Ramamoorthy Siva

Ramamoorthy Siva
VIT University | VIT · School of Bio Sciences and Technology (SBST)

Ph.D., FLS(UK) FRSB (UK) FRSC (UK) Prof. Siva Ramamoorthy is the among the top 2% Scientists of the world as per the survey of Stanford University

About

199
Publications
146,379
Reads
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3,328
Citations
Citations since 2017
116 Research Items
2716 Citations
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20172018201920202021202220230100200300400500600
20172018201920202021202220230100200300400500600
Introduction
Ramamoorthy Siva currently working as a Professor , Department of Biotechnology at Vellore Institute of Technology, India. He is among the top 2 % Scientists of the world. He has published more than 100 publications and received several awards. He is the Academic Editor of PLoS One, BMC Plant Biology, BMC Biotechnology, Peer J and Associate Editor of Journal of Natural Products and BioProspecting. His field of research is on various aspects of plant pigments, stress physiology and skin cancer
Additional affiliations
January 2006 - January 2022
VIT University
Position
  • Head of Faculty
January 2004 - March 2005
Ben-Gurion University of the Negev
Position
  • PostDoc Position

Publications

Publications (199)
Article
An efficient and reproducible protocol for Agrobacterium rhizogenes-mediated hairy root were efficiently induced from in vitro grown leaf explants of H. enneaspermus. Among the diverse factors analysed, acetosyringone (100 µM), sonication (40 s), and vacuum infiltration (2 min) followed by 2 days co-cultivation period revealed maximal percentage of...
Article
Full-text available
An upsurge in early onset of photoaging due to repeated skin exposure to environmental stressors such as UV radiation is a challenge for pharmaceutical and cosmeceutical divisions. Current reports indicate severe side effects because of chemical or synthetic inhibitors of matrix metalloproteases (MMPs) in anti-skin aging cosmeceuticals. We evaluate...
Article
Streptomyces spp. Produce a wide range of antimicrobial, anticancer, antioxidant, immunosuppressant, antiviral, and antimalarial compounds. Their genome harbour a vast biosynthetic potential genes. Herein, Streptomyces sp. VITGV100 has been investigated for its ability to produce antimicrobial secondary metabolites. To this purpose, the whole genom...
Article
Background Obesity and aging are linked in a cross talk, a phenomenon known as “Adipaging”. Here, we emphasize the similarity in the underlying mechanisms of obesity and aging and propose the probability of obesity being a risk factor for premature aging. In current times, several side effects of chemical usage in pharmaceuticals used for combattin...
Chapter
Methylmalonic acidemia (MMA) is a rare genetic disorder affecting multiple body systems. We aimed to investigate the pathogenic mutations in MMAA that are associated with isolated methylmalonic acidemia to identify the structural behavior of MMAA upon mutation. The algorithms such as PredictSNP, iStable, ConSurf, and Align GVGD were employed to ana...
Article
Multiple Sclerosis (MS) is a neurodegenerative autoimmune and organ-specific demyelinating disorder, known to affect the central nervous system (CNS). While genetic studies have revealed several critical genes and diagnostic biomarkers associated with MS, the etiology of the disease remains poorly understood. This study is aimed at screening and id...
Article
Background Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer. NSCLC accounts for 84% of all lung cancer cases. In recent years, advances in pathway understanding, methods for discovering novel genetic biomarkers, and new drugs designed to inhibit the signaling cascades has enabled clinicians to personalize therapy for NSCLC....
Chapter
Plant genetic resources constitute our invaluable assets to meet the growing needs to increase crop production and productivity. Plant genetic resources constitute a unique global heritage and their conservation and utilization are of immediate concern. Over 7.4 million accessions of crop germplasm are currently being conserved worldwide in gene ba...
Article
Background Recent studies revealed a substantial role of carotenoids to treat respiratory diseases. This review aimed to give an updated overview of the investigational evidence on the preventive properties of carotenoids against respiratory diseases both in vitro and in vivo along with their pathophysiology and mechanisms of action. Hypothesis Ca...
Article
Full-text available
The roots and shoots of Gentiana kurroo Royle are rich sources of gentiopicroside (GPD). The plant is used traditionally for curing many metabolic diseases. The exploitation of G. kurroo in its native habitat has placed the plant on the critically endangered list of plants in India. One of the ways of creating an alternative source of G. kurroo is...
Chapter
Breast cancer type 1 susceptibility protein (BRCA1) is closely related to the BRCA2 (breast cancer type 2 susceptibility protein) and BARD1 (BRCA1-associated RING domain-1) proteins. The homodimers were formed through their RING fingers; however they form more compact heterodimers preferentially, influencing BRCA1 residues 1–109 and BARD1 residues...
Article
Full-text available
Photosynthetic pigments are an integral and vital part of all photosynthetic machinery and are present in different types and abundances throughout the photosynthetic apparatus. Chlorophyll, carotenoids and phycobilins are the prime photosynthetic pigments which facilitate efficient light absorption in plants, algae, and cyanobacteria. The chloroph...
Article
Gentiopicroside (GPD) is one of the vital bioactive molecules present in the rhizomes, roots and aerial parts of Gentiana kurroo Royle. In this study, callus and in vitro shoots cultures of G. kurroo were treated with different doses of gamma radiation to assess its effect on the concentration of GPD. The callus was established on MS media fortifie...
Chapter
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmissions are occurring rapidly; it is raising the alarm around the globe. Though vaccines are currently available, the evolution and mutations in the SARS-CoV-2 threaten available vaccines' significance. The drugs are still undergoing clinical trials, and certain medications are appr...
Article
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Background Fruits are vital food resources as they are loaded with bioactive compounds varying with different stages of ripening. As the fruit ripens, a dynamic color change is observed from green to yellow to red due to the biosynthesis of pigments like chlorophyll, carotenoids, and anthocyanins. Apart from making the fruit attractive and being a...
Chapter
The SARS-CoV-2 was identified in December 2019 and spread quickly around the globe. Around 218 countries with 61,468,916 cases have been diagnosed as of November 27, 2020. The epidemic quarantine and symptomatic care plan control are the first step of the treatment in the absence of medicines and vaccines. The need for treatments/therapeutics is in...
Article
Background Despite the advancements in cancer research, cancer's molecular mechanism and therapeutic response frequently remain a mystery. Previous reports mainly focused on natural therapeutic compounds as drugs. Over the past few decades, several initiatives focused on isolating and identifying novel marine compounds as anticancer agents. This re...
Chapter
India is one among the top eight mega diversity countries in the globe enriched with bioresources, and has four biodiversity hotspots. India is a biologically diverse nation varied with climatic conditions, topography, flora, and fauna. Around 70% of medicinal and aromatic plants are found in the forest area, while the remaining 30% are present in...
Chapter
Plant genetic resources are the potential sources for farming, experimenting, and conserving plants. The crisis imparted by genetic erosion instigated global conservation schemes to protect plants. Dye-yielding plants are gaining much importance due to severe toxic effects of synthetic dyes. Biotechnology-based approaches like in vitro propagation,...
Article
The World Health Organization declared Ebola virus disease (EVD) as the major outbreak in the 20th century. EVD was first identified in 1976 in South Sudan and the Democratic Republic of the Congo. EVD was transmitted from infected fruit bats to humans via contact with infected animal body fluids. The Ebola virus (EBOV) has a genome size of~18,959...
Article
Background Betalain pigments are water soluble natural pigments which contains nitrogen. Betacyanin have been reported to posses several biological properties Method In the present work, the pigment from the rind of Hylocereus undatus was analyzed for its stability upon elevated temperature, pH, time, light period and metal ions. Further the effec...
Article
Background: Cardiovascular diseases (CVDs) are among the deadliest non-communicable diseases, and millions of dollars are spent every year to combat CVDs. Unfortunately, the multifactorial etiology of CVDs complicates the development of efficient therapeutics. Interestingly, phytopigments show significant pleiotropic cardioprotective effects both i...
Article
Background Despite advances in research on neurodegenerative diseases, the pathogenesis and treatment response of neurodegenerative diseases remain unclear. Recent studies revealed a significant role of carotenoids to treat neurodegenerative diseases. The aim of this study was to systematically review the neuroprotective potential of carotenoids in...
Article
A bright yellow pigment-producing endophytic fungus strain GMRS1 was isolated from the meristems of Delonix regia (Bojer ex Hook.) Raf. The fungus was identified as Fusarium solani on grounds of morphological and molecular analysis. The chemical composition of the crude pigments was partially analyzed by Quadrupole Time-of-flight Liquid chromatogra...
Preprint
Full-text available
Streptomyces species is one among the dominant group of bacteria in the family Actinobacteria with a rich repertoire of secondary metabolites. Secondary metabolites with antimicrobial activity and plant growth promotor have been isolated from various Streptomyces sp. Here in this investigation, we present the draft genome of a new species, Streptom...
Article
Carotenoids are economically valuable isoprenoids synthesized by plants and microorganisms, which play a paramount role in their overall growth and development. Carotenoid cleavage dioxygenases are a vast group of enzymes that specifically cleave these carotenoids to produce apocarotenoids. Recently, CCDs are a subject of talk because of their cont...
Article
Bixin is an apocarotenoid derived from Bixa orellana L. well known as a food colorant along with its numerous industrial and therapeutic applications. With the current surge in usage of natural products, bixin has contributed immensely to the world carotenoid market and showcases a spike in its requirement globally. To bridge the gap between bixin...
Article
Full-text available
Epimerase-deficiency galactosemia (EDG) is caused by mutations in the UDP-galactose 4'-epimerase enzyme, encoded by gene GALE. Catalyzing the last reaction in the Leloir pathway, UDP-galactose-4-epimerase catalyzes the interconversion of UDP-galactose and UDP-glucose. This study aimed to use in-depth computational strategies to prioritize the patho...
Article
Full-text available
Zingiber officinale (ZO) and Terminalia chebula (TC) are plants used for the treatment of diverse illnesses in traditional medicine. The present study investigates the preventive effect of Zingiber officinale–Terminalia chebula extract (ZOTC) against DMBA-induced breast cancer in a rat model. Bioactive compounds from ZO (6-gingerol, 6-shogaol) and...
Preprint
Full-text available
Streptomyces are well known to produce a large number of diverse antibiotic compounds. New environments are being explored and some new Streptomyces strains have been discovered; the potential of the plant endophytic environments has been highly explored during the last decade. In the present study, an endophytic actinomycete, VITGV01, was isolated...
Article
There is a colossal demand for natural pigments and its applications in recent times. In the study, a novel lactone pigment was isolated from a predominant endophytic fungus residing in Bixa orellana L. (Bixaceae) leaves. The endophyte was identified as Fusarium verticillioides through morphological and molecular investigations. The optimum growth...
Article
Full-text available
Since the beginning of the 21st century, Asian countries have been significantly prone to endemic diseases. This has been particularly true in India due to its increasing population, with the country having faced more than 10 outbreaks, such as Severe Acute Respiratory Syndrome (SARS), Zika virus (ZIKV) disease, and Nipah virus (NiV) disease in the...
Article
Full-text available
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder that is clinically complex and has increased production of autoantibodies. Via emerging technologies, researchers have identified genetic variants, expression profiling of genes, animal models, and epigenetic findings that have paved the way for a better understanding of the...
Poster
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KRAS is a small GTPase, a member of the RAS gene family that functions as a cellular signaling mediator for specific receptors. KRAS is the most common mutationally activated oncoprotein in humans. Mutated KRAS genes are frequently found in human cancers, with the highest frequencies of missense mutations reported in lung, colon, and pancreatic car...
Article
Krabbe disease (KD), also known as globoid cell leukodystrophy disease, is an autosomal recessive lysosomal storage genetic disorder, which is caused by the deficiency of galactocerebrosidase (GALC) coding gene (GALC). This study aimed to use an extensive computational pipelines in understanding the missense mutations in GALC. We retrieved 176 muta...
Article
Sjögren–Larsson syndrome (SLS) is an autoimmune disorder inherited in an autosomal recessive pattern. To date, 80 missense mutations have been identified in association with the Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) gene causing SLS. Disruption of the function of ALDH3A2 leads to excessive accumulation of fat in the cells, which inter...
Cover Page
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The contact maps were analyzed to explore the specific atomistic interactions between residues throughout the entire macromolecular simulation.
Article
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Watermelon is an annual fruit crop that faces various biotic and abiotic stresses. Genetic engineering is an efficient tool for improving plant traits that combat environmental stresses. In this study, we have developed an improved Agrobacterium-mediated genetic transformation system for watermelon and the same was evaluated in four cultivars (Arka...
Chapter
Carotenoid pigments are abundant in plants mainly in flowers and fruits and have diverse roles in photobiology, photochemistry, and medicine. Carotenoids properties, such as reactivity with singlet oxygen and with a range of free radicals, render them essential in dietary recommendations. These compounds have the particularity of acting to attenuat...
Article
Type I galactosemia is a very rare autosomal recessive genetic metabolic disorder that occurs because of the mutations present in the galactose-1-phosphate uridyl transferase (GALT) gene, resulting in a deficiency of the GALT enzyme. The action of the GALT enzyme is to convert galactose-1-phosphate and uridine diphosphate glucose into glucose-1-pho...
Article
Full-text available
Photosynthesis is currently a focus for crop improvement, however the majority of this work has taken place and been assessed in leaves, whilst limited consideration has been given to the contribution that other green tissues make to whole plant carbon assimilation. The major focus of this review is to evaluate the impact of non-foliar photosynthes...
Article
Full-text available
Background and aims: Ovarian cancer (OC) is the seventh most commonly detected cancer among women. This study aimed to map the hub and core genes and potential pathways that might be involved in the molecular pathogenesis of OC. Methods: In the present work, we analyzed a microarray dataset (GSE126519) from the Gene Expression Omnibus (GEO) databas...
Article
The aim of this study was to obtain high-yielding cell cultures of Rubia cordifolia by applying gamma irradiation and subsequently scaling up for anthraquinone production in a bioreactor. Calli cultured on MS medium was irradiated at variable doses between 2 Gy and 30 Gy. The callus cultures that were irradiated at 8 Gy accumulated a maximum alizar...
Article
Plant carotenoid cleavage oxygenase (CCO) is an enzyme which catalyzes carotenoids to apocarotenoid products that are involved in several vital physiological functions. The CCO exists in two forms, namely, CCD (Carotenoid Cleavage Dioxygenase) and NCED (Nine-Cis Epoxycarotenoid Dioxygenase). This paper relates to a comparative study on CCD and NCED...
Article
Full-text available
Colchicine, a well-known alkaloid, is a potent inhibitor of polymerization of tubulin leading to mitotic arrest. It is highly toxic to eukaryotic cells but also widely used in the field of medicine and plant breeding. Gloriosa superba (family: Colchicaceae) is an important natural source of colchicine. The seeds, tubers and leaves of this plant con...
Article
Full-text available
The effect of salt stress on pigment synthesis and antioxidant enzyme activity as well as in the genes involved in the biosynthetic pathway of bixin was studied. The 14-day germinated seedlings of Bixa orellana were induced into the various NaCl concentration (0, 25, 50, 75, 100 mM). After 45 days, leaves were taken for pigment analysis, antioxidan...
Article
Full-text available
Fungi are an understudied, biotechnologically valuable group of organisms. Due to the immense range of habitats that fungi inhabit, and the consequent need to compete against a diverse array of other fungi, bacteria, and animals, fungi have developed numerous survival mechanisms. The unique attributes of fungi thus herald great promise for their ap...
Article
Alcohol use disorder (AUD) is a multifactorial psychiatric behavior disorder. Disulfiram is the first approved drug by the Food and Drug Administration for alcohol‐dependent patients, which targets the ALDH2 enzyme. Several genes are known to be involved in alcohol metabolism; mutations in any of these genes are known to be associated with AUD. The...
Article
The G2019S substitution in the Leucine-rich repeat kinase 2 (LRRK2) is significantly associated with Parkinson's disease (PD). This substitution was identified in both familial and sporadic forms of PD with a higher frequency. Few computational studies have reported the impact of G2019S substitution on inhibitors of the kinase domain of LRRK2. Howe...
Article
The nucleotide salvage pathway is used to recycle degraded nucleotides (purines and pyrimidines); one of the enzymes that helps to recycle purines is hypoxanthine guanine phosphoribosyl transferase 1 (HPRT1). Therefore, defects in this enzyme lead to the accumulation of DNA and nucleotide lesions and hence replication errors and genetic disorders....
Chapter
Gaucher's disease (GD) is the most commonly known lysosomal disorder that occurs due to mutations in the β-glucocerebrosidase (GBA) protein. Our previous findings (Thirumal Kumar, Eldous, Mahgoub, George Priya Doss, Zayed, 2018) and other reports concluded that the mutations N370S and L444P are the most significant mutations that could cause disrup...
Chapter
Fabry's disease (FD) is the second most commonly occurring lysosomal storage disorders (LSDs). The mutations in GLA protein were widely found to be causative for the Fabry's disease. These mutations result in alternate splicing methods that affect the stability and function of the protein. The mutations near the active site of the protein results i...
Article
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Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by the mutations in survival motor neuron 1 gene (SMN1). The molecular pathology of missense mutations in SMN1 is not thoroughly investigated so far. Therefore, we collected all missense mutations in the SMN1 protein, using all possible search terms, from three databases (PubMed, PMC...
Article
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The NF1 gene encodes for neurofibromin protein, which is ubiquitously expressed, but most highly in the central nervous system. Non-synonymous SNPs (nsSNPs) in the NF1 gene were found to be associated with Neurofibromatosis Type 1 disease, which is characterized by the growth of tumors along nerves in the skin, brain, and other parts of the body. I...
Article
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The 2-hydroxyglutaric aciduria (2-HGA) is a rare neurometabolic disorder that leads to the development of brain damage. It is classified into three categories: D-2-HGA, L-2-HGA, and combined D,L-2-HGA. The D-2-HGA includes two subtypes: type I and type II caused by the mutations in D2HGDH and IDH2 proteins, respectively. In this study, we studied s...
Article
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Phyllanthus emblica and P. indofischeri, commonly known as the Indian gooseberry, are important nontimber forest product (NTFP) species widely distributed across the Indian subcontinent. The fruits of these species are rich in vitamin C and are used in the preparation of a number of herbal medicines for treating a wide range of disorders. Due to th...
Article
Galactosemia type 2 is an autosomal recessive disorder characterized by the deficiency of galactokinase (GALK) enzyme due to missense mutations in GALK1 gene, which is associated with various manifestations such as hyper galactosemia and formation of cataracts. GALK enzyme catalyzes the adenosine triphosphate (ATP)–dependent phosphorylation of α‐D‐...
Article
Full-text available
A rapid and efficient method for in vitro direct plant regeneration from immature leaf roll explants of Saccharum officinarum L. (sugarcane) cv. Co 86032 was developed by the application of exogenous polyamines (PA). The effect of explant source from apical meristems and pre-culture of explants in the dark on shoot regeneration was studied. Adventi...
Article
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Camptothecin (CPT), a monoterpene indole alkaloid, is a potent inhibitor of eukaryotic topoisomerase I (Top 1). Because of this property, several derivatives of CPT are widely used as chemotherapeutic agents. The compound is produced by several plant species, including Nothapodytes nimmoniana (Family: Icacinaceae) presumably as a deterrent to insec...
Data
Supplementary Table 1 Intra protein main chain-main chain hydrogen bonds interactions of native RAS-GAP domain
Data
Ramachandran plot of native model RAS-GAP domain of NF1 protein obtained by RAMPAGE server.
Data
RMSD plot of RAS-GAP domain of NF1 protein (a) first run (b) second run (c) third run of 50 ns of simulation.
Data
Analysis of secondary structure element contribution in native and K1444N mutant.
Data
Illustration of an explicit change in secondary structure conformation in native (blue) and mutant K1444N mutant (green) RAS-GAP domain of NF1 protein (a) 0 ns (b) 40 ns (c) 50 ns. Color magenta and red are representing the residue region in between 60 and 68 of native and mutant respectively, color yellow and cyan are representing the residue regi...
Data
Conservational analysis of residues of RAS-GAP domain of NF1 protein using the ConSurf server.
Article
Sustainable production of non-food oleaginous crops is highly desirable towards meeting increasing global demands for energy by supplementing the diminishing supply of fossil fuels without affecting food security. Jatropha curcas L., a high yielding oleaginous seed crop (30–48% oil), with a simple propagation system, short gestation period and high...