Ramendra Pati Pandey

• M.Sc. PhD
• Professor at SRM University Delhi-NCR

The gut microbiome plays a pivotal role in human health, influencing digestion, immunity, and disease prevention. Beneficial gut bacteria such as Akkermansia muciniphila, Adlercreutzia equolifaciens, and Christensenella minuta contribute to metabolic regulation and immune support through bioactive metabolites like short-chain fatty acids (SCFAs). D...

Background Mosquito-borne diseases have a significant public health threat worldwide, with arboviruses accounting for a high proportion of infectious diseases and mortality annually. Brazil, in particular, has been suffering outbreaks of diseases transmitted by mosquito viruses, notably those of the Aedes genus, such as dengue, Zika, and chikunguny...

Objective: To evaluate the efficacy and immunogenicity of the zeta domain over-expressing Leishmania donovani (Ld_ζ1domain) as a vaccination candidate against visceral leishmaniasis (VL). Methods: In this study, Leishmania overexpressor Ld_ζ1domain (OE) were transformed by electroporation using a GFP-tagged Ld_ζ1domain recombinant plasmid. The resu...

The interplay between host and parasite determines parasite burden and disease outcome. Parasite exploits host signaling pathways like p38-MAPK for its survival and pathogenesis. NR-7h, a proteolysis-targeting chimera (PROTAC) targeting human p38-MAPK was used to assess p38-MAPK's role in Leishmania donovani and Plasmodium falciparum infection in t...

Biopolymer based nano drug delivery systems are emerging and promising strategy for addressing the challenges of cancer treatment and wound healing. These natural nanocarrier like alginate, chitosan, gelation and hyaluronic acid. These nano systems offers biocompatibility, biodegradibility and reduced toxicity of the therapeutics. The nanoparticles...

Leishmaniasis, a neglected tropical disease caused by the protozoan parasite Leishmania, remains a significant public health concern in endemic regions. This disease manifests in various forms like cutaneous, mucocutaneous, and visceral leishmaniasis, each associated with specific Leishmania species and influenced by host immune responses. Over the...

The decline in dengue incidence and/or prevalence during the COVID-19 pandemic (2020–22) appears to be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted health services and reduced exposure to mosquito vectors due to prevailing lockdowns. There is limited scientific data on dengue virus (DENV) disease during th...

Chronic obstructive pulmonary disease (COPD) is a prevalent and debilitating condition with significant social and public health implications due to its high morbidity and mortality rates. The World Health Organization recognizes COPD as a major global health challenge. Despite extensive research, the complex pathophysiology of COPD has hindered th...

Background: Coinfections of Pseudomonas aeruginosa and Staphylococcus aureus usually fail to respond to antibiotic treatment, and combination therapy may prove to be a substantial approach to prevent the spread of antimicrobial resistance. Objectives: To evaluate the antimicrobial and antibiofilm effects of drugs against the sensitive as well as re...

Free radicals are highly reactive molecules that possess unpaired electrons, making them unstable and causing damage to macromolecules such as proteins, lipids, and DNA. The accumulation of free radicals and oxidative stress has been linked to the development of various metabolic disorders, including cardiovascular diseases, neurodegenerative disor...

The gut, often referred to as the "second brain," has significant contributions in the maintaining of the good bacteria contribute enormous role such as digestion, produce essential vitamins, support the immune system, and protect against harmful bacteria. The beneficial flora including Akkermansia muciniphila, Adlercreutzia equolifasciens, Barnesi...

Background Osteoarthritis (OA) is a common degenerative disease affecting people and animals, resulting in persistent pain and joint deformities. Its growing prevalence presents considerable difficulties to public health and veterinary care systems worldwide. Despite substantial research, the molecular pathways underlying OA pathogenesis remain poo...

Optimal irrigation water depth is a crucial parameter in irrigation engineering, often referred to as root zone depth. It is typically assumed to lie between 1 and 1.5 m below the ground surface, depending on the crop and soil types as well as the practitioner’s skill and experience. This approach can lead to inefficient irrigation scheduling. Coup...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants harboring mutations in the structural protein, especially in the receptor binding domain (RBD) of spike protein, have raised concern about potential immune escape. The spike protein of SARS-CoV-2 plays a vital role in infection and is an important target for neutralizing antibodi...

Globally increasing antibiotic resistance has been linked to the extensive use of antibiotics in medical, veterinary, and agricultural Practices. This study aims to investigate the correlations of antimicrobial-resistant of various pathogens in three compartments: humans, animals and the environment in India and Germany. A systematic search was car...

The global challenge of water resource availability is exacerbated by anthropogenic influences that promote the emergence of pollutants. Among these pollutants are microbiological agents, including viruses, which are ubiquitous in the biosphere and play a pivotal role in both ecological balance and the occurrence of diseases in animals and plants....

Breast cancer (BC) remains a leading cause of morbidity and mortality among women worldwide, with triple-negative breast cancer (TNBC) posing significant treatment challenges due to its aggressive phenotype and resistance to conventional therapies. Recent advancements in nanocarrier technology offer promising solutions for enhancing drug delivery,...

Background Osteoarthritis (OA) is a common degenerative disease affecting people and animals, resulting in persistent pain and joint deformities. Its growing prevalence presents considerable difficulties to public health and veterinary care systems worldwide. Despite substantial research, the molecular pathways underlying OA pathogenesis remain poo...

Metagenomic studies of mosquito viromes demonstrated a more diverse composition than just an exclusive composition of pathogenic arboviruses transmitted to humans. In our study, the virome of 866 female mosquitoes collected throughout 2020 at the São Paulo Zoo, located in the city of São Paulo/SP—Brazil, was obtained. Specifically, in this paper, w...

Leishmaniasis is a neglected disease with a global spread that affects both domestic and wild animals in addition to people. Leishmania donovani is the suspected anthroponotic cause of visceral leishmaniasis (VL) in India, where it is an endemic disease. The reservoir hosts play a crucial role in the life cycle of the Leishmania parasite. The compl...

Present case report describes an unusual instance of esophageal actinobacillosis in an adult cow presented to the university hospital with a history of inability to drink and swallow. Clinical evaluation revealed a noticeable five-inch swelling in the Juglar groove, while radiographic imaging indicated the presence of a small, round, and mildly rad...

In December 2023, we observed a notable shift in the COVID-19 landscape, when JN.1 omicron emerged as the predominant SARS-CoV-2 variant with a 95% incidence. We characterized the clinical profile, and genetic changes in JN.1, an emerging SARS-CoV-2 variant of interest. Whole genome sequencing was performed on SARS-CoV-2 positive clinical specimens...

Background: Exosome (EXOs) are rapidly being identified as key mediators of cell-to-cell communication. They convey biologically active molecules to target cells, serve important roles in a range of physiological and pathological processes, and have enormous potential as novel therapeutic strategies. Methods: Preclinical research published between...

Background: Dengue is a vector-borne viral disease impacting millions across the globe. Nevertheless, akin to many other diseases, reports indicated a decline in dengue incidence and seroprevalence during the COVID-19 pandemic (2020-22). This presumably could be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted...

Human exposure to antimicrobial resistance (AMR) through food is now very imperfectly understood, creating a significant gap in the design of interventions. The interchange of AMR genes and the transfer of AMR bacteria from animals to humans through the food chain necessitate comprehensive methods to risk reduction. With a focus on AMR in bacterial...

Concern for conservation and sustainable use of plant resources has been growing in many countries including India. The inhospitable and erratic climate in the desert ecosystem coupled with the high population of human and livestock make it susceptible to degradation and depletion. These depleting plant resources in the Rajasthan desert are discuss...

The term ‘alkaline rocks’ comprises alkali basalts, tephrites, phonolites, trachytes and their plutonic equivalents, including carbonatites and lamprophyres. Their study can aid the interpretation of ancient terranes and their geodynamic setting. Alkaline rocks may also host precious- and rare-metal mineralization, the latter representing critical...

70 taxa belonging to 60 genera under 25 families not reported by Bhandari in his "Flora of the Indian Desert" are enumerated.

Ten species of angiosperms are reported for the first time from Rajasthan.

The present paper includes the second supplementary list of 89 indigenous species belonging to 66 genera and 28 families, in continuation of earlier published works on the vegetation of Kota division. The specific names are followed by their field numbers, frequency and abundance in the area, habitat with exact locality of occurrence and flowering...

The present paper deals with the indigenous vegetation of a part of Chittorgarh district (submergence and catchment area under Gosunda Irrigation Project) and the major plant communities in different habitats, including plants frequently occurring in them. A total number of 276 species belonging to 237 genera and 77 families have been recorded.

In the face of escalating threats posed by antimicrobial resistance (AMR) to global health, this chapter explores the pivotal role of nanomedicine as a promising solution. Delving into the dynamic landscape of nanoscale interventions, the chapter offers a comprehensive analysis of the challenges and opportunities inherent in leveraging nanomedicine...

Nanotechnology, an interdisciplinary field that merges physics, chemistry, and biology, has emerged as a catalyst for innovation, offering far-reaching implications across various scientific disciplines. Gold nanoparticles (GNPs), with their unique physicochemical properties and biocompatibility, have become a focal point in this technological revo...

Recent advancements in gut microbiome research have highlighted the complex interplay between gut microbiota and various physiological and pathological processes, showing that gut microbiota plays a vital role in human health and disease. Imbalances in the gut microbiota, known as dysbiosis, have been associated with a range of health conditions, i...

Present case report describes an unusual instance of esophageal actinobacillosis in an adult cow presented to the university hospital with a history of inability to drink and swallow. Clinical evaluation revealed a noticeable five-inch swelling in the Juglar groove, while radiographic imaging indicated the presence of a small, round, and mildly rad...

In December 2023, we observed a notable shift in the COVID-19 landscape, when the JN.1 emerged as a predominant SARS-CoV-2 variant with a 95% incidence. We characterized the clinical profile, and genetic changes in JN.1, an emerging SARS-CoV-2 variant of interest. Whole genome sequencing was performed on SARS-CoV-2 positive samples, followed by seq...

In December 2023, we observed a notable shift in the COVID-19 landscape, when the JN.1 emerged as a predominant SARS-CoV-2 variant with a 95% incidence. We characterized the clinical profile, and genetic changes in JN.1, an emerging SARS-CoV-2 variant of interest. Whole genome sequencing was performed on SARS-CoV-2 positive samples, followed by seq...

Citation: Couto, R.d.S.; Abreu, W.U.; Rodrigues, L.R.R.; Marinho, L.F.; Morais, V.d.S.; Villanova, F.; Pandey, R.P.; Deng, X.; Delwart, E.; da Costa, A.C.; et al. Genomoviruses in Liver Samples of Molossus molossus Bats. Microorganisms 2024, 12, 688. Abstract: CRESS-DNA encompasses a broad spectrum of viruses documented across diverse organisms suc...

Citation: Couto, R.d.S.; Abreu, W.U.; Rodrigues, L.R.R.; Marinho, L.F.; Morais, V.d.S.; Villanova, F.; Pandey, R.P.; Deng, X.; Delwart, E.; da Costa, A.C.; et al. Genomoviruses in Liver Samples of Molossus molossus Bats. Microorganisms 2024, 12, 688. Abstract: CRESS-DNA encompasses a broad spectrum of viruses documented across diverse organisms suc...

Present case report describes a case of an atypical esophageal actinobacillosis in an adult cow presented to the university hospital with a history of inability to drink and swallow. Clinical examination revealed a five-inch swelling in the juglar groove. Skiagram revealed the presence of a small and slightly radio opaque round growth. Exploratory...

Background Animal-assisted therapy, also known as pet therapy, is a therapeutic intervention that involves animals to enhance the well-being of individuals across various populations and settings. Objective This systematic study aims to assess the outcomes of animal-assisted therapy interventions and explore the associated policies. Methods A tot...

Poultry eggs are a critical source of protein, vitamins, and minerals for people worldwide; facing the current global egg shortage is a significant concern. The shortage results from various factors, including avian flu outbreaks, changes in consumer demand, and supply chain disruptions caused by the COVID-19 pandemic. The economic crisis caused by...

Globally increasing antibiotic resistance has been connected to the use of antibiotics in medical, veterinary, and agricultural medicine, contributing to the burden of antibiotic resistance in Asia and Europe. The main objective of this study was to correlations of antimicrobial-resistant of various pathogens in three compartments: humans, animals...

Leishmaniasis is a deadly tropical disease that is neglected in many countries. World Health Organization, along with a few other countries, has been working together to protect against these parasites. Many novel drugs from the past few years have been discovered and subjected against leishmaniasis, which have been effective but they are quite exp...

The Totiviridae family of viruses has a unique genome consisting of double-stranded RNA with two open reading frames that encode the capsid protein (Cap) and the RNA-dependent RNA polymerase (RdRpol). Most virions in this family are isometric in shape, approximately 40 nm in diameter, and lack an envelope. There are five genera within this family,...

Probiotics have gained a significant attention as a promising way to improve gut health and overall well-being. The increasing recognition of the potential health advantages associated with functional food products, leading to a specific emphasis on co-encapsulating probiotic bacteria and bioactive compounds within a unified matrix. To further expl...

Background: Influenza represents a global One Health concern, and the utilization of nanoparticle-based vaccines or drugs emerges as a promising solution for its prevention and treatment. Nanoparticles, with their precision in drug distribution, heightened efficacy, and minimized adverse effects, have garnered attention as viable candidates in the...

These authors contributed equally to this work. Abstract: The "One Health" initiative is a critical strategy that recognizes the interconnectedness between human, animal, and environmental health in the spread and containment of infectious pathogens. With the ease of global transportation, transboundary disease outbreaks pose a significant threat t...

Breast cancer (BC) is one of the most common types of cancer in women. Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), exhibits a highly aggressive phenotype with increased metastasis and resistance to conventional treatmen...

The Totiviridae family of viruses has a unique genome consisting of double-stranded RNA with two open reading frames that encode the capsid protein (Cap) and the RNA-dependent RNA polymerase (RdRpol). Most virions in this family are isometric in shape, approximately 40 nm in diameter, and lack envelope. There are five genera within this family, inc...

Background The EMPA-KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression. We aimed to assess how effects of empagliflozin might differ by primary kidney disease across its broad populat...

Background Sodium glucose co-transport 2 inhibitors (SGLT2i) reduce progression of chronic kidney disease (CKD) and the risk of cardiovascular morbidity and mortality in a wide range of patients. However, their effects on kidney disease progression in some patients with CKD are unclear because few clinical kidney outcomes occurred among such patien...

Scrub typhus is one of the most neglected tropical diseases, a leading cause of acute undifferentiated febrile illness in areas of the ‘tsutsugamushi triangle’, diagnosed frequently in South Asian countries. The bacteria Orientia tsutsugamushi is the causative agent of the disease, which enters the human body through the bite of trombiculid mites (...

Osteoporosis, a chronic bone disease, alters both the microstructure and macrostructure of bones, endangering bone strength and increasing the susceptibility to fragility fractures. Its consequences on the aging population raise important sociological, healthcare, and economic issues. The relationship between the immune system and osteoporosis can...

Background Antimicrobial resistance (AMR) is a critical global issue that poses significant threats to human health, animal welfare, and the environment. With the increasing emergence of resistant microorganisms, the effectiveness of current antimicrobial medicines against common infections is diminishing. This study aims to conduct a competi‑ tive...

Background Antimicrobial resistance (AMR) is a critical global issue that poses significant threats to human health, animal welfare, and the environment. With the increasing emergence of resistant microorganisms, the effectiveness of current antimicrobial medicines against common infections is diminishing. This study aims to conduct a competitive m...

The parasitic Eimeria species are very harmful to chickens. The chicken sector suffers enormous financial losses as a result of these parasites, primarily due to reduced production efficiency and increased control costs. Clinical coccidiosis is caused by high levels of Eimeria infection, which is a serious hazard to chicken welfare and a contributi...

Salmonella is the intracellular pathogen and etiological known for the cause of asymptomatic carriage, gastroenteritis, systemic disease (typhoid fever), in severe cases death may also occur. Altered function of mitochondria due to Salmonella infection impacts the immune response. Mitochondria which are recognized as the “powerhouse” of the cells a...

Human exposure to antimicrobial resistance (AMR) through food is now very imperfectly understood, creating a significant gap in the design of interventions. The interchange of AMR genes and the transfer of AMR bacteria from animals to humans through the food chain necessitate comprehensive methods to risk reduction. With a focus on AMR in bacterial...

Current research shows that consuming high-fat and salt that are now the main ingredients of modern diets over a period of time can disrupt the gut ecosystem, leading to metabolic imbalances and metabolic diseases. However, which component of modern diets, such as high-fat and high-salt consumption for a short duration, is more harmful to health ba...

Citation: da Costa, H.H.M.; Bielavsky, M.; Orts, D.J.B.; Araujo, S.; Adriani, P.P.; Nogueira, J.S.; Astray, R.M.; Pandey, R.P.; Lancellotti, M.; Cunha-Junior, J.P.; et al. Production of Recombinant Zika Virus Envelope Protein by Airlift Bioreactor as a New Subunit Vaccine Platform. Int. J. Mol. Sci. 2023, 24, 13955. https://doi. Abstract: The Zika...

The chapter focuses on the interrelation of viruses in this epoch of great acceleration, also known as the Anthropocene. The increased frequency of viral pandemics and epidemics globally is a by-product of the Anthropocene. The severity of epidemics and pandemics have increased, which has magnified the number of cross-species responsible for variou...

Background Animal-assisted therapy, also known as pet therapy, is a therapeutic intervention that involves animals to enhance the well-being of individuals across various populations and settings. This systematic study aims to assess the outcomes of animal-assisted therapy interventions and explore the associated policies. Methods A total of 16 pa...

The management of proximal humeral fractures (PHF) remains controversial. Its incidence is increasing. Patients should be meticulously assessed clinically for co-morbidities and neuro-vascular injuries. Radiological investigation helps provide information on the fracture configuration and dislocations. Enhanced by 3-dimensional CT scanning, these f...

Antimicrobial resistance (AMR) is a growing public health concern worldwide, and it poses a significant threat to human, animal, and environmental health. The overuse and misuse of antibiotics have contributed significantly and others factors including gene mutation, bacteria living in biofilms, and enzymatic degradation/hydrolyses help in the emer...