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Introduction
Ramesh Z. Patel is a retired teacher of Pathology. His fields of intererst were hematology, especially inherited blood diseases like hemoglobinopathies and G-6-PD deficiency. Working in an under resourced laboratory, he modified the laboratory techniques to take it in the periphery to detect the cases of sickle hemoglobinopathies, which are highly prevalent in tribal (aboriginal) population in western India. At present he is actively working on developing simple technique for neonatal
detection of Hb S with micro quantity of blood. The technique is going to be highly cost effective.
Publications
Publications (18)
Background: The majority of adult tribal subjects in the western part of India, show microcytic hypochromic red cells, and borderline anemia with a normal iron profile, suggesting a high prevalence of thalassemia in this population. Methods: The current study was designed to perform qualitative (to screen for Hb Bart’s) and quantitative (to estimat...
The most popular buffer used for serum protein electrophoresis on either cellulose acetate membrane, or agarose gel was barbitone buffer (Barbital for USA !) at an alkaline pH of 8.6. The inherent property of the chemical, if consumed, was sedation, deep sleep, coma or even death depending on the amount consumed. This led to many restrictions being...
Background: G6PD enzyme deficiency has X-linked inheritance with variable prevalence in different population groups. Deficient subjects enjoy normal health unless were exposed to oxidative stress that yields haemolytic crises and may lead to fatalities. Aim/objective: Few reports available on haematological parameters among G6PD deficient subjects...
Abstract Although iron deficiency anemia is very common in India, systematic large studies on the prevalence and hematological consequences of iron deficiency among carriers of β-thalassemia (β-thal) and other hemoglobinopathies are lacking. A multi center project was undertaken to screen college/university students and pregnant women for iron defi...
The Ghanchi Hindu community is distributed across Gujarat state, forming endogamous
groups known by the city they live in. Sporadic cases of the genetic disorders like beta-
thalassaemia and von Willebrand Disease were encountered from this community that has
prompted us to carry out this project. Standard screening tests were employed for blood
gr...
The population of India is extremely diverse comprising of more than 3,000 ethnic groups who still follow endogamy. Haemoglobinopathies are the commonest hereditary disorders in India and pose a major health problem. The data on the prevalence of β-thalassemias and other haemoglobinopathies in different caste/ethnic groups of India is scarce. There...
Although the average frequency of beta-thalassaemia carriers in India is 3-4% and the prevalent mutations have been studied, no micromapping has been done. This is the first attempt to provide an accurate estimate of the frequencies of beta-thalassaemia and the expected annual births of homozygous children in different districts of Maharashtra and...
Hb Q-India is a rare alpha chain variant and usually it presents in the heterozygous state. It's presence along with beta thalassemia trait again adds to its rarity. Such a rare entity can be diagnosed by careful screening in routine practice with the use of the techniques like Hb electrophoresis, Solubility test. We report a case of Hb Q in a conc...
Aim: To study the stability and effect of storage, at 4° C temperature in the refrigerator, on blood, on the Hematofluorometer readings of Zinc Protoporphyrin (ZPP) over time. Study: 48 randomly collected samples were tested for ZPP values using Hematofluorometers. Results were compared using paired t-test. Results: Data analysis showed that ZPP re...
Sporadic cases of drug-induced haemolytic anaemia due to glucose-6-phosphate dehydrogenase (G6PD) deficiency in patients belonging to Vataliya Prajapati community prompted us to study the prevalence of G6PD deficiency in the community.
Screening for G6PD deficiency was carried out using the dichlorophenol-indophenol (DPIP) dye decolorization method...
50 patients (45 males + 5 females) suffering from acute uncomplicated attack of Plasmodium falciparum (Pf) malaria were treated with 1500 mg of halofantrine divided in three doses of 500 mg each given at an interval of 6 h. Results showed there were no primary treatment failures. Average Parasite Clearance Time (av. PCT) was 51.12 h and average Fev...
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