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Ramiro Quintanilla-Licea

Ramiro Quintanilla-Licea
Universidad Autónoma de Nuevo León (UANL) · Facultad de Ciencias Biológicas

PHd

About

60
Publications
7,598
Reads
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368
Citations
Additional affiliations
June 2011 - August 2011
Georg-August-Universität Göttingen
Position
  • PostDoc Position
January 2001 - January 2015
Autonomous University of Nuevo León
Position
  • Researcher
January 1990 - present
Universidad Autónoma de NuevoLeón
Position
  • Researcher and Lecturer

Publications

Publications (60)
Article
Full-text available
Plant-associated microorganisms represent a potential source of new antitumor compounds. The aim of the present study was to isolate endophytic and rhizosphere Gram-positive bacteria from Ibervillea sonorae and produce extracts with antitumor activity. Methanol and ethyl acetate extracts were obtained from 28 d bacterial fermentation, after which m...
Article
Endophytic fungi have become potential sources of antitumor agents, particularly against antineoplastic-resistant cancer cells, with marginal or nil adverse effects for the oncological patient. Endophytic fungi were isolated from stems of the Lophocereus marginatus cactus, commonly found in Mexico. Methanol extracts were then obtained from fungus l...
Article
Full-text available
Endophytic fungi have become potential sources of antitumor agents, particularly againstantineoplastic-resistant cancer cells, with marginal or nil adverse effects for the oncological patient.Endophytic fungi were isolated from stems of theLophocereus marginatuscactus, commonly foundin Mexico. Methanol extracts were then obtained from fungus liquid...
Article
Full-text available
Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine...
Article
Full-text available
Amebiasis caused by Entamoeba histolytica is nowadays a serious public health problem worldwide, especially in developing countries. Annually, up to 100,000 deaths occur across the world. Due to the resistance that pathogenic protozoa exhibit against commercial antiprotozoal drugs, a growing emphasis has been placed on plants used in traditional me...
Article
Full-text available
Cancer is one of the leading causes of death worldwide and commonly becomes resistant to chemotherapy, therefore, it is important to search for and evaluate novel sources of nontoxic antitumor agents. The cactus Pachycereus marginatus is native to Mexico and is traditionally recommended to treat gastrointestinal infections. Tumor-bearing mice survi...
Article
Full-text available
Cancer cases result in 13% of all deaths worldwide. Unwanted side effects in patients under conventional treatments have led to the search for beneficial alternative therapies. Microalgae synthesize compounds with known in vitro and in vivo biological activity against different tumor cell lines. Therefore, native microalgae from the State of Nuevo...
Data
Timecourse (14 days) of Chlorella y Scenedesmus culture in matraz (500 mL medio)
Data
Timecourse of the microalgae culture in matraz (A) Chlorella sorokiniana; (B) Scenedesmus sp.
Data
Bioreactor tanks Bioreactor tanks designed by López-Chuken, Young & Guzman-Mar (2010) consisting of circular acrylic tanks (30 cm of diameter and height) where aeration was supplemented by air pumps with an adapted 0.2 µm filter at 1-L min-1 flow rate; radiated by continuous artificial illumination (LED white lights at 1,500 lux of intensity), and...
Data
Microalgae production Bioreactor tanks showing the Chlorella sorokinian a and Scenedesmus sp. for biomass production in tanks after 29 days fermentation.
Data
Chloroformic and hexane extracts and vincristine cytotoxicity analysis dataset
Article
Full-text available
Dental diseases play an important role in public health. The use of conventional antibiotics for treatment can create microbial resistance; therefore, it is critical to search for alternatives to which there is no such an effect. In this regard, we have studied the in vitro effect of chalepensin, from the plant Ruta chalepensis L., against the dent...
Article
Full-text available
Background Prolonged use of antibiotics may lead to the selection of drug-resistant bacteria; as a result, efforts are being made to identify new and effective antimicrobial agents, particularly, from medicinal plants, against bacterial infections. Antimicrobial activity of Gymnosperma glutinosum against Helicobacter pylori has not yet been reporte...
Article
Full-text available
This work evaluated the fungicidal activity of dermatophytes, antioxidant depending on the capacity to catch the ABTS radical and identification of active compounds from methanolic extracts of 20 medicinal plants; being the most active extracts: that of celery seed, with a minimal inhibitory concentration (MIC) of 1.4 mg/mL and a minimal fungicide...
Article
Full-text available
In the present study, the effect of traditionally prepared infusions of 19 traditional Mexican medicinal plants on the metabolic syndrome related peroxisome proliferator-activated receptors (PPAR) α, β/δ, and γ was investigated using a novel luciferase reporter gene assay [1]. COS-1 cells were co-transfected with the luciferase reporter plasmid p17...
Article
Full-text available
Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality is becoming a major public health problem worldwide, especially in developing countries. Because of the side-effects and the resistance that pathogenic protozoa build against the standard antiparasitic drugs, e.g., metronidazole, much recent attention has bee...
Article
Full-text available
The aim of this study was to screen the trypanocidal activity of plants used in traditional Mexican medicine for the treatment of various diseases related to parasitic infections. Cultured Trypanosoma cruzi epimastigotes were incubated for 96h with different concentrations of methanolic extracts obtained from Artemisia mexicana, Castela texana, Cym...
Article
Bioassay-guided fractionation of hexane extracts of Gymnosperma glutinosum (Asteraceae) leaves, collected in North Mexico, afforded the known compounds hentriacontane ( 1 ) and (+)-13 S ,14 R ,15-trihydroxy- ent -labd-7-ene ( 2 ), as well as the new ent -labdane diterpene (-)-13 S ,14 R ,15-trihydroxy-7-oxo- ent -labd-8(9)-ene ( 3 ). In addition, D...
Article
The antitumor potential of Gymnosperma glutinosum was previously reported using the in vitro and in vivo L5178Y-R lymphoma murine model. The present study was carried out to isolate and identify the cytotoxic compounds present in the Gymnosperma glutinosum leaf hexane extract. Gymnosperma glutinosum was collected in the semi-arid region of Escobedo...
Article
Full-text available
Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality becoming a major public health problem, especially in developing countries. Because of the side-effects and the resistance that pathogenic protozoa build against the antiparasitic drugs, e.g. metronidazole, much recent attention has been paid to plants used i...
Article
Full-text available
The present study was undertaken to validate the antitumor potential of Gymnosperma glutinosum from regional people's account, using the in vitro and in vivo L5178Y-R lymphoma murine model. Non-polar G. glutinosum crude extracts were tested on L5178Y-R cells. We found significant (p < 0.05) cytotoxic activity (up to 40%) of the hexane extract, whic...
Article
Full-text available
Tuberculosis is considered a re-emerging disease and one of the most important health problems worldwide. It causes approximately three million deaths every year. In the last decades multi-drug resistant Mycobacterium tuberculosis has been detected, exacerbating the situation. The main objective of this research was to test the effect of Persea ame...
Article
Full-text available
Synthesis of 5,5’-biindole was carried out by the Madelung indole reaction. Under strong basic conditions and high temperatures (350 ºC), N,N’-bis-formyl-o-tolidine underwent cyclization to produce high amounts of the dimeric indole. Full and unambiguous assignments of all 1H- and 13C-NMR resonances of indole and 5,5’-biindole in DMSO-d6 are also r...
Article
3-Acetyl-7,12-dihydro-2-methyl-6H-indolo[2,3-a]chinoliziniumchlorid (1) reagiert mit Benzaldehyd oder Furfural im Mol-Verhältnis 2:1 unter Piperidin-Katalyse zu den „Dimeren” 2a, b bzw. 3 mit Bicyclo[3.3.1]nonan-Gerüst. Natriumtetrahydroborat reduziert 2a zum Bicyclo[3.3.1]nonadien 7, Chlorwasserstoff in Essigsäure dehydratisiert 2a zum Mono- und D...
Article
Indoloquinolizines are natural alkaloid indole products grouped as beta-carbolines. These compounds are commonly associated with neurological activities, but little is known about their role as immunomodulating agents. The present study was undertaken to evaluate the effects of synthetic indoloquinolizines on in vitro parameters of rat lymphocyte a...
Article
Full-text available
Full and unambiguous assignment of all 1H- and 13C-NMR resonances of the isomers due to restricted C-N amide bond rotation of N-formyl-o-toluidine and N,N'-bis-formyl-o-tolidine in DMSO-d6 is reported. The cis-isomer predominates in the equilibrium mixture of both compounds as 1D-NOE difference experiments show.
Article
In 1960 Teuber et al. started with the study of the reactions of several derivatives of acetylacetaldehyde with aromatic and biogenic amines (dopamine and tryptamine), as well as indole compounds. Teuber's scientific work resulted in a series of heterocyclic skeletons that are related to alkaloids such as strychnine, yohimbine, ajmalicine and emeti...
Article
Synthesis of Heterocyclic Compounds with Hydroxymethylene Ketones. XIV. Contribution to the Regioselectivity of the Reaction of Acetoacetaldehyde with TryptamineThe range of substitution products of tryptamine with acetoacetaldehyde as substituent at the basic or the indole nitrogen (2, 3) is completed by a product containing the substituent in the...
Article
3-Acetyl-7,12-dihydro-2-methyl-6H-indolo[2,3-a]quinolizinium chloride (1) forms “dimers” (5a, b) by condensation with benzaldehyde and by means of kinetically controlled acetal ring closure (piperidine catalysis). In 5a, b the two quinolizinium units are connected by intercalation of a hydrogenated chroman system whose reactivity is attributed to t...
Article
Die Reaktion von DL-Tryptophan mit Acetylacetaldehyd (als Acetal oder Enolether) gibt rac-3-Acetyl-6-carboxy-2-methyl-7,12-dihydro-6H-indolo[2,3-a]chinoliziniumbetain (5). Die zu 5 führende Reaktion sowie Spektren und biologische Relevanz werden diskutiert. A Quinolizine Derivative from Tryptophan and Acetoacetaldehyde The reaction of DL-tryptophan...
Article
Full-text available
The reaction of DL-tryptophan with acetoacetaldehyde (as its acetal or enolether) yields rac-3-acetyl-6-carboxy-2-methyl-7,12-dihydro-6H-indolo[2,3-a]quinolizi nium betaine (5). Thge course of the reaction, the spectra, and biological implications are discussed.
Article
Full-text available
C 43 H 44 N 4 O 2 •5,4H 2 O cristallise dans P2 1 /n avec a=10,967, b=13,181, c=28,268 A, β=98,12 o , Z=4; affinement jusqu'a R=0,054. La molecule rigide comprend 10 cycles fusionnes et contient une cavite hydrophile flanquee de 2 groupements hydroxyl et 2 groupements amino. Cette cavite contient 2 molecules d'eau hydratantes. Trois molecules d'eau...
Article
The endo-positioned OH groups of (III) are fixed by hydrogen bonding as it can be seen from the 1H NMR spectrum.
Article
The unsaturated side chain in (III), required for the construction of alkaloid structures, is obtained by the base-catalyzed reaction of the 2-methyl group of (I) with aldehydes (II); further elaboration of (III) to the corresponding tetrahydropyridines can be accomplished by treatment with NaBH4.
Article
In dem aus Tryptamin-hydrochlorid und Acetylacetaldehyd-dimethylacetal gebildeten 3-Acetyl-7,12-dihydro-2-methyl-6H-indolo[2,3-a]chinolizinium-chlorid (1a) und seinem Acetal 1b wird die Methyl-Seitenkette durch Umsetzung mit Carbonyl-Verbindungen kondensiert. Benzaldehyd und Furfural führen ausgehend von 1b zu den Stilbazolen 4a–d, nach Hydrierung...
Article
Reaction of tryptamine·HCl (I) with the acetals (II) gives rise to the salts (IIIa) (+ by-product (IVa)) or (IIIb).
Article
Das aus Tryptamin-hydrochlorid und Acetylacetaldehyd (als Enolether oder Acetal) gebildete 3-Acetyl-7,12-dihydro-2-methyl-6H-indolo[2,3-a]chinolizinium-chlorid (2a) wird hinsichtlich Bildungsweise und reaktivem Verhalten, besonders bei Reduktion und Oxidation, untersucht. Dies gilt auch für das durch (stereoselektive) Disproportionierung gebildete...
Article
Full-text available
(Z)-6-heneicosen-11-one was prepared using the reductive cleavage of 2-tetrahydrofuryldecylketone 6 to 5-oxo-pentadecan-1-ol 7 as the key step of the synthesis.

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Projects (2)
Project
Screening of 21 plants used in the Mexican traditional medicine for the effects on the growth of Trypanosoma cruzi epimastigotes Chagas disease, known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi. 6 to 7 million people worldwide are estimated to be infected with the parasite that causes Chagas disease (WHO, 2017). Medicinal plants have played an important role in the discovery and development of new therapeutic drugs. Nowadays, approximately 30 % of drugs used in industrialized countries come from plants or are derived from plant secondary metabolites (Newman and Cragg, 2016). The aim of this study is to screen the trypanocidal activity of plants used in Mexican traditional medicine for the treatment of various diseases related to parasitic infections.