Ramesh K Goyal

• Vice Chancellor at Delhi Pharmaceutical Science and Research University

Objectives Diabetes management requires continuous monitoring of glucose, medication, diet, and activity. With over 537 million cases globally, digital health solutions support self-care. This study assesses the Madhumeh Setu app, comparing its functionality, quality, and user experience with top diabetes apps using Mobile App Rating Scale (MARS)....

Propose of Review The purpose of this systematic review was to present a current and thorough list of sensory processing assessment tools for children with cerebral palsy (CP). It also aimed to discover different sensory processing issues that children with cerebral palsy experience. Recent Findings A thorough search of the literature was carried...

The dopamine (DA) system is central to mood regulation, motivation, and reward processing, making it a critical focus for understanding Major Depressive Disorder (MDD). While the dopaminergic system's role in MDD pathophysiology has been acknowledged, gaps remain in linking specific receptor subtypes and genetic factors to depression-like phenotype...

Cerebral palsy (CP) is not just caused by neuromuscular abnormalities; it is also a result of an impaired sensory system. Since there is not a standardized measure to evaluate sensory processing of children with spastic CP, therefore an in-depth assessment of sensory processing deficits in children with spastic CP would require an understanding of...

A noteworthy rise in cardiovascular disease and mortality is allied with the metabolic syndrome, which is defined as the concurrent development of multiple factors that comprise this syndrome such as glucose intolerance, dyslipidaemia, obesity, and hypertension. One of the key elements of metabolic syndrome is hypertension. However, establishing th...

Depression is a serious mental health disorder that impacts more than 350 million individuals globally. While the roles of serotonin and norepinephrine in depression have been extensively studied, the importance of dopaminergic pathways-essential for mood, cognition, motor control, and endocrine function-often gets overlooked. This review focuses o...

Background and Aims: Scutellaria barbata D. Don, a perennial herb with a rich history in traditional medicine, is known for its bioactive compounds, including wogonin. It possesses anti-inflammatory, antioxidant, and anticancer properties. Together with other bi-oactive compounds, wogonin contributes to the pharmacological activities associated wit...

Objective The present systematic review and meta-analysis was intended to evaluate the efficacy of Sensory Integration Therapy (SIT) in ameliorating postural and balance dysfunctions in pediatric populations with cerebral palsy (CP). Methods An exhaustive literature search was directed through several well-known systematic databases, including Pub...

Depression is a widespread mental health challenge, necessitating diverse therapeutic approaches. Emerging research suggests that laughter may offer a valuable adjunctive intervention for individuals grappling with depressive symptoms. This review systematically investigates the multifaceted relationship between laughter and depression, elucidating...

Depression, a debilitating mental health disorder affecting millions worldwide, con-tinues to challenge the medical community. While several pharmacological interventions ex-ist, their efficacy and side effects often warrant the exploration of alternative treatments. Natu-ral products derived from plants have gained attention for their potential an...

This review summarizes various polyherbal formulations investigated for antidepres-sant activity in preclinical and clinical studies. Ayurveda, an alternative medical system from India, employs both single herbs and polyherbal formulations to enhance therapeutic efficacy. Evidence suggests that whole herb extracts can be more potent than isolated c...

Background Hispidulin, a flavonoid renowned for its diverse pharmacological activities, is abundant in S. barbata D. Don. Given its prevalence, it is essential to establish a dependable analytical method for quantifying hispidulin in this plant. Methods This study introduces a sensitive and reliable high-performance thin-layer chromatographic (HPT...

Depression, a pervasive and disabling mental health disorder, presents a global healthcare challenge. Despite persistent research on its etiology and pathophysiology, many aspects remain unclear. Predominant neurobiological research and traditional pharmacotherapies have pointed out the monoamine hypothesis as a pivotal factor in the pathophysiolog...

With an ageing global population, understanding the potential links between mental health and neurodegenerative disorders has become increasingly crucial for comprehensive patient care. A comprehensive search of electronic databases yielded a selection of studies encompassing clinical trials, longitudinal cohorts, and cross-sectional analyses, publ...

The emergence of PROTACs as a transformative class of therapeutic agents has prompted an intense investigation into their potential role in breast cancer. This chapter consolidates current knowledge on the application of PROTACs in breast cancer treatment. The primary objective is to elucidate the mechanisms by which PROTACs operate, emphasizing th...

Background Wogonin, a bioactive compound isolated from S. barbata D. Don, has been identified in the literature as a potential inhibitor of monoamine oxidase (MAO), a key enzyme involved in the degradation of neurotransmitters associated with mood regulation. This study aims to investigate the antidepressant-like activity of wogonin in vivo, utiliz...

Background S. barbata D. Don, a perennial herb from the Lamiaceae family, is renowned for its medicinal properties, with scutellarin and scutellarein being key bioactive constituents. Aim In this study, we present the development and validation of a High-Performance Thin- Layer Chromatography (HPTLC) method for the simultaneous quantitative and qu...

Background Diabetic Cardiomyopathy (DCM) poses a substantial healthcare challenge, necessitating innovative therapeutic strategies. This review delves into the evolving role of traditional Indian dietary herbs in managing DCM, aiming to shed light on their potential contributions. Methods A comprehensive examination of the existing body of literat...

Background S. barbata D. Don is a Chinese herb, that belongs to the family Lami-aceae. It has established traditional use in ethnomedicine for treating various ailments, includ-ing mood disorders and sleep disorders, which led to growing interest in exploring its neuro-logical potential, particularly as a potential anti-depressant agent. Aims This...

p> Aim: This systematic review critically evaluates the efficacy of bibliotherapy in addressing mental health concerns across various populations and intervention modalities. Methods: A comprehensive bibliographic search was conducted, identifying 20 articles from databases PubMed, Scopus, and Google Scholar, representing studies published in Eng...

In recent years, regulatory agencies have raised concerns about the presence of potentially carcinogenic substances in certain formulations of Angiotensin Receptor Blockers (ARBs). Specifically, nitrosamines and azido compounds have been identified in some ARB products. Nitrosamines are known to have carcinogenic properties and are associated with...

This chapter delivers a comprehensive examination of the intricate tapestry of drugs regulation in India, a nation that stands at the crossroads of pharmaceutical innovation, public health imperatives, and regulatory dynamics. As one of the world’s largest pharmaceutical markets, India plays a pivotal role in the global healthcare ecosystem. The ch...

Diabetes mellitus is associated with secondary complications such as diabetic retinopathy (DR), nephropathy (DN), and cardiomyopathy (DCM), all of which significantly impact patient health. Intercellular adhesion molecule‐1 (ICAM‐1) has been implicated in inflammatory responses and endothelial dysfunction, both crucial in the pathogenesis of these...

Depression, a pervasive mental health disorder, affects millions worldwide, necessitating the widespread use of synthetic anti-depressant medications. While these pharmaceutical interventions have demonstrated efficacy in alleviating depressive symptoms, they are not without their associated side effects. This review provides a comprehensive overvi...

This study aims to analyze the prevalence and patterns of sensory processing deficits (SPD) in Indian children with spastic cerebral palsy (CP) using child sensory profile-2 (CSP-2) caregiver questionnaire. The authors surveyed 230 caregivers of children aged 3 to 14 y with spastic CP, using CSP-2. The difference in prevalence and distribution of S...

The renin-angiotensin system is involved in maintaining the body’s homeostasis across various functions. Its primary significance lies in blood pressure maintenance and cardiovascular functions, well-recognized for which many drug classes—such as angiotensin-converting enzyme inhibitors (ACE inhibitors), direct renin inhibitors, and angiotensin rec...

Cancer is one of the life-threatening diseases accountable for millions of demises globally. The inadequate effectiveness of the existing chemotherapy and its harmful effects has resulted in the necessity of developing innovative anticancer agents. Thiazolidin-4-one scaffold is among the most important chemical skeletons that illustrate anticancer...

The "serotonin hypothesis of depression" is approximately fifty years old, and in spite of vast literature, the exact role of serotonin in depression pathophysiology is still unclear, as whether a lower serotonin level causes depression or depression causes a reduction in serotonin level has become a tough challenge for researchers to understand th...

The pandemic of COVID-19 is an unprecedented calamity that has seriously affected entire human race. The treatment guidelines for COVID-19 were obviously unavailable to the lack of prior data on the mode of transmission of this viral infection and due to the unknown pathogenesis of symptoms associated with it. Due to an obvious lack of guidelines f...

Natural products with immunomodulatory activity are widely used to treat many diseases, including autoimmune diseases, inflammatory disorders and other cancer treatments. Over the last decades, the immunomodulators agent increased their interest as the therapeutic agents against various conditions, including cancer diseases. Furthermore, they also...

The looming threat of rising antimicrobial resistance (AMR) is one of the major threats to public health, and there is an immediate unmet need of discovery and development of new antimicrobial agents. Traditional drug discovery and development involves several stages for the discovery of a new drug and to obtain marketing approval. Drug repurposing...

Cancer treatment costs are rising due to high expense of clinical trials and a low success rate of around 12%. This necessitates cost-effective and safe anticancer medications. Repurposing of existing drugs may be beneficial in alleviating current medicine scarcity issues in anticancer therapy. It is conceivable to expedite the drug repurposing pro...

COVID-19 is caused by severe acute respiratory syndrome coronavirus-2, SARS-CoV-2. COVID-19 has changed the world scenario and caused mortality around the globe. Patients who recovered from COVID-19 have shown neurological, psychological, renal, cardiovascular, pulmonary, and hematological complications. In some patients, complications lasted more...

the article is about the Myofascial release

Introduction The use of telehealth interventions has been evaluated in different perspectives in women and also supported with various clinical trials, but its overall efficacy is still ascertained. The objective of the present review is to identify, appraise and analyze randomized controlled trials on breast cancer survivors who have participated...

The renin angiotensin system (RAS) plays a vital role in the maintenance of cardiovascular function and physiology. Direct renin inhibitors, angiotensin receptor blockers, and angiotensin-converting enzymes are widely used to treat a wide range of cardiovascular diseases. Identification and decoding of the role of ACE2 in physiology made the RAS in...

Objective:In the present study, hydroethanolic extract of aerial part of S. barbatawas investigated for acute oral toxicity in female mice as per OECD guidelines. Material and methods:Ten mice were divided into 2 groups (n=5) i.e. control and test. Control group received normal water and the test group received a single dose of 2000 mg/kg per oral...

The development of new drugs and their approval has become very low as only few molecular entities were approved between 2010 and 2019 with an average of 31 drugs/year between 2010 and 2014 and 44 drugs/year between 2015 and 2019. In 2018 and 2019, the US FDA has approved 59 and 48 new molecular entities (NMEs), respectively, based on their potenti...

In conventional drug discovery process, the attrition in clinical development as a consequence of late clinical trial failure has been very high. One of the main reasons for high attrition rate during clinical trials is the limitation of animal models used for preclinical testing of drugs, which are not able to clearly predict drug response in pati...

BA.2, a sublineage of Omicron BA.1, is now prominent in many parts of the world. Early reports have indicated that BA.2 is more infectious than BA.1. To gain insight into BA.2 mutation profile and the resulting impact of mutations on interactions with receptor and/or monoclonal antibodies, we analyzed available sequences, structures of Spike/recept...

COVID-19 has emerged as the most severe pandemic with rapid transmissibility. Initially the pathophysiology was not clear and the drugs and their basis to be used have been a great challenge. Even after over 1 year of COVID-19, strategies of the usage of drugs for the treatment have been to use existing drugs that have been repurposed and/or have b...

Environmental risk factors such as Western diet, pollution, alcoholism, tobacco intake, and physical inactivity may be associated with lower intake of Mediterranean-style foods, which may predispose the person to deficiencies in antioxidant vitamins and minerals in all the body systems. A deficiency in these vitamins and minerals, as well as other...

Background The placenta maintains and regulates the growth of foetus and consists of various biologically active nutrients such as cytomedines, vitamins, trace elements, amino acids, peptides, growth factors and other biologically active constituents. Introduction The therapeutic effectiveness of the placenta can be well defined with respect to se...

Background Medication adherence in type 2 diabetes mellitus (T2DM) patients is often suboptimal resulting in complications. There has been a growing interest in using mobile apps for improving medication adherence. Objective The objective of this work was to systematically review the clinical trials that have used mobile app–based interventions in...

Depression is one of the most frequently observed psychological disorders, affecting thoughts, feelings, behavior and a sense of well-being in person. As per the WHO, it is projected to be the primitive cause of various other diseases by 2030. Clinically, depression is treated by various types of synthetic medicines that have several limitations su...

Severe acute respiratory syndrome-coronavirus-2 (COVID-19) virus uses Angiotensin-Converting Enzyme 2 (ACE2) as a gateway for their entry into the human body. The ACE2 with cleaved products have emerged as major contributing factors to multiple physiological functions and pathogenic complications leading to the clinical consequences of the COVID-19...

Cancer cachexia is mainly characterized by wasting of skeletal muscles and fat and body weight loss, along with severe complications of major organs like liver, heart, brain and bone. There can be diminishing performance of these major organs as cancer cachexia progresses, one such drastic effect on the cardiac system. In the present study, differe...

It is a major concern to treat cancer successfully, due to the distinctive pathophysiology of cancer cells and the gradual manifestation of resistance. Specific action, adverse effects and development of resistance has prompted the urgent requirement of exploring alternative anti-tumour treatment therapies. The naturally derived microbial toxins as...

Objective: In this study, evaluation of physicochemical, phytochemical parameters, and antioxidant activity of S. barbata was done to ensure the quality of plant material and analysis of the phytoconstituents qualitatively as well as quantitatively responsible for its pharmacological values. Material and methods: The physicochemical parameters such...

The pandemic of Serious Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) that produces corona virus disease (COVID-19) has challenged the entire mankind by rapidly spreading globally in 210 countries affecting over 25 million people and about 1 million deaths worldwide. It continues to spread, afflicting the health system globally. So far the...

Changes in human lifestyles and environmental deterioration globally causes emergence of new viruses posing research challenges. Recent outburst of disease COVID-19 (nCoV19) is a recent example wherein effective management of virus using conventional medication or adopting preventive and effective diagnostic measures is a challenge. While many ongo...

Myofascial Pain Syndrome (MFPS) is a disorder common among patients who experience musculoskeletal pain. The condition originates from the muscles and the fascia which surrounds it. Initially, this condition used to be prevalent among people in their 40s and 50s. But presently, even young adults are affected. In this review, several databases have...

Background and Objective With the initial case of corona reported from Wuhan, China on 31st December 2020, there has been an unprecedented rise in the coronavirus disease (COVID-19), with over 200 countries all across the world in less than 3 months. By the October 2020, about 40 million population of the world got infected and over one million dea...

Ethnopharmacological relevance Ashwagandha has been used as an ayurvedic medicine in the form of 'Rasayana' (as a tonic) even before 3000 BC in India. As per Ayurveda, it has long been used traditionally for the treatment of inflammation, weakness, impotence, pulmonary tuberculosis. This plant is also beneficial in lumbago and leucorrhea in the fem...

The article has been withdrawn at the request of the authors and editor of the journal Current Traditional Medicine due to incoherent content. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-...

Background While COVID-19 outbreak has had adverse psychological effects in children with special needs, the mental state and burden on their caregivers during this pandemic has yet to be reported. Aims The objectives of this study were to describe the mental health status and the change in perceived strain among caregivers during the COVID-19 out...

In the central nervous system (CNS), a specific loss of focal neurons leads to mental and neurological disorders like dementia, Alzheimer’s disease (AD), Huntington’s disease, Parkinson’s disease, etc. AD is a neurological degenerative disorder, which isprogressive and irreversible in nature and is the widely recognized reason for dementia in the g...

Cardiovascular diseasesCardiovascular disease are the leading cause of death worldwide including various complications like atherosclerosisAtherosclerosis, myocardial infarctionMyocardial infarction, diabetic cardiomyopathyDiabetic cardiomyopathy, cardiac hypertrophyCardiac hypertrophy and cardiac fibrosisFibrosis. Looking into the limitations and...

Angiotensin-converting enzyme 2 (ACE2), the host cell-binding site for SAR-CoV-2, poses two-fold drug development problems. First, the role of ACE2 itself is still a matter of investigation, and no specific drugs are available targeting ACE2. Second, as a consequence of SARS-CoV-2 interaction with ACE2, there is an impairment of the renin-angiotens...

The Glioblastoma Multiforme (GBM; grade IV astrocytoma) exhorts tumors of star-shaped glial cells in the brain. It is a fast-growing tumor that spreads to nearby brain regions specifically to cerebral hemispheres in frontal and temporal lobes. The etiology of GBM is unknown, but major risk factors are genetic disorders like neurofibromatosis and sc...

Background Protecting intellectual property rights are important and particularly pertinent for inventions which are an outcome of rigorous research and development. While the grant of patents is subject to establishing novelty and inventive step, it further indicates the technological development and helpful for researchers working in the same tec...

Aim While there are rampant deaths reported worldwide due to novel corona virus (COVID-19) on one side, hypertension, diabetes and renal failure are emerging comorbidities with mortality risk due to respiratory failure on the other side. The link of these morbidities with renin angiotensin system (RAS) and angiotensin converting enzyme-2 (ACE2) as...

Background Capparis decidua (Forssk.) Edgew. (Kareel) is a multifunctional perennial woody plant belongs to the family Capparaceae, widely distributed in the hot arid regions of different parts of the world especially in the Indian subcontinent, Africa and Saudi Arabia. Objective: The review aims at presenting updated information with respect to et...

Obesity is a major issue and has a prevalence of about 13% around the world. Obese patients are prone to have certain diseases like cardiovascular, metabolic disorders and cancers such as breast, endometrial and colon. There are certain treatments available for obesity like exercise, lifestyle modification, pharmacological treatment and surgery. Mo...

Tuberculosis (TB) is one of the oldest fatal diseases of history. Multidrugresistant tuberculosis (MDRTB) is a major public health issue in the world. In India, the incidence is getting up despite the Indian revised National Tuberculosis Control Programme. India has six recognize medicine systems in this category, namely Ayurveda, Siddha, Unani and...

Recombinant drug products successfully treat many life-threatening and chronic diseases. The high cost of these drugs makes them inaccessible to the patients particularly in developing countries. Patent expiration of innovator recombinant drug products has led to the development of biosimilars or similar biologics by several manufacturers. Unlike g...

Recombinant drug products successfully treat many life-threatening and chronic diseases. The high cost of these drugs makes them inaccessible to the patients particularly in developing countries. Patent expiration of innovator recombinant drug products has led to the development of biosimilars or similar biologics by several manufacturers. Unlike g...

Hepatic and systemic insulin resistance form the core of metabolic syndrome which is also associated with cardiovascular abnormalities, inflammation, and dyslipidemia. Skeletal muscles and adipose tissues are two main target organs for glucose disposal and hence have been studied for insulin resistance too. The liver is the first organ where insuli...

Background Onychomycosis is a nail fungal infection which accounts for 50% of the nail diseases and is characterized by disfigurement and discoloration of nails. The current therapy includes oral and topical formulations both of which come with their own drawbacks. This has left a room for developing patient- compliant novel strategies which can fa...

Autonomic nervous system, as complex, multi-faceted neural networks has now emerged as an important system involved in various neuropsychiatric and neurodegenerative including memory disorders in addition to cardiovascular diseases. Earlier research in auto-pharmacology was focussed on receptor characterisation and understanding mechanism involved...

According to a relatively recent UNICEF report, 15 percent of the infant population of the world is of low birth weight with India accounting for one third of all the world's low-weight newborns. Twenty percent of all low birth weight infants die within a month. This mortality figure is higher in developing countries due to inadequate nutritional i...

Diabetic foot ulcer (DFU) is one of the major complications of diabetes and about 1% of people with diabetes have to go for lower limb amputation. With better understanding of the pathological basis of DFU, number of biomarkers like atrial natriuretic peptides, galectin-3, and cardiac troponins for diabetic cardiomyopathy, cystatin C for diabetics...

Introduction: The present investigation was carried out to study antihyperglycemic activity of formulation prepared by spray-dried powder of fruit juice of E. officinalis (SDF) on animal model of type 1 diabetes. Methods: Hyperglycemia was produced by streptozotocin 45 mg/kg i.v. and formulation was administered orally (100 mg/kg) for 28 days to d...

The regulatory paradigm in cardiac hypertrophy involves alterations in gene expression that is mediated by chromatin remodeling. Various data suggest that class I and class II histone deacetylases (HDACs) play opposing roles in the regulation of hypertrophic pathways. To address this, we tested the effect of magnesium valproate (MgV), an HDAC inhib...

Globally, diabetes is a serious health issue affecting one in 11 adults and consumes 12% of global health expenditure. Prevalence of dyslipidemia in diabetes is not uncommon since decades. Further, patients with type II diabetes have 2-4 folds more risk for cardiovascular disease (CVD). Plants with antioxidant potential are known to have beneficial...

A high-performance liquid chromatographic method was developed and validated for the quantitative determination of swertiamarin antidiabetic drug that constitutes one of the biomarkers in Enicostemma littorale, a first line of regimens in antidiabetic herbal therapy. Different analytical performance parameters such as linearity, precision, accuracy...

Government has many programmes for agricultural and rural development which have not reached the target groups up to a satisfactory level. Therefore, by using proper methods attempts should be made to motivate them through an emphasis on the deprived need areas. We know that Indian economy is based on agriculture with a vast segment of its populati...

Tephrosia purpurea has been reported to possess antidiabetic activity, however, its effects on cardiovascular complications and cataract associated with diabetes have not been studied. The objective of the present study was to investigate the effects of aqueous extract of Tephrosia purpurea on cardiovascular complications and cataract associated wi...

Fifty milk samples were collected from Godaulia and Pandeypur milk mandi of Varanasi district. A standard milk adulteration kit manufactured by HIMEDIA laboratories, Mumbai (India) was used for present study. The milk samples were tested for adulterants used and these were grouped in three classes i.e. Group I: Starch, Sucrose, Glucose and Skim Mil...

Our first Prime Minister Shri J. L. Nehru visited Soviet Russia in 1927. He was impressed by the Five Year Plans of Russia. In 1938, he proposed to adopt the Five Year Plans in India. On the recommendations of the Advisory Planning Board constituted in 1946, under the Chairmanship of K. C. Neogi, the Planning Commission was established in March 195...