Ramdas Bhat

Ramdas Bhat
Srinivas Group of Colleges · Pharmacology

Master of Pharmacy
Hello, I am Mr. Ramdas Bhat, Associate Professor in the Department of Pharmacology at Srinivas College of Pharmacy.

About

77
Publications
21,293
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130
Citations
Introduction
Hello, I am Mr. Ramdas Bhat, an Associate Professor at Srinivas College of Pharmacy. My research focuses on the pharmacological evaluation of plant-based products, pharmacogenomics, and target-based therapies to advance personalized medicine. I also guide postgraduate students, review scientific articles, and serve as an editor for reputed pharmacy and healthcare journals.
Additional affiliations
January 2022 - September 2022
Rajiv Gandhi University of Health Sciences
Position
  • Professor (Associate)
July 2016 - January 2022
Rajiv Gandhi University of Health Sciences
Position
  • Assistant professor
Education
June 2014 - May 2016

Publications

Publications (77)
Article
Full-text available
The present study was aimed to evaluate the hepatoprotective effect of Jasminum Sambac flower extract (JSFE) in acute experimental liver injury induced by Carbon tetrachloride (CCl 4), alcohol, paracetamol (PCM) and thioacetamide (TAA) in rats. In Ccl 4, alcohol, PCM and TAA models rats were treated with 10, 15, 5 and 7 days respectively. To induce...
Article
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The main moto of the present study is to evaluate the anticonvulsant property of Ficus carica fruits in Swiss albino mice using Maximal electroshock seizures (MES) model. Animals were divided into 5 groups of n=6 each using Phenytoin (25 mg/kg i.p) as the standard drug. The Aqueous extract of Ficus carica was given at three doses of 250 mg/kg, 500...
Article
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The purpose of this study is to evaluate if a hydroalcoholic root extract of Carica papaya has any nephroprotective qualities in Wistar rats with paracetamol-induced nephrotoxicity (PCM). When used in excessive doses, paracetamol (PCM), an analgesic and antipyretic, can cause liver and kidney necrosis in humans and animals. The animals were put int...
Article
Full-text available
The main moto of the present study is to evaluate the anticonvulsant property of Ficus carica fruits in Swiss albino mice using Maximal electroshock seizures (MES) model. Animals were divided into 5 groups of n=6 each using Phenytoin (25 mg/kg i.p) as the standard drug. The Aqueous extract of Ficus carica was given at three doses of 250 mg/kg, 500...
Article
Full-text available
CAR-NK cells are a novel development within cancer immunotherapy that merges the innate cancer killing features of NK cells with the targeted nature of CAR technologies. Unlike CAR-T cells, CAR-NK compels cells among which there are lower side effects and the ability to target cancer cells regardless of MHC expression. These kinds of NK cells a...
Article
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Clerodendrum paniculatum L., commonly known as the Pagoda flower or Red Glorybower, is a significant medicinal plant species belonging to the Lamiaceae family. This review synthesizes current knowledge about its botanical characteristics, geographical distribution, phytochemical composition, and therapeutic applications. Native to tropical Southeas...
Article
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Ficus religiosa (F. religiosa), commonly known as the "Peepal" tree, is a sacred fig variety native to India with immense medicinal and cultural importance. The tree, belonging to the Moraceae family, is widely distributed across South and Southeast Asia. Phytochemical screening reveals the presence of various bioactive compounds including tannins,...
Article
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Ayurveda and many other traditional medicines are part and parcel of human life for millions of years worldwide. Among a long list of medicinal plants, one such medicinally important Oleaceae family of genus Jasminum is J. auriculatum. In this paper, the various aspects of this species, especially botanical characteristics, traditional uses, and ph...
Article
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Sechium edule (Jacq.) Swartz, or simply chayote, is the common name assigned to this tropical and subtropical diploid herbaceous climbing plant belonging to Cucurbitaceae, generally cultivated in Brazil, Costa Rica, Mexico, as well as across several regions in India. A review on S. edule includes its botanical traits, phytochemicals' composition, a...
Article
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Misophonia, characterized by intense emotional and physiological responses to specific sounds, represents a complex neurophysiological and behavioral syndrome first identified in 1997. This review synthesizes current understanding of its epidemiology, etiology, pathophysiology, and clinical implications. Population studies indicate prevalence rates...
Article
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Background and Objective: Anxiety, a complex psychological and physiological state, negatively impacts various aspects of life. This study aimed to evaluate the anti-anxiety effects of the hydroalcoholic extract of Ficus religiosa leaves in experimental animals. Methodology: The anxiolytic effects were investigated in mice using the elevated plus-m...
Article
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Background: Cardiovascular diseases are the leading cause of death in the world, causing 17.9 million deaths annually. In India, with cities like Mangalore included, the burden of cardiovascular disease is increasing rapidly. Objectives: To assess knowledge, attitudes, and practices regarding cardiovascular disease risk factors among adults in Mang...
Research
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Urolithiasis, or kidney stones, is a prevalent and burdensome condition globally, including in the Dakshina Kannada community. This cross-sectional study aims to assess the knowledge, attitudes, and dietary practices related to urolithiasis among residents of Dakshina Kannada, with the goal of identifying areas for targeted intervention to improve...
Research
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, affecting millions worldwide. As synthetic medications often prove ineffective or cause severe side effects, natural remedies are gaining attention. This review explores the potential of Centella asiatica, a herb traditionally us...
Article
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Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that remains a significant challenge for both healthcare providers and researchers. Despite advances in understanding its mechanisms, finding effective therapies is still difficult. This review highlights a potential therapeutic target in SLE research: tumor necrosis factor su...
Article
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A BSTRACT Stem cells offer great promise in dentistry by regenerating critical oral tissues. Derived from sources such as dental pulp, periodontal ligament, and dental follicle, these cells can be pluripotent or multipotent and are capable of differentiating into various cell types, including odontoblasts and osteoblasts. This regenerative potentia...
Conference Paper
Background and Aim: Menstruation is a fundamental physiological process affecting women's health and well-being. Despite advancements, many women still face challenges in menstrual hygiene management due to lack of awareness, cultural taboos, and limited access to proper menstrual products and disposal methods. This study aimed to assess the knowle...
Article
Background and Aim: Acne vulgaris is a common dermatological condition affecting youth worldwide. While its pathogenesis is well-understood, individual experiences with aggravating factors and treatment choices vary. This study aimed to evaluate self-reported factors aggravating acne and determine treatment choices among youth with acne while asses...
Research
Diabetes mellitus is a chronic metabolic disorder with the condition where there is an abnormally high blood glucose level. Home medication review (HMR) is a patient-centered process that provides the effective and quality use of medication at the patient’s home. According to a study, nearly 50% of Type II diabetes fail to recite adequate glycemic...
Research
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Pharmacogenomics is emerging as a promising approach to optimize psychotropic drug therapy in psychiatry. This comprehensive review explores the potential of pharmacogenomics to address the challenges of individual variability in patient responses to psychiatric medications. The fundamentals of pharmacogenomics are discussed, including relevant gen...
Research
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Background: Helminth infections are one of the utmost health and economic problems in developing tropical countries. Synthetic anthelmintics are present and have some limitations, like inaccessibility and drug resistance, and so alternative anthelmintics become inevitable. Among medicinal plants, Macaranga peltata shows many bioactive compounds. Th...
Article
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Background and Objective: Pain significantly impacts global health, and conventional medications often have serious side effects, prompting the exploration of safer alternatives from natural sources. This study aimed to evaluate the analgesic activity of ethanolic extracts from Macaranga peltata leaves, traditionally used for pain management in par...
Research
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Fragile X Syndrome (FXS) is a complex neurodevelopmental disorder associated with intellectual disability, behavioral challenges, and various physical manifestations. Central to understanding FXS is the Fragile X Mental Retardation 1 (FMR1) gene, pivotal in the disorder's pathogenesis. This review examines FMR1 as a key biomarker in FXS, drawing on...
Research
Full-text available
Pharmacogenomics is emerging as a promising approach to optimize psychotropic drug therapy in psychiatry. This comprehensive review explores the potential of pharmacogenomics to address the challenges of individual variability in patient responses to psychiatric medications. The fundamentals of pharmacogenomics are discussed, including relevant gen...
Research
Full-text available
Monkeypox represents a zoonotic viral affliction instigated by the monkeypox virus, which is classified within the Poxviridae family and is distinct from the virus that causes chickenpox. Initially recognized in 1958, this infection has recently attracted international scrutiny due to its escalating incidence beyond traditional endemic territories....
Research
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This review explores the emerging field of nanorobotics and its applications in precision cancer treatment. Nanorobots, engineered devices ranging from 0.1-10 micrometers in size, offer unprecedented capabilities for targeted drug delivery, diagnostics, and therapeutic interventions at the cellular level. We examine the key types of nanorobots-orga...
Research
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Cardiovascular diseases (CVD) continue to pose a significant global health challenge, contributing substantially to morbidity and mortality worldwide. Despite advances in medical science, the intricate interplay of genetic predispositions, environmental factors, and lifestyle choices complicates effective CVD management. Precision medicine offers a...
Article
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Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor symptoms such as tremor, rigidity, and bradykinesia. Beyond these motor manifestations, Parkinson's disease encompasses non-motor symptoms, including cognitive impairment and auton...
Article
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This comprehensive review deals with the multifaceted aspects of electronic cigarettes (e-cigarettes), examining their composition, health implications, regulatory challenges, and market dynamics. E-cigarettes, also known as vaping devices, function by warming a solution of liquid containing flavors, nicotine, and various other compounds to produce...
Article
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COVID-19 can lead to a wide range of cardiac complications, affecting 20-30% of hospitalized patients, including myocardial injury, arrhythmias, heart failure, and thromboembolic events. Mechanisms involve direct viral injury, immune-mediated damage, and consequences of critical illness. Emerging evidence suggests cardiac effects can persist long a...
Article
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Precision medicine, propelled by genomic advancements, is transforming the healthcare landscape by transitioning from traditional evidence-based methods to individualized care. Despite originating from personalized care roots, psychiatry has been hesitant in embracing this approach compared to disciplines such as oncology and haematology. Objective...
Article
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Autophagy, a cellular degradation process, is a key regulator of immune function, interacting with the major histocompatibility complex (MHC) and human leukocyte antigen (HLA) systems, and the NF-KB pathway. It encompasses three main types: macroautophagic, micro autophagy, and chaperone-mediated autophagy (CMA). Autophagy plays a crucial role in b...
Patent
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This document certifies the registration of a novel design for "Pole Climbing Equipment to Track Neurological Behavior of Animals," under Serial No. 173487 and Design No. 412266-001, recorded on April 1, 2024, in Class 30-99. Developed by Dr. Satish S, Mr. Ramdas Bhat, Dr. Viresh K Chandur, Dr. Krishnananda Kamath K, Mr. Gopi Krishna Uv, Dr. Palaks...
Article
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With 1.5 million fatalities worldwide a year from tuberculosis (TB), this disease continues to be a serious global public health issue. Extrapulmonary TB (EPTB), which affects one out of every five cases of TB, presents significant diagnostic and treatment problems. In addition to adapting to a physiological state of quiescence, Mycobacterium TB is...
Article
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Cigarette smoking presents a significant global health challenge, with approximately 8 million deaths attributed annually to tobacco use. The intricate chemical composition of cigarettes, containing over 5,000 harmful substances like nicotine and tar, disrupts cellular functions, fostering chronic inflammation and immune dysregulation. This not onl...
Article
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The swift advancement of artificial intelligence (AI) has sparked significant interest in its potential applications in the healthcare domain, particularly in pharmacy. Understanding the knowledge, attitudes, and practices (KAP) of pharmacists towards AI is essential for its successful integration. This study sought to assess the KAP of pharmacists...
Article
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The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has posed significant global challenges, impacting millions and straining healthcare systems. With over 600 million confirmed cases worldwide and a death rate of approximately 1% as of May 2024, there is an urgent need for effective treatments. Kinase inhibitors, traditionally used in cancer th...
Article
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Antimicrobial resistance (AMR) poses a significant global health threat, primarily driven by the excessive and inappropriate use of antibiotics. This leads to ineffective treatments, prolonged illnesses, increased healthcare costs, and higher mortality rates. Understanding public attitudes towards antibiotic use is crucial for developing strategies...
Research
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Background and Objective: The escalating healthcare costs globally have necessitated cost-effective solutions without compromising quality. Generic medicines offer a promising avenue, but their adoption varies across healthcare systems and is influenced by perceptions of healthcare providers and patients. To assess knowledge, attitudes, and practic...
Research
Full-text available
Fragile X Syndrome (FXS) is a complex neurodevelopmental disorder associated with intellectual disability, behavioral challenges, and various physical manifestations. Central to understanding FXS is the Fragile X Mental Retardation 1 (FMR1) gene, pivotal in the disorder's pathogenesis. This review examines FMR1 as a key biomarker in FXS, drawing on...
Research
Full-text available
Background and Objective: Diabetes mellitus is a prevalent chronic metabolic disorder necessitating effective therapeutic approaches. Traditional medicinal practices offer a promising avenue for novel antidiabetic agents, with polyherbal formulations garnering attention for their synergistic potential. This study aimed to evaluate the antidiabetic...
Article
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This research examines the viable usage of blockchain innovation in pharmaceutical supply chain administration. Through an arrangement of tests and comparative examinations, the ponder assesses the effect of blockchain on key execution pointers such as traceability, straightforwardness, security, and proficiency. Results show noteworthy changes in...
Article
This study aimed to investigate the potential of the aqueous extract of Tabernaemontana divaricata (Dwarf) leaves as a natural antibacterial agent against antibiotic-resistant bacteria. The extract was subjected to phytochemical screening to identify its bioactive constituents. The antibacterial effectiveness was assessed against S. aureus and E. c...
Article
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This study aimed to investigate the potential of the aqueous extract of Tabernaemontana divaricata (Dwarf) leaves as a natural antibacterial agent against antibiotic-resistant bacteria. The extract was subjected to phytochemical screening to identify its bioactive constituents. The antibacterial effectiveness was assessed against S. aureus and E. c...
Article
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Nanomedicine stands at the forefront of healthcare advancements, leveraging nanotechnology to enhance diagnosis, treatment, and disease prevention. Within this rapidly growing field, nanoparticles exhibit unique traits, such as a notable surface area-to-volume ratio and precise targeting abilities, making them valuable in medical applications. The...
Article
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Kidney injury, a global health challenge, necessitates a nuanced understanding of molecular intricacies for effective interventions. Long non-coding RNAs (lncRNAs), once dismissed as transcriptional noise, now emerge as pivotal players in orchestrating renal health. Dysregulation of specific lncRNAs like TUG1, MALAT1, H19, and NEAT1 provides molecu...
Article
Background and Objective: Gastric ulcer is a common gastrointestinal disorder, and traditional medicines have been used for centuries to treat various ailments, including gastric ulcer. Ventilago maderaspatana bark is a traditional remedy used in Ayurvedic and Malay medicine for the treatment of gastric ulcer. This study aimed to investigate the an...
Article
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Introduction: Pharmacovigilance (PV) is crucial to identify, managing, and reporting adverse drug reactions (ADRs) in the healthcare sector. Young healthcare professionals (HCPs) play an essential role in the PV system. Objective: This study aimed to assess awareness, understand the causes of underreporting, and find solutions to encourage ADR repo...
Article
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The emergence of the Omicron variant of SARS-CoV-2 has raised concerns about the effectiveness of existing COVID-19 vaccines. Initially, spike protein was identified as a key target for vaccine development, leading to the creation of mRNA vaccines like Pfizer-BioNTech and Moderna, which have shown high efficacy. The immune response to SARS-CoV-2 in...
Article
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Introduction: Epilepsy is a neurological disorder with recurrent seizures, often inadequately controlled by existing medications. Despite the availability of antiepileptic drugs, many patients experience inadequate seizure control and adverse effects, prompting the exploration of alternative treatments. Bixa orellana Linn., known as Annatto or Achi...
Poster
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CRISPR-Cas9 revolutionized molecular biology and shows promise in cancer treatment. This review outlines current status, future prospects, benefits, and challenges.
Article
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Alzheimer's disease (AD) stands as an intricate neurodegenerative condition impacting numerous individuals globally. In pursuit of enhancing the efficacy and safety of AD treatments, pharmacogenomic strategies have emerged. These methods encompass the identification of genetic variations influencing drug metabolism, the utilization of genetic testi...
Article
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The Marburg virus disease (MVD) is a severe and deadly viral hemorrhagic fever caused by the Marburg virus. Recent outbreaks have raised global concerns due to the severity of the disease, high mortality rate, and limited treatment options. This review provides an overview of the latest outbreak and current research on MVD, including efforts to und...
Article
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Background: Antimicrobial resistance (AMR) is a growing global public health issue that requires immediate attention. Aim: This study aimed to assess the knowledge, attitudes, and practices related to antibiotics and AMR among the general population in Mangalore, India. Materials and Method: A cross-sectional survey was conducted among 250 particip...
Article
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Multiple sclerosis (MS) poses a complex challenge, impacting countless individuals worldwide. The disease's multifaceted pathogenesis has stymied researchers and clinicians. Yet, headway has been made in understanding its immunological roots, leading to novel therapies like Anti-CD20 Monoclonal Antibodies (mAbs) that target B cells. These mAbs offe...
Research
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Background and Objective: Convulsion is a sudden, involuntary muscle contraction causing rapid and repetitive movements of the body. Ruta Chalepensis Linn. In is a medicinal plant used to treat a wide range of disorders including seizure. But, the anticonvulsant activity of this plant has not been studied in deep. We therefore sought to evaluate th...
Article
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The present research examined the diuretic potential of the ethanolic derivatives of Bauhinia tomentosa Linn roots. The roots of this plant have been traditionally used for their diuretic effects, but scientific evidence supporting this claim is limited. The study utilized Wistar rats and evaluated urine volume, electrolyte excretion, and renal fun...
Article
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siRNA-mediated silencing of oncogenes holds great promise as a potential cancer therapy. By selectively silencing genes involved in cancer progression, siRNA-based therapies have the potential to be highly specific and effective, while minimizing off-target effects and toxicity. However, several challenges need to be addressed before siRNA-based th...
Article
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Zika virus is a single-stranded RNA virus that belongs to the Flaviviridae family and was first identified in the Zika Forest of Uganda in 1947. Since 2007, there have been several outbreaks of Zika virus in various countries, with the most significant outbreak occurring in Brazil in 2015. The virus is primarily transmitted by infected Aedes mosqui...
Article
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Norovirus is a highly contagious virus that is the leading cause of acute gastroenteritis worldwide. It is a small, non-enveloped RNA virus that is classified as a member of the Caliciviridae family. Norovirus is spread through contaminated food or water, close contact with infected individuals, or by touching contaminated surfaces and then ingesti...
Article
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2023ABSTRACTObjective: To evaluate the anti-depressant activity of "Nelumbo nucifera" in experimental mice. Methods: The acute toxicitystudies were conducted on fresh "Nelumbo nucifera" flower extract. The extract (100–200 mg/kg) was able to induce the mice'simmobility duration in the Forced swimming and Tail suspension tests in a dose-dependent ma...
Article
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This paper intends to accomplish the following objectives: The goals of this review are threefold: The goals of this review are threefold: first, to evaluate the current state of cartilage substitution and regeneration; second, to analyse the patented biomaterials currently used in preclinical and clinical stages; and third, to investigate the pote...
Article
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The scope and complexity of current pharmaceutical business practices and innovations provide managers with a broad variety of challenges in terms of the organisational structure and management of staff. These challenges may be broken down into many categories. The administration and expansion of distribution systems both come with significant fina...
Article
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Objective and background: Malus sylvestris Linn are a plant widely used as a traditional medicinal herb has a wide range of Pharmacotherapeutic activities. The current study was carried out to investigate the diuretic activity of Malus sylvestris Linn fruit aqueous extract (AEMS) in experimental animals. Methods: In the current study Wister rats we...
Article
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The locked-in syndrome (pseudocoma) defines people who are awake and conscious but selectively deafferented, i.e., have no means of creating speech, limb, or facial movements. It is most commonly caused by acute ventral pontine lesions. People with such brainstem lesions frequently remain unconscious for days or weeks, requiring artificial respir...
Article
Full-text available
Objective and background: Malus sylvestris Linn are a plant widely used as a traditional medicinal herb has a wide range of Pharmacotherapeutic activities. The current study was carried out to investigate the diuretic activity of Malus sylvestris Linn fruit aqueous extract (AEMS) in experimental animals. Methods: In the current study Wister rats we...
Article
Full-text available
The present study was conducted to examine the anti-inflammatory activity of aqueous fruits extract of Malus sylvestris using suitable experimental models. Wister rats were divided into 5 groups of n=6 each using Aspirin (300 mg/kg, p.o) as the standard drug. The Aqueous extract of Malus sylvestris was given at three doses of 200 mg/kg, 400 mg/kg a...
Article
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The Staircase Model (SCM) and Light and Dark Chamber (LDM) in albino rats are used in this study to investigate the possible anxiolytic-like effects of the Hydroalcoholic extract of leaves of Plectranthus scutellarioides (HEPS). The creatures were split up into four groups of six apiece. The HEPS was administered orally in 2 doses of 100 mg/kg and...
Article
Vanishing white matter (VWM) disease is a type of disorder which mainly affects the brain and spinal cord. This disorder mainly causes deterioration of white matters in Central nervous system specifically the nerve fibres covered with myelin. The basic defect of the disease is caused by mutations in one of the five genes eIF2B1, eIF2B2, eIF2B3, eIF...
Article
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Gilbert’s syndrome (GS) is an extensively mild condition characterized by periods of elevated levels of bilirubin in the blood. The bilirubin is an orange yellowish tinted molecule which is produced when red blood cells are broken down and this substance is eliminated from the body only after it undergoes bio-transformation in the liver which conve...
Article
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Acanthosis nigricans (AN) is an uncommon skin condition that involves dermatosis, hyperkeratosis, and skin darkening followed by velvety thickening of the epidermis. It mostly affects the posterior neck fold, axillae, umbilicus and flexor skin surfaces although it can also affect the mucosal surfaces. Despite the fact that the majority of cause...
Presentation
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