Rama Krishna Raparla

Vaageswari Colleges · Department of Pharmaceutics

Background A series of novel 2 substituted 4-anilinoquinazolines-pyrrole hybrids were synthesized, and cytotoxic activity were evaluated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. Methods The cell line used for the activity was MCF-7 breast cancer cell line and A459 human lung adenocarcinoma cell line. The new...

Objective: The aim of this investigation was to develop and optimize metformin hydrochloride matrix tablets for sustained release application. The sustained release matrix tablet of metformin hydrochloride was prepared by wet granulation technique using chitosan, xanthan gum, and hydroxypropyl methylcellulose at varying concentrations.Material and...

The objective of the study conducted was to screen & isolate fungi capable of degrading the fruit litter of Albizia lebbeck. These fruit Biomass are often disposed by burning, which pose an environmental pollution problem. The fruit biomass can be potentially converted to various value added products like bio fuels, cheap energy sources for ferment...

In the present study, an attempt was made to know the activity of different plant extracts against the dandruff causing organism Malassezia furfur. Various parts of twelve different plants were collected and their crude as well as powered extracts were used for the activity studies. The evaluation was done using cup plate method. Sensitivity of the...

An effective high performance liquid chromatography-tandem mass spectrophotometric (LCMS/MS) simultaneous quantitation of Escitalopram (ESC) and Etizolam (ETZ) in spiked human plasma method was developed. Analytes extraction from plasma was performed by Liquid-liquid extraction (LLE) technique. Separation was performed on a Waters symmetry shield,...

Traditional medicines derived from medicinal plants are used by about 60 per cent world population. Diabetes is an important human ailment officiating many from various walk of life in different countries including India. It providing to a major health problem, especially in the rural and subrural areas. Gymnema sylvestre R.Br. (Asclepiadaceae) is...

The present paper reports the development of novel, stable & validated RP HPLC method for the simultaneous estimation of Artemether (ART) and lumefantrine (LUM) in bulk and tablet dosage form. Good chromatographic separation was achieved by isocratic mode with a mixture of phosphate buffer: methanol in the ratio of 50: 50 as the mobile phase with w...

In the treatment of type 2 diabetes mellitus a continuous therapy is required which is a more complex one. As in these patients there may be a defect in both insulin secretion and insulin action exists. Hence, the treatment depends on the pathophysiology and the disease state. In the present study, multilayered tablets of pioglitazone hydrochloride...

Gymnema sylvestre has been used medicinally throughout history by many different cultures. Many compounds have been found in the exudates of the Gymnema sylvestre plant that have been used medically by humans. We have examined the pharmacological hypoglycemic action of Gymnema sylvestre in diabetic rats. Gymnema sylvestre 100mg/kg (single dose stud...

Gliclazide is an oral hypoglycemic agent used in the treatment of non-insulin dependent diabetes mellitus. Among the people who are suffering from long term disorders, the major had been categorized under the people who are suffering from diabetes and a dosage form is needed for them that should provide continuous therapy and should have a high mar...

Diabetes is a metabolic disease in which a person has high blood sugar, either because the body does not produce enough insulin. Different studies have established the antidiabetic activity of fenugreek and neem. In present study our aim is to evaluate the antidiabetic effect of combined extracts in diabetic rats and find out the synergistic activi...

Mucoadhesive microcapsules are proposed for the antidiabetic drug glipizide, to obtain controlled release. Glipizide microcapsules with a coat consisting of alginate and gum kondagogu were prepared by employing ionic gelation process and emulsification ionotropic gelation process. The microcapsules were evaluated for flow properties, Carr's index,...

Many compounds extracted from the Azadirachta indica (neem plant) are used by humans throughout the medical history of many different cultures. In this paper, we examined the pharmacological hypoglycemic action of Azadirachta indica in diabetic rats. 24 hours after the initial treatment with Azadirachta indica 250mg/kg (single dose study) we detect...

Mucoadhesive microcapsules are proposed for the antidiabetic drug, glipizide, to obtain the controlled release. Glipizide microcapsules with a coat consisting of alginate and gum kondagogu were prepared by employing ionic gelation process and emulsification ionotropic gelation process. The microcapsules were evaluated for flow properties, Carr's in...

Mucoadhisive microcapsules are proposed for the antidiabetic drug glipizide, to obtain controlled release. Glipizidemicrocapsules with a coat consisting of alginate and gum karaya were prepared by employing ionic gelation process andemulsification ionotropic gelation process. The microcapsules were evaluated for flow properties, Carr’s index, hausn...

Ambroxol hydrochloride tablets were prepared by wet granulation method using hydrophilic polymer HPMC K4M with different compositions of drug: polymer ratio of 1:0.33, 1:0.5, 1:0.75, and 1:1 as F-1, F-2, F-3 and F-4 formulations respectively in order to have a sustained release of the drug in a predetermined interval. The prepared matrix tablets we...