
Ramamoorthy SivaVellore Institute of Technology University | VIT · School of Bio Sciences and Technology (SBST)
Ramamoorthy Siva
Ph.D., FLS(UK) FRSB (UK) FRSC (UK) Prof. Siva Ramamoorthy is the among the top 2% Scientists of the world as per the survey of Stanford University
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231
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Introduction
Ramamoorthy Siva currently working as a Professor , Department of Biotechnology at Vellore Institute of Technology, India. He is among the top 2 % Scientists of the world. He has published more than 100 publications and received several awards. He is the Academic Editor of PLoS One, BMC Plant Biology, BMC Biotechnology, Peer J and Associate Editor of Journal of Natural Products and BioProspecting. His field of research is on various aspects of plant pigments, stress physiology and skin cancer
Additional affiliations
January 2006 - January 2022
January 2004 - March 2005
Publications
Publications (231)
Astaxanthin (ASX), “king of carotenoids”, is a xanthophyll carotenoid that is characterized by a distinct reddish-orange hue, procured from diverse sources including plants, microalgae, fungi, yeast, and lichens. It exhibits potent antioxidant and anti-ageing properties and has been demonstrated to mitigate ultraviolet-induced cellular and DNA dama...
This paper reports on an exploratory research work carried out aiming to identify the barriers in the usage of traditional medicines by the holders of the knowledge. The focus is on the usage of the traditional medicines by the homogenous people, Malayali tribe community at Shervaroy hills of Eastern Ghats. Semi-structured interviews were conducted...
Introduction
The marine microalga Isochrysis galbana is prolific producer of fucoxanthin, which is a xanthophyll carotenoid with substantial global market value boasting extensive applications in the food, nutraceutical, pharmaceutical, and cosmetic industries. This study presented a novel integrated experimental approach coupled with machine learn...
Introduction: The marine microalga Isochrysis galbana is prolific producer of fucoxanthin, which is a xanthophyll carotenoid with substantial global market value boasting extensive applications in the food, nutraceutical, pharmaceutical, and cosmetic industries. This study presented a novel integrated experimental approach coupled with machine lear...
Phyllanthus emblica is a well-known medicinal and non-timber forest product species, widely distributed in the Indian subcontinent. Multiple disturbances like intensive fruit harvest, the spread of invasive species such as Lantana camara and Taxillus tomentosus, and other anthropogenic disturbances threaten population viability by altering ecologic...
DNA is one of the important targets for therapeutic drugs. Investigating the interaction between these drug molecules and DNA yields valuable insights for the further advancement of medication formulations. In this study, we explore the interaction between calf thymus-DNA and temozolomide with apocarotenoids such as bixin and crocin, which are know...
The marine microalgae, Isochrysis galbana is a prolific producer of fucoxanthin which is a xanthophyll carotenoid with substantial global market value boasting extensive applications in the food, nutraceutical, pharmaceutical, and cosmetic industries. Although supplementation of different phytohormones to medium enhances fucoxanthin production, the...
The demand for the fruits of Phyllanthus emblica, an important tree species with a long history of medicinal use, has risen tremendously in recent years. The rapid decline in the distribution of the species can be attributed to habitat loss, climate change, invasive species, extensive harvesting, and various other anthropogenic disturbances. In the...
Advancements in genome mining, high-throughput sequencing and experimental techniques have generated an enormous amount of data on natural products. This has led to the design and development of advanced machine learning (ML) and artificial intelligence (AI) algorithms which have simplified the search for novel natural products in the 21st century....
The surroundings in which living things operate for survival from time immemorial have undergone sea changes. Technologies have been introduced to endure the requirements of our current and forthcoming generations. The rise and fall in planning, development in trade and commerce, town planning and architecture have contributed to factors affecting...
Objectives:
DNA is one of the targets of cancer-therapeutic small molecules. Cisplatin, a DNA intercalator, is one of the first-line drugs in the cancer chemo regimen which comes with health-compromising side effects during chemotherapy. The synergistic effect of natural molecules with cisplatin can help to potentiate its anti-cancer efficacy and...
During the last decade, genomic, transcriptomic, proteomic, metabolomic, and other omics datasets have been generated for a wide range of marine organisms, and even more are still on the way. Marine organisms possess unique and diverse biosynthetic pathways contributing to the synthesis of novel secondary metabolites with significant bioactivities....
Improving photosynthesis is a promising avenue to increase food security. Studying photosynthetic traits with the aim to improve efficiency has been one of many strategies to increase crop yield but analyzing large data sets presents an ongoing challenge. Machine learning (ML) represents a ubiquitous tool that can provide a more elaborate data anal...
Carotenoids are a vast group of natural pigments that come in a variety of colors ranging from red to orange. Apocarotenoids are derived from these carotenoids, which are hormones, pigments, retinoids, and volatiles employed in the textiles, cosmetics, pharmaceutical, and food industries. Due to the high commercial value and poor natural host abund...
Rauwolfia serpentina is a valuable medicinal plant belonging to Apocynaceae family. The plant is rich with various phytochemicals particularly indole alkaloids like reserpine. Root extracts of plant have been used from centuries for the ailment of neurological disorders. Successful clinical studies have unravelled the properties like antihypertensi...
Plant diversity in biocultural landscapes faces a critical challenge at the onset of the Anthropocene with its numerous challenges aggravated by the climate change issues. Two opposing perspectives or philosophies, i.e., anthropocentrism and ecocentrism, prevail. Hence, understanding plant diversity dynamics is imperative in order to formulate appr...
Seaweeds are an essential primary producers and are considered the most important life forms in the coastal ecology. They shelter marine and other aquatic organisms by regulating abiotic parameters, offering nutrients in the water column, stabilizing sediments, and providing valuable natural products. Seaweeds are also important to humans in multip...
The proposal on the Anthropocene suggests that the Earth has entered a contemporary ecological era, in which climate changes and human activities massively impact the environment universally. This new anthropogenic epoch brings exceptional challenges to the plant diversity in biocultural landscapes, thus preventing their benefits to human well-bein...
Anthropogenic chemicals are substances that are created mainly in industries for agriculture, medicine, and other commercial purposes. When exposed to the environment at moderate to high levels, they become toxic to plants, humans, and animals. The continuous addition of toxins to the environment causes their accumulation in the tissues of the orga...
Background:
Lung cancer is one of the leading causes of malignancy in the world. Several therapeutical and chemopreventive approaches have been practised to mitigate the disease. The use of phytopigments including carotenoids is a well-known approach. However, some of the prominent clinical trials interrogated the efficacy of carotenoids in lung c...
Breast cancer biomarkers that detect marginally advanced stages are still challenging. The detection of specific abnormalities, targeted therapy selection, prognosis, and monitoring of treatment effectiveness over time are all made possible by circulating free DNA (cfDNA) analysis. The proposed study will detect specific genetic abnormalities from...
The pigments play a vital role in the insect’s defence, attraction, camouflage, sun protection, photoperiodism, etc. Carotenoids are isoprenoid pigments synthesized exclusively by plants and microorganisms. Notably, animals cannot synthesize carotenoids themselves, they get them only from the plants they consume and, they are transported to tissues...
Food colorants are imperative ingredients for attracting consumers and in deciding their preferences. Here we discuss the current status of natural colorants and synthetic food colorants on the Indian market by appraising the growth of the food colorant market both globally and nationally, based on published case studies on synthetic food colorants...
An efficient and reproducible protocol for Agrobacterium rhizogenes-mediated hairy root were efficiently induced from in vitro grown leaf explants of H. enneaspermus. Among the diverse factors analysed, acetosyringone (100 µM), sonication (40 s), and vacuum infiltration (2 min) followed by 2 days co-cultivation period revealed maximal percentage of...
An upsurge in early onset of photoaging due to repeated skin exposure to environmental stressors such as UV radiation is a challenge for pharmaceutical and cosmeceutical divisions. Current reports indicate severe side effects because of chemical or synthetic inhibitors of matrix metalloproteases (MMPs) in anti-skin aging cosmeceuticals. We evaluate...
Streptomyces spp. Produce a wide range of antimicrobial, anticancer, antioxidant, immunosuppressant, antiviral, and antimalarial compounds. Their genome harbour a vast biosynthetic potential genes. Herein, Streptomyces sp. VITGV100 has been investigated for its ability to produce antimicrobial secondary metabolites. To this purpose, the whole genom...
Background
Obesity and aging are linked in a cross talk, a phenomenon known as “Adipaging”. Here, we emphasize the similarity in the underlying mechanisms of obesity and aging and propose the probability of obesity being a risk factor for premature aging. In current times, several side effects of chemical usage in pharmaceuticals used for combattin...
Methylmalonic acidemia (MMA) is a rare genetic disorder affecting multiple body systems. We aimed to investigate the pathogenic mutations in MMAA that are associated with isolated methylmalonic acidemia to identify the structural behavior of MMAA upon mutation. The algorithms such as PredictSNP, iStable, ConSurf, and Align GVGD were employed to ana...
A prompt and dynamic clonal propagation system was developed for Hybanthus enneaspermus a medicinally significant plant using shoot tip as explants. Multiple shoots were induced on Murashige and Skoog (MS) medium invigorated with different levels of 6-benzylaminopurine (BAP), kinetin (Kin) and thidiazuron (TDZ) and AgNPs. The optimum concentration...
Multiple Sclerosis (MS) is a neurodegenerative autoimmune and organ-specific demyelinating disorder, known to affect the central nervous system (CNS). While genetic studies have revealed several critical genes and diagnostic biomarkers associated with MS, the etiology of the disease remains poorly understood. This study is aimed at screening and id...
Background
Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer. NSCLC accounts for 84% of all lung cancer cases. In recent years, advances in pathway understanding, methods for discovering novel genetic biomarkers, and new drugs designed to inhibit the signaling cascades has enabled clinicians to personalize therapy for NSCLC....
Plant genetic resources constitute our invaluable assets to meet the growing needs to increase crop production and productivity. Plant genetic resources constitute a unique global heritage and their conservation and utilization are of immediate concern. Over 7.4 million accessions of crop germplasm are currently being conserved worldwide in gene ba...
Background
Recent studies revealed a substantial role of carotenoids to treat respiratory diseases. This review aimed to give an updated overview of the investigational evidence on the preventive properties of carotenoids against respiratory diseases both in vitro and in vivo along with their pathophysiology and mechanisms of action.
Hypothesis
Ca...
The roots and shoots of Gentiana kurroo Royle are rich sources of gentiopicroside (GPD). The plant is used traditionally for curing many metabolic diseases. The exploitation of G. kurroo in its native habitat has placed the plant on the critically endangered list of plants in India. One of the ways of creating an alternative source of G. kurroo is...
Breast cancer type 1 susceptibility protein (BRCA1) is closely related to the BRCA2 (breast cancer type 2 susceptibility protein) and BARD1 (BRCA1-associated RING domain-1) proteins. The homodimers were formed through their RING fingers; however they form more compact heterodimers preferentially, influencing BRCA1 residues 1–109 and BARD1 residues...
Photosynthetic pigments are an integral and vital part of all photosynthetic machinery and are present in different types and abundances throughout the photosynthetic apparatus. Chlorophyll, carotenoids and phycobilins are the prime photosynthetic pigments which facilitate efficient light absorption in plants, algae, and cyanobacteria. The chloroph...
Gentiopicroside (GPD) is one of the vital bioactive molecules present in the rhizomes, roots and aerial parts of Gentiana kurroo Royle. In this study, callus and in vitro shoots cultures of G. kurroo were treated with different doses of gamma radiation to assess its effect on the concentration of GPD. The callus was established on MS media fortifie...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmissions are occurring rapidly; it is raising the alarm around the globe. Though vaccines are currently available, the evolution and mutations in the SARS-CoV-2 threaten available vaccines' significance. The drugs are still undergoing clinical trials, and certain medications are appr...
Background
Fruits are vital food resources as they are loaded with bioactive compounds varying with different stages of ripening. As the fruit ripens, a dynamic color change is observed from green to yellow to red due to the biosynthesis of pigments like chlorophyll, carotenoids, and anthocyanins. Apart from making the fruit attractive and being a...
The SARS-CoV-2 was identified in December 2019 and spread quickly around the globe. Around 218 countries with 61,468,916 cases have been diagnosed as of November 27, 2020. The epidemic quarantine and symptomatic care plan control are the first step of the treatment in the absence of medicines and vaccines. The need for treatments/therapeutics is in...
Background
Despite the advancements in cancer research, cancer's molecular mechanism and therapeutic response frequently remain a mystery. Previous reports mainly focused on natural therapeutic compounds as drugs. Over the past few decades, several initiatives focused on isolating and identifying novel marine compounds as anticancer agents.
This re...
India is one among the top eight mega diversity countries in the globe enriched with bioresources, and has four biodiversity hotspots. India is a biologically diverse nation varied with climatic conditions, topography, flora, and fauna. Around 70% of medicinal and aromatic plants are found in the forest area, while the remaining 30% are present in...
Plant genetic resources are the potential sources for farming, experimenting, and conserving plants. The crisis imparted by genetic erosion instigated global conservation schemes to protect plants. Dye-yielding plants are gaining much importance due to severe toxic effects of synthetic dyes. Biotechnology-based approaches like in vitro propagation,...
The World Health Organization declared Ebola virus disease (EVD) as the major outbreak in the 20th century. EVD was first identified in 1976 in South Sudan and the Democratic Republic of the Congo. EVD was transmitted from infected fruit bats to humans via contact with infected animal body fluids. The Ebola virus (EBOV) has a genome size of~18,959...
Background
Betalain pigments are water soluble natural pigments which contains nitrogen. Betacyanin have been reported to posses several biological properties
Method
In the present work, the pigment from the rind of Hylocereus undatus was analyzed for its stability upon elevated temperature, pH, time, light period and metal ions. Further the effec...
Background: Cardiovascular diseases (CVDs) are among the deadliest non-communicable diseases, and millions of dollars are spent every year to combat CVDs. Unfortunately, the multifactorial etiology of CVDs complicates the development of efficient therapeutics. Interestingly, phytopigments show significant pleiotropic cardioprotective effects both i...
Background
Despite advances in research on neurodegenerative diseases, the pathogenesis and treatment response of neurodegenerative diseases remain unclear. Recent studies revealed a significant role of carotenoids to treat neurodegenerative diseases. The aim of this study was to systematically review the neuroprotective potential of carotenoids in...
A bright yellow pigment-producing endophytic fungus strain GMRS1 was isolated from the meristems of Delonix regia (Bojer ex Hook.) Raf. The fungus was identified as Fusarium solani on grounds of morphological and molecular analysis. The chemical composition of the crude pigments was partially analyzed by Quadrupole Time-of-flight Liquid chromatogra...
Streptomyces species is one among the dominant group of bacteria in the family Actinobacteria with a rich repertoire of secondary metabolites. Secondary metabolites with antimicrobial activity and plant growth promotor have been isolated from various Streptomyces sp. Here in this investigation, we present the draft genome of a new species, Streptom...
Carotenoids are economically valuable isoprenoids synthesized by plants and microorganisms, which play a paramount role in their overall growth and development. Carotenoid cleavage dioxygenases are a vast group of enzymes that specifically cleave these carotenoids to produce apocarotenoids. Recently, CCDs are a subject of talk because of their cont...
Bixin is an apocarotenoid derived from Bixa orellana L. well known as a food colorant along with its numerous industrial and therapeutic applications. With the current surge in usage of natural products, bixin has contributed immensely to the world carotenoid market and showcases a spike in its requirement globally. To bridge the gap between bixin...
Epimerase-deficiency galactosemia (EDG) is caused by mutations in the UDP-galactose 4'-epimerase enzyme, encoded by gene GALE. Catalyzing the last reaction in the Leloir pathway, UDP-galactose-4-epimerase catalyzes the interconversion of UDP-galactose and UDP-glucose. This study aimed to use in-depth computational strategies to prioritize the patho...
Zingiber officinale (ZO) and Terminalia chebula (TC) are plants used for the treatment of diverse illnesses in traditional medicine. The present study investigates the preventive effect of Zingiber officinale–Terminalia chebula extract (ZOTC) against DMBA-induced breast cancer in a rat model. Bioactive compounds from ZO (6-gingerol, 6-shogaol) and...
Streptomyces are well known to produce a large number of diverse antibiotic compounds. New environments are being explored and some new Streptomyces strains have been discovered; the potential of the plant endophytic environments has been highly explored during the last decade. In the present study, an endophytic actinomycete, VITGV01, was isolated...
There is a colossal demand for natural pigments and its applications in recent times. In the study, a novel lactone pigment was isolated from a predominant endophytic fungus residing in Bixa orellana L. (Bixaceae) leaves. The endophyte was identified as Fusarium verticillioides through morphological and molecular investigations. The optimum growth...
Since the beginning of the 21st century, Asian countries have been significantly prone to endemic diseases. This has been particularly true in India due to its increasing population, with the country having faced more than 10 outbreaks, such as Severe Acute Respiratory Syndrome (SARS), Zika virus (ZIKV) disease, and Nipah virus (NiV) disease in the...
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder that is clinically complex and has increased production of autoantibodies. Via emerging technologies, researchers have identified genetic variants, expression profiling of genes, animal models, and epigenetic findings that have paved the way for a better understanding of the...
KRAS is a small GTPase, a member of the RAS gene family that functions as a cellular signaling mediator for specific receptors. KRAS is the most common mutationally activated oncoprotein in humans. Mutated KRAS genes are frequently found in human cancers, with the highest frequencies of missense mutations reported in lung, colon, and pancreatic car...
Krabbe disease (KD), also known as globoid cell leukodystrophy disease, is an autosomal recessive lysosomal storage genetic disorder, which is caused by the deficiency of galactocerebrosidase (GALC) coding gene (GALC). This study aimed to use an extensive computational pipelines in understanding the missense mutations in GALC. We retrieved 176 muta...
Sjögren–Larsson syndrome (SLS) is an autoimmune disorder inherited in an autosomal recessive pattern. To date, 80 missense mutations have been identified in association with the Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) gene causing SLS. Disruption of the function of ALDH3A2 leads to excessive accumulation of fat in the cells, which inter...
The contact maps were analyzed to explore the specific atomistic interactions between residues throughout the entire macromolecular simulation.
Watermelon is an annual fruit crop that faces various biotic and abiotic stresses. Genetic engineering is an efficient tool for improving plant traits that combat environmental stresses. In this study, we have developed an improved Agrobacterium-mediated genetic transformation system for watermelon and the same was evaluated in four cultivars (Arka...
Carotenoid pigments are abundant in plants mainly in flowers and fruits and have diverse roles in photobiology, photochemistry, and medicine. Carotenoids properties, such as reactivity with singlet oxygen and with a range of free radicals, render them essential in dietary recommendations. These compounds have the particularity of acting to attenuat...
Type I galactosemia is a very rare autosomal recessive genetic metabolic disorder that occurs because of the mutations present in the galactose-1-phosphate uridyl transferase (GALT) gene, resulting in a deficiency of the GALT enzyme. The action of the GALT enzyme is to convert galactose-1-phosphate and uridine diphosphate glucose into glucose-1-pho...
Photosynthesis is currently a focus for crop improvement, however the majority of this work has taken place and been assessed in leaves, whilst limited consideration has been given to the contribution that other green tissues make to whole plant carbon assimilation. The major focus of this review is to evaluate the impact of non-foliar photosynthes...
Background and aims: Ovarian cancer (OC) is the seventh most commonly detected cancer among women. This study aimed to map the hub and core genes and potential pathways that might be involved in the molecular pathogenesis of OC.
Methods: In the present work, we analyzed a microarray dataset (GSE126519) from the Gene Expression Omnibus (GEO) databas...
The aim of this study was to obtain high-yielding cell cultures of Rubia cordifolia by applying gamma irradiation and subsequently scaling up for anthraquinone production in a bioreactor. Calli cultured on MS medium was irradiated at variable doses between 2 Gy and 30 Gy. The callus cultures that were irradiated at 8 Gy accumulated a maximum alizar...
Plant carotenoid cleavage oxygenase (CCO) is an enzyme which catalyzes carotenoids to apocarotenoid products that are involved in several vital physiological functions. The CCO exists in two forms, namely, CCD (Carotenoid Cleavage Dioxygenase) and NCED (Nine-Cis Epoxycarotenoid Dioxygenase). This paper relates to a comparative study on CCD and NCED...