Ramesh Monajemi

Islamic Azad University of Falavarjan · Department of Biology

The Coronavirus disease-2019 (COVID-19) pandemic is a global concern, with updated pharmacological therapeutic strategies needed. Cancer patients have been found to be more susceptible to severe COVID-19 and death, and COVID-19 can also lead to cancer progression. Traditional medicinal plants have long been used as anti-infection and anti-inflammat...

Background: One of the complications of diabetes mellitus is the glycosylation of various proteins in the body. The purpose of this study was to explore the glycosylation reaction of albumin (Alb) and hemoglobin (Hb) in the presence of varying concentrations of the hydroalcoholic extract derived from dried walnut leaves. Materials and Methods: The...

Background The fruit known as Black grape (Vitis vinifera), due to its antioxidant properties, possesses therapeutic effects and is widely consumed around the globe. Resveratrol is a polyphenolic compound with notable efficacy, primarily found in grapes. The objective of this study was to conduct a comparative investigation into the impact of resve...

Background: Chelidonine is a potent anticancer against several cell lines. However, low bioavailability and water solubility restrict the clinical applications of this compound. Objective: The aim of this research was to develop a novel formulation of chelidonine encapsulated in the nanoparticles of poly(d l-lactic-co-glycolic acid) (PLGA) emplo...

The effectiveness of chemical drugs has been reduced by the resistance of cancer cells to chemical drugs, such as breast cancer as one of the most common cancers in women. Hence, it is important to study the development of more effective drugs with fewer side effects, such as herbs. Thus, the present study aimed to assess the effects of Moringa ole...

The objective of this study was to determine the effect of Trachyspermum ammi (T. ammi) on the liver of streptozotocin (STZ)-induced diabetic rats. This study began by identifying the methanolic composition of T. ammi. The presence of three compounds was determined using gas chromatography-mass spectrometry (GC-MS), with Thymol (60.705%), ϒ-Terpine...

Purpose: Leishmaniasis is one of the most serious health problems in developing countries. Iran is one of the endemic regions of cutaneous leishmaniasis. Leishmania RNA virus (LRV) is a dsRNA virus member of the Totiviridae family, which was first detected in the promastigotes of Leishmania braziliensis guyanensis. Our study aimed to investigate p...

Phosphoenolpyruvate carboxykinase (PEPCK) is a key enzyme in the glyconeogenesis pathway. The AMP‐activated protein kinase alpha (AMPK‐α) pathway regulates PEPCK, which itself is activated by the AMP/ATP ratio and liver kinase B1 (KB1). The Abelmoschus esculentus (L.) Moench (okra) plant contains a large amount of quercetin that can function as an...

Background and aims: Highly active oxygen causes DNA or protein damage. This study aimed to determine the effect of the extract of three medicinal plants, royal jelly, and metformin on the survival of human dermal fibroblast (HDF) cells under oxidative stress induced by H2 O2 . Methods: Hydroalcoholic extracts were prepared from Nigella sativa, Car...

Melanoma is a metastatic cancer resistant to a wide range of therapies, including standard chemotherapy and radiation therapy, and cannot be treated with existing treatments owing to its intrinsic drug resistance. In terms of convenience and cheap cost of fabrication, one of the novel treatments is using polydopamine-coated iron oxide nanoparticles...

Diabetic nephropathy is a major cause of renal tissue damage and complications of diabetes. In this in‐vitro experimental study, diabetes was induced by a single injection of Streptozotocin (55 mg/kg) in rats. STZ‐diabetic rats were treated with oral doses of methanolic extract T. ammi seeds (300 ‐ 400 mg/kg). After eight weeks, serum levels of glu...

Objective: Hypercholesterolemia is now considered a major risk factor for development of atherosclerosis. The phospholipase A2 superfamily of enzymes has causal involvement in atherosclerosis. Atherosclerosis is one of the main causes of mortality in developed countries and in some developing countries such as Iran. The present study was designed...

Okra (Abelmoschus esculentus (L.) Moench) is one of the most important medicinal plants for the treatment of diabetes. Flavonoids are one of the most significant components of okra and are responsible for their antioxidant, anti‐inflammatory, and anti‐diabetic effects. The aim of this research was to investigate the effect of okra extract on bioche...

The prevalence of multidrug-resistant (MDR) strains has caused serious problems in the treatment of burn infections. MDR Enterobactercloacae and Enterobacterhormaechei have been defined as the causative agents of nosocomial infections in burn patients. In this situation, examination of phages side effects on human cell lines before any investigatio...

Introduction: Chelidonine, a bio-active component of Chelidonium majus, has been investigated for its anti-proliferative effects on various cancer cell lines with multidrug resistance (MDR). Although the results are auspicious, its poor water solubility and low bioavailability are the main limitations for clinical applications. This study aimed to...

Introduction:The emergence of Escherichia coli resistance to common antibiotics in burn wound patients has become a controversial problem in Iran trauma and burn hospitals. The emergence of more and more drug resistance by infectious pathogens paves the way for further study of the nature of phages, and phage therapy can significantly address this...

Background and Objectives: Prevalence of extended spectrum β-lactamase (ESBL) leads to the development of antibiotic resistance and mortality in burn patients. One of the alternative strategies for controlling ESBL bacterial infections is clinical trials of bacteriophage therapy. The aim of this study was to isolate and characterize specific bacter...

Objectives: With emergence of drug resistance, novel approaches such as phage therapy for treatment of bacterial infections have received significant attention. The purpose of this study was to isolate and identify effective bacteriophages on extremely drug-resistant (XDR) bacteria isolated from burn wounds. Materials and methods: Pathogenic bac...

Background: Curcumin, a bioactive component of Curcuma langa, has been investigated for its anti-proliferative effects against various cancer cell lines. Although results are very promising, the poor water solubility and low bioavailability of curcumin are its main limitations for clinical application. Objectives: The purpose of this study was to d...

Background: Expansion of the use of magnetic fields in metals, mining, transport, research, and medicine industries has led to a discussion about the effects of magnetic fields and whether their strength is negligible. The aim of this study was to investigate the effects of magnetic field on the viability and proliferation rate of HeLa cells. Mater...

Introduction: The salt diet during the pregnancy may disturb the adult offspring's organs functions. Objectives: This study was designed to determine the role of high salt intake during pregnancy on the outcome of renal ischemia reperfusion (IR) in adult offspring. Materials and Methods: Renal IR was induced in 55 adult male and female offspring fr...

Plant natural products have contributed extraordinary to the discovery of drugs for use in modern medicine. The aim of this study was to assay the analgesic and anti-inflammatory effects of sesquiterpene lactone extracts of Tanacetum lingulatum flowers. In this study, rats were used and they divided into 10 groups. Formalin test was used to evaluat...

Background: Renal ischemia-reperfusion injury (IRI) is one of the most important causes of kidney injury, which is possibly gender-related. This study was designed to investigate the role of γ-aminobutyric acid (GABA) against IRI in ovariectomized estradiol-treated rats. Methods: Thirty-five ovariectomized Wistar rats were used in six experiment...

Background: The most important cause of kidney injury is renal ischemia/reperfusion injury (IRI), which is gender-related. This study was designed to investigate the protective role of Γ-aminobutyric acid (GABA (against IRI in male and female rats. Materials and methods: Thirty-six female and male wistar rats were assigned to six experimental gr...

For years the plants as a natural resource are used for the treatment of cancer. However, the development of anticancer drugs from natural sources such as plants needs to screening tests. This study aimed to assess the cytotoxic effect of Pyracanthacoccinea fruit methanol extracton Helacellline and evaluation of antioxidant properties and total phe...

Background: Infertility is estimated to affect up to 15% of couples of reproductive age. Globozoospermia is a rare (incidence < 0.1%) but severe disorder in male infertility. It is characterized by the absence of acrosome in round-headed spermatozoa. Cases with partial globozoospermic are a group of patients whose semen samples show only a fraction...

Herbal medicine plays an important role in the human healthcare and they are common form of treatment in the different regions. Therefore, the aim of this study was investigated the analgesic and anti-inflammatory effects of methanolic extract of Artemisia deserti Krasch in male rats. In this study after collecting plant, they were dried and ground...

Background: Chemotherapy with cisplatin (CP) is accompanied with nephrotoxicity. Objectives: In the current study, pomegranate flower extract (PFE) has been evaluated as an antioxidant agent against CP-induced-renal toxicity. Materials and Methods: Thirty two male Wistar rats were divided into five groups (6-8 in each group). The animals in group...

Background and Objective: Free radicals cause many diseases in human and their neutralizing by antioxidants reduces risk of cancers. Salvia Officinalis from Lamiaceae family is one of the valuable plants in traditional medicine. The present study aimed to evaluate the antioxidative and cytotoxic properties of ethanolic extract of the aerial parts o...

Abstract Herbal medicine plays an important role in the human healthcare and they are common form of treatment in the different regions. Therefore, the aim of this study was investigated the analgesic and anti-inflammatory effects of methanolic extract of Artemisia deserti Krasch in male rats. In this study after collecting plant, they were dried a...

Introduction: Achillea wilhelmsii C.Koch, was used in traditional medicine such as antiinflammation, antispasmodic and gastrointestinal disorders. The aim of this study was to survey the cytotoxic effects of methanol and essential oil of leaf aerial parts of Achillea wilhelmsii on HT-29 cell line Materials and Methods: Achillea wilhelmsii was colle...

The application of herbal plants instead of synthetic drugs is increasing in recent years. The aim of this study was to evaluate the analgesic and anti-inflammatory effects of ethanolic extracts of Tanacetum lingulatum flowers. In this study, male Wistar rats were used and they divided into 10 groups. Formalin test was used to evaluate the analgesi...

The herbal drugs are important to treatment of various diseases. The purpose of this study was to evaluate the analgesic and anti-inflammatory effects of ethanolic extracts of Anthemis gayana flowers. In this study, male Wistar rats were used and they divided into 10 groups. The groups for inflammation test include: Negative control group that rece...

Abstract Background & Aim: Hyper lipidemy is one of the main factors in progressing cardiovascular diseases. Thymus deanensis celak and Satureja bachtiarica Bunge are medicinal herbs which are used in folklore medicine in Iran. In this research, hypolipidemic effects of essential oils of these herbs in rats fed with a fatty diet were investigated....

Lithium has a significant impact in reducing the symptoms of bipolar mania but in long periods of use with therapeutic doses can cause several disorders in various organs including the reproductive system. In this study, the effect of lithium on the sperm concentration and motility and forms of abnormal cells has been examined. Male Wistar rats und...

There have been efforts to overcome the problem in treatment of cancer using medicinal plants. It has been shown that Citrus essential oil of contains different terpens with antitumoractivities. In this study we sought to determine the cytotoxicity of essential oils of Iranian Citrus limon (L.), C. medica (L.), C. sinsensis (L.) peels on cancer cel...