Ramon Diaz

Ramon Diaz
Navarrabiomed

Proteomics Specialist. PhD Biochemistry and Molecular Biology.

About

15
Publications
5,462
Reads
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124
Citations
Introduction
Additional affiliations
October 2017 - March 2022
Sanford Burnham Prebys Medical Discovery Institute
Position
  • Proteomics Specialist
May 2010 - October 2017
Barcelona Science Park
Position
  • Proteomics Specialist
January 2010 - May 2010
VHIR Vall d’Hebron Research Institute
Position
  • Proteomics Specialist
Education
October 2009 - June 2010
University of Barcelona-Inkemia group
Field of study
  • HPLC, GC and mass spectrometry
October 2003 - June 2004
University of Barcelona
Field of study
  • Postgrade in R+D and registers in pharmaceutical industry
March 2003 - March 2011
Autonomous University of Barcelona
Field of study
  • Universitat Autònoma de Barcelona

Publications

Publications (15)
Article
Full-text available
The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here, the cellular impact of expressing SAR...
Article
This study aimed to evaluate the response of HepaRG cells after co-exposure to phthalates and heavy metals, using a high-dimensional biology paradigm (HDB). Liver is the main metabolism site for the majority of xenobiotics. For this reason, the HepaRG cell line was used as an in vitro model, and cells were exposed to two characteristic mixtures of...
Article
Full-text available
Transcriptomics and candidate gene/protein expression studies have indicated several biological processes modulated by methylphenidate (MPH), widely used in attention-deficit/hyperactivity disorder (ADHD) treatment. However, the lack of a differential proteomic profiling of MPH treatment limits the understanding of the most relevant mechanisms by w...
Article
Full-text available
Background: Uncontrolled proteolysis contributes to cell injury and organ dysfunction in animal models of circulatory shock. We investigated in humans the relationship between septic shock, proteolysis, and outcome. Methods: Intensive care patients with septic shock (n=29) or sepsis (n=6) and non-hospitalised subjects (n=9) were recruited as part o...
Article
Full-text available
In this work, we examined plasma metabolome, proteome and clinical features in patients with severe septic shock enrolled in the multicenter ALBIOS study. The objective was to identify changes in the levels of metabolites involved in septic shock progression and to integrate this information with the variation occurring in proteins and clinical dat...
Article
Full-text available
Salmonella possesses virulence determinants that allow replication under extreme conditions and invasion of host cells, causing disease. Here, we examined four putative genes predicted to encode membrane proteins (ydiY, ybdJ, STM1441 and ynaJ) and a putative transcriptional factor (yedF). These genes were identified in a previous study of a S. Typh...
Article
To the best of our knowledge, this is the first study describing the proteome of equine umbilical cord intervascular matrix mesenchymal stem cells (UCIM-MSCs) in a global and functional manner. The aim of this work was to analyze the proteome of previously characterized UCIM-MSCs to determine protein abundance and classify the identified proteins a...
Article
Full-text available
Quality control (QC) is becoming increasingly important in proteomic experiments in order to guarantee the quality of research results. Deployment of QC metrics helps in monitoring stability, overall performance and reproducibility of analytical techniques. In an attempt to dispel some of the notions that LC-MS-based proteomics is poorly reproducib...
Article
Full-text available
Incisional hernia often occurs following laparotomy and can be a source of serious problems. Although there is evidence that a biological cause may underlie its development, the mechanistic link between the local tissue microenvironment and tissue rupture is lacking. In this study, we used matched tissue-based and in vitro primary cell culture syst...
Article
Background: Incisional hernia is a common and important complication of laparotomies. Epidemiological studies allude to an underlying biological cause, at least in a subset of population. Interest has mainly focused on abnormal collagen metabolism. However, the role played by other determinants of extracellular matrix (ECM) composition is unknown....

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Projects

Project (1)