as food seasoning and traditional medicine, however, there is not enough information about its biological activities, as antioxidant and the compounds responsible of this activity. The antioxidant activity and the total phenolic c...

Na + /K +-ATPase is an essential transmembrane enzyme found in all mammalian cells with critical functions for cell ion homeostasis. The inhibition of this enzyme by several cardiotonic steroids (CTS) has been associated with the cytotoxic effect on cancer cell lines of phytochemicals such as ouabain and digitoxin. This study evaluated the inhibito...

Consultation was requested for a 7-year-old Gypsy Vanner male horse with a 2-year history of foreskin injury. Upon revision, an ulcer, 153cm² in size, with yellowish granules was observed; a RESVECH 2.0 evaluation revealed a score of 32/35 points. Medical history confirmed multiple, failed deworming, anti-inflammatory, and antibiotic treatments wit...

Tree nuts are rich in polar (phenolic compounds) and non-polar (tocols) antioxidants, with recognized effects in the prevention of diseases such as cancer. These biomolecules possess antiproliferative activity on cancer cells; however, the combined effect of both types of compounds has been scarcely studied, and this approach could give valuable in...

Context Molecular tests are useful in detecting COVID-19, but they are expensive in developing countries. COVID-19-sniffing dogs are an alternative due to their reported sensitivity (>80%) and specificity (>90%). However, most of the published evidence is experimental, and there is a need to determine the performance of the dogs in field conditions...

Introduction: Fouquieria splendens commonly named "ocotillo", is a native plant from Mexico, used in folk medicine against different illnesses. However, scientific evidence about its biological activities is limited. The objective of this study is to determine phenolic composition, antioxidant and antiproliferative effect of F. splendens. Methods:...

Background and Objective The objective of the present study is to use docking and ADME analysis to determine if the cardenolides of Asclepias subulata are potential stabilizing drugs of the p53-Y220C mutant. Materials and Methods Two different receptors, wild-type p53, and the mutant p53-Y220C, were used for docking. Three independent stochastic s...

Background: Haematoxylum brasiletto is a tree that grows in Central America, commonly known as "Palo de Brasil," which is used in the traditional medicine for the treatment of cancer and gastric ulcers. Objective: The aim of this study was to isolate the compounds responsible for antiproliferative activity of H. brasiletto. Materials and method...