Rama Jayasundar

Rama Jayasundar
All India Institute of Medical Sciences | AIIMS · Department of Nuclear Magnetic Resonance

PhD (NMR, Cambridge University, UK), BAMS (Bachelor of Ayurvedic Medicine and Surgery)

About

50
Publications
11,799
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580
Citations
Citations since 2016
13 Research Items
194 Citations
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201620172018201920202021202205101520253035
201620172018201920202021202205101520253035
201620172018201920202021202205101520253035
Introduction
Rama Jayasundar currently is a Professor at the Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India. She is a physicist with a PhD in NMR from Cambridge University, UK. She is also a professionally qualified medical doctor in Ayurveda (Indian system of medicine), also trained in Western medicine. Her MR expertise: experimental and clinical MRI & MRS; low cost MR coil development; RF pulse sequence programming. Her MR research interests - applications in neuroscience Her current research interests are: NMR metabolomics of medicinal plants used in Ayurveda and their chemosensory signatures; MR in stroke; MR applications in Ayurveda and yoga; Scientific validation of Ayurvedic treatments; Scientific explanations for Ayurveda;
Additional affiliations
September 1993 - present
All India Institute of Medical Sciences, New Delhi, India
Position
  • Faculty Member
Description
  • I am an NMR physicist and a medical doctor trained in ayurveda and allopathy. Have experience in RF pulse programming, NMR RF coil development, clinical MRS in neurological applications, NMR of medicinal plants, novel applications of MR in ayurveda.

Publications

Publications (50)
Article
Full-text available
Background: Ayurveda, the indigenous medical system of India, has chemosensory property ( rasa ) as one of its major pharmacological metric. Medicinal plants have been classified in Ayurveda under six rasas /tastes—sweet, sour, saline, pungent, bitter and astringent. This study has explored for the first time, the use of Electronic tongue for studi...
Article
Parkinson's disease (PD) is second most common neurodegenerative disorder, which is a progressive motor disease that affects 10 million people worldwide and around 5.5 million Indian. The hallmark neuropathology in PD are damage to dopaminergic neurons located in the pars compacta of the substantia nigra (SN) that project to the striatum and alpha...
Article
Full-text available
Background: Although Electronic tongue is used in pharmaceutical, food and beverage industries for objective evaluation of taste, its use in medicinal plants from an ayurvedic perspective is novel. Control experiments are therefore necessary to standardise and optimise parameters. Objective: The aim is to optimise the use of solvent and standardise...
Article
Full-text available
There is growing interest in understanding how ayurveda, the indigenous medical system of India, uses plants for therapeutic purpose. The aim of this two parts article is to explore how the analytical technique of Electronic tongue (E-tongue) can be used for studying rasa, one of the major ayurvedic parameter in the study of medicinal and nutrition...
Article
Full-text available
The world is experiencing an unprecedented health crisis as a result of the highly infectious novel coronavirus. Even economically powerful countries with the best healthcare and technology infrastructure are struggling to contain COVID-19. Conventional medicine is racing against time to produce vaccine and repurpose drugs used in other viral disea...
Article
Full-text available
Background and aims: Many studies have conclusively proven that meditative techniques derived from the Indian systems of philosophy, meditation and ritual classified as "Tantra" can bring about sustained changes in the structure and function of the nervous system of practitioners. The aim of this study is to provide neuroscientists a framework thr...
Article
Full-text available
Background: Information from Ayurveda meeting the analytical challenges of modern technology is an area of immense relevance. Apart from the cerebral task of bringing together two different viewpoints, the question at the pragmatic level remains 'who benefits whom'. Objective: The aim is to highlight the challenges in integration of information...
Article
Full-text available
With a shift in focus from genes to cells, systems approach is not only revolutionizing cell biology, but is also providing impetus for clinical medicine to shift from a reductionistic to a holistic approach for efficient disease management. This inevitably brings into focus one of the longest unbroken healthcare systems in the world, namely ayurve...
Article
Full-text available
Background: The use of medicinal plants in Ayurveda is based on rasa, generally taken to represent taste as a sensory perception. This chemosensory parameter plays an important role in Ayurvedic pharmacology. Objective: The aim is to explore the use of structuro-functional information deduced from analytical techniques for the rasa-based classifica...
Chapter
The traditional medicinal systems of various civilizations are well known to use herbal remedies for various ocular conditions. Plant derived compounds came to ocular use in the last century in which cocaine, physostigmine, pilocarpine and atropine are still holding a place in modern ophthalmology practice. The traditional knowledge available at di...
Article
Full-text available
Although plants have long been a major source of medicine, there is renewed interest in studying the phytochemistry and use of herbal formulations. This paper reports spectroscopic analysis using Laser Induced Breakdown Spectroscopy (LIBS) of a polyherbal formulation, whose antidiabetic activity has also been demonstrated on rat models. LIBS analys...
Chapter
Mechanistic biomedical model based on Newtonian physics and the classical worldview is the basis of our current understanding of human system. Real world, however, is nonclassical as predicted by quantum physics, which in a nutshell says everything in the universe is interrelated and a change in one part of the system will be reflected in the other...
Article
Full-text available
Ayurveda, the indigenous medical system of India, has integrated the concept of interconnectedness into its understanding of health and disease. It considers the human body as an indivisible whole with a network of interrelated functions, mind and consciousness, wherein a disturbance in one part will have repercussions in other parts as well. The k...
Article
This study reports in vivo MRS findings in 11 patients with histologically diagnosed central neurocytomas, which are rare intraventricular tumors of neuronal origin. Single-voxel (1)H MRS was carried out prior to surgery using a point-resolved spectroscopy sequence with TR=6 s, TE=135 ms and 128 scans. In vitro high-resolution (1)H spectroscopy was...
Article
To evaluate the role of MR spectroscopy (MRS) as a noninvasive tool for characterization of intraventricular brain tumors. Twenty-three intraventricular tumors, all histologically classified (11 central neurocytomas [CNC], 5 meningiomas [Men], other intraventricular tumors [OIV], including 2 anaplastic gliomas [WHO III], 1 tumor each of rhabdoid tu...
Article
Superparamagnetic iron oxide nanoparticles (SPIONs) have been receiving great attention lately in biomedical applications, such as in magnetic resonance imaging and drug delivery. However, their systemic administration still remains a challenge due to their hydrophobic nature with instances of aggregation leading to fast reticuloendothelial system...
Article
Full-text available
The enormous complexity of human body offers scope to conceptualize its dynamic organization in a number of ways such as structural, biochemical, functional, etc. The conventional western medicine views the body from a structural perspective, whereas ayurveda, the ancient medical system of India, understands the human body from the perspective of f...
Article
Full-text available
Relaxation time measurements were carried out during the preacute stage of lesion progression in an animal model of demyelination created in the internal capsule (ic) area of the rat brain using lysophosphatidyl choline (LPC). T1 and T2 were determined both before and after 36 h of lesion creation. Histology carried out on the rats after MR measure...
Article
Full-text available
In the last three decades a range of non-invasive biophysical techniques have been developed, of which Magnetic Resonance (MR) has proved to be the most versatile. Its non-invasive and safe nature has made it the most important diagnostic and research tool in clinical medicine. MR Spectroscopy (MRS) is the only technique in clinical medicine that p...
Article
This study reports in vivo and in vitro magnetic resonance spectroscopic findings in two cases of central neurocytomas (CNC) confirmed by immunohistochemistry. Volume localized in vivo proton magnetic resonance spectroscopy (MRS) was carried out before surgery using a point resolved spectroscopy (PRESS) sequence with a repetition time of six second...
Article
Full-text available
The chemical shift difference between the water resonance and the methyl resonance of N-acetylaspartate was used to determine the in vivo temperature in 43 patients with histologically proven brain tumors. Temperatures were also estimated from the contralateral side in 15 of these patients. There was a significant difference (p < 0.05) ] in tempera...
Article
Full-text available
Chemical asymmetries in normal human brain were studied using the non-invasive technique of volume localized proton magnetic resonance spectroscopy (MRS). The technique of STEAM was used to acquire water-suppressed proton spectra from 8 ml voxels placed in bilaterally symmetrical positions in the two hemispheres of the brain. One hundred and sixty...
Article
Full-text available
To differentiate the surrounding edema from the focal demyelinating lesion during the early phase of the lesion using an apparent diffusion coefficient (ADC), and to monitor the changes in ADCs during the complete progression of a lysophosphatidyl choline (LPC)-induced experimental demyelinating lesion, an animal model of multiple sclerosis (MS). E...
Article
Full-text available
Metabolite changes in rat brain internal capsule (ic) area were monitored using volume localized in vivo proton MR spectroscopy (MRS) in a lysophosphatidyl choline (LPC)-induced experimental demyelinating lesion model of multiple sclerosis (MS), during the early phase (pre-acute) as well as during the complete pathological cycle of de- and re-myeli...
Article
Volume localized proton Magnetic Resonance Spectroscopy was carried out in both the left and right basal ganglia of three patients with clinically proven Wilson's Disease. While the untreated patient died 15 days after the spectroscopy study, the other 2 patients have been under treatment and have shown clinical improvement. The spectral features o...
Article
Full-text available
Hyperthermia is an experimental/adjuvant therapeutic modality for cancer. Combining hyperthermia with the non-invasive metabolic studies using magnetic resonance (MR) is an interesting area of research and can provide useful information. In this paper, feasibility of using the same radio frequency source for carrying out combined hyperthermia and M...
Article
Combining hyperthermia, an experimental/adjuvant therapeutic modality for cancer, with the non-invasive metabolic studies using Magnetic Resonance (MR) is an interesting area of research. This two parts article discusses the development and testing of a conventional RF hyperthermia applicator for MR studies and vice versa. In this first part, an in...
Article
Single loop surface coil, often used in MR studies, was evaluated for its performance as an inductive hyperthermic applicator. The heat deposition pattern produced by the surface coil at 84 MHz and 34 MHz was mapped in muscle-mimicking agar phantoms. Temperatures were measured simultaneously at 64 points using multiple-junction thermocouples.
Article
31P-magnetic resonance spectroscopy (MRS) and a fiberoptic pH meter were used simultaneously to follow the changes in intra- (pHi) and extracellular pH (pHe), respectively, of murine RIF-1 tumors with hyperthermia. Hyperthermia was induced at 34 MHz using the same coil used for MR. The study was carried out until 3.5 hr after hyperthermia. In untre...
Article
This study presents the development and testing of an experimental set-up for simultaneous measurements of pH (intracellular by MR and extracellular by fibre-optic pH meter), tumour bio-energetics (by MR), and core/tumour temperatures (by thermocouples) in tumour-bearing mice. Potential sources of measurement errors when using these techniques conc...
Article
Full-text available
Intracranial inflammatory lesions consisting mainly of tuberculomas (n = 28), neurocysticercosis (NCC) (n = 10), and non-specific inflammatory granulomas (IG) (n = 22) were evaluated with proton MRS. Water-suppressed proton spectra were acquired from 60 patients using the STEAM sequence with an echo time of 135 ms and metabolite ratios determined f...
Article
Full-text available
Hyperthermic oncology deals with selective tumour cell killing by induced local or general heating to temperatures between 41°C and 45°C. The technique of magnetic resonance (MR) has been used for the non-invasive study of metabolic changes occurring as a result of hyperthermia, as well as for delivering hyperthermia using the radiofrequency coils...
Article
Full-text available
Evaluation of the pituitary gland has been carried out in idiopathic hypogonadotropic hypogonadism (IHH) to test the potential of MR imaging in differentiating IHH patients from normals. Thirty-seven patients (aged 18-30 years), and 20 volunteers (aged 20-30 years) were studied by T1-weighted MR imaging. Length (LA and LP), height (H), width (W), a...
Article
The effects of pentobarbital anesthetic and physical restraint have been evaluated in murine RIF-1 tumors in terms of their suitability in providing minimal temporal variations in core and tumor temperatures, intracellular (pHMR) and extracellular (pHF) tumor pH, and tumor bioenergetics. pHF was measured using a fibreoptic pH probe. The implication...
Article
In-vivo proton magnetic resonance imaging and relaxation time measurements were carried out on raw and cooked eggs. The relaxation time measurements revealed several interesting results. While there was very little change in the T1 values between the raw and cooked egg white, the T2 values followed the decreasing trend expected of water becoming bo...
Article
Although there is ample evidence in the literature for structural, functional and physiological asymmetries in the two hemispheres of human brain, direct evidence of a similar asymmetry in the in vivo distribution of brain metabolites has been lacking. In this study, the existence of chemical asymmetries in six different regions in normal human bra...
Article
Intramedullary (subpial) lipomas not associated with spinal dysraphism are very unusual [1]. A confident preoperative diagnosis is usually possible with MRI. We present a case of an isolated cervical intramedullary lipoma with unusual imaging morphology and imaging characteristics (distinctly low-signal on T2-weighted images) on MRI. An explanation...
Article
Proton Magnetic Resonance Spectroscopy was carried out at 1.5 T on a patient with histologically proven Pott's spine affecting D11 vertebral body. In addition to the significantly reduced signals from the lipids in the region between 1 and 2 ppm, a prominent resonance at 5.1 ppm is seen. The spectrum is very different from that recorded on the one...
Article
Proton magnetic resonance spectroscopy (MRS) was carried out on a patient with histologically proven non-Hodgkin lymphoma (NHL) of the central nervous system (CNS). The observation of the presence of a huge resonance in the region between 0.5-1.5 ppm and the absence of any other signals is not in agreement with those published for NHL in the litera...
Article
Although the measurement of the pH of biological systems using the 31P NMR response of inorganic phosphate is well known, sometimes in blood absolute determination of the intensity and position of the Pi resonance is precluded by overlap from the doublet resonance of 2,3-diphosphoglycerate. Three techniques which overcome this problem by eliminatin...

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